SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wyu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KAW_A_SUZA91_1
(SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1)		 4wyu PROTEIN SCRIBBLE
HOMOLOG
(Homo
sapiens) 		5 / 11 LEU A 121
GLY A 122
ILE A 123
SER A 124
ILE A 125
 None
IOD  A 301 (-4.2A)
None
None
None
 0.72A 2kawA-4wyuA:
10.9		 2kawA-4wyuA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1001_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4wyu PROTEIN SCRIBBLE
HOMOLOG
(Homo
sapiens) 		4 / 6 SER A  60
ARG A  59
PRO A  53
GLY A  55
 None
 1.42A 2y7pA-4wyuA:
undetectable		 2y7pA-4wyuA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX5_B_MIYB1103_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4wyu PROTEIN SCRIBBLE
HOMOLOG
(Homo
sapiens) 		5 / 12 GLY A  30
SER A  36
ILE A  28
ALA A  84
VAL A  85
 None
 1.05A 4dx5B-4wyuA:
undetectable		 4dx5B-4wyuA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8V_B_MIYB1103_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4wyu PROTEIN SCRIBBLE
HOMOLOG
(Homo
sapiens) 		5 / 12 GLY A  30
SER A  36
ILE A  28
ALA A  84
VAL A  85
 None
 1.09A 4u8vB-4wyuA:
undetectable		 4u8vB-4wyuA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8Y_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4wyu PROTEIN SCRIBBLE
HOMOLOG
(Homo
sapiens) 		5 / 12 GLY A  30
SER A  36
ILE A  28
ALA A  84
VAL A  85
 None
 1.06A 4u8yB-4wyuA:
undetectable		 4u8yB-4wyuA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U95_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4wyu PROTEIN SCRIBBLE
HOMOLOG
(Homo
sapiens) 		5 / 12 GLY A  30
SER A  36
ILE A  28
ALA A  84
VAL A  85
 None
 1.04A 4u95B-4wyuA:
undetectable		 4u95B-4wyuA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_E_CHDE104_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4wyu PROTEIN SCRIBBLE
HOMOLOG
(Homo
sapiens) 		5 / 11 LEU A  95
GLU A  14
LEU A  97
LEU A  62
LEU A  26
 None
 0.98A 4wg0C-4wyuA:
undetectable
4wg0D-4wyuA:
undetectable
4wg0E-4wyuA:
undetectable		 4wg0C-4wyuA:
8.70
4wg0D-4wyuA:
8.70
4wg0E-4wyuA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_H_CHDH103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4wyu PROTEIN SCRIBBLE
HOMOLOG
(Homo
sapiens) 		5 / 11 LEU A  24
LEU A  26
GLU A  94
LEU A  17
LEU A  97
 None
 1.20A 4wg0H-4wyuA:
undetectable
4wg0I-4wyuA:
undetectable
4wg0J-4wyuA:
undetectable		 4wg0H-4wyuA:
8.70
4wg0I-4wyuA:
8.70
4wg0J-4wyuA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N1T_W_CUW201_0
(COPC)		 4wyu PROTEIN SCRIBBLE
HOMOLOG
(Homo
sapiens) 		3 / 3 HIS A  81
ASP A  33
HIS A  34
 None
 0.92A 5n1tW-4wyuA:
undetectable		 5n1tW-4wyuA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UL4_A_SAMA803_0
(OXSB PROTEIN)		 4wyu PROTEIN SCRIBBLE
HOMOLOG
(Homo
sapiens) 		5 / 12 ALA A  79
ARG A  77
GLY A  45
GLY A  30
LEU A  62
 None
 1.11A 5ul4A-4wyuA:
undetectable		 5ul4A-4wyuA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_B_ACTB207_0
(DUF1778
DOMAIN-CONTAINING
PROTEIN
N-ACETYLTRANSFERASE)		 4wyu PROTEIN SCRIBBLE
HOMOLOG
(Homo
sapiens) 		4 / 6 LEU A 165
CYH A 199
GLY A 201
ARG A 166
 None
 1.39A 6gtqB-4wyuA:
undetectable
6gtqD-4wyuA:
undetectable		 6gtqB-4wyuA:
21.80
6gtqD-4wyuA:
15.82