SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wzw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXH_B_PACB1001_0
(PENICILLIN ACYLASE)		 4wzw PUMILIO
DOMAIN-CONTAINING
PROTEIN KIAA0020
(Homo
sapiens) 		4 / 7 SER A 215
SER A 179
ALA A 174
ILE A 173
 None
 0.96A 1fxhA-4wzwA:
undetectable
1fxhB-4wzwA:
undetectable		 1fxhA-4wzwA:
17.97
1fxhB-4wzwA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_A_J01A500_1
(ORF12)		 4wzw PUMILIO
DOMAIN-CONTAINING
PROTEIN KIAA0020
(Homo
sapiens) 		4 / 8 VAL A 618
LEU A 537
GLY A 599
ALA A 549
 None
 0.81A 2xfsA-4wzwA:
undetectable		 2xfsA-4wzwA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1436_1
(ORF12)		 4wzw PUMILIO
DOMAIN-CONTAINING
PROTEIN KIAA0020
(Homo
sapiens) 		4 / 8 VAL A 618
LEU A 537
GLY A 599
ALA A 549
 None
 0.80A 2xh9A-4wzwA:
undetectable		 2xh9A-4wzwA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_2
(PROTEASE)		 4wzw PUMILIO
DOMAIN-CONTAINING
PROTEIN KIAA0020
(Homo
sapiens) 		5 / 11 LEU A 606
GLY A 599
GLY A 554
ILE A 548
ILE A 562
 None
 1.09A 3ebzB-4wzwA:
undetectable		 3ebzB-4wzwA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_B_MTXB164_1
(DIHYDROFOLATE
REDUCTASE)		 4wzw PUMILIO
DOMAIN-CONTAINING
PROTEIN KIAA0020
(Homo
sapiens) 		5 / 12 ILE A 411
LEU A 404
SER A 423
ILE A 422
LEU A 445
 None
 1.23A 3ia4B-4wzwA:
undetectable		 3ia4B-4wzwA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_C_VIAC901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 4wzw PUMILIO
DOMAIN-CONTAINING
PROTEIN KIAA0020
(Homo
sapiens) 		4 / 7 MET A 309
GLN A 281
PHE A 280
VAL A 294
 None
 1.14A 3jwqC-4wzwA:
undetectable		 3jwqC-4wzwA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 4wzw PUMILIO
DOMAIN-CONTAINING
PROTEIN KIAA0020
(Homo
sapiens) 		5 / 12 LEU A 490
ALA A 518
LEU A 483
LEU A 445
ILE A 426
 None
 1.16A 3olsB-4wzwA:
undetectable		 3olsB-4wzwA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_1
(16S RRNA METHYLASE)		 4wzw PUMILIO
DOMAIN-CONTAINING
PROTEIN KIAA0020
(Homo
sapiens) 		4 / 5 ASN A 468
ASP A 379
THR A 386
SER A 471
 None
 1.28A 3p2kC-4wzwA:
undetectable		 3p2kC-4wzwA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4APJ_A_ACTA1635_0
(ANGIOTENSIN-CONVERTI
NG ENZYME
BRADYKININ-POTENTIAT
ING PEPTIDE B)		 4wzw PUMILIO
DOMAIN-CONTAINING
PROTEIN KIAA0020
(Homo
sapiens) 		4 / 6 HIS A 538
HIS A 547
SER A 592
PRO A 539
 None
 1.30A 4apjA-4wzwA:
undetectable
4apjP-4wzwA:
undetectable		 4apjA-4wzwA:
22.50
4apjP-4wzwA:
2.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4wzw PUMILIO
DOMAIN-CONTAINING
PROTEIN KIAA0020
(Homo
sapiens) 		3 / 3 ARG A 449
TRP A 373
GLY A 465
 None
 1.04A 4e7cA-4wzwA:
undetectable		 4e7cA-4wzwA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_B_MTXB603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 4wzw PUMILIO
DOMAIN-CONTAINING
PROTEIN KIAA0020
(Homo
sapiens) 		5 / 12 ALA A 533
LEU A 581
LEU A 590
LYS A 591
LEU A 642
 None
 1.14A 4ky8B-4wzwA:
undetectable		 4ky8B-4wzwA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		 4wzw PUMILIO
DOMAIN-CONTAINING
PROTEIN KIAA0020
(Homo
sapiens) 		4 / 6 SER A 517
LEU A 446
ASP A 513
LEU A 483
 None
 0.98A 4wozA-4wzwA:
undetectable
4wozB-4wzwA:
undetectable		 4wozA-4wzwA:
22.81
4wozB-4wzwA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVP_B_GBMB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 4wzw PUMILIO
