SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wzb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_A_DVAA8_0
(ACTINOMYCIN D)		 4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN
(Azotobacter
vinelandii) 		3 / 3 THR A 303
THR A 305
PRO A 302
 None
 0.84A 1a7yA-4wzbA:
undetectable		 1a7yA-4wzbA:
4.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_B_DVAB2_0
(ACTINOMYCIN D)		 4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN
(Azotobacter
vinelandii) 		3 / 3 THR A 305
PRO A 302
THR A 303
 None
 0.88A 1a7yB-4wzbA:
undetectable		 1a7yB-4wzbA:
4.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC8_0
(ACTINOMYCIN D)		 4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN
(Azotobacter
vinelandii) 		3 / 3 THR A 303
THR A 305
PRO A 302
 None
 0.69A 1dscC-4wzbA:
undetectable		 1dscC-4wzbA:
4.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4002_1
(SERUM ALBUMIN)		 4wzb NITROGENASE IRON
PROTEIN 1
(Azotobacter
vinelandii) 		4 / 6 LEU E 109
VAL E  86
VAL E 102
SER E  88
 None
 1.11A 1e7aB-4wzbE:
undetectable		 1e7aB-4wzbE:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FJA_C_DVAC8_0
(ACTINOMYCIN D)		 4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN
(Azotobacter
vinelandii) 		3 / 3 THR A 303
THR A 305
PRO A 302
 None
 0.83A 1fjaC-4wzbA:
undetectable		 1fjaC-4wzbA:
4.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FJA_D_DVAD8_0
(ACTINOMYCIN D)		 4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN
(Azotobacter
vinelandii) 		3 / 3 THR A 303
THR A 305
PRO A 302
 None
 0.84A 1fjaD-4wzbA:
undetectable		 1fjaD-4wzbA:
4.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_C_EAAC223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN
(Azotobacter
vinelandii) 		4 / 8 TYR A 401
GLY A 376
VAL A 363
MET A 394
 None
 1.03A 1gsfC-4wzbA:
undetectable		 1gsfC-4wzbA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_A_TRPA81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4wzb NITROGENASE IRON
PROTEIN 1
(Azotobacter
vinelandii) 		4 / 7 GLY E 167
ALA E 172
ILE E 168
SER E 174
 None
 0.83A 1gtnA-4wzbE:
undetectable
1gtnK-4wzbE:
undetectable		 1gtnA-4wzbE:
15.38
1gtnK-4wzbE:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_A_URFA1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN
(Azotobacter
vinelandii) 		4 / 6 ILE A  47
ASN A 384
SER A  42
THR A 390
 None
 1.20A 1h7xA-4wzbA:
undetectable		 1h7xA-4wzbA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_B_URFB1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN
(Azotobacter
vinelandii) 		4 / 6 ILE A  47
ASN A 384
SER A  42
THR A 390
 None
 1.20A 1h7xB-4wzbA:
3.1		 1h7xB-4wzbA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_C_URFC1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN
(Azotobacter
vinelandii) 		4 / 6 ILE A  47
ASN A 384
SER A  42
THR A 390
 None
 1.20A 1h7xC-4wzbA:
undetectable		 1h7xC-4wzbA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_D_URFD1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN
(Azotobacter
vinelandii) 		4 / 6 ILE A  47
ASN A 384
SER A  42
THR A 390
 None
 1.19A 1h7xD-4wzbA:
undetectable		 1h7xD-4wzbA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE8_0
(ACTINOMYCIN D)		 4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN
(Azotobacter
vinelandii) 		3 / 3 THR A 303
THR A 305
PRO A 302
 None
 0.81A 1i3wE-4wzbA:
undetectable		 1i3wE-4wzbA:
4.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_F_DVAF8_0
(ACTINOMYCIN D)		 4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN
(Azotobacter
vinelandii) 		3 / 3 THR A 303
THR A 305
PRO A 302
 None
 0.85A 1i3wF-4wzbA:
undetectable		 1i3wF-4wzbA:
4.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_G_DVAG2_0
(ACTINOMYCIN D)		 4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN
