SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wz9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_A_TESA325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 4wz9 AGAP004809-PA
(Anopheles
gambiae) 		4 / 7 LEU A 581
THR A 518
TRP A 558
ASN A 554
 None
 1.29A 1afsA-4wz9A:
undetectable		 1afsA-4wz9A:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_B_TESB325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 4wz9 AGAP004809-PA
(Anopheles
gambiae) 		4 / 7 LEU A 581
THR A 518
TRP A 558
ASN A 554
 None
 1.29A 1afsB-4wz9A:
undetectable		 1afsB-4wz9A:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_D_ADND604_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4wz9 AGAP004809-PA
(Anopheles
gambiae) 		4 / 5 THR A 249
GLU A 244
THR A 245
HIS A  83
 None
 1.50A 1d4fD-4wz9A:
undetectable		 1d4fD-4wz9A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_0
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 4wz9 AGAP004809-PA
(Anopheles
gambiae) 		4 / 4 THR A 291
LEU A 294
LEU A 319
GLN A 371
 None
 1.27A 1fbmA-4wz9A:
undetectable		 1fbmA-4wz9A:
3.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC8_0
(GRAMICIDIN A)		 4wz9 AGAP004809-PA
(Anopheles
gambiae) 		3 / 4 VAL A 610
TRP A 645
TRP A 617
 None
 1.34A 1gmkC-4wz9A:
undetectable
1gmkD-4wz9A:
undetectable		 1gmkC-4wz9A:
2.23
1gmkD-4wz9A:
2.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		 4wz9 AGAP004809-PA
(Anopheles
gambiae) 		3 / 3 GLN A 371
TYR A 340
ARG A 341
 None
 0.82A 1gtbA-4wz9A:
undetectable		 1gtbA-4wz9A:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4wz9 AGAP004809-PA
(Anopheles
gambiae) 		6 / 12 THR A 363
HIS A 366
GLU A 367
HIS A 370
GLU A 389
TYR A 452
 None
ZN  A1001 (-3.3A)
ZN  A1001 ( 4.3A)
ZN  A1001 (-3.2A)
ZN  A1001 (-2.4A)
None
 0.76A 1j36A-4wz9A:
4.8		 1j36A-4wz9A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4wz9 AGAP004809-PA
(Anopheles
gambiae) 		6 / 12 THR A 363
HIS A 366
GLU A 367
HIS A 370
GLU A 389
TYR A 452
 None
ZN  A1001 (-3.3A)
ZN  A1001 ( 4.3A)
ZN  A1001 (-3.2A)
ZN  A1001 (-2.4A)
None
 0.77A 1j36B-4wz9A:
4.7		 1j36B-4wz9A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_A_X8ZA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4wz9 AGAP004809-PA
(Anopheles
gambiae) 		5 / 11 HIS A 366
GLU A 367
HIS A 370
GLU A 389
TYR A 452
 ZN  A1001 (-3.3A)
ZN  A1001 ( 4.3A)
ZN  A1001 (-3.2A)
ZN  A1001 (-2.4A)
None
 0.79A 1j37A-4wz9A:
4.5		 1j37A-4wz9A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_B_X8ZB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4wz9 AGAP004809-PA
(Anopheles
gambiae) 		5 / 11 HIS A 366
GLU A 367
HIS A 370
GLU A 389
TYR A 452
 ZN  A1001 (-3.3A)
ZN  A1001 ( 4.3A)
ZN  A1001 (-3.2A)
ZN  A1001 (-2.4A)
None
 0.79A 1j37B-4wz9A:
5.2		 1j37B-4wz9A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT3_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4wz9 AGAP004809-PA
(Anopheles
gambiae) 		4 / 7 LEU A 466
LEU A 475
MET A 402
LEU A 459
 None
 1.03A 1kt3A-4wz9A:
undetectable		 1kt3A-4wz9A:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT3_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4wz9 AGAP004809-PA
(Anopheles
gambiae) 		4 / 7 LEU A 466
LEU A 475
TYR A 398
LEU A 459
 None
 0.93A 1kt3A-4wz9A:
undetectable		 1kt3A-4wz9A:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA154_1
(CALMODULIN)		 4wz9 AGAP004809-PA
(Anopheles
gambiae) 		4 / 7 LEU A 806
MET A 775
LEU A 751
GLU A 754
 None
 1.11A 1linA-4wz9A:
undetectable		 1linA-4wz9A:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_SAMA500_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 4wz9 AGAP004809-PA
(Anopheles
gambiae) 		5 / 12 ASP A 176
GLY A 177
ALA A 194
PHE A 198
LEU A 263
 None
 1.32A 1nw3A-4wz9A:
undetectable		 1nw3A-4wz9A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4wz9 AGAP004809-PA
(Anopheles
gambiae) 		5 / 12 HIS A 366
GLU A 367
HIS A 370
GLU A 389
TYR A 452
 ZN  A1001 (-3.3A)
ZN  A1001 ( 4.3A)
ZN  A1001 (-3.2A)
ZN  A1001 (-2.4A)
None
 0.74A 1o86A-4wz9A:
5.3		 1o86A-4wz9A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_F_RTLF2_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 4wz9 AGAP004809-PA
(Anopheles
gambiae) 		5 / 12 ALA A 365
ALA A 369
LEU A 496
TYR A 398
LEU A 459
 None
 1.23A 1qabF-4wz9A:
undetectable		 1qabF-4wz9A:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_C_ADNC1503_1
(CLASS B ACID
PHOSPHATASE)		 4wz9 AGAP004809-PA
(Anopheles
gambiae) 		4 / 8 ASP A 401
TYR A 670
LEU A 723
GLY A 406
 None
 1.02A 1rmtC-4wz9A:
undetectable		 1rmtC-4wz9A:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		 4wz9 AGAP004809-PA
(Anopheles
gambiae) 		4 / 7 ALA A 344
TYR A 340
TYR A 404
TYR A 409
 None
 1.06A 2ajvH-4wz9A:
2.2
2ajvL-4wz9A:
2.0		 2ajvH-4wz9A:
13.38
2ajvL-4wz9A:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		 4wz9 AGAP004809-PA
(Anopheles
gambiae) 		4 / 7 ALA A 403
TYR A 404
TYR A 368
TYR A 340
 None
 1.12A 2ajvH-4wz9A:
2.2
2ajvL-4wz9A:
2.0		 2ajvH-4wz9A:
13.38
2ajvL-4wz9A:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2002_1
(SERUM ALBUMIN)		 4wz9 AGAP004809-PA
(Anopheles
gambiae) 		5 / 11 ALA A 323
LEU A 345
ALA A 290
GLU A 289
VAL A 360
 None
 1.08A 2bxeB-4wz9A:
undetectable		 2bxeB-4wz9A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2002_1
(SERUM ALBUMIN)		 4wz9 AGAP004809-PA
(Anopheles
gambiae) 		4 / 8 ALA A 323
ALA A 290
GLU A 289
VAL A 360
 None
 0.79A 2bxgA-4wz9A:
undetectable		 2bxgA-4wz9A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 4wz9 AGAP004809-PA
(Anopheles
gambiae) 		6 / 12 ALA A 331
HIS A 366
GLU A 367
HIS A 370
GLU A 389
TYR A 452
 None
ZN  A1001 (-3.3A)
ZN  A1001 ( 4.3A)
ZN  A1001 (-3.2A)
ZN  A1001 (-2.4A)
None
 0.70A 2c6nA-4wz9A:
5.3		 2c6nA-4wz9A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 4wz9 AGAP004809-PA
(Anopheles
gambiae) 		5 / 12 HIS A 366
GLU A 367
HIS A 370
GLU A 389
TYR A 452
 ZN  A1001 (-3.3A)
ZN  A1001 ( 4.3A)
ZN  A1001 (-3.2A)
ZN  A1001 (-2.4A)
None
 0.77A 2c6nB-4wz9A:
3.9		 2c6nB-4wz9A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_G_BEZG2352_0
