SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wyi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_D_SAMD200_0
(METHIONINE REPRESSOR)		 4wyi MONOGALACTOSYLDIACYL
GLYCEROL SYNTHASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 ALA A 483
PHE A 486
GLY A 487
LEU A 369
ALA A 372
 None
 1.08A 1mjqC-4wyiA:
undetectable
1mjqD-4wyiA:
undetectable		 1mjqC-4wyiA:
14.44
1mjqD-4wyiA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_J_SAMJ200_0
(METHIONINE REPRESSOR)		 4wyi MONOGALACTOSYLDIACYL
GLYCEROL SYNTHASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 ALA A 483
PHE A 486
GLY A 487
LEU A 369
ALA A 372
 None
 1.08A 1mjqI-4wyiA:
undetectable
1mjqJ-4wyiA:
undetectable		 1mjqI-4wyiA:
14.44
1mjqJ-4wyiA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2888_0
(AMINOMETHYLTRANSFERA
SE)		 4wyi MONOGALACTOSYLDIACYL
GLYCEROL SYNTHASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 10 LEU A 373
LEU A 369
ILE A 406
ILE A 414
LEU A 352
 None
 1.15A 1wopA-4wyiA:
undetectable		 1wopA-4wyiA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_D_CHDD702_0
(FERROCHELATASE)		 4wyi MONOGALACTOSYLDIACYL
GLYCEROL SYNTHASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		3 / 3 ARG A 324
GLY A 434
PRO A 433
 None
 0.72A 2hreD-4wyiA:
5.1		 2hreD-4wyiA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4wyi MONOGALACTOSYLDIACYL
GLYCEROL SYNTHASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 6 PRO A 461
ILE A 436
ASN A 466
LEU A 503
 None
 1.38A 2wekB-4wyiA:
5.1		 2wekB-4wyiA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_D_LOCD502_1
(TUBULIN BETA CHAIN)		 4wyi MONOGALACTOSYLDIACYL
GLYCEROL SYNTHASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 LEU A 493
MET A 421
ALA A 439
ALA A 500
ILE A 427
 None
 1.18A 3ut5D-4wyiA:
3.9		 3ut5D-4wyiA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_2
(ANDROGEN RECEPTOR)		 4wyi MONOGALACTOSYLDIACYL
GLYCEROL SYNTHASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 6 ASN A 449
MET A 417
LEU A 351
VAL A 482
 None
 1.12A 4okbA-4wyiA:
undetectable		 4okbA-4wyiA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_D_LOCD502_1
(TUBULIN BETA CHAIN)		 4wyi MONOGALACTOSYLDIACYL
GLYCEROL SYNTHASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 LEU A 493
MET A 421
ALA A 439
ALA A 500
ILE A 427
 None
 1.16A 4x1iD-4wyiA:
4.0		 4x1iD-4wyiA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_2
(TUBULIN BETA CHAIN)		 4wyi MONOGALACTOSYLDIACYL
GLYCEROL SYNTHASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 LEU A 493
MET A 421
ALA A 439
ALA A 500
ILE A 427
 None
 1.16A 4x1kD-4wyiA:
3.9		 4x1kD-4wyiA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4wyi MONOGALACTOSYLDIACYL
GLYCEROL SYNTHASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 5 SER A 158
ALA A 159
HIS A 155
MET A 148
 None
 1.45A 5dzkb-4wyiA:
2.7
5dzkp-4wyiA:
undetectable		 5dzkb-4wyiA:
20.99
5dzkp-4wyiA:
1.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4wyi MONOGALACTOSYLDIACYL
GLYCEROL SYNTHASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 5 SER A 158
ALA A 161
HIS A 155
LEU A 321
 None
 1.42A 5dzkb-4wyiA:
2.7
5dzkp-4wyiA:
undetectable		 5dzkb-4wyiA:
20.99
5dzkp-4wyiA:
1.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Q_BEZQ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4wyi MONOGALACTOSYLDIACYL
GLYCEROL SYNTHASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 5 SER A 158
ALA A 159
HIS A 155
MET A 148
 None
 1.45A 5dzkc-4wyiA:
1.9
5dzkq-4wyiA:
undetectable		 5dzkc-4wyiA:
20.99
5dzkq-4wyiA:
1.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Q_BEZQ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4wyi MONOGALACTOSYLDIACYL
GLYCEROL SYNTHASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 5 SER A 158
ALA A 161
HIS A 155
LEU A 321
 None
 1.46A 5dzkc-4wyiA:
1.9
5dzkq-4wyiA:
undetectable		 5dzkc-4wyiA:
20.99
5dzkq-4wyiA:
1.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4wyi MONOGALACTOSYLDIACYL
GLYCEROL SYNTHASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 5 SER A 158
ALA A 159
HIS A 155
MET A 148
 None
 1.46A 5dzkf-4wyiA:
2.6
5dzkt-4wyiA:
undetectable		 5dzkf-4wyiA:
20.99
5dzkt-4wyiA:
1.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4wyi MONOGALACTOSYLDIACYL
GLYCEROL SYNTHASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 5 SER A 158
ALA A 161
HIS A 155
LEU A 321
 None
 1.38A 5dzkf-4wyiA:
2.6
5dzkt-4wyiA:
undetectable		 5dzkf-4wyiA:
20.99
5dzkt-4wyiA:
1.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB201_0
(HYDROXYNITRILE LYASE)		 4wyi MONOGALACTOSYLDIACYL
GLYCEROL SYNTHASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 11 VAL A 176
PHE A 166
ILE A 512
ILE A 162
TYR A 296
 None
 1.12A 5e4dB-4wyiA:
undetectable		 5e4dB-4wyiA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_C_ACTC1740_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT)		 4wyi MONOGALACTOSYLDIACYL
GLYCEROL SYNTHASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 4 VAL A 331
GLU A 418
GLY A 422
LEU A 337
 None
 1.09A 5g5gC-4wyiA:
undetectable		 5g5gC-4wyiA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_2
(TUBULIN BETA-2B
CHAIN)		 4wyi MONOGALACTOSYLDIACYL
GLYCEROL SYNTHASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 LEU A 493
MET A 421
ALA A 439
ALA A 500
ILE A 427
 None
 1.19A 5nm5B-4wyiA:
5.1		 5nm5B-4wyiA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA411_0
(UNCHARACTERIZED
PROTEIN KDOO)		 4wyi MONOGALACTOSYLDIACYL
GLYCEROL SYNTHASE 1,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		3 / 3 LYS A 398
LEU A 402
ARG A 367
 None
 0.93A 5yw0A-4wyiA:
undetectable		 5yw0A-4wyiA:
24.34