(Azotobacter
vinelandii) 		3 / 3 THR A 305
PRO A 302
THR A 303
 None
 0.87A 1i3wG-4wzbA:
undetectable		 1i3wG-4wzbA:
4.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_G_DVAG8_0
(ACTINOMYCIN D)		 4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN
(Azotobacter
vinelandii) 		3 / 3 THR A 303
THR A 305
PRO A 302
 None
 0.80A 1i3wG-4wzbA:
undetectable		 1i3wG-4wzbA:
4.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_H_DVAH8_0
(ACTINOMYCIN D)		 4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN
(Azotobacter
vinelandii) 		3 / 3 THR A 303
THR A 305
PRO A 302
 None
 0.80A 1i3wH-4wzbA:
undetectable		 1i3wH-4wzbA:
4.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_A_CILA451_1
(RENAL DIPEPTIDASE)		 4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN
(Azotobacter
vinelandii) 		5 / 12 HIS A 362
HIS A 451
ARG A 359
TYR A 229
ASP A 228
 None
None
ICS  A1496 (-3.9A)
ICS  A1496 (-4.1A)
None
 1.36A 1ituA-4wzbA:
undetectable		 1ituA-4wzbA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD2_0
(ACTINOMYCIN D)		 4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN
(Azotobacter
vinelandii) 		3 / 3 THR A 305
PRO A 302
THR A 303
 None
 0.80A 1mnvD-4wzbA:
undetectable		 1mnvD-4wzbA:
4.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD8_0
(ACTINOMYCIN D)		 4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN
(Azotobacter
vinelandii) 		3 / 3 THR A 303
THR A 305
PRO A 302
 None
 0.79A 1mnvD-4wzbA:
undetectable		 1mnvD-4wzbA:
4.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN
(Azotobacter
vinelandii) 		5 / 12 GLY A  73
VAL A 110
ALA A 198
GLY A 255
SER A 254
 None
 1.14A 1nbiB-4wzbA:
undetectable		 1nbiB-4wzbA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OVF_B_DVAB2_0
(ACTINOMYCIN D)		 4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN
(Azotobacter
vinelandii) 		3 / 3 THR A 305
PRO A 302
THR A 303
 None
 0.88A 1ovfB-4wzbA:
undetectable		 1ovfB-4wzbA:
4.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_A_DVAA8_0
(ACTINOMYCIN X2)		 4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN
(Azotobacter
vinelandii) 		3 / 3 THR A 303
THR A 305
PRO A 302
 None
 0.83A 1qfiA-4wzbA:
undetectable		 1qfiA-4wzbA:
4.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_C_URFC2081_1
(URIDINE
PHOSPHORYLASE)		 4wzb NITROGENASE IRON
PROTEIN 1
(Azotobacter
vinelandii) 		4 / 7 GLY E 167
ILE E 168
VAL E 169
PRO E 256
 None
 1.03A 1rxcC-4wzbE:
undetectable		 1rxcC-4wzbE:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_F_URFF2001_1
(URIDINE
PHOSPHORYLASE)		 4wzb NITROGENASE IRON
PROTEIN 1
(Azotobacter
vinelandii) 		4 / 7 GLY E 167
ILE E 168
VAL E 169
PRO E 256
 None
 1.06A 1rxcF-4wzbE:
undetectable		 1rxcF-4wzbE:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_L_URFL2071_1
(URIDINE
PHOSPHORYLASE)		 4wzb NITROGENASE IRON
PROTEIN 1
(Azotobacter
vinelandii) 		4 / 7 GLY E 167
ILE E 168
VAL E 169
PRO E 256
 None
 1.07A 1rxcL-4wzbE:
undetectable		 1rxcL-4wzbE:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF2_0
(7-AMINO-ACTINOMYCIN
D)		 4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN
(Azotobacter
vinelandii) 		3 / 3 THR A 305
PRO A 302
THR A 303
 None
 0.84A 1unjF-4wzbA:
undetectable		 1unjF-4wzbA:
4.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_L_DVAL2_0
(7-AMINO-ACTINOMYCIN
D)		 4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN
(Azotobacter
vinelandii) 		3 / 3 THR A 305
PRO A 302
THR A 303
 None
 0.81A 1unjL-4wzbA:
undetectable		 1unjL-4wzbA:
4.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_L_DVAL8_0
(7-AMINO-ACTINOMYCIN
D)		 4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN
(Azotobacter
vinelandii) 		3 / 3 THR A 303
THR A 305
PRO A 302
 None
 0.77A 1unjL-4wzbA:
undetectable		 1unjL-4wzbA:
