SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wzs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYR_A_TOPA407_1
(DIHYDROFOLATE
REDUCTASE)		 4wzs ECU04_1440 PROTEIN
(Encephalitozoon
cuniculi) 		5 / 11 ILE D 101
ILE D  81
ILE D  64
PRO D  67
ILE D 100
 None
 1.07A 1dyrA-4wzsD:
undetectable		 1dyrA-4wzsD:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXV_B_PNNB1001_0
(PENICILLIN ACYLASE)		 4wzs SIMILARITY TO
HELICASE MOT1
(Encephalitozoon
cuniculi) 		4 / 7 PHE C 588
SER C 498
PHE C 566
PHE C 469
 None
 1.10A 1fxvA-4wzsC:
undetectable
1fxvB-4wzsC:
undetectable		 1fxvA-4wzsC:
14.92
1fxvB-4wzsC:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_B_NIOB702_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4wzs SIMILARITY TO
HELICASE MOT1
(Encephalitozoon
cuniculi) 		4 / 5 PHE C 588
GLY C 568
THR C 573
PHE C 606
 None
 1.36A 1icvA-4wzsC:
undetectable
1icvB-4wzsC:
undetectable		 1icvA-4wzsC:
14.67
1icvB-4wzsC:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_B_SAMB400_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 4wzs SIMILARITY TO
HELICASE MOT1
(Encephalitozoon
cuniculi) 		5 / 9 ARG C 217
LEU C 295
GLU C 299
PHE C 259
GLY C 261
 None
 1.00A 1mjlA-4wzsC:
undetectable
1mjlB-4wzsC:
undetectable		 1mjlA-4wzsC:
8.59
1mjlB-4wzsC:
8.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_A_9CRA131_1
(TRANSTHYRETIN)		 4wzs SIMILARITY TO
HELICASE MOT1
(Encephalitozoon
cuniculi) 		4 / 6 LEU C 462
LEU C 431
SER C 430
THR C 487
 None
 1.30A 1tyrA-4wzsC:
undetectable		 1tyrA-4wzsC:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_C_DESC129_1
(TRANSTHYRETIN)		 4wzs SIMILARITY TO
HELICASE MOT1
(Encephalitozoon
cuniculi) 		4 / 6 LEU C 282
ALA C 298
LEU C 285
SER C 288
 None
 1.06A 1tz8C-4wzsC:
undetectable
1tz8D-4wzsC:
undetectable		 1tz8C-4wzsC:
10.68
1tz8D-4wzsC:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XR2_B_C2FB1201_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 4wzs SIMILARITY TO
HELICASE MOT1
ECU04_1440 PROTEIN
(Encephalitozoon
cuniculi;
Encephalitozoon
cuniculi) 		4 / 8 LYS D  41
LYS C 168
SER C  91
GLU C 144
 None
 1.30A 1xr2B-4wzsD:
undetectable		 1xr2B-4wzsD:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_A_CQAA403_0
(HISTAMINE
N-METHYLTRANSFERASE)		 4wzs SIMILARITY TO
HELICASE MOT1
(Encephalitozoon
cuniculi) 		4 / 8 ASP C 224
GLY C 261
PHE C 249
ASP C 254
 None
 0.98A 2aouA-4wzsC:
undetectable		 2aouA-4wzsC:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3K_A_SAMA1254_0
(ESSENTIAL FOR
MITOTIC GROWTH 1)		 4wzs ECU04_1440 PROTEIN
(Encephalitozoon
cuniculi) 		5 / 10 GLY D 105
GLY D  77
LEU D  34
SER D  35
ALA D 108
 None
 0.89A 2v3kA-4wzsD:
undetectable		 2v3kA-4wzsD:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		 4wzs SIMILARITY TO
HELICASE MOT1
(Encephalitozoon
cuniculi) 		3 / 3 LEU C 236
ARG C 232
ILE C 237
 None
 0.62A 2xn5B-4wzsC:
undetectable		 2xn5B-4wzsC:
4.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGR_A_T27A556_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H
