SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wyq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_C_ADNC2502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4wyq RISC-LOADING COMPLEX
SUBUNIT TARBP2
(Homo
sapiens) 		3 / 3 GLU B 328
THR B 335
LEU B 298
 None
 0.71A 1v8bC-4wyqB:
undetectable		 1v8bC-4wyqB:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR4_X_PNTX101_0
(PROTEIN S100-B)		 4wyq ENDORIBONUCLEASE
DICER
RISC-LOADING COMPLEX
SUBUNIT TARBP2
(Homo
sapiens;
Homo
sapiens) 		3 / 3 CYH B 337
HIS B 338
PHE A 353
 None
 1.00A 3cr4X-4wyqB:
undetectable		 3cr4X-4wyqB:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_A_ACTA1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 4wyq RISC-LOADING COMPLEX
SUBUNIT TARBP2
(Homo
sapiens) 		4 / 5 GLY B 349
ALA B 352
GLY B 291
PRO B 292
 None
 0.79A 4u9uA-4wyqB:
undetectable		 4u9uA-4wyqB:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_B_ACTB1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 4wyq RISC-LOADING COMPLEX
SUBUNIT TARBP2
(Homo
sapiens) 		4 / 5 GLY B 349
ALA B 352
GLY B 291
PRO B 292
 None
 0.80A 4u9uB-4wyqB:
undetectable		 4u9uB-4wyqB:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_E_MFXE2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4wyq RISC-LOADING COMPLEX
SUBUNIT TARBP2
(Homo
sapiens) 		4 / 5 SER B 302
ARG B 353
GLY B 349
GLU B 350
 None
 1.12A 5cdqA-4wyqB:
undetectable
5cdqB-4wyqB:
undetectable
5cdqC-4wyqB:
undetectable		 5cdqA-4wyqB:
10.73
5cdqB-4wyqB:
17.01
5cdqC-4wyqB:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_V_MFXV2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4wyq RISC-LOADING COMPLEX
SUBUNIT TARBP2
(Homo
sapiens) 		4 / 5 SER B 302
ARG B 353
GLY B 349
GLU B 350
 None
 1.11A 5cdqR-4wyqB:
undetectable
5cdqS-4wyqB:
undetectable
5cdqT-4wyqB:
undetectable		 5cdqR-4wyqB:
10.73
5cdqS-4wyqB:
17.01
5cdqT-4wyqB:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5INZ_D_DVAD2_0
(THETA DEFENSIN-2,
D-PEPTIDE
THETA DEFENSIN-2,
L-PEPTIDE)		 4wyq RISC-LOADING COMPLEX
SUBUNIT TARBP2
(Homo
sapiens) 		4 / 4 GLY B 339
CYH B 325
ARG B 354
GLY B 349
 None
 1.34A 5inzA-4wyqB:
undetectable
5inzC-4wyqB:
undetectable
5inzD-4wyqB:
undetectable		 5inzA-4wyqB:
13.64
5inzC-4wyqB:
13.64
5inzD-4wyqB:
13.64