SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wxz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_B_KANB559_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 4wxz PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Geobacillus
kaustophilus) 		4 / 8 GLU A 141
LYS A 118
ASP A 131
GLU A 103
 None
 1.16A 1knyA-4wxzA:
undetectable
1knyB-4wxzA:
undetectable		 1knyA-4wxzA:
22.86
1knyB-4wxzA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDT_A_VIAA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4wxz PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Geobacillus
kaustophilus) 		5 / 12 ASN A  27
ALA A  39
ILE A  76
VAL A  25
ALA A  44
 None
 1.26A 1udtA-4wxzA:
undetectable		 1udtA-4wxzA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4wxz PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Geobacillus
kaustophilus) 		3 / 3 HIS A 226
ASP A 220
ASN A 156
 None
 0.77A 1wg8B-4wxzA:
undetectable		 1wg8B-4wxzA:
26.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB927_0
(FERROCHELATASE)		 4wxz PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Geobacillus
kaustophilus) 		3 / 3 LEU A 205
PRO A 206
ARG A 138
 None
None
LRK  A 149 ( 3.0A)
 0.65A 2qd4B-4wxzA:
2.4		 2qd4B-4wxzA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL6_A_NIMA614_1
(LACTOPEROXIDASE)		 4wxz PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Geobacillus
kaustophilus) 		4 / 7 GLU A  46
ARG A  60
GLU A  89
PRO A  64
 None
 1.35A 3ql6A-4wxzA:
undetectable		 3ql6A-4wxzA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA2)		 4wxz PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Geobacillus
kaustophilus) 		4 / 6 SER A 104
ARG A 147
GLY A 214
GLY A 153
 L5P  A  81 ( 3.8A)
None
L5P  A  81 ( 3.7A)
L5P  A  81 ( 3.8A)
 0.86A 4koeA-4wxzA:
undetectable
4koeB-4wxzA:
undetectable
4koeC-4wxzA:
undetectable		 4koeA-4wxzA:
21.33
4koeB-4wxzA:
21.33
4koeC-4wxzA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA4)		 4wxz PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Geobacillus
kaustophilus) 		4 / 7 ARG A 147
SER A 104
GLY A 214
GLY A 153
 None
L5P  A  81 ( 3.8A)
L5P  A  81 ( 3.7A)
L5P  A  81 ( 3.8A)
 0.86A 4koeA-4wxzA:
undetectable
4koeB-4wxzA:
undetectable
4koeD-4wxzA:
undetectable		 4koeA-4wxzA:
21.33
4koeB-4wxzA:
21.33
4koeD-4wxzA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_1
(ANDROGEN RECEPTOR)		 4wxz PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Geobacillus
kaustophilus) 		5 / 12 LEU A  93
LEU A  96
GLY A  97
MET A  71
VAL A  70
 None
 1.07A 4olmA-4wxzA:
undetectable		 4olmA-4wxzA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4wxz PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Geobacillus
kaustophilus) 		5 / 9 ILE A 116
LEU A  45
LEU A  93
ILE A  67
PHE A 125
 None
L5P  A  81 ( 4.8A)
None
None
None
 1.32A 4r38C-4wxzA:
undetectable		 4r38C-4wxzA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 4wxz PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Geobacillus
kaustophilus) 		4 / 6 GLY A 214
GLY A 153
SER A 104
ARG A 147
 L5P  A  81 ( 3.7A)
L5P  A  81 ( 3.8A)
L5P  A  81 ( 3.8A)
None
 0.83A 4z53A-4wxzA:
undetectable
4z53B-4wxzA:
undetectable		 4z53A-4wxzA:
18.45
4z53B-4wxzA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 4wxz PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Geobacillus
kaustophilus) 		4 / 7 ARG A 147
GLY A 214
GLY A 153
SER A 104
 None
L5P  A  81 ( 3.7A)
L5P  A  81 ( 3.8A)
L5P  A  81 ( 3.8A)
 0.81A 4z53A-4wxzA:
undetectable
4z53B-4wxzA:
undetectable		 4z53A-4wxzA:
18.45
4z53B-4wxzA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_1
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 4wxz PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Geobacillus
kaustophilus) 		5 / 12 ALA A 191
VAL A 193
GLN A 188
MET A 177
GLU A 181
 None
 1.35A 4zj8A-4wxzA:
undetectable		 4zj8A-4wxzA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5K_B_017B201_2
(HIV-1 PROTEASE)		 4wxz PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Geobacillus
kaustophilus) 		5 / 12 LEU A 223
GLY A 228
ALA A 229
ASP A 230
ILE A 157
 None
 0.69A 5e5kB-4wxzA:
undetectable		 5e5kB-4wxzA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 4wxz PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS
(Geobacillus
kaustophilus) 		5 / 12 ALA A 211
GLY A 231
ALA A 160
ALA A 221
PRO A 152
 None
None
None
None
L5P  A  81 ( 4.2A)
 1.02A 5jglB-4wxzA:
undetectable		 5jglB-4wxzA:
19.50