DOMAIN-CONTAINING
PROTEIN KIAA0020
(Homo
sapiens) 		5 / 12 LEU A 537
HIS A 547
VAL A 596
LEU A 581
LEU A 558
 None
 1.22A 4yvpB-4wzwA:
undetectable		 4yvpB-4wzwA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_ACTA608_0
(SERUM ALBUMIN)		 4wzw PUMILIO
DOMAIN-CONTAINING
PROTEIN KIAA0020
(Homo
sapiens) 		3 / 3 LYS A 546
ARG A 598
HIS A 555
 None
 0.84A 4zbrA-4wzwA:
3.8		 4zbrA-4wzwA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4wzw PUMILIO
DOMAIN-CONTAINING
PROTEIN KIAA0020
(Homo
sapiens) 		5 / 12 ILE A 432
GLY A 438
HIS A 401
PHE A 408
ILE A 426
 None
 1.05A 5n0wB-4wzwA:
undetectable		 5n0wB-4wzwA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4wzw PUMILIO
DOMAIN-CONTAINING
PROTEIN KIAA0020
(Homo
sapiens) 		5 / 12 ILE A 432
GLY A 438
HIS A 401
PHE A 408
ILE A 426
 None
 1.06A 5n4iA-4wzwA:
undetectable		 5n4iA-4wzwA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 4wzw PUMILIO
DOMAIN-CONTAINING
PROTEIN KIAA0020
(Homo
sapiens) 		3 / 3 HIS A 547
GLU A 550
TRP A 593
 None
 1.03A 5odiD-4wzwA:
undetectable		 5odiD-4wzwA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 4wzw PUMILIO
DOMAIN-CONTAINING
PROTEIN KIAA0020
(Homo
sapiens) 		3 / 3 HIS A 547
GLU A 550
TRP A 593
 None
 1.14A 5odqD-4wzwA:
undetectable		 5odqD-4wzwA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODR_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 4wzw PUMILIO
DOMAIN-CONTAINING
PROTEIN KIAA0020
(Homo
sapiens) 		3 / 3 HIS A 547
GLU A 550
TRP A 593
 None
 1.01A 5odrD-4wzwA:
undetectable		 5odrD-4wzwA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_B_RITB602_1
(CYTOCHROME P450 3A5)		 4wzw PUMILIO
DOMAIN-CONTAINING
PROTEIN KIAA0020
(Homo
sapiens) 		5 / 12 SER A 237
PHE A 222
PHE A 199
ALA A 263
ILE A 264
 None
 1.08A 5veuB-4wzwA:
undetectable		 5veuB-4wzwA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7B_A_PA1A206_1
(ACYLOXYACYL
HYDROLASE SMALL
SUBUNIT
ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT)		 4wzw PUMILIO
DOMAIN-CONTAINING
PROTEIN KIAA0020
(Homo
sapiens) 		4 / 4 TYR A 444
GLY A 465
ASN A 468
ARG A 478
 None
 1.33A 5w7bA-4wzwA:
0.4
5w7bC-4wzwA:
undetectable		 5w7bA-4wzwA:
10.44
5w7bC-4wzwA:
8.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_A_BEZA502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 4wzw PUMILIO
DOMAIN-CONTAINING
PROTEIN KIAA0020
(Homo
sapiens) 		4 / 6 VAL A 502
LEU A 561
LEU A 558
HIS A 555
 None
 0.96A 6e43A-4wzwA:
1.4		 6e43A-4wzwA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_B_BEZB502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 4wzw PUMILIO
DOMAIN-CONTAINING
PROTEIN KIAA0020
(Homo
sapiens) 		4 / 6 VAL A 502
LEU A 561
LEU A 558
HIS A 555
 None
 0.92A 6e43B-4wzwA:
2.7		 6e43B-4wzwA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_C_BEZC502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 4wzw PUMILIO
DOMAIN-CONTAINING
PROTEIN KIAA0020
(Homo
sapiens) 		4 / 6 VAL A 502
LEU A 561
LEU A 558
HIS A 555
 None
 0.93A 6e43C-4wzwA:
undetectable		 6e43C-4wzwA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_D_BEZD502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 4wzw PUMILIO
DOMAIN-CONTAINING
PROTEIN KIAA0020
(Homo
sapiens) 		4 / 6 VAL A 502
LEU A 561
LEU A 558
HIS A 555
 None
 1.01A 6e43D-4wzwA:
undetectable		 6e43D-4wzwA:
22.68