SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wy5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)		 4wy5 ESTERASE
(Rhizomucor
miehei) 		6 / 12 GLY A  88
GLY A  89
GLY A  90
SER A 161
PHE A 221
HIS A 292
 None
 0.84A 1dx6A-4wy5A:
18.6		 1dx6A-4wy5A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		 4wy5 ESTERASE
(Rhizomucor
miehei) 		6 / 12 GLY A  88
GLY A  89
GLY A  90
SER A 161
PHE A 221
HIS A 292
 None
 0.86A 1qtiA-4wy5A:
4.0		 1qtiA-4wy5A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W6R_A_GNTA1536_1
(ACETYLCHOLINESTERASE)		 4wy5 ESTERASE
(Rhizomucor
miehei) 		6 / 12 GLY A  88
GLY A  89
GLY A  90
SER A 161
PHE A 221
HIS A 292
 None
 0.84A 1w6rA-4wy5A:
18.3		 1w6rA-4wy5A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_A_GNTA1538_1
(ACETYLCHOLINESTERASE)		 4wy5 ESTERASE
(Rhizomucor
miehei) 		5 / 11 GLY A  89
GLY A  90
SER A 161
PHE A 221
HIS A 292
 None
 0.89A 1w76A-4wy5A:
17.3		 1w76A-4wy5A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)		 4wy5 ESTERASE
(Rhizomucor
miehei) 		5 / 10 GLY A  88
GLY A  89
SER A 161
PHE A 221
HIS A 292
 None
 0.82A 1w76B-4wy5A:
17.3		 1w76B-4wy5A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACE_A_ACHA998_0
(ACETYLCHOLINESTERASE)		 4wy5 ESTERASE
(Rhizomucor
miehei) 		6 / 9 GLY A  89
GLY A  90
SER A 161
ALA A 162
PHE A 221
HIS A 292
 None
 0.90A 2aceA-4wy5A:
4.9		 2aceA-4wy5A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_C_SALC4006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4wy5 ESTERASE
(Rhizomucor
miehei) 		4 / 6 THR A 114
VAL A 113
LEU A  80
ALA A 110
 None
 1.05A 2e1qC-4wy5A:
undetectable		 2e1qC-4wy5A:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACTA544_0
(ACETYLCHOLINESTERASE)		 4wy5 ESTERASE
(Rhizomucor
miehei) 		5 / 8 GLY A  89
GLY A  90
ALA A 162
PHE A 221
HIS A 292
 None
 0.95A 2ha4A-4wy5A:
19.2		 2ha4A-4wy5A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACTB601_0
(ACETYLCHOLINESTERASE)		 4wy5 ESTERASE
(Rhizomucor
miehei) 		5 / 7 GLY A  89
GLY A  90
ALA A 162
PHE A 221
HIS A 292
 None
 0.95A 2ha4B-4wy5A:
19.3		 2ha4B-4wy5A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_A_MXDA551_1
(PROSTACYCLIN
SYNTHASE)		 4wy5 ESTERASE
(Rhizomucor
miehei) 		4 / 6 TYR A 271
ALA A 272
LEU A 275
THR A 185
 None
 0.75A 3b6hA-4wy5A:
undetectable		 3b6hA-4wy5A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_B_MXDB551_1
(PROSTACYCLIN
SYNTHASE)		 4wy5 ESTERASE
(Rhizomucor
miehei) 		4 / 6 TYR A 271
ALA A 272
LEU A 275
THR A 185
 None
 0.87A 3b6hB-4wy5A:
undetectable		 3b6hB-4wy5A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHX_B_PXLB313_1
(PYRIDOXAL KINASE)		 4wy5 ESTERASE
(Rhizomucor
miehei) 		4 / 8 SER A  95
THR A  68
TYR A  97
VAL A 103
 None
 1.05A 3fhxB-4wy5A:
2.8		 3fhxB-4wy5A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM201_1
(PROTEIN S100-A4)		 4wy5 ESTERASE
(Rhizomucor
miehei) 		4 / 7 GLY A  88
PHE A 306
GLY A 293
PHE A 294
 None
 0.94A 3ko0M-4wy5A:
undetectable
3ko0P-4wy5A:
undetectable		 3ko0M-4wy5A:
13.62
3ko0P-4wy5A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6W_A_SAMA465_0
(RRNA METHYLASE)		 4wy5 ESTERASE
(Rhizomucor
miehei) 		5 / 12 ALA A 137
GLY A  62
LYS A  63
VAL A 141
VAL A 157
 None
 0.97A 3m6wA-4wy5A:
2.5		 3m6wA-4wy5A:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_1
(CYTOCHROME P450 3A4)		 4wy5 ESTERASE
(Rhizomucor
miehei) 		5 / 12 LEU A 106
PHE A  85
ILE A 295
ILE A  46
ALA A  44
 None
 0.99A 3nxuA-4wy5A:
undetectable		 3nxuA-4wy5A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_1
(CYTOCHROME P450 3A4)		 4wy5 ESTERASE
(Rhizomucor
miehei) 		5 / 12 LEU A 106
PHE A  85
ILE A 295
ILE A  46
ALA A  44
 None
 1.02A 3nxuB-4wy5A:
undetectable		 3nxuB-4wy5A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_A_BEZA999_0
(CHOLINESTERASE)		 4wy5 ESTERASE
(Rhizomucor
miehei) 		5 / 7 GLY A  89
GLY A  90
SER A 161
LEU A 218
HIS A 292
 None
 0.73A 3o9mA-4wy5A:
4.1		 3o9mA-4wy5A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_B_BEZB999_0
(CHOLINESTERASE)		 4wy5 ESTERASE
(Rhizomucor
miehei) 		5 / 6 GLY A  89
GLY A  90
SER A 161
LEU A 218
HIS A 292
 None
 0.76A 3o9mB-4wy5A:
8.3		 3o9mB-4wy5A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXZ_A_0LIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4wy5 ESTERASE
(Rhizomucor
miehei) 		5 / 9 LEU A 188
VAL A 113
ILE A  84
ARG A 104
VAL A 312
 None
None
None
SO4  A 402 (-3.7A)
None
 1.45A 3oxzA-4wy5A:
undetectable		 3oxzA-4wy5A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_B_9PLB501_1
(CYTOCHROME P450 2E1)		 4wy5 ESTERASE
(Rhizomucor
miehei) 		4 / 6 LEU A 242
ALA A 192
THR A 165
LEU A 226
 None
 0.98A 3t3zB-4wy5A:
undetectable		 3t3zB-4wy5A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_D_9PLD501_1
(CYTOCHROME P450 2E1)		 4wy5 ESTERASE
(Rhizomucor
miehei) 		4 / 6 LEU A 242
ALA A 192
THR A 165
LEU A 226
 None
 0.99A 3t3zD-4wy5A:
undetectable		 3t3zD-4wy5A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_A_RITA401_2
(SECRETED ASPARTIC
PROTEASE)		 4wy5 ESTERASE
(Rhizomucor
miehei) 		4 / 6 PRO A  72
SER A 147
VAL A  82
THR A  75
 None
 1.06A 3tneA-4wy5A:
undetectable		 3tneA-4wy5A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_A_GNTA604_1
(ACETYLCHOLINESTERASE)		 4wy5 ESTERASE
(Rhizomucor
miehei) 		6 / 12 GLY A  88
GLY A  89
GLY A  90
SER A 161
PHE A 221
HIS A 292
 None
 0.85A 4ey6A-4wy5A:
8.2		 4ey6A-4wy5A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY6_B_GNTB605_1
(ACETYLCHOLINESTERASE)		 4wy5 ESTERASE
(Rhizomucor
miehei) 		6 / 12 GLY A  88
GLY A  89
GLY A  90
SER A 161
PHE A 221
HIS A 292
 None
 0.84A 4ey6B-4wy5A:
17.7		 4ey6B-4wy5A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LJ0_A_ACTA505_0
(NAB2)		 4wy5 ESTERASE
(Rhizomucor
miehei) 		3 / 3 LEU A 242
LYS A 236
THR A 239
 None
 0.63A 4lj0A-4wy5A:
undetectable		 4lj0A-4wy5A:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE3_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4wy5 ESTERASE
(Rhizomucor
miehei) 		4 / 7 ILE A 134
PHE A  91
GLY A 163
LEU A 240
 None
 0.82A 4ze3A-4wy5A:
undetectable		 4ze3A-4wy5A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4wy5 ESTERASE
(Rhizomucor
miehei) 		4 / 8 SER A 161
ALA A 162
HIS A 292
LEU A 218
 None
 1.17A 5dzkd-4wy5A:
undetectable
5dzkr-4wy5A:
undetectable		 5dzkd-4wy5A:
24.16
5dzkr-4wy5A:
0.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 4wy5 ESTERASE
(Rhizomucor
miehei) 		5 / 12 VAL A  92
GLY A  88
PHE A  93
VAL A 263
LEU A 218
 None
 1.14A 5ergB-4wy5A:
2.3		 5ergB-4wy5A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_C_RAPC999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 4wy5 ESTERASE
(Rhizomucor
miehei) 		4 / 8 GLU A 267
SER A 202
PHE A 206
GLY A 207
 None
 0.84A 5flcB-4wy5A:
undetectable		 5flcB-4wy5A:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_G_RAPG999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 4wy5 ESTERASE
(Rhizomucor
miehei) 		4 / 8 GLU A 267
SER A 202
PHE A 206
GLY A 207
 None
 0.84A 5flcF-4wy5A:
undetectable		 5flcF-4wy5A:
15.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6IEY_A_CLMA401_0
(ESTERASE)		 4wy5 ESTERASE
(Rhizomucor
miehei) 		5 / 11 HIS A  99
ASP A 160
LEU A 213
HIS A 292
GLY A 293
 None
 0.63A 6ieyA-4wy5A:
34.8
6ieyB-4wy5A:
34.9		 6ieyA-4wy5A:
36.18
6ieyB-4wy5A:
36.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA605_0
(SERUM ALBUMIN)		 4wy5 ESTERASE
(Rhizomucor
miehei) 		4 / 8 LYS A 245
GLY A 250
LEU A 251
GLU A 176
 None
 0.72A 6mdqA-4wy5A:
undetectable		 6mdqA-4wy5A:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4wy5 ESTERASE
(Rhizomucor
miehei) 		4 / 7 ARG A 265
GLU A 269
ASP A 266
GLU A 201
 SO4  A 401 (-3.6A)
None
None
SO4  A 401 ( 4.7A)
 1.32A 6mn4F-4wy5A:
undetectable		 6mn4F-4wy5A:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_D_LLLD301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4wy5 ESTERASE
(Rhizomucor
miehei) 		4 / 6 ARG A 265
GLU A 269
ASP A 266
GLU A 201
 SO4  A 401 (-3.6A)
None
None
SO4  A 401 ( 4.7A)
 1.29A 6mn5D-4wy5A:
undetectable		 6mn5D-4wy5A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4wy5 ESTERASE
(Rhizomucor
miehei) 		4 / 7 ARG A 265
GLU A 269
ASP A 266
GLU A 201
 SO4  A 401 (-3.6A)
None
None
SO4  A 401 ( 4.7A)
 1.33A 6mn5E-4wy5A:
undetectable		 6mn5E-4wy5A:
16.67