4.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_R_DVAR2_0
(7-AMINO-ACTINOMYCIN
D)		 4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN
(Azotobacter
vinelandii) 		3 / 3 THR A 305
PRO A 302
THR A 303
 None
 0.79A 1unjR-4wzbA:
undetectable		 1unjR-4wzbA:
4.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_R_DVAR8_0
(7-AMINO-ACTINOMYCIN
D)		 4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN
(Azotobacter
vinelandii) 		3 / 3 THR A 303
THR A 305
PRO A 302
 None
 0.79A 1unjR-4wzbA:
undetectable		 1unjR-4wzbA:
4.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_W_DVAW8_0
(7-AMINO-ACTINOMYCIN
D)		 4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN
(Azotobacter
vinelandii) 		3 / 3 THR A 303
THR A 305
PRO A 302
 None
 0.73A 1unjW-4wzbA:
undetectable		 1unjW-4wzbA:
4.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_X_DVAX2_0
(7-AMINO-ACTINOMYCIN
D)		 4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN
(Azotobacter
vinelandii) 		3 / 3 THR A 305
PRO A 302
THR A 303
 None
 0.78A 1unjX-4wzbA:
undetectable		 1unjX-4wzbA:
4.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_X_DVAX8_0
(7-AMINO-ACTINOMYCIN
D)		 4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN
(Azotobacter
vinelandii) 		3 / 3 THR A 303
THR A 305
PRO A 302
 None
 0.77A 1unjX-4wzbA:
undetectable		 1unjX-4wzbA:
4.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_E_DVAE2_0
(7-AMINOACTINOMYCIN D)		 4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN
(Azotobacter
vinelandii) 		3 / 3 THR A 305
PRO A 302
THR A 303
 None
 0.75A 1unmE-4wzbA:
undetectable		 1unmE-4wzbA:
4.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_E_DVAE8_0
(7-AMINOACTINOMYCIN D)		 4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN
(Azotobacter
vinelandii) 		3 / 3 THR A 303
THR A 305
PRO A 302
 None
 0.75A 1unmE-4wzbA:
undetectable		 1unmE-4wzbA:
4.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_F_DVAF2_0
(7-AMINOACTINOMYCIN D)		 4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN
(Azotobacter
vinelandii) 		3 / 3 THR A 305
PRO A 302
THR A 303
 None
 0.83A 1unmF-4wzbA:
undetectable		 1unmF-4wzbA:
4.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_F_DVAF8_0
(7-AMINOACTINOMYCIN D)		 4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN
(Azotobacter
vinelandii) 		3 / 3 THR A 303
THR A 305
PRO A 302
 None
 0.79A 1unmF-4wzbA:
undetectable		 1unmF-4wzbA:
4.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN
(Azotobacter
vinelandii) 		3 / 3 ILE A  81
ASP A 117
PHE A 118
 None
 0.66A 1uwjB-4wzbA:
undetectable		 1uwjB-4wzbA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA472_1
(CYTOCHROME P450 51)		 4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN
(Azotobacter
vinelandii) 		4 / 6 MET A 279
VAL A 206
LEU A 207
MET A 286
 None
 1.11A 1x8vA-4wzbA:
undetectable		 1x8vA-4wzbA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC8_0
(N8-ACTINOMYCIN D)		 4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN
(Azotobacter
vinelandii) 		3 / 3 THR A 303
THR A 305
PRO A 302
 None
 0.87A 209dC-4wzbA:
undetectable		 209dC-4wzbA:
4.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN
(Azotobacter
vinelandii) 		4 / 8 ASN A  49
SER A  48
VAL A 189
TYR A 387
 None
 1.20A 2wekA-4wzbA:
2.8		 2wekA-4wzbA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN
(Azotobacter
vinelandii) 		4 / 8 ASN A  49
SER A  48
VAL A 189
TYR A 387
 None
 1.20A 2wekB-4wzbA:
2.8		 2wekB-4wzbA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN
(Azotobacter
vinelandii) 		4 / 6 SER A  82
LYS A  68
TYR A  64
CYH A  62
 None
None
CLF  A1498 (-4.7A)
CLF  A1498 (-2.5A)
 1.42A 2x7hA-4wzbA:
2.2		 2x7hA-4wzbA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN
(Azotobacter
