SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wzi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_1
(ESTROGEN RECEPTOR)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		5 / 12 TRP A 348
LEU A 421
LEU A 422
ILE A 371
LEU A 645
 None
 1.15A 1errB-4wziA:
undetectable		 1errB-4wziA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_0
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		4 / 4 THR A 222
LEU A 226
LEU A 233
GLN A 237
 None
 1.20A 1fbmA-4wziA:
undetectable		 1fbmA-4wziA:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_A_EAAA224_1
(GLUTATHIONE
TRANSFERASE)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		5 / 12 ARG A 375
LEU A 437
LEU A 506
VAL A 510
ALA A 444
 None
 1.03A 1gseA-4wziA:
undetectable		 1gseA-4wziA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_A_ESTA600_1
(ESTRADIOL RECEPTOR)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		5 / 10 ALA A 563
LEU A 421
LEU A 422
MET A 368
ILE A 371
 None
 1.09A 1qkuA-4wziA:
1.9		 1qkuA-4wziA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_B_ESTB600_1
(ESTRADIOL RECEPTOR)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		5 / 10 ALA A 563
LEU A 421
LEU A 422
MET A 368
ILE A 371
 None
 1.08A 1qkuB-4wziA:
1.9		 1qkuB-4wziA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_C_ESTC600_1
(ESTRADIOL RECEPTOR)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		5 / 10 ALA A 563
LEU A 421
LEU A 422
MET A 368
ILE A 371
 None
 1.09A 1qkuC-4wziA:
1.9		 1qkuC-4wziA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		6 / 10 TYR A 405
HIS A 406
PHE A 586
GLN A 615
GLY A 617
PHE A 618
 None
MG  A 804 ( 4.9A)
None
None
None
None
 0.42A 1uhoA-4wziA:
36.2		 1uhoA-4wziA:
22.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		12 / 12 TYR A 405
HIS A 406
HIS A 450
MET A 519
LEU A 565
ASN A 567
THR A 579
ILE A 582
MET A 583
SER A 614
GLN A 615
PHE A 618
 None
MG  A 804 ( 4.9A)
None
None
None
None
None
None
None
None
None
None
 0.65A 1xlxA-4wziA:
52.1		 1xlxA-4wziA:
61.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XLX_B_CIOB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		9 / 12 TYR A 405
HIS A 406
HIS A 450
ILE A 582
MET A 583
PHE A 586
MET A 603
SER A 614
GLN A 615
 None
MG  A 804 ( 4.9A)
None
None
None
None
None
None
None
 1.05A 1xlxB-4wziA:
52.3		 1xlxB-4wziA:
61.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XLX_B_CIOB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		10 / 12 TYR A 405
HIS A 406
HIS A 450
MET A 519
ILE A 582
MET A 583
PHE A 586
SER A 614
GLN A 615
PHE A 618
 None
MG  A 804 ( 4.9A)
None
None
None
None
None
None
None
None
 0.88A 1xlxB-4wziA:
52.3		 1xlxB-4wziA:
61.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XLX_B_CIOB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		10 / 12 TYR A 405
HIS A 406
HIS A 450
MET A 519
THR A 579
ILE A 582
MET A 583
PHE A 586
GLN A 615
PHE A 618
 None
MG  A 804 ( 4.9A)
None
None
None
None
None
None
None
None
 0.72A 1xlxB-4wziA:
52.3		 1xlxB-4wziA:
61.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XLX_B_CIOB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		9 / 12 TYR A 405
HIS A 406
HIS A 450
THR A 579
ILE A 582
MET A 583
PHE A 586
MET A 603
GLN A 615
 None
MG  A 804 ( 4.9A)
None
None
None
None
None
None
None
 0.81A 1xlxB-4wziA:
52.3		 1xlxB-4wziA:
61.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		11 / 12 TYR A 405
HIS A 406
ASP A 564
LEU A 565
PRO A 568
TYR A 575
TRP A 578
ILE A 582
PHE A 586