P51 RT)		 4wzs SIMILARITY TO
HELICASE MOT1
(Encephalitozoon
cuniculi) 		5 / 11 LEU C 587
TYR C 595
PHE C 566
LEU C 495
GLU C 470
 None
 1.48A 3bgrA-4wzsC:
0.7
3bgrB-4wzsC:
undetectable		 3bgrA-4wzsC:
21.35
3bgrB-4wzsC:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E00_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4wzs SIMILARITY TO
HELICASE MOT1
(Encephalitozoon
cuniculi) 		5 / 12 ILE C 263
ALA C 227
ALA C 264
ALA C 226
ILE C 293
 None
 1.08A 3e00A-4wzsC:
undetectable		 3e00A-4wzsC:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB500_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4wzs ECU04_1440 PROTEIN
(Encephalitozoon
cuniculi) 		4 / 7 THR D  70
VAL D  80
THR D  82
VAL D  29
 None
 0.53A 3em0B-4wzsD:
2.5		 3em0B-4wzsD:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4wzs SIMILARITY TO
HELICASE MOT1
(Encephalitozoon
cuniculi) 		3 / 3 ASN C 757
MET C 714
PHE C 754
 None
 0.83A 3g4lD-4wzsC:
undetectable		 3g4lD-4wzsC:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_A_4CHA191_0
(DEHALOPEROXIDASE A)		 4wzs SIMILARITY TO
HELICASE MOT1
(Encephalitozoon
cuniculi) 		4 / 6 PHE C  77
PHE C 180
THR C  75
VAL C  74
 None
 1.26A 3lb3A-4wzsC:
undetectable		 3lb3A-4wzsC:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_2
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT
LIGHT CHAIN OF
ANTIBODY FAB
FRAGMENT)		 4wzs SIMILARITY TO
HELICASE MOT1
(Encephalitozoon
cuniculi) 		4 / 5 GLN C  70
ILE C  63
LEU C  67
PHE C  71
 None
 1.17A 3ls4L-4wzsC:
undetectable		 3ls4L-4wzsC:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M7R_A_VDXA425_1
(VITAMIN D3 RECEPTOR)		 4wzs ECU04_1440 PROTEIN
(Encephalitozoon
cuniculi) 		5 / 12 LEU D 162
LEU D 172
VAL D 171
SER D 121
LEU D 130
 None
 1.03A 3m7rA-4wzsD:
undetectable		 3m7rA-4wzsD:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_B_VORB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 4wzs ECU04_1440 PROTEIN
(Encephalitozoon
cuniculi) 		5 / 11 PHE D 113
VAL D  32
ALA D  71
ALA D  84
THR D  69
 None
 1.13A 3mdtB-4wzsD:
undetectable		 3mdtB-4wzsD:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_B_CL6B506_1
(CHOLESTEROL
24-HYDROXYLASE)		 4wzs ECU04_1440 PROTEIN
(Encephalitozoon
cuniculi) 		6 / 12 PHE D 113
VAL D  32
ALA D  94
ALA D  71
ALA D  84
THR D  69
 None
 1.46A 3mdvB-4wzsD:
undetectable		 3mdvB-4wzsD:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_D_BEZD1_0
(HEME-BINDING PROTEIN
HUTZ)		 4wzs ECU04_1440 PROTEIN
(Encephalitozoon
cuniculi) 		4 / 6 ARG D 178
TYR D 182
PRO D  23
LEU D  25
 None
 1.41A 3tgvD-4wzsD:
undetectable		 3tgvD-4wzsD:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_D_BEZD1_0
(HEME-BINDING PROTEIN
HUTZ)		 4wzs SIMILARITY TO
HELICASE MOT1
(Encephalitozoon
cuniculi) 		4 / 6 GLN C 245
TYR C  81
PHE C 198
LEU C 230
 None
 1.35A 3tgvD-4wzsC:
undetectable		 3tgvD-4wzsC:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFG_B_LEUB289_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 4wzs SIMILARITY TO