vinelandii) 		5 / 12 GLY A 194
GLY A  66
LEU A 193
ALA A 198
ASN A 199
 None
 1.15A 3kkzA-4wzbA:
2.1		 3kkzA-4wzbA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)		 4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN
(Azotobacter
vinelandii) 		4 / 7 SER A 165
LEU A 131
ASP A 128
LYS A 129
 None
 1.16A 3lslA-4wzbA:
undetectable
3lslD-4wzbA:
undetectable		 3lslA-4wzbA:
19.01
3lslD-4wzbA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_C_AG2C1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN
(Azotobacter
vinelandii) 		4 / 8 HIS A 383
ASP A  27
ASP A 402
ASP A 403
 None
 1.26A 3n2oC-4wzbA:
undetectable
3n2oD-4wzbA:
undetectable		 3n2oC-4wzbA:
20.88
3n2oD-4wzbA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_B_AICB376_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 4wzb NITROGENASE IRON
PROTEIN 1
(Azotobacter
vinelandii) 		5 / 11 LEU E 203
LEU E 179
GLY E 181
ASN E 201
LEU E 252
 None
 1.31A 3ndvA-4wzbE:
undetectable
3ndvB-4wzbE:
undetectable		 3ndvA-4wzbE:
25.20
3ndvB-4wzbE:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_C_AICC375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 4wzb NITROGENASE IRON
PROTEIN 1
(Azotobacter
vinelandii) 		5 / 11 GLY E 181
ASN E 201
LEU E 252
LEU E 203
LEU E 179
 None
 1.33A 3ndvC-4wzbE:
undetectable
3ndvD-4wzbE:
undetectable		 3ndvC-4wzbE:
25.20
3ndvD-4wzbE:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN
(Azotobacter
vinelandii) 		5 / 12 GLU A 261
GLY A 257
ILE A  75
GLY A 255
ASN A  98
 None
 1.24A 3ps9A-4wzbA:
undetectable		 3ps9A-4wzbA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		 4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN
(Azotobacter
vinelandii) 		5 / 11 LEU A 242
ASP A 228
ASN A 230
GLY A 233
ASP A 234
 None
 1.44A 3sfuC-4wzbA:
undetectable		 3sfuC-4wzbA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_1
(PUTATIVE REGULATORY
PROTEIN)		 4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN
(Azotobacter
vinelandii) 		3 / 3 TYR A 401
MET A 372
LEU A 420
 None
 0.98A 3vw1D-4wzbA:
undetectable		 3vw1D-4wzbA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_1
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN
(Azotobacter
vinelandii) 		3 / 3 TYR A 354
ASP A 402
ASP A 386
 None
 0.71A 4a6eA-4wzbA:
2.2		 4a6eA-4wzbA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_C_MIYC392_1
(TETX2 PROTEIN)		 4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN
(Azotobacter
vinelandii) 		5 / 12 PHE A 431
VAL A 404
ILE A  59
ILE A 355
TYR A 354
 None
None
None
ICS  A1496 (-4.1A)
None
 1.13A 4a99A-4wzbA:
undetectable
4a99C-4wzbA:
undetectable		 4a99A-4wzbA:
20.32
4a99C-4wzbA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_B_URFB1301_1
(URIDINE
PHOSPHORYLASE)		 4wzb NITROGENASE IRON
PROTEIN 1
(Azotobacter
vinelandii) 		4 / 7 GLY E 167
ILE E 168
VAL E 169
PRO E 256
 None
 1.05A 4e1vB-4wzbE:
undetectable		 4e1vB-4wzbE:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HIV_D_DVAD2_0
(ACTINOMYCIN D)		 4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN
(Azotobacter
vinelandii) 		3 / 3 THR A 305
PRO A 302
THR A 303
 None
 0.83A 4hivD-4wzbA:
undetectable		 4hivD-4wzbA:
4.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_ACTA303_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN
(Azotobacter
vinelandii) 		3 / 3 TYR A 276
HIS A 383
ARG A 277
 None
 0.76A 4htfA-4wzbA:
undetectable		 4htfA-4wzbA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A601_1
(SERUM ALBUMIN)		 4wzb NITROGENASE IRON
PROTEIN 1
(Azotobacter
vinelandii) 		4 / 7 LEU E 253
VAL E 254
PRO E 256
GLU E 146
 None
 1.03A 4lb2A-4wzbE:
undetectable		 4lb2A-4wzbE:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA207_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN
(Azotobacter
