SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wy4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB501_1
(CYTOCHROME P450 2C8)		 4wy4 SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 29
SYNTAXIN-17
VESICLE-ASSOCIATED
MEMBRANE PROTEIN 8
(Homo
sapiens) 		5 / 9 ARG A  37
GLY A  38
ILE D 227
VAL B 193
VAL B 186
 None
 1.24A 2nnhB-4wy4A:
undetectable		 2nnhB-4wy4A:
8.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_A_J01A500_1
(ORF12)		 4wy4 SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 29
(Homo
sapiens) 		5 / 10 VAL C  75
ILE D 219
LEU C  64
LEU D 216
GLY D 212
 None
 1.21A 2xf3A-4wy4C:
undetectable		 2xf3A-4wy4C:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_A_EAAA214_1
(GLUTATHIONE
S-TRANSFERASE P)		 4wy4 SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 29
SYNTAXIN-17
(Homo
sapiens) 		5 / 9 PHE B 189
VAL B 186
VAL B 193
GLN C  84
GLY C  74
 None
 1.27A 3kmoA-4wy4B:
undetectable		 3kmoA-4wy4B:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 4wy4 VESICLE-ASSOCIATED
MEMBRANE PROTEIN 8
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 29
(Homo
sapiens;
Homo
sapiens) 		3 / 3 ASP D 218
ASN A  30
GLN D 224
 None
 0.76A 5k7uA-4wy4D:
undetectable		 5k7uA-4wy4D:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_A_ADNA502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 4wy4 SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 29
SYNTAXIN-17
VESICLE-ASSOCIATED
MEMBRANE PROTEIN 8
(Homo
sapiens) 		4 / 4 GLU B 215
THR B 218
THR A  54
LEU D 244
 None
 1.45A 5v96A-4wy4B:
undetectable		 5v96A-4wy4B:
9.42