SER A 614
PHE A 618
 None
MG  A 804 ( 4.9A)
ZN  A 801 (-2.5A)
None
None
None
None
None
None
None
None
 0.53A 1xmuA-4wziA:
52.5		 1xmuA-4wziA:
61.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		10 / 12 TYR A 405
HIS A 406
ASP A 564
PRO A 568
TYR A 575
TRP A 578
ILE A 582
PHE A 586
MET A 603
SER A 614
 None
MG  A 804 ( 4.9A)
ZN  A 801 (-2.5A)
None
None
None
None
None
None
None
 1.00A 1xmuA-4wziA:
52.5		 1xmuA-4wziA:
61.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_A_ROFA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		5 / 5 MET A 519
ASN A 567
THR A 579
MET A 583
GLN A 615
 None
 0.42A 1xmuA-4wziA:
52.5		 1xmuA-4wziA:
61.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_B_ROFB102_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		10 / 12 TYR A 405
HIS A 406
ASP A 564
PRO A 568
TYR A 575
TRP A 578
ILE A 582
PHE A 586
MET A 603
SER A 614
 None
MG  A 804 ( 4.9A)
ZN  A 801 (-2.5A)
None
None
None
None
None
None
None
 1.03A 1xmuB-4wziA:
52.4		 1xmuB-4wziA:
61.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_B_ROFB102_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		11 / 12 TYR A 405
HIS A 406
MET A 519
ASP A 564
LEU A 565
PRO A 568
TYR A 575
TRP A 578
ILE A 582
PHE A 586
SER A 614
 None
MG  A 804 ( 4.9A)
None
ZN  A 801 (-2.5A)
None
None
None
None
None
None
None
 0.67A 1xmuB-4wziA:
52.4		 1xmuB-4wziA:
61.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_B_ROFB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		5 / 5 ASN A 567
THR A 579
MET A 583
GLN A 615
PHE A 618
 None
 0.29A 1xmuB-4wziA:
52.4		 1xmuB-4wziA:
61.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		8 / 12 TYR A 405
HIS A 406
ILE A 582
MET A 583
PHE A 586
MET A 603
SER A 614
GLN A 615
 None
MG  A 804 ( 4.9A)
None
None
None
None
None
None
 0.89A 1xomA-4wziA:
52.8		 1xomA-4wziA:
48.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		11 / 12 TYR A 405
HIS A 406
MET A 519
ASP A 564
LEU A 565
ILE A 582
MET A 583
PHE A 586
SER A 614
GLN A 615
PHE A 618
 None
MG  A 804 ( 4.9A)
None
ZN  A 801 (-2.5A)
None
None
None
None
None
None
None
 0.61A 1xomA-4wziA:
52.8		 1xomA-4wziA:
48.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		11 / 12 TYR A 405
HIS A 406
MET A 519
LEU A 565
THR A 579
ILE A 582
MET A 583
PHE A 586
SER A 614
GLN A 615
PHE A 618
 None
MG  A 804 ( 4.9A)
None
None
None
None
None
None
None
None
None
 0.62A 1xomB-4wziA:
52.5		 1xomB-4wziA:
48.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		9 / 12 TYR A 405
HIS A 406
THR A 579
ILE A 582
MET A 583
PHE A 586
MET A 603
SER A 614
GLN A 615
 None
MG  A 804 ( 4.9A)
None
None
None
None
None
None
None
 0.84A 1xomB-4wziA:
52.5		 1xomB-4wziA:
48.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		7 / 12 TYR A 405
HIS A 410
MET A 519
LEU A 565
THR A 579
GLN A 615
PHE A 618
 None
ZN  A 801 (-3.2A)
None
None
None
None
None
 1.45A 1xomB-4wziA:
52.5		 1xomB-4wziA:
48.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		5 / 12 HIS A 410
MET A 519
LEU A 565
MET A 583
PHE A 618
 ZN  A 801 (-3.2A)
None
None
None
None
 1.30A 1xoqA-4wziA:
53.0		 1xoqA-4wziA:
48.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		10 / 12 TYR A 405
HIS A 406
ASP A 564
LEU A 565
PRO A 568
THR A 579
ILE A 582
MET A 603
SER A 614
PHE A 618
 None
MG  A 804 ( 4.9A)
ZN  A 801 (-2.5A)
None
None
None
None
None
None
None
 0.78A 1xoqA-4wziA:
53.0		 1xoqA-4wziA:
48.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		10 / 12 TYR A 405
HIS A 406
ASP A 564