vinelandii) 		5 / 12 PRO A 180
ALA A 201
ALA A  63
GLY A 194
LEU A 193
 None
 1.10A 4oaeA-4wzbA:
undetectable		 4oaeA-4wzbA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_A_ML1A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN
(Azotobacter
vinelandii) 		4 / 8 TYR A 367
TRP A 444
GLY A 424
ILE A  59
 None
None
HCA  A1494 (-3.5A)
None
 0.90A 4qoiA-4wzbA:
undetectable
4qoiB-4wzbA:
undetectable		 4qoiA-4wzbA:
19.68
4qoiB-4wzbA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIL_H_QI9H1223_0
(FAB 314.1)		 4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN
(Azotobacter
vinelandii) 		5 / 12 TRP A 444
HIS A 451
GLY A 232
GLN A 252
GLY A 255
 None
 1.12A 4uilH-4wzbA:
undetectable
4uilL-4wzbA:
undetectable		 4uilH-4wzbA:
17.71
4uilL-4wzbA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2O_B_CLQB1079_0
(SAPOSIN-B)		 4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN
(Azotobacter
vinelandii) 		3 / 3 MET A   4
GLU A   8
LEU A  12
 None
 0.71A 4v2oB-4wzbA:
undetectable		 4v2oB-4wzbA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_F_TR6F101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN
(Azotobacter
vinelandii) 		4 / 5 GLY A 188
ARG A 187
GLY A 185
GLU A 184
 None
None
CLF  A1498 (-3.5A)
None
 1.10A 4z2eB-4wzbA:
undetectable
4z2eC-4wzbA:
2.9		 4z2eB-4wzbA:
22.14
4z2eC-4wzbA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_D_ACTD403_0
(PROTON-GATED ION
CHANNEL)		 4wzb NITROGENASE IRON
PROTEIN 1
(Azotobacter
vinelandii) 		4 / 4 ILE E 208
ARG E   3
TYR E 148
GLU E 146
 None
 1.37A 4zzbD-4wzbE:
undetectable		 4zzbD-4wzbE:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_1
(DIHYDROFOLATE
REDUCTASE)		 4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN
(Azotobacter
vinelandii) 		3 / 3 ASP A 234
ARG A 461
ARG A 439
 None
 0.92A 5eajB-4wzbA:
undetectable		 5eajB-4wzbA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_B_FUAB1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4wzb NITROGENASE IRON
PROTEIN 1
(Azotobacter
vinelandii) 		4 / 5 ILE E 106
LEU E  76
LYS E  84
VAL E 122
 None
 1.20A 5jmnB-4wzbE:
undetectable		 5jmnB-4wzbE:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN
(Azotobacter
vinelandii) 		5 / 10 THR A 377
GLY A 356
ALA A 382
ASP A 402
SER A  48
 None
ICS  A1496 (-3.4A)
None
None
None
 1.43A 5l66K-4wzbA:
undetectable
5l66L-4wzbA:
undetectable		 5l66K-4wzbA:
18.22
5l66L-4wzbA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN
(Azotobacter
vinelandii) 		5 / 10 THR A 377
GLY A 357
ALA A 382
ASP A 402
SER A  48
 None
ICS  A1496 (-3.6A)
None
None
None
 1.30A 5l66K-4wzbA:
undetectable
5l66L-4wzbA:
undetectable		 5l66K-4wzbA:
18.22
5l66L-4wzbA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN
(Azotobacter
vinelandii) 		5 / 10 THR A 377
GLY A 356
ALA A 382
ASP A 402
SER A  48
 None
ICS  A1496 (-3.4A)
None
None
None
 1.43A 5l66Y-4wzbA:
undetectable
5l66Z-4wzbA:
undetectable		 5l66Y-4wzbA:
18.22
5l66Z-4wzbA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN
(Azotobacter
vinelandii) 		5 / 10 THR A 377
GLY A 357
ALA A 382
ASP A 402
SER A  48
 None
ICS  A1496 (-3.6A)
None
None
None
 1.30A 5l66Y-4wzbA:
undetectable
5l66Z-4wzbA:
undetectable		 5l66Y-4wzbA:
18.22
5l66Z-4wzbA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN
(Azotobacter
vinelandii) 		4 / 7 LEU A 242
ILE A 282
MET A 279
TRP A 253
 None
 1.06A 5ljcA-4wzbA:
undetectable		 5ljcA-4wzbA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4wzb NITROGENASE IRON
PROTEIN 1
(Azotobacter
vinelandii) 		4 / 4 SER E  44
ALA E  42
GLN E  54
THR E  56
 None
 1.31A 5n0rA-4wzbE:
undetectable		 5n0rA-4wzbE:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4wzb NITROGENASE IRON
PROTEIN 1
(Azotobacter
vinelandii) 		4 / 4 SER E  44
ALA E  42
GLN E  54
THR E  56
 None
