SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wzh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3004_1
(SERUM ALBUMIN)		 4wzh DIHYDROOROTATE
DEHYDROGENASE
(Leishmania
braziliensis) 		4 / 6 GLU A 278
LEU A 275
VAL A  22
MET A  23
 None
 0.97A 1hk1A-4wzhA:
undetectable		 1hk1A-4wzhA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3004_1
(SERUM ALBUMIN)		 4wzh DIHYDROOROTATE
DEHYDROGENASE
(Leishmania
braziliensis) 		4 / 7 GLU A 278
LEU A 275
VAL A  22
MET A  23
 None
 1.01A 1hk3A-4wzhA:
undetectable		 1hk3A-4wzhA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 4wzh DIHYDROOROTATE
DEHYDROGENASE
(Leishmania
braziliensis) 		4 / 7 ILE A 181
TYR A 169
MET A 166
LEU A 129
 None
 0.99A 1v54N-4wzhA:
undetectable
1v54W-4wzhA:
undetectable		 1v54N-4wzhA:
21.76
1v54W-4wzhA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_B_SAMB302_0
(RRNA
METHYLTRANSFERASE)		 4wzh DIHYDROOROTATE
DEHYDROGENASE
(Leishmania
braziliensis) 		5 / 10 GLU A 277
GLY A 223
GLY A  65
ILE A 282
LEU A 275
 None
FMN  A 401 (-3.3A)
None
None
None
 1.03A 1x7pA-4wzhA:
undetectable
1x7pB-4wzhA:
undetectable		 1x7pA-4wzhA:
21.39
1x7pB-4wzhA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		 4wzh DIHYDROOROTATE
DEHYDROGENASE
(Leishmania
braziliensis) 		4 / 7 ALA A 179
ARG A 240
TYR A 142
PHE A 144
 None
 1.01A 2ajvH-4wzhA:
undetectable
2ajvL-4wzhA:
undetectable		 2ajvH-4wzhA:
19.03
2ajvL-4wzhA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		 4wzh DIHYDROOROTATE
DEHYDROGENASE
(Leishmania
braziliensis) 		4 / 7 SER A  45
LEU A  72
GLY A  53
ILE A 212
 FMN  A 401 (-2.6A)
None
None
None
 1.03A 2bdmA-4wzhA:
undetectable		 2bdmA-4wzhA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wzh DIHYDROOROTATE
DEHYDROGENASE
(Leishmania
braziliensis) 		4 / 7 ILE A 181
TYR A 169
MET A 166
LEU A 129
 None
 1.00A 2dyrN-4wzhA:
undetectable
2dyrW-4wzhA:
undetectable		 2dyrN-4wzhA:
21.76
2dyrW-4wzhA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_D_SALD5006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4wzh DIHYDROOROTATE
DEHYDROGENASE
(Leishmania
braziliensis) 		4 / 5 ARG A 224
THR A 254
LEU A 286
ALA A 274
 None
 1.39A 2e1qD-4wzhA:
undetectable		 2e1qD-4wzhA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wzh DIHYDROOROTATE
DEHYDROGENASE
(Leishmania
braziliensis) 		4 / 6 ILE A 181
TYR A 169
MET A 166
LEU A 129
 None
 0.99A 2einN-4wzhA:
undetectable
2einW-4wzhA:
undetectable		 2einN-4wzhA:
21.76
2einW-4wzhA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O5Y_H_STRH249_1
(CHIMERIC ANTIBODY
FAB 1E9-DB3)		 4wzh DIHYDROOROTATE
DEHYDROGENASE
(Leishmania
braziliensis) 		4 / 7 ASN A 107
GLY A 101
THR A  47
SER A  98
 None
None
None
FMN  A 401 ( 4.5A)
 1.25A 2o5yH-4wzhA:
undetectable
2o5yL-4wzhA:
undetectable		 2o5yH-4wzhA:
18.64
2o5yL-4wzhA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4wzh DIHYDROOROTATE
DEHYDROGENASE
(Leishmania
braziliensis) 		4 / 7 ILE A 181
TYR A 169
MET A 166
LEU A 129
 None
 0.96A 3ablA-4wzhA:
undetectable
3ablJ-4wzhA:
undetectable		 3ablA-4wzhA:
21.76
3ablJ-4wzhA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4wzh DIHYDROOROTATE
DEHYDROGENASE
(Leishmania
braziliensis) 		6 / 12 LEU A  41
GLY A 163
ALA A  20
LEU A  95
VAL A 123
ILE A 124
 None
None
FMN  A 401 (-3.7A)
None
None
None
 1.34A 3adxB-4wzhA:
undetectable		 3adxB-4wzhA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4wzh DIHYDROOROTATE
DEHYDROGENASE
(Leishmania
braziliensis) 		3 / 3 ILE A  97
PHE A  77
HIS A 160
 None
 0.75A 3h0aA-4wzhA:
undetectable		 3h0aA-4wzhA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 4wzh DIHYDROOROTATE
DEHYDROGENASE
(Leishmania
braziliensis) 		5 / 12 HIS A 261
GLY A 222
GLY A 223
LEU A  64
ALA A 230
 None
FMN  A 401 ( 3.9A)
FMN  A 401 (-3.3A)
None
None
 1.19A 3i5uA-4wzhA:
undetectable		 3i5uA-4wzhA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 4wzh DIHYDROOROTATE
DEHYDROGENASE