(D-AMINO-ACID OXIDASE)		 4wz9 AGAP004809-PA
(Anopheles
gambiae) 		4 / 5 TYR A 740
TYR A 708
ILE A 731
GLY A 739
 None
 1.18A 2du8G-4wz9A:
2.3		 2du8G-4wz9A:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_J_BEZJ3352_0
(D-AMINO-ACID OXIDASE)		 4wz9 AGAP004809-PA
(Anopheles
gambiae) 		4 / 5 TYR A 740
TYR A 708
ILE A 731
GLY A 739
 None
 1.11A 2du8J-4wz9A:
undetectable		 2du8J-4wz9A:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4wz9 AGAP004809-PA
(Anopheles
gambiae) 		5 / 12 LEU A 337
VAL A 282
ALA A 344
VAL A 280
TYR A 368
 None
 1.41A 2g70B-4wz9A:
undetectable		 2g70B-4wz9A:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4wz9 AGAP004809-PA
(Anopheles
gambiae) 		5 / 12 LEU A 337
VAL A 282
ALA A 344
VAL A 280
TYR A 368
 None
 1.40A 2g72A-4wz9A:
undetectable		 2g72A-4wz9A:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		 4wz9 AGAP004809-PA
(Anopheles
gambiae) 		4 / 8 THR A 363
HIS A 366
GLU A 367
HIS A 370
 None
ZN  A1001 (-3.3A)
ZN  A1001 ( 4.3A)
ZN  A1001 (-3.2A)
 0.25A 2jihB-4wz9A:
undetectable		 2jihB-4wz9A:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_2
(MINERALOCORTICOID
RECEPTOR)		 4wz9 AGAP004809-PA
(Anopheles
gambiae) 		4 / 5 LEU A 878
LEU A 856
MET A 861
THR A 913
 None
 1.24A 2oaxD-4wz9A:
undetectable		 2oaxD-4wz9A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0I_A_BEZA990_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 4wz9 AGAP004809-PA
(Anopheles
gambiae) 		4 / 8 ASP A 136
GLU A 164
SER A 121
LEU A 133
 None
 0.94A 2q0iA-4wz9A:
undetectable		 2q0iA-4wz9A:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4wz9 AGAP004809-PA
(Anopheles
gambiae) 		4 / 8 LEU A 301
LEU A 319
LYS A 318
ALA A 277
 None
 1.05A 2wekA-4wz9A:
undetectable		 2wekA-4wz9A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X8Z_A_X8ZA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4wz9 AGAP004809-PA
(Anopheles
gambiae) 		5 / 11 HIS A 366
GLU A 367
HIS A 370
GLU A 389
TYR A 452
 ZN  A1001 (-3.3A)
ZN  A1001 ( 4.3A)
ZN  A1001 (-3.2A)
ZN  A1001 (-2.4A)
None
 0.69A 2x8zA-4wz9A:
7.4		 2x8zA-4wz9A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4wz9 AGAP004809-PA
(Anopheles
gambiae) 		5 / 12 HIS A 366
GLU A 367
HIS A 370
GLU A 389
TYR A 452
 ZN  A1001 (-3.3A)
ZN  A1001 ( 4.3A)
ZN  A1001 (-3.2A)
ZN  A1001 (-2.4A)
None
 0.71A 2x91A-4wz9A:
3.9		 2x91A-4wz9A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1470_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 4wz9 AGAP004809-PA
(Anopheles
gambiae) 		4 / 5 ARG A 665
ALA A 702
ASP A 701
GLU A 705
 None
None
GOL  A1002 (-4.2A)
None
 1.38A 2xrzA-4wz9A:
2.9		 2xrzA-4wz9A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_F_RTLF178_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4wz9 AGAP004809-PA
(Anopheles
gambiae) 		5 / 11 LEU A 412
ALA A 361
PHE A 292
TYR A 354
GLN A 407
 None
 1.37A 3bszF-4wz9A:
undetectable		 3bszF-4wz9A:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CO4_A_GCSA401_1
(CHITINASE)		 4wz9 AGAP004809-PA
(Anopheles
gambiae) 		3 / 3 GLU A 244
HIS A 225
