SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wyr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_CCSB381_0
(ESTROGEN RECEPTOR)		 4wyr ACETYL-COA
ACETYLTRANSFERASE
(Clostridium
acetobutylicum) 		3 / 3 GLU A 188
ALA A 186
SER A 182
 None
 0.69A 1errB-4wyrA:
undetectable		 1errB-4wyrA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		 4wyr ACETYL-COA
ACETYLTRANSFERASE
(Clostridium
acetobutylicum) 		4 / 6 SER A 182
ILE A 344
ALA A 320
ALA A 327
 None
 0.89A 1w0gA-4wyrA:
undetectable		 1w0gA-4wyrA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_B_SAMB302_0
(RRNA
METHYLTRANSFERASE)		 4wyr ACETYL-COA
ACETYLTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 10 THR A  94
GLY A 114
GLY A 351
ILE A 387
LEU A 358
 None
 1.15A 1x7pA-4wyrA:
undetectable
1x7pB-4wyrA:
undetectable		 1x7pA-4wyrA:
22.71
1x7pB-4wyrA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		 4wyr ACETYL-COA
ACETYLTRANSFERASE
(Clostridium
acetobutylicum) 		4 / 4 LEU A 358
PRO A 271
ILE A 258
LEU A 256
 None
 0.85A 1ya4B-4wyrA:
undetectable		 1ya4B-4wyrA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		 4wyr ACETYL-COA
ACETYLTRANSFERASE
(Clostridium
acetobutylicum) 		4 / 4 LEU A 358
PRO A 271
ILE A 258
LEU A 256
 None
 0.93A 1ya4C-4wyrA:
undetectable		 1ya4C-4wyrA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4wyr ACETYL-COA
ACETYLTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 12 LEU A  21
GLY A  30
ASN A 117
ALA A  33
ALA A  37
 None
 1.10A 2bm9C-4wyrA:
undetectable		 2bm9C-4wyrA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 4wyr ACETYL-COA
ACETYLTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 12 VAL A 241
ASN A 316
ILE A 344
VAL A 337
PHE A 178
 None
 1.14A 2ft9A-4wyrA:
undetectable		 2ft9A-4wyrA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		 4wyr ACETYL-COA
ACETYLTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 12 ILE A 357
LEU A 358
GLY A  91
ALA A 386
ALA A 375
 None
 0.97A 2oc8A-4wyrA:
undetectable		 2oc8A-4wyrA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1467_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 4wyr ACETYL-COA
ACETYLTRANSFERASE
(Clostridium
acetobutylicum) 		4 / 5 ARG A  11
ASP A 216
ILE A 190
GLU A 198
 None
 0.77A 2xrzA-4wyrA:
undetectable
2xrzB-4wyrA:
undetectable		 2xrzA-4wyrA:
22.92
2xrzB-4wyrA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_E_RTLE177_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4wyr ACETYL-COA
ACETYLTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 11 LEU A  92
ALA A 295
ALA A 386
VAL A  95
LEU A 389
 None
 1.31A 3bszE-4wyrA:
undetectable		 3bszE-4wyrA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCM_X_SAMX5452_0
(UNCHARACTERIZED
PROTEIN TM_1570)		 4wyr ACETYL-COA
ACETYLTRANSFERASE
(Clostridium
acetobutylicum) 		6 / 11 GLY A 113
GLY A  54
ILE A 101
SER A  96
VAL A  95
ALA A  98
 None
 1.27A 3dcmX-4wyrA:
undetectable		 3dcmX-4wyrA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FXR_A_ASCA3001_0
(LYSR TYPE REGULATOR
OF TSAMBCD)		 4wyr ACETYL-COA
ACETYLTRANSFERASE
(Clostridium
acetobutylicum) 		4 / 8 ALA A 189
ILE A 190
ARG A  11
PRO A 219
 None
None
None
GOL  A 502 (-4.2A)
 0.99A 3fxrA-4wyrA:
undetectable		 3fxrA-4wyrA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4wyr ACETYL-COA
ACETYLTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 12 LEU A 377
GLU A 198
GLY A 354
SER A 353
LEU A 358
 None
 1.28A 3ou6D-4wyrA:
undetectable		 3ou6D-4wyrA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4wyr ACETYL-COA
ACETYLTRANSFERASE
(Clostridium
acetobutylicum) 		3 / 3 TYR A  17
ASP A 251
ASP A  23
 None
 0.64A 3ou7B-4wyrA:
undetectable		 3ou7B-4wyrA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA5_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 4wyr ACETYL-COA
ACETYLTRANSFERASE
(Clostridium
acetobutylicum) 		3 / 3 LYS A 367
SER A 192
GLN A 194
 None
 0.96A 3si7A-4wyrA:
undetectable		 3si7A-4wyrA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_C_SAMC300_0
(PUTATIVE
METHYLTRANSFERASE)		 4wyr ACETYL-COA
ACETYLTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 12 ARG A 220
GLY A 342
GLN A 183
ALA A 343
ASN A 316
 None
 1.44A 3t7sC-4wyrA:
undetectable		 3t7sC-4wyrA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_A_NCAA1163_0
(TANKYRASE-2)		 4wyr ACETYL-COA
ACETYLTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 8 HIS A 218
GLY A 248
ALA A 343
SER A 247
GLU A 317
 None
PEG  A 503 ( 4.4A)
None
None
None
 1.25A 3u9hA-4wyrA:
undetectable		 3u9hA-4wyrA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_B_NCAB1164_0
(TANKYRASE-2)		 4wyr ACETYL-COA
ACETYLTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 8 HIS A 218
GLY A 248
ALA A 343
SER A 247
GLU A 317
 None
PEG  A 503 ( 4.4A)
None
None
None
 1.27A 3u9hB-4wyrA:
undetectable		 3u9hB-4wyrA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_0
(MNMC2)		 4wyr ACETYL-COA
ACETYLTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 12 GLY A 248
LEU A 249
TYR A  17
ALA A 179
LEU A 228
 PEG  A 503 ( 4.4A)
PEG  A 503 ( 4.7A)
None
None
None
 1.17A 3vywA-4wyrA:
undetectable		 3vywA-4wyrA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_B_SAMB401_0
(MNMC2)		 4wyr ACETYL-COA
ACETYLTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 12 GLY A 248
LEU A 249
TYR A  17
ALA A 179
LEU A 228
 PEG  A 503 ( 4.4A)
PEG  A 503 ( 4.7A)
None
None
None
 1.15A 3vywB-4wyrA:
undetectable		 3vywB-4wyrA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_0
(MNMC2)		 4wyr ACETYL-COA
ACETYLTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 12 GLY A 248
LEU A 249
TYR A  17
ALA A 179
LEU A 228
 PEG  A 503 ( 4.4A)
PEG  A 503 ( 4.7A)
None
None
None
 1.17A 3vywD-4wyrA:
undetectable		 3vywD-4wyrA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG503_1
(HEMOLYTIC LECTIN
CEL-III)		 4wyr ACETYL-COA
ACETYLTRANSFERASE
(Clostridium
acetobutylicum) 		3 / 3 ASP A 150
GLY A 382
TYR A 153
 None
 0.80A 3w9tG-4wyrA:
undetectable		 3w9tG-4wyrA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		 4wyr ACETYL-COA
ACETYLTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 8 HIS A 218
GLY A 248
ALA A 343
SER A 247
GLU A 317
 None
PEG  A 503 ( 4.4A)
None
None
None
 1.24A 4bjcA-4wyrA:
undetectable		 4bjcA-4wyrA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EVY_B_TOYB201_1
(AMINOGLYCOSIDE
N(6')-ACETYLTRANSFER
ASE TYPE 1)		 4wyr ACETYL-COA
ACETYLTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 10 ASN A 338
GLU A 317
ASP A 216
GLU A 198
GLY A 354
 None
 1.47A 4evyA-4wyrA:
undetectable
4evyB-4wyrA:
undetectable		 4evyA-4wyrA:
19.50
4evyB-4wyrA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F93_B_SANB3004_1
(U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE)		 4wyr ACETYL-COA
ACETYLTRANSFERASE
(Clostridium
acetobutylicum) 		4 / 8 GLU A 188
GLN A 194
GLY A 193
SER A 192
 None
 0.91A 4f93B-4wyrA:
undetectable		 4f93B-4wyrA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FR0_A_SAMA401_0
(ARSENIC
METHYLTRANSFERASE)		 4wyr ACETYL-COA
ACETYLTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 12 GLY A 291
GLY A 282
MET A 288
GLN A 383
LEU A 377
 None
 1.10A 4fr0A-4wyrA:
undetectable		 4fr0A-4wyrA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		 4wyr ACETYL-COA
ACETYLTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 12 LEU A 389
ALA A 254
ALA A   9
VAL A 359
GLY A 354
 None
 1.03A 4hfpD-4wyrA:
undetectable		 4hfpD-4wyrA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_B_IMNB201_1
(TRANSTHYRETIN)		 4wyr ACETYL-COA
ACETYLTRANSFERASE
(Clostridium
acetobutylicum) 		4 / 6 LEU A 374
ALA A 386
LEU A 388
SER A 277
 None
 0.84A 4ikiB-4wyrA:
undetectable		 4ikiB-4wyrA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 4wyr ACETYL-COA
ACETYLTRANSFERASE
(Clostridium
acetobutylicum) 		4 / 8 ARG A  11
SER A 247
ALA A 345
SER A 182
 None
 1.01A 4lv9A-4wyrA:
undetectable
4lv9B-4wyrA:
undetectable		 4lv9A-4wyrA:
23.19
4lv9B-4wyrA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P66_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4wyr ACETYL-COA
ACETYLTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 11 ILE A 275
ALA A 273
MET A 365
LEU A  92
ILE A 387
 None
 1.17A 4p66A-4wyrA:
undetectable		 4p66A-4wyrA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4wyr ACETYL-COA
ACETYLTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 9 ALA A 386
THR A 296
ALA A 299
ILE A 379
GLY A 291
 None
 1.18A 4qvqK-4wyrA:
undetectable
4qvqL-4wyrA:
undetectable		 4qvqK-4wyrA:
19.74
4qvqL-4wyrA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4wyr ACETYL-COA
ACETYLTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 9 ALA A 386
THR A 296
ALA A 299
ILE A 379
GLY A 291
 None
 1.18A 4qvqY-4wyrA:
undetectable
4qvqZ-4wyrA:
undetectable		 4qvqY-4wyrA:
19.74
4qvqZ-4wyrA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN)		 4wyr ACETYL-COA
ACETYLTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 12 ALA A 295
SER A 280
GLY A 282
GLN A 383
GLY A 289
 None
 1.30A 4r29A-4wyrA:
undetectable		 4r29A-4wyrA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_A_ACTA1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 4wyr ACETYL-COA
ACETYLTRANSFERASE
(Clostridium
acetobutylicum) 		4 / 5 GLY A 384
ALA A 281
GLY A 291
PRO A 292
 None
 0.95A 4u9uA-4wyrA:
undetectable		 4u9uA-4wyrA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHD_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 4wyr ACETYL-COA
ACETYLTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 12 GLN A 183
ARG A 356
PRO A 349
ASN A 250
ILE A  14
 None
 1.32A 5uhdC-4wyrA:
0.0		 5uhdC-4wyrA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V02_R_657R201_0
(CALMODULIN-1
SMALL CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
PROTEIN 2)		 4wyr ACETYL-COA
ACETYLTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 10 ALA A 112
LEU A 256
VAL A 257
LEU A 358
ILE A 275
 None
 1.14A 5v02B-4wyrA:
undetectable
5v02R-4wyrA:
undetectable		 5v02B-4wyrA:
12.97
5v02R-4wyrA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_1
(CYTOCHROME P450 2C9)		 4wyr ACETYL-COA
ACETYLTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 12 ASN A  55
ASP A  28
GLY A  30
ALA A  31
LEU A  75
 None
 0.98A 5xxiA-4wyrA:
undetectable		 5xxiA-4wyrA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6M_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4wyr ACETYL-COA
ACETYLTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 11 ILE A 275
ALA A 273
MET A 365
LEU A  92
ILE A 387
 None
 1.05A 5z6mA-4wyrA:
undetectable		 5z6mA-4wyrA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CGG_B_84GB600_0
(BIFUNCTIONAL AAC/APH)		 4wyr ACETYL-COA
ACETYLTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 10 SER A 353
ASN A 316
HIS A 348
GLU A 314
GLU A 198
 None
None
PEG  A 503 (-4.7A)
None
None
 1.44A 6cggB-4wyrA:
undetectable		 6cggB-4wyrA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_0
(CYTOCHROME P450 1A1)		 4wyr ACETYL-COA
ACETYLTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 12 SER A 119
LEU A  53
ASN A  55
ASP A 251
ASP A  28
 None
 1.21A 6dwnA-4wyrA:
undetectable		 6dwnA-4wyrA:
11.25