SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wxx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4wxx DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		5 / 12 GLY A1302
THR A1309
ALA A1335
GLY A1521
THR A1364
 None
 0.88A 1gtnL-4wxxA:
undetectable
1gtnV-4wxxA:
undetectable		 1gtnL-4wxxA:
4.84
1gtnV-4wxxA:
4.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_0
(MODIFICATION
METHYLASE RSRI)		 4wxx DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		5 / 12 ASP A1190
CYH A1191
PRO A1225
PHE A1145
GLY A1147
 SAH  A1706 (-3.3A)
SAH  A1706 (-3.8A)
SAH  A1706 ( 4.7A)
SAH  A1706 (-4.8A)
SAH  A1706 (-3.2A)
 0.55A 1nw5A-4wxxA:
5.5		 1nw5A-4wxxA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4wxx DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		4 / 6 GLY A1147
GLN A1575
TRP A1170
ALA A1174
 SAH  A1706 (-3.2A)
None
None
None
 1.02A 1p6kA-4wxxA:
undetectable		 1p6kA-4wxxA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R9O_A_FLPA501_1
(CYTOCHROME P450 2C9)		 4wxx DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		5 / 12 ASN A 462
ILE A 461
ASP A 376
GLY A 459
LEU A 407
 None
 1.09A 1r9oA-4wxxA:
undetectable		 1r9oA-4wxxA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_2
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 4wxx DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		3 / 3 LEU A1565
HIS A1573
ILE A1569
 None
 0.67A 1s9pB-4wxxA:
undetectable		 1s9pB-4wxxA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_L_TRPL81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4wxx DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		5 / 12 GLY A1521
THR A1364
GLY A1302
THR A1309
ALA A1335
 None
 0.86A 1utdL-4wxxA:
undetectable
1utdM-4wxxA:
undetectable		 1utdL-4wxxA:
4.84
1utdM-4wxxA:
4.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_O_TRPO81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4wxx DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		5 / 12 GLY A1521
THR A1364
GLY A1302
THR A1309
ALA A1335
 None
 0.88A 1utdO-4wxxA:
undetectable
1utdP-4wxxA:
undetectable		 1utdO-4wxxA:
4.84
1utdP-4wxxA:
4.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_P_TRPP81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4wxx DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		5 / 11 GLY A1521
THR A1364
GLY A1302
THR A1309
ALA A1335
 None
 0.88A 1utdP-4wxxA:
undetectable
1utdQ-4wxxA:
undetectable		 1utdP-4wxxA:
4.84
1utdQ-4wxxA:
4.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPM_A_SAMA300_0
(PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1))		 4wxx DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		5 / 12 PHE A1145
GLY A1147
GLY A1149
ASP A1190
PRO A1225
 SAH  A1706 (-4.8A)
SAH  A1706 (-3.2A)
SAH  A1706 ( 4.3A)
SAH  A1706 (-3.3A)
SAH  A1706 ( 4.7A)
 0.95A 2dpmA-4wxxA:
6.4		 2dpmA-4wxxA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMY_B_SAMB328_0
(PROTEIN
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI))		 4wxx DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		7 / 12 PHE A1145
GLY A1147
GLY A1150
ASP A1190
PRO A1225
LEU A1247
VAL A1580
 SAH  A1706 (-4.8A)
SAH  A1706 (-3.2A)
SAH  A1706 (-3.2A)
SAH  A1706 (-3.3A)
SAH  A1706 ( 4.7A)
SAH  A1706 (-4.6A)
SAH  A1706 (-4.4A)
 1.02A 2hmyB-4wxxA:
16.8		 2hmyB-4wxxA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_1
(MINERALOCORTICOID
RECEPTOR)		 4wxx DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		5 / 12 ALA A1579
GLN A1557
LEU A1584
THR A1163
PHE A1177
 SAH  A1706 (-4.0A)
None
None
None
None
 1.35A 2oaxF-4wxxA:
undetectable		 2oaxF-4wxxA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1104_0