HIS A  83
 None
 0.74A 3co4A-4wz9A:
undetectable		 3co4A-4wz9A:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_1
(UNCHARACTERIZED
PROTEIN)		 4wz9 AGAP004809-PA
(Anopheles
gambiae) 		3 / 3 THR A 291
LYS A 725
GLU A 295
 None
 0.94A 3ijdB-4wz9A:
undetectable		 3ijdB-4wz9A:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA201_1
(PROTEIN S100-A4)		 4wz9 AGAP004809-PA
(Anopheles
gambiae) 		5 / 9 GLY A 169
ILE A 223
PHE A 219
GLY A 177
PHE A 198
 None
 1.47A 3ko0A-4wz9A:
undetectable
3ko0C-4wz9A:
undetectable		 3ko0A-4wz9A:
9.13
3ko0C-4wz9A:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_G_TFPG201_1
(PROTEIN S100-A4)		 4wz9 AGAP004809-PA
(Anopheles
gambiae) 		5 / 9 GLY A 177
PHE A 198
GLY A 169
ILE A 223
PHE A 219
 None
 1.49A 3ko0F-4wz9A:
undetectable
3ko0G-4wz9A:
0.0		 3ko0F-4wz9A:
9.13
3ko0G-4wz9A:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ202_1
(PROTEIN S100-A4)		 4wz9 AGAP004809-PA
(Anopheles
gambiae) 		5 / 11 LEU A 856
ASP A 854
LEU A 819
PHE A 818
ILE A 845
 None
 1.26A 3ko0A-4wz9A:
undetectable
3ko0B-4wz9A:
undetectable
3ko0I-4wz9A:
undetectable
3ko0J-4wz9A:
undetectable		 3ko0A-4wz9A:
9.13
3ko0B-4wz9A:
9.13
3ko0I-4wz9A:
9.13
3ko0J-4wz9A:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM202_1
(PROTEIN S100-A4)		 4wz9 AGAP004809-PA
(Anopheles
gambiae) 		5 / 12 LEU A 819
PHE A 818
ILE A 845
LEU A 856
ASP A 854
 None
 1.23A 3ko0M-4wz9A:
undetectable
3ko0N-4wz9A:
undetectable
3ko0O-4wz9A:
undetectable
3ko0P-4wz9A:
undetectable		 3ko0M-4wz9A:
9.13
3ko0N-4wz9A:
9.13
3ko0O-4wz9A:
9.13
3ko0P-4wz9A:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK2_X_LDPX433_1
(6-HYDROXY-L-NICOTINE
OXIDASE)		 4wz9 AGAP004809-PA
(Anopheles
gambiae) 		4 / 7 TYR A 478
LEU A 479
PHE A 391
TRP A 471
 None
 1.03A 3nk2X-4wz9A:
undetectable		 3nk2X-4wz9A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXZ_A_0LIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4wz9 AGAP004809-PA
(Anopheles
gambiae) 		5 / 9 LEU A 723
TYR A 726
VAL A 700
ILE A 707
VAL A 678
 None
 1.47A 3oxzA-4wz9A:
undetectable		 3oxzA-4wz9A:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_D_MTXD2000_2
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4wz9 AGAP004809-PA
(Anopheles
gambiae) 		3 / 3 LEU A 193
ARG A 341
ASN A 334
 None
 0.65A 3qxvD-4wz9A:
undetectable		 3qxvD-4wz9A:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4wz9 AGAP004809-PA
(Anopheles
gambiae) 		4 / 8 LEU A 492
VAL A 377
TRP A 471
LEU A 496
 None
 0.98A 3v81C-4wz9A:
2.6		 3v81C-4wz9A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_1
(PROTEASE)		 4wz9 AGAP004809-PA
(Anopheles
gambiae) 		5 / 9 LEU A 856
ALA A 844
ASP A 804
LEU A 806
ILE A 845
 None
 1.14A 3wsjA-4wz9A:
undetectable		 3wsjA-4wz9A:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C2P_A_X8ZA709_1
(ANGIOTENSIN-CONVERTI
NG ENZYME)		 4wz9 AGAP004809-PA
(Anopheles
gambiae) 		5 / 11 HIS A 366
GLU A 367
HIS A 370
GLU A 389
TYR A 452
 ZN  A1001 (-3.3A)
ZN  A1001 ( 4.3A)
ZN  A1001 (-3.2A)
ZN  A1001 (-2.4A)
None
 0.77A 4c2pA-4wz9A:
5.3		 4c2pA-4wz9A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DPR_A_X8ZA702_1
(LEUKOTRIENE A-4
HYDROLASE)		 4wz9 AGAP004809-PA
(Anopheles
gambiae) 		5 / 9 GLY A 330
HIS A 366
GLU A 367
GLU A 389
TYR A 452
 None
ZN  A1001 (-3.3A)
ZN  A1001 ( 4.3A)
ZN  A1001 (-2.4A)
None
 0.37A 4dprA-4wz9A:
23.2		 4dprA-4wz9A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4wz9 AGAP004809-PA
(Anopheles
gambiae) 		4 / 6 TYR A 608
LEU A 646
VAL A 678
ALA A 679
 None
 1.11A 4nkvC-4wz9A:
undetectable		 4nkvC-4wz9A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4wz9 AGAP004809-PA
(Anopheles
gambiae) 		4 / 5 ILE A 443
LEU A 446
ASP A  60
VAL A 488
 None
 1.04A 4nkxB-4wz9A:
undetectable		 4nkxB-4wz9A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_2
(GLUCOCORTICOID
RECEPTOR)		 4wz9 AGAP004809-PA
(Anopheles
gambiae) 		3 / 3 MET A 661
MET A 935
TYR A 644
 None
 1.17A 4p6xI-4wz9A:
undetectable		 4p6xI-4wz9A:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAH_A_LNRA600_1
(PHENYLALANINE
HYDROXYLASE)		 4wz9 AGAP004809-PA
(Anopheles
gambiae) 		4 / 6 LEU A 459
HIS A 370
HIS A 366
GLU A 389
 None
ZN  A1001 (-3.2A)
ZN  A1001 (-3.3A)
ZN  A1001 (-2.4A)
 0.94A 4pahA-4wz9A:
undetectable		 4pahA-4wz9A:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 4wz9 AGAP004809-PA
(Anopheles
gambiae) 		3 / 3 PRO A 507
LEU A 506
GLN A 514
 None
 0.66A 4pevB-4wz9A:
undetectable		 4pevB-4wz9A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_A_RBFA201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4wz9 AGAP004809-PA
(Anopheles
gambiae) 		5 / 12 ALA A 264
ALA A 323
ILE A 322
GLY A 336
GLN A 371
 None
 0.97A 4r38A-4wz9A:
undetectable		 4r38A-4wz9A:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4wz9 AGAP004809-PA
(Anopheles
gambiae) 		5 / 12 ALA A 264
ALA A 323
ILE A 322
GLY A 336
GLN A 371
 None
 0.96A 4r38B-4wz9A:
undetectable		 4r38B-4wz9A:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4wz9 AGAP004809-PA
(Anopheles
gambiae) 		5 / 12 ALA A 264
ALA A 323
ILE A 322
GLY A 336
GLN A 371
 None
 0.94A 4r38C-4wz9A:
undetectable		 4r38C-4wz9A:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4wz9 AGAP004809-PA
(Anopheles
gambiae) 		5 / 12 ALA A 264
ALA A 323
ILE A 322
GLY A 336
GLN A 371
 None
 0.95A 4r38D-4wz9A:
undetectable		 4r38D-4wz9A:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4wz9 AGAP004809-PA
(Anopheles
gambiae) 		5 / 12 ALA A 264
ALA A 323
ILE A 322
ILE A 364
GLN A 371
 None
 1.13A 4r3aA-4wz9A:
undetectable		 4r3aA-4wz9A:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_B_RBFB402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4wz9 AGAP004809-PA
(Anopheles
gambiae) 		5 / 12 ALA A 264
ALA A 323
ILE A 322
GLY A 336
GLN A 371
 None
 0.89A 4r3aB-4wz9A:
undetectable		 4r3aB-4wz9A:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_B_RBFB402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4wz9 AGAP004809-PA
(Anopheles
gambiae) 		5 / 12 ALA A 323
ILE A 322
ILE A 364
GLY A 336
GLN A 371
 None
 1.01A 4r3aB-4wz9A:
undetectable		 4r3aB-4wz9A:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 4wz9 AGAP004809-PA
(Anopheles
gambiae) 		7 / 12 HIS A 366
GLU A 367
HIS A 370
TRP A 382
PHE A 447
GLU A 389
TYR A 452
 ZN  A1001 (-3.3A)
ZN  A1001 ( 4.3A)
ZN  A1001 (-3.2A)
None
None
ZN  A1001 (-2.4A)
None
 1.20A 4r7lA-4wz9A:
27.6		 4r7lA-4wz9A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		 4wz9 AGAP004809-PA
(Anopheles
gambiae) 		4 / 4 ALA A 421
VAL A 450
GLY A 390
THR A 393
 None
 1.00A 4ubeA-4wz9A:
undetectable		 4ubeA-4wz9A:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DWK_C_ACTC207_0
(DIACYLGLYCEROL
KINASE)		 4wz9 AGAP004809-PA
(Anopheles
gambiae) 		4 / 5 GLU A 333
ALA A 331
GLU A 367
GLU A 389
 ZN  A1001 ( 4.4A)
None
ZN  A1001 ( 4.3A)
ZN  A1001 (-2.4A)
 1.39A 5dwkC-4wz9A:
undetectable		 5dwkC-4wz9A:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB203_0
(HYDROXYNITRILE LYASE)		 4wz9 AGAP004809-PA
(Anopheles
gambiae) 		4 / 4 VAL A 338
ALA A 331
ILE A 364
THR A 363
 None
 0.91A 5e4dB-4wz9A:
undetectable		 5e4dB-4wz9A:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 4wz9 AGAP004809-PA
(Anopheles
gambiae) 		3 / 3 ALA A 921
ASN A 924
LEU A 925
 None
 0.37A 5i1nB-4wz9A:
undetectable		 5i1nB-4wz9A:
3.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UOC_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4wz9 AGAP004809-PA
(Anopheles
gambiae) 		4 / 6 TRP A 617
PHE A 660
VAL A 599
ARG A 636
 None
 0.93A 5uocA-4wz9A:
0.0
5uocB-4wz9A:
0.0		 5uocA-4wz9A:
19.11
5uocB-4wz9A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XPR_A_K86A1201_1
(ENDOTHELIN B
RECEPTOR,ENDOLYSIN,E
NDOTHELIN B RECEPTOR)		 4wz9 AGAP004809-PA
(Anopheles
gambiae) 		5 / 12 VAL A 866
LEU A 856
LEU A 901
ILE A 902
ALA A 904
 None
 1.41A 5xprA-4wz9A:
undetectable		 5xprA-4wz9A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC609_0
(ALPHA-AMYLASE)		 4wz9 AGAP004809-PA
(Anopheles
gambiae) 		4 / 7 GLY A 390
TRP A 386
ASP A 448
TYR A 452
 None
 1.35A 6ag0C-4wz9A:
undetectable		 6ag0C-4wz9A:
6.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 4wz9 AGAP004809-PA
(Anopheles
gambiae) 		5 / 12 LEU A 301
ALA A 392
ASN A 375
VAL A 338
TYR A 340
 None
ZN  A1001 ( 3.9A)
None
None
None
 1.32A 6drxA-4wz9A:
undetectable		 6drxA-4wz9A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLP_A_GAWA1501_1
(SUBSTANCE-P
RECEPTOR,SUBSTANCE-P
RECEPTOR)		 4wz9 AGAP004809-PA
(Anopheles
gambiae) 		4 / 5 ASN A 234
GLN A 197
TYR A 452
MET A 258
 None
 0.81A 6hlpA-4wz9A:
1.1		 6hlpA-4wz9A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		 4wz9 AGAP004809-PA
(Anopheles
gambiae) 		4 / 6 THR A 770
LEU A 751
MET A 801
LEU A 744
 None
 1.18A 6mvxA-4wz9A:
undetectable
6mvxB-4wz9A:
undetectable
6mvxC-4wz9A:
undetectable		 6mvxA-4wz9A:
15.17
6mvxB-4wz9A:
15.17
6mvxC-4wz9A:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 4wz9 AGAP004809-PA
(Anopheles
gambiae) 		4 / 6 LEU A 459
HIS A 370
HIS A 366
GLU A 389
 None
ZN  A1001 (-3.2A)
ZN  A1001 (-3.3A)
ZN  A1001 (-2.4A)
 0.92A 6pahA-4wz9A:
undetectable		 6pahA-4wz9A:
15.51