LEU A 565
PRO A 568
TYR A 575
THR A 579
MET A 603
SER A 614
PHE A 618
 None
MG  A 804 ( 4.9A)
ZN  A 801 (-2.5A)
None
None
None
None
None
None
None
 0.66A 1xoqA-4wziA:
53.0		 1xoqA-4wziA:
48.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		10 / 12 TYR A 405
HIS A 406
MET A 519
ASP A 564
LEU A 565
PRO A 568
THR A 579
ILE A 582
SER A 614
PHE A 618
 None
MG  A 804 ( 4.9A)
None
ZN  A 801 (-2.5A)
None
None
None
None
None
None
 0.56A 1xoqA-4wziA:
53.0		 1xoqA-4wziA:
48.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		10 / 12 TYR A 405
HIS A 406
MET A 519
ASP A 564
LEU A 565
PRO A 568
TYR A 575
THR A 579
SER A 614
PHE A 618
 None
MG  A 804 ( 4.9A)
None
ZN  A 801 (-2.5A)
None
None
None
None
None
None
 0.38A 1xoqA-4wziA:
53.0		 1xoqA-4wziA:
48.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		3 / 3 ASN A 567
TRP A 578
GLN A 615
 None
 0.15A 1xoqA-4wziA:
53.0		 1xoqA-4wziA:
48.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		11 / 12 TYR A 405
HIS A 406
ASP A 564
LEU A 565
PRO A 568
TRP A 578
THR A 579
ILE A 582
MET A 603
SER A 614
PHE A 618
 None
MG  A 804 ( 4.9A)
ZN  A 801 (-2.5A)
None
None
None
None
None
None
None
None
 0.73A 1xoqB-4wziA:
52.6		 1xoqB-4wziA:
48.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		11 / 12 TYR A 405
HIS A 406
ASP A 564
LEU A 565
PRO A 568
TYR A 575
TRP A 578
THR A 579
MET A 603
SER A 614
PHE A 618
 None
MG  A 804 ( 4.9A)
ZN  A 801 (-2.5A)
None
None
None
None
None
None
None
None
 0.61A 1xoqB-4wziA:
52.6		 1xoqB-4wziA:
48.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		3 / 3 MET A 519
ASN A 567
GLN A 615
 None
 0.43A 1xoqB-4wziA:
52.6		 1xoqB-4wziA:
48.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOS_A_VIAA1_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		9 / 12 TYR A 405
HIS A 406
ASP A 564
LEU A 565
MET A 583
PHE A 586
GLN A 615
PHE A 618
ILE A 622
 None
MG  A 804 ( 4.9A)
ZN  A 801 (-2.5A)
None
None
None
None
None
None
 0.56A 1xosA-4wziA:
52.2		 1xosA-4wziA:
61.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOS_A_VIAA1_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		7 / 12 TYR A 405
HIS A 406
ASP A 564
MET A 583
PHE A 586
SER A 601
GLN A 615
 None
MG  A 804 ( 4.9A)
ZN  A 801 (-2.5A)
None
None
None
None
 1.10A 1xosA-4wziA:
52.2		 1xosA-4wziA:
61.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOS_A_VIAA1_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		6 / 12 TYR A 405
HIS A 406
MET A 583
PHE A 586
MET A 603
GLN A 615
 None
MG  A 804 ( 4.9A)
None
None
None
None
 0.84A 1xosA-4wziA:
52.2		 1xosA-4wziA:
61.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOS_A_VIAA1_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		6 / 12 TYR A 405
HIS A 410
LEU A 565
GLN A 615
PHE A 618
ILE A 622
 None
ZN  A 801 (-3.2A)
None
None
None
None
 1.45A 1xosA-4wziA:
52.2		 1xosA-4wziA:
61.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOS_A_VIAA1_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		8 / 12 TYR A 405
MET A 519
ASP A 564
LEU A 565
MET A 583
PHE A 586
GLN A 615
PHE A 618
 None
None
ZN  A 801 (-2.5A)
None
None
None
None
None
 0.80A 1xosA-4wziA:
52.2		 1xosA-4wziA:
61.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOS_A_VIAA1_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		7 / 12 TYR A 405
MET A 519
ASP A 564
MET A 583
PHE A 586
SER A 601
GLN A 615
 None
None
ZN  A 801 (-2.5A)
None
None
None
None
 1.22A 1xosA-4wziA:
52.2		 1xosA-4wziA:
61.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		7 / 12 TYR A 405