(Leishmania
braziliensis) 		5 / 12 HIS A 261
GLY A 222
GLY A 223
LEU A  64
ALA A 230
 None
FMN  A 401 ( 3.9A)
FMN  A 401 (-3.3A)
None
None
 1.19A 3i5uB-4wzhA:
undetectable		 3i5uB-4wzhA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD201_1
(PROTEIN S100-A4)		 4wzh DIHYDROOROTATE
DEHYDROGENASE
(Leishmania
braziliensis) 		4 / 8 GLY A 251
MET A  23
CYH A  24
PHE A 283
 FMN  A 401 (-3.5A)
None
None
None
 1.08A 3ko0D-4wzhA:
undetectable
3ko0E-4wzhA:
undetectable		 3ko0D-4wzhA:
15.11
3ko0E-4wzhA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S79_A_ASDA601_1
(CYTOCHROME P450 19A1)		 4wzh DIHYDROOROTATE
DEHYDROGENASE
(Leishmania
braziliensis) 		5 / 12 PHE A  96
ILE A 246
ALA A 266
VAL A   5
LEU A   8
 None
None
None
None
EPE  A 402 (-4.7A)
 1.16A 3s79A-4wzhA:
undetectable		 3s79A-4wzhA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4wzh DIHYDROOROTATE
DEHYDROGENASE
(Leishmania
braziliensis) 		4 / 6 ILE A 181
TYR A 169
MET A 166
LEU A 129
 None
 0.95A 3wg7N-4wzhA:
undetectable
3wg7W-4wzhA:
undetectable		 3wg7N-4wzhA:
21.76
3wg7W-4wzhA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_ACTC202_0
(RETINOL-BINDING
PROTEIN 2)		 4wzh DIHYDROOROTATE
DEHYDROGENASE
(Leishmania
braziliensis) 		4 / 6 TYR A 225
GLU A 277
THR A 273
LEU A  64
 None
None
FMN  A 401 (-3.5A)
None
 1.24A 4qzuC-4wzhA:
undetectable		 4qzuC-4wzhA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4wzh DIHYDROOROTATE
DEHYDROGENASE
(Leishmania
braziliensis) 		4 / 7 ILE A 181
TYR A 169
MET A 166
LEU A 129
 None
 0.96A 5b1bA-4wzhA:
undetectable
5b1bJ-4wzhA:
undetectable		 5b1bA-4wzhA:
21.76
5b1bJ-4wzhA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4wzh DIHYDROOROTATE
DEHYDROGENASE
(Leishmania
braziliensis) 		4 / 7 ILE A 181
TYR A 169
MET A 166
LEU A 129
 None
 0.99A 5iy5A-4wzhA:
undetectable
5iy5J-4wzhA:
undetectable		 5iy5A-4wzhA:
21.76
5iy5J-4wzhA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKV_A_ASDA602_1
(AROMATASE)		 4wzh DIHYDROOROTATE
DEHYDROGENASE
(Leishmania
braziliensis) 		5 / 12 PHE A  96
ILE A 246
ALA A 266
VAL A   5
LEU A   8
 None
None
None
None
EPE  A 402 (-4.7A)
 1.15A 5jkvA-4wzhA:
undetectable		 5jkvA-4wzhA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKL_B_SAMB8009_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN,HISTONE H3.1
PEPTIDE,ZINC FINGER
DOMAIN-CONTAINING
PROTEIN)		 4wzh DIHYDROOROTATE
DEHYDROGENASE
(Leishmania
braziliensis) 		5 / 12 GLY A 122
TYR A  90
ASN A  10
PHE A 247
MET A 268
 None
 1.19A 5kklB-4wzhA:
undetectable		 5kklB-4wzhA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7F_A_SAMA301_0
(PUTATIVE
O-METHYLTRANSFERASE
RV1220C)		 4wzh DIHYDROOROTATE
DEHYDROGENASE
(Leishmania
braziliensis) 		5 / 12 GLY A 200
VAL A 202
GLY A 222
GLY A 220
ILE A 194
 None
None
FMN  A 401 ( 3.9A)
None
None
 0.80A 5x7fA-4wzhA:
undetectable		 5x7fA-4wzhA:
28.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4wzh DIHYDROOROTATE
DEHYDROGENASE
(Leishmania
braziliensis) 		4 / 6 TYR A 253
GLU A 256
GLY A 251
GLY A 223
 None
None
FMN  A 401 (-3.5A)
FMN  A 401 (-3.3A)
 0.79A 5x7pB-4wzhA:
undetectable		 5x7pB-4wzhA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4wzh DIHYDROOROTATE
DEHYDROGENASE
(Leishmania
braziliensis) 		4 / 6 ILE A 181
TYR A 169
MET A 166
LEU A 129
 None
 0.95A 5z86N-4wzhA:
undetectable
5z86W-4wzhA:
undetectable		 5z86N-4wzhA:
21.76
5z86W-4wzhA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4wzh DIHYDROOROTATE
DEHYDROGENASE
(Leishmania
braziliensis) 		4 / 8 ILE A 181
TYR A 169
MET A 166
LEU A 129
 None
 0.96A 5zcoA-4wzhA:
undetectable
5zcoJ-4wzhA:
undetectable		 5zcoA-4wzhA:
21.76
5zcoJ-4wzhA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4wzh DIHYDROOROTATE
DEHYDROGENASE
(Leishmania
braziliensis) 		4 / 6 ILE A 181
TYR A 169
MET A 166
LEU A 129
 None
 0.98A 5zcoN-4wzhA:
undetectable
5zcoW-4wzhA:
undetectable		 5zcoN-4wzhA:
21.76
5zcoW-4wzhA:
11.37