SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wzf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_1
(PROTEIN (HIV-1
PROTEASE))		 4wzf 1,3-BETA-GLUCANASE
(Mycobacterium
tuberculosis) 		5 / 10 LEU A  57
ASP A  71
ASP A  60
VAL A 291
GLY A 132
 None
 1.20A 1d4sA-4wzfA:
undetectable		 1d4sA-4wzfA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA2001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 4wzf 1,3-BETA-GLUCANASE
(Mycobacterium
tuberculosis) 		4 / 6 TRP A 134
TRP A 142
GLY A 139
PRO A 218
 None
 1.38A 1dedA-4wzfA:
undetectable		 1dedA-4wzfA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_SAMA635_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 4wzf 1,3-BETA-GLUCANASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 275
GLY A 274
GLY A 179
PRO A 153
PHE A  90
 None
 1.17A 1qzzA-4wzfA:
undetectable		 1qzzA-4wzfA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4wzf 1,3-BETA-GLUCANASE
(Mycobacterium
tuberculosis) 		4 / 8 TRP A 156
GLU A 176
VAL A 205
TRP A 177
 EDO  A 402 (-4.1A)
EDO  A 402 (-3.5A)
None
None
 1.00A 1rs6A-4wzfA:
undetectable
1rs6B-4wzfA:
undetectable		 1rs6A-4wzfA:
20.86
1rs6B-4wzfA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S19_A_MC9A500_0
(VITAMIN D3 RECEPTOR)		 4wzf 1,3-BETA-GLUCANASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 108
VAL A 288
CYH A 150
VAL A 106
LEU A 129
 None
None
None
None
EDO  A 403 (-4.7A)
 1.15A 1s19A-4wzfA:
undetectable		 1s19A-4wzfA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_A_SAMA500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 4wzf 1,3-BETA-GLUCANASE
(Mycobacterium
tuberculosis) 		5 / 11 GLU A 199
ALA A 191
ASP A 194
PRO A 253
PHE A 254
 None
 1.18A 2admA-4wzfA:
undetectable		 2admA-4wzfA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4wzf 1,3-BETA-GLUCANASE
(Mycobacterium
tuberculosis) 		3 / 3 ASP A 289
ASP A  60
ASN A 111
 CA  A 401 (-3.2A)
None
None
 0.81A 2bm9D-4wzfA:
undetectable		 2bm9D-4wzfA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G6H_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4wzf 1,3-BETA-GLUCANASE
(Mycobacterium
tuberculosis) 		4 / 8 VAL A 205
TRP A 177
TRP A 156
GLU A 176
 None
None
EDO  A 402 (-4.1A)
EDO  A 402 (-3.5A)
 1.10A 2g6hA-4wzfA:
undetectable
2g6hB-4wzfA:
undetectable		 2g6hA-4wzfA:
20.59
2g6hB-4wzfA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B3P_B_H4BB760_1
(NITRIC-OXIDE
SYNTHASE)		 4wzf 1,3-BETA-GLUCANASE
(Mycobacterium
tuberculosis) 		4 / 8 TRP A 156
GLU A 176
VAL A 205
TRP A 177
 EDO  A 402 (-4.1A)
EDO  A 402 (-3.5A)
None
None
 0.94A 3b3pA-4wzfA:
undetectable
3b3pB-4wzfA:
undetectable		 3b3pA-4wzfA:
20.81
3b3pB-4wzfA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD47_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 4wzf 1,3-BETA-GLUCANASE
(Mycobacterium
tuberculosis) 		4 / 4 GLY A 154
GLY A 275
GLY A 273
GLY A 270
 None
 0.62A 3bogD-4wzfA:
undetectable		 3bogD-4wzfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCH_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4wzf 1,3-BETA-GLUCANASE
(Mycobacterium
tuberculosis) 		4 / 8 TRP A 156
GLU A 176
VAL A 205
TRP A 177
 EDO  A 402 (-4.1A)
EDO  A 402 (-3.5A)
None
None
 1.05A 4uchA-4wzfA:
undetectable
4uchB-4wzfA:
undetectable		 4uchA-4wzfA:
20.05
4uchB-4wzfA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4wzf 1,3-BETA-GLUCANASE
(Mycobacterium
tuberculosis) 		4 / 5 ARG A  81
PRO A  93
ILE A  84
ASP A  91
 None
 1.37A 4z4hA-4wzfA:
undetectable		 4z4hA-4wzfA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_1
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 4wzf 1,3-BETA-GLUCANASE
(Mycobacterium
tuberculosis) 		3 / 3 GLU A 176
TRP A 183
HIS A 190
 EDO  A 402 (-3.5A)
None
None
 1.11A 5xipA-4wzfA:
undetectable		 5xipA-4wzfA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H0G_E_Y70E502_0
(PROTEIN CEREBLON
ZINC FINGER PROTEIN
692)		 4wzf 1,3-BETA-GLUCANASE
(Mycobacterium
tuberculosis) 		5 / 12 PRO A 157
GLU A 176
SER A 185
TRP A 177
GLY A 273
 None
EDO  A 402 (-3.5A)
None
None
None
 1.42A 6h0gE-4wzfA:
0.0
6h0gF-4wzfA:
undetectable		 6h0gE-4wzfA:
13.07
6h0gF-4wzfA:
10.81