HIS A 406
ILE A 582
MET A 583
SER A 601
MET A 603
GLN A 615
 None
MG  A 804 ( 4.9A)
None
None
None
None
None
 0.96A 1xotA-4wziA:
52.2		 1xotA-4wziA:
61.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		10 / 12 TYR A 405
HIS A 406
LEU A 565
ILE A 582
MET A 583
SER A 601
SER A 614
GLN A 615
PHE A 618
ILE A 622
 None
MG  A 804 ( 4.9A)
None
None
None
None
None
None
None
None
 0.93A 1xotA-4wziA:
52.2		 1xotA-4wziA:
61.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		10 / 12 TYR A 405
HIS A 406
MET A 519
LEU A 565
ILE A 582
MET A 583
SER A 601
SER A 614
GLN A 615
PHE A 618
 None
MG  A 804 ( 4.9A)
None
None
None
None
None
None
None
None
 0.95A 1xotA-4wziA:
52.2		 1xotA-4wziA:
61.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		7 / 12 TYR A 405
ASN A 567
ILE A 582
MET A 583
SER A 601
MET A 603
GLN A 615
 None
 1.09A 1xotB-4wziA:
52.1		 1xotB-4wziA:
61.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		10 / 12 TYR A 405
HIS A 406
LEU A 565
ASN A 567
ILE A 582
MET A 583
SER A 601
SER A 614
GLN A 615
PHE A 618
 None
MG  A 804 ( 4.9A)
None
None
None
None
None
None
None
None
 0.83A 1xotB-4wziA:
52.1		 1xotB-4wziA:
61.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		10 / 12 TYR A 405
MET A 519
LEU A 565
ASN A 567
ILE A 582
MET A 583
SER A 601
SER A 614
GLN A 615
PHE A 618
 None
 0.87A 1xotB-4wziA:
52.1		 1xotB-4wziA:
61.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		5 / 11 TYR A 405
HIS A 406
PHE A 586
GLN A 615
PHE A 618
 None
MG  A 804 ( 4.9A)
None
None
None
 0.32A 2h42A-4wziA:
36.1		 2h42A-4wziA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		5 / 12 TYR A 405
LEU A 565
PHE A 586
GLN A 615
PHE A 618
 None
 0.52A 2h42C-4wziA:
35.9		 2h42C-4wziA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_1
(ESTROGEN RECEPTOR)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		5 / 12 ALA A 563
TRP A 348
LEU A 421
LEU A 422
MET A 368
 None
 1.11A 2jfaA-4wziA:
3.2		 2jfaA-4wziA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_A_EV1A1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		8 / 12 TYR A 405
HIS A 406
LEU A 565
ILE A 582
GLU A 585
PHE A 586
GLN A 615
PHE A 618
 None
MG  A 804 ( 4.9A)
None
None
None
None
None
None
 0.83A 2weyA-4wziA:
37.7		 2weyA-4wziA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_B_EV1B1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		4 / 8 ILE A 582
PHE A 586
GLN A 615
PHE A 618
 None
 0.56A 2weyB-4wziA:
37.6		 2weyB-4wziA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_P_CHDP1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		4 / 5 ARG A 503
PHE A 388
LEU A 487
PHE A 484
 IOD  A 805 (-4.3A)
None
None
IOD  A 805 ( 4.9A)
 1.17A 2y69P-4wziA:
undetectable
2y69W-4wziA:
undetectable		 2y69P-4wziA:
16.59
2y69W-4wziA:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YJA_B_ESTB1550_1
(ESTROGEN RECEPTOR)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		5 / 12 ALA A 563
LEU A 421
LEU A 422
MET A 368
ILE A 371
 None
 1.12A 2yjaB-4wziA:
undetectable		 2yjaB-4wziA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		4 / 5 ARG A 503
PHE A 388
LEU A 487
PHE A 484
 IOD  A 805 (-4.3A)
None
None
IOD  A 805 ( 4.9A)
 1.25A 3abmP-4wziA:
undetectable
3abmW-4wziA:
undetectable		 3abmP-4wziA:
16.59
3abmW-4wziA:
6.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		4 / 5 ARG A 503
PHE A 388
LEU A 487
PHE A 484
 IOD  A 805 (-4.3A)
None
None
IOD  A 805 ( 4.9A)
 1.34A 3ag3C-4wziA:
undetectable
