SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wyk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_B_VIBB501_1
(THIAMIN
PYROPHOSPHOKINASE)		 4wyk NTF2-RELATED EXPORT
PROTEIN 1
NUCLEAR RNA EXPORT
FACTOR 1
(Homo
sapiens) 		4 / 7 GLN B 136
ASP B 137
LEU A 370
SER B  98
 None
 1.18A 1ig3A-4wykB:
undetectable
1ig3B-4wykB:
undetectable		 1ig3A-4wykB:
18.25
1ig3B-4wykB:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P9G_A_ACTA42_0
(EAFP 2)		 4wyk NUCLEAR RNA EXPORT
FACTOR 1
NTF2-RELATED EXPORT
PROTEIN 1
(Homo
sapiens;
Homo
sapiens) 		3 / 3 CYH B  77
ARG A 440
CYH B  14
 None
 1.01A 1p9gA-4wykB:
undetectable		 1p9gA-4wykB:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4wyk NUCLEAR RNA EXPORT
FACTOR 1
(Homo
sapiens) 		3 / 3 LYS A 230
ASP A 352
CYH A 328
 None
 1.44A 2br4F-4wykA:
undetectable		 2br4F-4wykA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_F_SPMF1433_1
(NITROALKANE OXIDASE)		 4wyk NTF2-RELATED EXPORT
PROTEIN 1
NUCLEAR RNA EXPORT
FACTOR 1
(Homo
sapiens) 		5 / 11 LEU A 469
LEU A 455
SER A 417
LEU A 418
ASP B  76
 None
 1.28A 2c12F-4wykA:
undetectable		 2c12F-4wykA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CAS_A_ASDA332_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 4wyk NTF2-RELATED EXPORT
PROTEIN 1
(Homo
sapiens) 		5 / 10 TYR B  25
TYR B  39
VAL B  94
VAL B  93
LEU B 115
 None
 1.37A 3casA-4wykB:
undetectable		 3casA-4wykB:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ9_A_MTXA2001_1
(DIHYDROFOLATE
REDUCTASE)		 4wyk NUCLEAR RNA EXPORT
FACTOR 1
(Homo
sapiens) 		5 / 12 ALA A 255
LEU A 212
LEU A 247
LEU A 270
ILE A 260
 None
 0.97A 3tq9A-4wykA:
undetectable		 3tq9A-4wykA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQB_A_FOLA2001_0
(DIHYDROFOLATE
REDUCTASE)		 4wyk NUCLEAR RNA EXPORT
FACTOR 1
(Homo
sapiens) 		5 / 11 ALA A 255
LEU A 212
LEU A 247
LEU A 270
ILE A 260
 None
 1.08A 3tqbA-4wykA:
undetectable		 3tqbA-4wykA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 4wyk NUCLEAR RNA EXPORT
FACTOR 1
(Homo
sapiens) 		4 / 6 LEU A 270
LEU A 296
ILE A 312
MET A 283
 None
 1.01A 4do3B-4wykA:
undetectable		 4do3B-4wykA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4wyk NUCLEAR RNA EXPORT
FACTOR 1
(Homo
sapiens) 		3 / 3 ASP A 399
LEU A 534
ARG A 515
 None
 0.88A 5e8qA-4wykA:
undetectable		 5e8qA-4wykA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA504_1
(CYTOCHROME P450 2C9)		 4wyk NTF2-RELATED EXPORT
PROTEIN 1
(Homo
sapiens) 		4 / 8 PHE B  70
ILE B  72
PHE B 109
PHE B 113
 None
 0.65A 5x23A-4wykB:
undetectable		 5x23A-4wykB:
14.74