HELICASE MOT1
(Encephalitozoon
cuniculi) 		3 / 3 PHE C  96
SER C  90
SER C  91
 None
 0.81A 3ufgB-4wzsC:
undetectable		 3ufgB-4wzsC:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4wzs SIMILARITY TO
HELICASE MOT1
(Encephalitozoon
cuniculi) 		5 / 12 TYR C 554
ILE C 603
PHE C 606
ALA C 574
GLY C 568
 None
 0.93A 4e1gA-4wzsC:
undetectable		 4e1gA-4wzsC:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4wzs SIMILARITY TO
HELICASE MOT1
(Encephalitozoon
cuniculi) 		5 / 12 TYR C 554
ILE C 603
PHE C 606
ALA C 574
GLY C 568
 None
 0.93A 4e1gB-4wzsC:
undetectable		 4e1gB-4wzsC:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_A_TESA503_1
(CYTOCHROME P450
MONOOXYGENASE)		 4wzs SIMILARITY TO
HELICASE MOT1
(Encephalitozoon
cuniculi) 		5 / 12 PHE C 154
PHE C 153
ALA C 178
ALA C 175
ALA C  61
 None
 1.11A 4j6dA-4wzsC:
undetectable		 4j6dA-4wzsC:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB603_1
(SERUM ALBUMIN)		 4wzs SIMILARITY TO
HELICASE MOT1
(Encephalitozoon
cuniculi) 		5 / 11 LEU C 285
SER C 297
VAL C 247
LEU C 265
LEU C 262
 None
 1.23A 4or0B-4wzsC:
undetectable		 4or0B-4wzsC:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZGF_A_BEZA210_0
(UNCHARACTERIZED
PROTEIN)		 4wzs TATA-BINDING
PROTEIN-ASSOCIATED
PHOSPHOPROTEIN
ECU04_1440 PROTEIN
(Encephalitozoon
cuniculi;
Encephalitozoon
cuniculi) 		4 / 4 VAL D 191
ALA B 129
ASN B 128
GLN B 132
 None
 1.26A 4zgfA-4wzsD:
undetectable		 4zgfA-4wzsD:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 4wzs SIMILARITY TO
HELICASE MOT1
(Encephalitozoon
cuniculi) 		4 / 8 LEU C 467
LEU C 462
HIS C 586
LEU C 587
 None
 1.12A 5dxeA-4wzsC:
undetectable		 5dxeA-4wzsC:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_1
(CYP51 VARIANT1)		 4wzs ECU04_1440 PROTEIN
SIMILARITY TO
HELICASE MOT1
(Encephalitozoon
cuniculi) 		5 / 12 GLY C  93
GLN C  95
LEU D 104
PHE C 213
ILE C 293
 None
 1.10A 5fsaB-4wzsC:
undetectable		 5fsaB-4wzsC:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFP_A_8W5A804_2
(GLUCOCORTICOID
RECEPTOR)		 4wzs SIMILARITY TO
HELICASE MOT1
(Encephalitozoon
cuniculi) 		4 / 4 LEU C 236
MET C 179
ILE C 242
LEU C 197
 None
 1.37A 5nfpA-4wzsC:
undetectable		 5nfpA-4wzsC:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIY_A_OAQA302_0
(SULFOTRANSFERASE)		 4wzs SIMILARITY TO
HELICASE MOT1
(Encephalitozoon
cuniculi) 		5 / 11 ILE C 358
VAL C 369
SER C 364
LEU C 338
THR C 339
 None
 1.48A 5tiyA-4wzsC:
undetectable		 5tiyA-4wzsC:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 4wzs SIMILARITY TO
HELICASE MOT1
(Encephalitozoon
cuniculi) 		4 / 6 LYS C 281
LEU C 282
PHE C 304
LEU C 300
 None
 1.11A 5x19P-4wzsC:
undetectable		 5x19P-4wzsC:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 4wzs SIMILARITY TO
HELICASE MOT1
(Encephalitozoon
cuniculi) 		4 / 8 LEU C 467
LEU C 462
HIS C 586
LEU C 587
 None
 1.12A 6cbzA-4wzsC:
undetectable		 6cbzA-4wzsC:
7.57