3ag3J-4wziA:
undetectable		 3ag3C-4wziA:
16.59
3ag3J-4wziA:
6.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		4 / 4 ARG A 503
PHE A 388
LEU A 487
PHE A 484
 IOD  A 805 (-4.3A)
None
None
IOD  A 805 ( 4.9A)
 1.30A 3ag3P-4wziA:
0.9
3ag3W-4wziA:
1.5		 3ag3P-4wziA:
16.59
3ag3W-4wziA:
6.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA607_1
(CHITINASE A)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		4 / 7 VAL A 414
SER A 566
THR A 418
LEU A 421
 None
 1.20A 3arrA-4wziA:
undetectable		 3arrA-4wziA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		6 / 12 TYR A 405
HIS A 406
LEU A 565
PHE A 586
GLN A 615
PHE A 618
 None
MG  A 804 ( 4.9A)
None
None
None
None
 0.70A 3b2rA-4wziA:
31.5		 3b2rA-4wziA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		5 / 11 TYR A 405
HIS A 406
LEU A 565
GLN A 615
PHE A 618
 None
MG  A 804 ( 4.9A)
None
None
None
 0.64A 3b2rB-4wziA:
31.4		 3b2rB-4wziA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZV_A_AZMA263_1
(CARBONIC ANHYDRASE
13)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		5 / 12 HIS A 410
HIS A 446
PHE A 618
THR A 517
VAL A 623
 ZN  A 801 (-3.2A)
ZN  A 801 (-3.2A)
None
None
None
 1.18A 3czvA-4wziA:
undetectable
3czvB-4wziA:
undetectable		 3czvA-4wziA:
17.21
3czvB-4wziA:
17.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_A_ROFA901_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		11 / 12 TYR A 405
HIS A 406
MET A 519
ASN A 567
PRO A 568
TRP A 578
THR A 579
ILE A 582
MET A 603
SER A 614
PHE A 618
 None
MG  A 804 ( 4.9A)
None
None
None
None
None
None
None
None
None
 0.74A 3g4lA-4wziA:
52.2		 3g4lA-4wziA:
47.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_A_ROFA901_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		11 / 12 TYR A 405
HIS A 406
MET A 519
ASN A 567
PRO A 568
TYR A 575
TRP A 578
THR A 579
MET A 603
SER A 614
PHE A 618
 None
MG  A 804 ( 4.9A)
None
None
None
None
None
None
None
None
None
 0.60A 3g4lA-4wziA:
52.2		 3g4lA-4wziA:
47.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		3 / 3 ASP A 564
LEU A 565
GLN A 615
 ZN  A 801 (-2.5A)
None
None
 0.17A 3g4lA-4wziA:
52.2		 3g4lA-4wziA:
47.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_B_ROFB902_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		11 / 12 TYR A 405
HIS A 406
ASP A 564
LEU A 565
PRO A 568
TRP A 578
THR A 579
ILE A 582
MET A 583
MET A 603
PHE A 618
 None
MG  A 804 ( 4.9A)
ZN  A 801 (-2.5A)
None
None
None
None
None
None
None
None
 0.73A 3g4lB-4wziA:
52.2		 3g4lB-4wziA:
47.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_B_ROFB902_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		11 / 12 TYR A 405
HIS A 406
MET A 519
ASP A 564
LEU A 565
PRO A 568
TRP A 578
THR A 579
ILE A 582
MET A 583
PHE A 618
 None
MG  A 804 ( 4.9A)
None
ZN  A 801 (-2.5A)
None
None
None
None
None
None
None
 0.58A 3g4lB-4wziA:
52.2		 3g4lB-4wziA:
47.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_C_ROFC903_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		10 / 12 TYR A 405
HIS A 406
ASP A 564
LEU A 565
ASN A 567
PRO A 568
TRP A 578
THR A 579
ILE A 582
MET A 603
 None
MG  A 804 ( 4.9A)
ZN  A 801 (-2.5A)
None
None
None
None
None
None
None
 0.68A 3g4lC-4wziA:
52.4		 3g4lC-4wziA:
47.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_C_ROFC903_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		10 / 12 TYR A 405
HIS A 406
ASP A 564
LEU A 565
ASN A 567
PRO A 568
TYR A 575
TRP A 578
THR A 579
MET A 603
 None
MG  A 804 ( 4.9A)