(FERROCHELATASE)		 4wxx DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		3 / 3 LEU A1439
PRO A1440
LEU A1495
 None
 0.42A 2qd5B-4wxxA:
1.9		 2qd5B-4wxxA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1470_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 4wxx DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		4 / 5 ARG A 582
ALA A 699
ASP A 702
GLU A 703
 None
 1.38A 2xrzA-4wxxA:
undetectable		 2xrzA-4wxxA:
17.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AV6_A_SAMA1_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1)		 4wxx DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		12 / 12 PHE A1145
GLY A1147
GLY A1150
LEU A1151
MET A1169
TRP A1170
CYH A1191
PRO A1225
LEU A1247
ASN A1578
ALA A1579
VAL A1580
 SAH  A1706 (-4.8A)
SAH  A1706 (-3.2A)
SAH  A1706 (-3.2A)
SAH  A1706 (-3.9A)
SAH  A1706 (-3.9A)
None
SAH  A1706 (-3.8A)
SAH  A1706 ( 4.7A)
SAH  A1706 (-4.6A)
SAH  A1706 (-4.5A)
SAH  A1706 (-4.0A)
SAH  A1706 (-4.4A)
 0.26A 3av6A-4wxxA:
49.7		 3av6A-4wxxA:
82.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AV6_A_SAMA1_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1)		 4wxx DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		7 / 12 PHE A1145
GLY A1149
LEU A1151
PRO A1225
LEU A1247
ASN A1578
ALA A1579
 SAH  A1706 (-4.8A)
SAH  A1706 ( 4.3A)
SAH  A1706 (-3.9A)
SAH  A1706 ( 4.7A)
SAH  A1706 (-4.6A)
SAH  A1706 (-4.5A)
SAH  A1706 (-4.0A)
 1.02A 3av6A-4wxxA:
49.7		 3av6A-4wxxA:
82.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		 4wxx DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		3 / 3 HIS A1460
GLU A1480
HIS A1459
 None
 0.76A 3ba0A-4wxxA:
undetectable		 3ba0A-4wxxA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_0
(MODIFICATION
METHYLASE HHAI)		 4wxx DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		5 / 12 PHE A1145
GLY A1149
PRO A1225
LEU A1247
ASN A1578
 SAH  A1706 (-4.8A)
SAH  A1706 ( 4.3A)
SAH  A1706 ( 4.7A)
SAH  A1706 (-4.6A)
SAH  A1706 (-4.5A)
 0.95A 3eeoA-4wxxA:
18.3		 3eeoA-4wxxA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_0
(MODIFICATION
METHYLASE HHAI)		 4wxx DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		6 / 12 PHE A1145
GLY A1150
ASP A1190
PRO A1225
LEU A1247
ASN A1578
 SAH  A1706 (-4.8A)
SAH  A1706 (-3.2A)
SAH  A1706 (-3.3A)
SAH  A1706 ( 4.7A)
SAH  A1706 (-4.6A)
SAH  A1706 (-4.5A)
 0.79A 3eeoA-4wxxA:
18.3		 3eeoA-4wxxA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL6_A_NIMA614_1
(LACTOPEROXIDASE)		 4wxx DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		4 / 7 GLU A 877
GLU A1322
PHE A1262
PRO A1325
 None
 1.35A 3ql6A-4wxxA:
undetectable		 3ql6A-4wxxA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_E_9PLE1_1
(CYTOCHROME P450 2A13)		 4wxx DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		4 / 8 PHE A 628
ALA A 618
ASN A1245
PHE A1243
 None
 1.13A 3t3sE-4wxxA:
undetectable		 3t3sE-4wxxA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_D_SALD404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 4wxx DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		4 / 5 ASN A 383
ALA A 439
TYR A 486
ALA A 484
 None
 1.36A 3twpD-4wxxA:
undetectable		 3twpD-4wxxA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UGR_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 4wxx DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		5 / 12 LEU A1042
SER A1045
SER A1030
PHE A 948
PHE A 946
 None
 1.26A 3ugrA-4wxxA:
undetectable		 3ugrA-4wxxA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_1
(MNMC2)		 4wxx DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		4 / 6 GLY A1147
GLU A1168
ASP A1190
ASP A1143
 SAH  A1706 (-3.2A)
SAH  A1706 (-2.8A)
SAH  A1706 (-3.3A)
None
 0.84A 3vywC-4wxxA:
7.7		 3vywC-4wxxA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4wxx DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		3 / 3 LEU A1439
PRO A1440
LEU A1495
 None
 0.42A 3w1wB-4wxxA:
undetectable		 3w1wB-4wxxA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV1_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		 4wxx DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		3 / 3 LYS A 406
LYS A 440
PRO A 441
 None
 1.01A 4dv1L-4wxxA:
undetectable		 4dv1L-4wxxA:
7.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_F_ACTF402_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 4wxx DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		3 / 3 PHE A 545
ASP A 548
ARG A 552
 None
 0.71A 4eahF-4wxxA:
undetectable		 4eahF-4wxxA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_G_ACTG401_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 4wxx DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		3 / 3 PHE A 545
ASP A 548
ARG A 552
 None
 0.71A 4eahG-4wxxA:
undetectable		 4eahG-4wxxA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_0
(METHYLTRANSFERASE
NSUN4)		 4wxx DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		5 / 12 GLY A1149
GLY A1150
ASP A1190
PRO A1225
LEU A1247
 SAH  A1706 ( 4.3A)
SAH  A1706 (-3.2A)
SAH  A1706 (-3.3A)
SAH  A1706 ( 4.7A)
SAH  A1706 (-4.6A)
 0.85A 4fp9D-4wxxA:
7.2		 4fp9D-4wxxA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_0
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 4wxx DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		5 / 12 GLY A1149
GLY A1150
ASP A1190
PRO A1225
LEU A1247
 SAH  A1706 ( 4.3A)
SAH  A1706 (-3.2A)
SAH  A1706 (-3.3A)
SAH  A1706 ( 4.7A)
SAH  A1706 (-4.6A)
 0.89A 4fzvA-4wxxA:
6.8		 4fzvA-4wxxA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		 4wxx DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		5 / 12 LEU A1265
MET A1169
GLU A1168
ILE A1167
ALA A1166
 None
SAH  A1706 (-3.9A)
SAH  A1706 (-2.8A)
None
None
 1.08A 4ltwA-4wxxA:
undetectable		 4ltwA-4wxxA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4wxx DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		4 / 5 LEU A1513
ASP A 583
GLU A1531
VAL A1527
 None
 1.30A 4nkvA-4wxxA:
undetectable		 4nkvA-4wxxA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB102_1
(CHROMOBOX PROTEIN
HOMOLOG 7)		 4wxx DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		3 / 3 LYS A1275
ARG A1269
VAL A1268
 None
 0.96A 4x3uA-4wxxA:
1.0
4x3uB-4wxxA:
0.8		 4x3uA-4wxxA:
4.85
4x3uB-4wxxA:
4.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDQ_A_BEZA306_0
(GLYCOSIDE HYDROLASE
FAMILY PROTEIN)		 4wxx DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		3 / 3 ARG A1437
ASP A1435
TRP A1436
 None
 1.07A 4xdqA-4wxxA:
undetectable		 4xdqA-4wxxA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4wxx DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		5 / 12 GLY A1297
THR A1295
ASN A1353
ILE A1315
ILE A1588
 None
 1.05A 4zvmA-4wxxA:
3.1
4zvmB-4wxxA:
3.6		 4zvmA-4wxxA:
11.01
4zvmB-4wxxA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1R_A_STRA600_1
(CYTOCHROME P450 3A4)		 4wxx DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		4 / 5 PHE A1229
PHE A 628
PHE A1243
VAL A1248
 None
 1.18A 5a1rA-4wxxA:
undetectable		 5a1rA-4wxxA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_A_SAMA301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4wxx DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		5 / 12 ASP A1190
PRO A1225
PHE A1145
GLY A1147
GLU A1168
 SAH  A1706 (-3.3A)
SAH  A1706 ( 4.7A)
SAH  A1706 (-4.8A)
SAH  A1706 (-3.2A)
SAH  A1706 (-2.8A)
 0.57A 5hfjA-4wxxA:
5.9		 5hfjA-4wxxA:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_D_SAMD301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4wxx DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		5 / 12 ASP A1190
PRO A1225
PHE A1145
GLY A1147
GLU A1168
 SAH  A1706 (-3.3A)
SAH  A1706 ( 4.7A)
SAH  A1706 (-4.8A)
SAH  A1706 (-3.2A)
SAH  A1706 (-2.8A)
 0.51A 5hfjD-4wxxA:
undetectable		 5hfjD-4wxxA:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_F_SAMF301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4wxx DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		5 / 12 ASP A1190
PRO A1225
PHE A1145
GLY A1147
GLU A1168
 SAH  A1706 (-3.3A)
SAH  A1706 ( 4.7A)
SAH  A1706 (-4.8A)
SAH  A1706 (-3.2A)
SAH  A1706 (-2.8A)
 0.53A 5hfjF-4wxxA:
3.9		 5hfjF-4wxxA:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HJI_A_ADNA401_1
(TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A)		 4wxx DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		5 / 11 PHE A1145
GLY A1147
GLU A1168
ASP A1190
PRO A1225
 SAH  A1706 (-4.8A)
SAH  A1706 (-3.2A)
SAH  A1706 (-2.8A)
SAH  A1706 (-3.3A)
SAH  A1706 ( 4.7A)
 0.66A 5hjiA-4wxxA:
4.7		 5hjiA-4wxxA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4wxx DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		5 / 12 ILE A1314
PHE A1263
ALA A1317
SER A1161
ILE A1160
 None
 1.36A 5iwuA-4wxxA:
undetectable		 5iwuA-4wxxA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_A_ACTA803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 4wxx DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		4 / 4 GLU A1591
PRO A1325
ILE A1592
LEU A1594
 None
 1.27A 5m45A-4wxxA:
undetectable		 5m45A-4wxxA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_D_ACTD803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 4wxx DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		4 / 4 GLU A1591
PRO A1325
ILE A1592
LEU A1594
 None
 1.24A 5m45D-4wxxA:
undetectable		 5m45D-4wxxA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_G_ACTG803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 4wxx DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		4 / 4 GLU A1591
PRO A1325
ILE A1592
LEU A1594
 None
 1.25A 5m45G-4wxxA:
undetectable		 5m45G-4wxxA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_J_ACTJ803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 4wxx DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		4 / 4 GLU A1591
PRO A1325
ILE A1592
LEU A1594
 None
 1.24A 5m45J-4wxxA:
undetectable		 5m45J-4wxxA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 4wxx DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		5 / 12 VAL A1479
HIS A1459
ARG A 974
PRO A1501
LEU A1455
 None
 1.37A 5m50B-4wxxA:
5.0		 5m50B-4wxxA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4wxx DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		3 / 3 SER A1418
ALA A1419
THR A1450
 None
 0.61A 5n0xB-4wxxA:
2.9		 5n0xB-4wxxA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGC_B_TA1B601_1
(TUBULIN BETA CHAIN)		 4wxx DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		5 / 12 ASP A 470
GLU A 473
PRO A 537
GLY A 539
LEU A 540
 None
 0.97A 5ogcB-4wxxA:
4.5		 5ogcB-4wxxA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 4wxx DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		3 / 3 ASP A1067
PHE A1085
ARG A 995
 None
 1.13A 5yw0A-4wxxA:
undetectable		 5yw0A-4wxxA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MHT_D_SAMD328_0
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI)		 4wxx DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens) 		6 / 12 PHE A1145
GLY A1147
GLY A1150
ASP A1190
ASN A1578
VAL A1580
 SAH  A1706 (-4.8A)
SAH  A1706 (-3.2A)
SAH  A1706 (-3.2A)
SAH  A1706 (-3.3A)
SAH  A1706 (-4.5A)
SAH  A1706 (-4.4A)
 0.93A 6mhtA-4wxxA:
16.4		 6mhtA-4wxxA:
13.52