 1.29A 5n0sA-4wzbE:
undetectable		 5n0sA-4wzbE:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4wzb NITROGENASE IRON
PROTEIN 1
(Azotobacter
vinelandii) 		4 / 5 SER E  44
ALA E  42
GLN E  54
THR E  56
 None
 1.35A 5n0tA-4wzbE:
undetectable		 5n0tA-4wzbE:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4wzb NITROGENASE IRON
PROTEIN 1
(Azotobacter
vinelandii) 		4 / 4 SER E  44
ALA E  42
GLN E  54
THR E  56
 None
 1.27A 5n0wA-4wzbE:
undetectable		 5n0wA-4wzbE:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4wzb NITROGENASE IRON
PROTEIN 1
(Azotobacter
vinelandii) 		4 / 5 SER E  44
ALA E  42
GLN E  54
THR E  56
 None
 1.27A 5n0wB-4wzbE:
2.8		 5n0wB-4wzbE:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4wzb NITROGENASE IRON
PROTEIN 1
(Azotobacter
vinelandii) 		4 / 4 SER E  44
ALA E  42
GLN E  54
THR E  56
 None
 1.32A 5n0xA-4wzbE:
undetectable		 5n0xA-4wzbE:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4wzb NITROGENASE IRON
PROTEIN 1
(Azotobacter
vinelandii) 		4 / 5 SER E  44
ALA E  42
GLN E  54
THR E  56
 None
 1.26A 5n4iA-4wzbE:
undetectable		 5n4iA-4wzbE:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_A_SALA201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN
(Azotobacter
vinelandii) 		4 / 5 ARG A  96
PRO A  74
GLY A 255
TYR A 229
 ICS  A1496 (-4.0A)
None
None
ICS  A1496 (-4.1A)
 1.14A 5x80A-4wzbA:
undetectable
5x80B-4wzbA:
undetectable		 5x80A-4wzbA:
17.04
5x80B-4wzbA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_C_SALC201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN
(Azotobacter
vinelandii) 		5 / 7 ARG A  96
VAL A 110
PRO A  74
GLY A 255
TYR A 229
 ICS  A1496 (-4.0A)
None
None
None
ICS  A1496 (-4.1A)
 1.24A 5x80C-4wzbA:
undetectable
5x80D-4wzbA:
undetectable		 5x80C-4wzbA:
17.04
5x80D-4wzbA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_D_SALD201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN
(Azotobacter
vinelandii) 		4 / 5 PRO A  74
GLY A 255
TYR A 229
ARG A  96
 None
None
ICS  A1496 (-4.1A)
ICS  A1496 (-4.0A)
 1.12A 5x80C-4wzbA:
undetectable
5x80D-4wzbA:
undetectable		 5x80C-4wzbA:
17.04
5x80D-4wzbA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4wzb NITROGENASE IRON
PROTEIN 1
(Azotobacter
vinelandii) 		3 / 3 GLY E 113
VAL E 122
MET E  34
 None
 0.52A 5ycpA-4wzbE:
undetectable		 5ycpA-4wzbE:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN
(Azotobacter
vinelandii) 		3 / 3 ASP A 228
PHE A 300
ARG A 359
 None
None
ICS  A1496 (-3.9A)
 1.15A 5yw0A-4wzbA:
undetectable		 5yw0A-4wzbA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_1
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN
(Azotobacter
vinelandii) 		4 / 6 SER A  67
GLU A 184
ARG A 187
ASP A 161
 None
 1.25A 5zw4A-4wzbA:
3.0		 5zw4A-4wzbA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_D_ECLD1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 4wzb NITROGENASE IRON
PROTEIN 1
(Azotobacter
vinelandii) 		4 / 7 ALA E 200
ILE E 147
LEU E 179
ILE E  13
 None
 0.88A 6b5vB-4wzbE:
undetectable
6b5vD-4wzbE:
undetectable		 6b5vB-4wzbE:
18.41
6b5vD-4wzbE:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CHG_C_SAMC1101_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-4 SPECIFIC)		 4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN
(Azotobacter
vinelandii) 		5 / 12 ILE A  79
ASN A 113
SER A 152
TYR A  64
LEU A 131
 None
None
None
CLF  A1498 (-4.7A)
None
 1.33A 6chgC-4wzbA:
undetectable		 6chgC-4wzbA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ2_B_AB1B201_0
(HIV-1 PROTEASE)		 4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN
(Azotobacter
vinelandii) 		5 / 10 ILE A 355
GLY A 422
ILE A 421
VAL A 404
ILE A  59
 ICS  A1496 (-4.1A)
None
None
None
None
 1.01A 6dj2A-4wzbA:
undetectable		 6dj2A-4wzbA:
10.80