ZN  A 801 (-2.5A)
None
None
None
None
None
None
None
 0.55A 3g4lC-4wziA:
52.4		 3g4lC-4wziA:
47.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_C_ROFC903_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		10 / 12 TYR A 405
HIS A 406
MET A 519
ASP A 564
LEU A 565
ASN A 567
PRO A 568
TRP A 578
THR A 579
ILE A 582
 None
MG  A 804 ( 4.9A)
None
ZN  A 801 (-2.5A)
None
None
None
None
None
None
 0.59A 3g4lC-4wziA:
52.4		 3g4lC-4wziA:
47.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_C_ROFC903_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		10 / 12 TYR A 405
HIS A 406
MET A 519
ASP A 564
LEU A 565
ASN A 567
PRO A 568
TYR A 575
TRP A 578
THR A 579
 None
MG  A 804 ( 4.9A)
None
ZN  A 801 (-2.5A)
None
None
None
None
None
None
 0.41A 3g4lC-4wziA:
52.4		 3g4lC-4wziA:
47.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_C_ROFC903_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		3 / 3 SER A 614
GLN A 615
PHE A 618
 None
 0.20A 3g4lC-4wziA:
52.4		 3g4lC-4wziA:
47.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_D_ROFD904_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		12 / 12 TYR A 405
HIS A 406
MET A 519
ASP A 564
LEU A 565
PRO A 568
TRP A 578
THR A 579
ILE A 582
MET A 583
SER A 614
GLN A 615
 None
MG  A 804 ( 4.9A)
None
ZN  A 801 (-2.5A)
None
None
None
None
None
None
None
None
 0.61A 3g4lD-4wziA:
52.2		 3g4lD-4wziA:
47.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_D_ROFD904_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		3 / 3 ASN A 567
MET A 603
PHE A 618
 None
 0.89A 3g4lD-4wziA:
52.2		 3g4lD-4wziA:
47.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IAK_A_EV1A415_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		8 / 9 TYR A 405
MET A 519
ASN A 567
ILE A 582
PHE A 586
GLN A 615
PHE A 618
ILE A 622
 None
 0.56A 3iakA-4wziA:
51.6		 3iakA-4wziA:
48.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_C_VIAC901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		4 / 7 TYR A 405
HIS A 406
GLN A 615
PHE A 618
 None
MG  A 804 ( 4.9A)
None
None
 0.41A 3jwqC-4wziA:
38.9		 3jwqC-4wziA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_D_VIAD901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		5 / 11 TYR A 405
HIS A 406
PHE A 586
GLN A 615
PHE A 618
 None
MG  A 804 ( 4.9A)
None
None
None
 0.46A 3jwqA-4wziA:
39.0
3jwqD-4wziA:
38.9		 3jwqA-4wziA:
22.26
3jwqD-4wziA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		4 / 5 SER A 241
THR A 238
GLU A 244
ASP A 281
 None
 1.06A 3tm4A-4wziA:
undetectable		 3tm4A-4wziA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		4 / 5 SER A 241
THR A 238
GLU A 244
ASP A 281
 None
 1.05A 3tm4B-4wziA:
undetectable		 3tm4B-4wziA:
20.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TVX_A_PNXA902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		5 / 9 ASN A 567
THR A 579
ILE A 582
MET A 603
GLN A 615
 None
 1.03A 3tvxA-4wziA:
52.5		 3tvxA-4wziA:
50.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TVX_A_PNXA902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		8 / 9 TYR A 405
LEU A 565
ASN A 567
PRO A 568
THR A 579
ILE A 582
GLN A 615
PHE A 618
 None
 0.56A 3tvxA-4wziA:
52.5		 3tvxA-4wziA:
50.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		5 / 7 ASN A 567
ILE A 582
PHE A 586
MET A 603
GLN A 615
 None
 1.01A 3tvxB-4wziA:
52.3		 3tvxB-4wziA:
50.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		6 / 7 TYR A 405
ASN A 567
ILE A 582
PHE A 586
GLN A 615
PHE A 618
 None
 0.62A 3tvxB-4wziA:
52.3		 3tvxB-4wziA:
50.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WFH_B_P2EB301_1
(MAB FAB H FRAGMENT
MAB FAB L FRAGMENT)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		5 / 12 HIS A 479
VAL A 482
HIS A 450
PRO A 451
LEU A 465
 None
 1.36A 3wfhA-4wziA:
undetectable
3wfhB-4wziA:
undetectable		 3wfhA-4wziA:
16.21
3wfhB-4wziA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WHX_B_XPGB301_1
(MAB FAB H FRAGMENT
MAB FAB L FRAGMENT)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		5 / 12 HIS A 479
VAL A 482
HIS A 450
PRO A 451
LEU A 465
 None
 1.35A 3whxA-4wziA:
undetectable
3whxB-4wziA:
undetectable		 3whxA-4wziA:
16.69
3whxB-4wziA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_1
(WBDD)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		4 / 6 TYR A 469
ASP A 449
GLU A 489
LEU A 480
 None
 1.23A 4ax8A-4wziA:
undetectable		 4ax8A-4wziA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_1
(ESTROGEN RECEPTOR)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		5 / 12 ALA A 563
TRP A 348
LEU A 421
LEU A 422
MET A 368
 None
 1.09A 4xi3D-4wziA:
undetectable		 4xi3D-4wziA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_A_SALA801_1
(PROTEIN POLYBROMO-1)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		4 / 7 ILE A 371
LEU A 364
ALA A 443
ILE A 440
 None
 0.76A 4y03A-4wziA:
undetectable		 4y03A-4wziA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA202_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		5 / 8 GLU A 585
VAL A 403
HIS A 406
ASP A 447
HIS A 479
 None
None
MG  A 804 ( 4.9A)
MG  A 804 ( 2.7A)
None
 1.27A 5f8yA-4wziA:
undetectable		 5f8yA-4wziA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB201_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		5 / 8 GLU A 585
VAL A 403
HIS A 406
ASP A 447
HIS A 479
 None
None
MG  A 804 ( 4.9A)
MG  A 804 ( 2.7A)
None
 1.29A 5f8yB-4wziA:
undetectable		 5f8yB-4wziA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_A_RAUA400_1
(IMINE REDUCTASE)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		5 / 11 LEU A 395
MET A 392
PHE A 388
MET A 368
GLY A 483
 None
 1.20A 5g6sA-4wziA:
undetectable
5g6sG-4wziA:
undetectable		 5g6sA-4wziA:
19.85
5g6sG-4wziA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_A_RAUA400_1
(IMINE REDUCTASE)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		5 / 11 LEU A 395
MET A 392
TYR A 391
MET A 368
GLY A 483
 None
 0.92A 5g6sA-4wziA:
undetectable
5g6sG-4wziA:
undetectable		 5g6sA-4wziA:
19.85
5g6sG-4wziA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_B_RAUB400_1
(IMINE REDUCTASE)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		5 / 11 LEU A 395
MET A 392
PHE A 388
MET A 368
GLY A 483
 None
 1.21A 5g6sB-4wziA:
undetectable
5g6sC-4wziA:
undetectable		 5g6sB-4wziA:
19.85
5g6sC-4wziA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_B_RAUB400_1
(IMINE REDUCTASE)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		5 / 11 LEU A 395
MET A 392
TYR A 391
MET A 368
GLY A 483
 None
 0.93A 5g6sB-4wziA:
undetectable
5g6sC-4wziA:
undetectable		 5g6sB-4wziA:
19.85
5g6sC-4wziA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_C_RAUC400_1
(IMINE REDUCTASE)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		5 / 12 MET A 368
GLY A 483
LEU A 395
MET A 392
PHE A 388
 None
 1.20A 5g6sB-4wziA:
undetectable
5g6sC-4wziA:
undetectable		 5g6sB-4wziA:
19.85
5g6sC-4wziA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_C_RAUC400_1
(IMINE REDUCTASE)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		5 / 12 MET A 368
GLY A 483
LEU A 395
MET A 392
TYR A 391
 None
 0.93A 5g6sB-4wziA:
undetectable
5g6sC-4wziA:
undetectable		 5g6sB-4wziA:
19.85
5g6sC-4wziA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_D_RAUD400_1
(IMINE REDUCTASE)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		5 / 10 LEU A 395
MET A 392
PHE A 388
MET A 368
GLY A 483
 None
 1.21A 5g6sD-4wziA:
undetectable
5g6sF-4wziA:
undetectable		 5g6sD-4wziA:
19.85
5g6sF-4wziA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_D_RAUD400_1
(IMINE REDUCTASE)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		5 / 10 LEU A 395
MET A 392
TYR A 391
MET A 368
GLY A 483
 None
 0.93A 5g6sD-4wziA:
undetectable
5g6sF-4wziA:
undetectable		 5g6sD-4wziA:
19.85
5g6sF-4wziA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_E_RAUE400_1
(IMINE REDUCTASE)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		5 / 11 LEU A 395
MET A 392
PHE A 388
MET A 368
GLY A 483
 None
 1.21A 5g6sE-4wziA:
undetectable
5g6sH-4wziA:
undetectable		 5g6sE-4wziA:
19.85
5g6sH-4wziA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_E_RAUE400_1
(IMINE REDUCTASE)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		5 / 11 LEU A 395
MET A 392
TYR A 391
MET A 368
GLY A 483
 None
 0.93A 5g6sE-4wziA:
undetectable
5g6sH-4wziA:
undetectable		 5g6sE-4wziA:
19.85
5g6sH-4wziA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		5 / 12 ALA A 563
LEU A 421
LEU A 422
MET A 368
ILE A 371
 None
 1.07A 5gtrA-4wziA:
3.3		 5gtrA-4wziA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_A_NCAA402_0
(NADPH DEHYDROGENASE
3)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		4 / 8 HIS A 561
PHE A 618
PRO A 568
TYR A 405
 None
 1.28A 5v4vA-4wziA:
undetectable		 5v4vA-4wziA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_B_NCAB402_0
(NADPH DEHYDROGENASE
3)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		4 / 8 HIS A 561
PHE A 618
PRO A 568
TYR A 405
 None
 1.28A 5v4vB-4wziA:
undetectable		 5v4vB-4wziA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		4 / 5 ARG A 503
PHE A 388
LEU A 487
PHE A 484
 IOD  A 805 (-4.3A)
None
None
IOD  A 805 ( 4.9A)
 1.32A 5wauC-4wziA:
undetectable
5wauJ-4wziA:
undetectable		 5wauC-4wziA:
16.59
5wauJ-4wziA:
6.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		4 / 5 ARG A 503
PHE A 388
LEU A 487
PHE A 484
 IOD  A 805 (-4.3A)
None
None
IOD  A 805 ( 4.9A)
 1.31A 5wauc-4wziA:
undetectable
5wauj-4wziA:
undetectable		 5wauc-4wziA:
16.59
5wauj-4wziA:
6.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		3 / 3 ARG A 503
PHE A 388
LEU A 487
 IOD  A 805 (-4.3A)
None
None
 0.67A 5x1bC-4wziA:
undetectable		 5x1bC-4wziA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_A_DAHA60_1
(PUTATIVE CYTOCHROME
C)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		4 / 6 HIS A 400
VAL A 453
LEU A 475
GLN A 589
 None
 1.49A 5xdhA-4wziA:
undetectable
5xdhC-4wziA:
undetectable		 5xdhA-4wziA:
8.59
5xdhC-4wziA:
8.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		4 / 5 ARG A 503
PHE A 388
LEU A 487
PHE A 484
 IOD  A 805 (-4.3A)
None
None
IOD  A 805 ( 4.9A)
 1.24A 5xdqC-4wziA:
undetectable
5xdqJ-4wziA:
undetectable		 5xdqC-4wziA:
16.59
5xdqJ-4wziA:
6.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens) 		4 / 5 ARG A 503
PHE A 388
LEU A 487
PHE A 484
 IOD  A 805 (-4.3A)
None
None
IOD  A 805 ( 4.9A)
 1.25A 5xdqP-4wziA:
undetectable
5xdqW-4wziA:
undetectable		 5xdqP-4wziA:
16.59
5xdqW-4wziA:
6.48