SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4wzz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)
4wzz PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Lachnoclostridiu
m
phytofermentans)
5 / 9 ASN A 116
ILE A 113
ALA A  54
ILE A  56
THR A 142
None
1.33A 1aj6A-4wzzA:
undetectable
1aj6A-4wzzA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_2
(POL POLYPROTEIN)
4wzz PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Lachnoclostridiu
m
phytofermentans)
5 / 12 ASP A 342
GLY A 344
ALA A 340
ILE A 348
ALA A 191
EDO  A 402 ( 4.2A)
None
None
None
EDO  A 402 ( 3.6A)
1.01A 1sguB-4wzzA:
undetectable
1sguB-4wzzA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_B_CHDB1130_0
(FATTY ACID-BINDING
PROTEIN)
4wzz PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Lachnoclostridiu
m
phytofermentans)
5 / 12 TYR A 335
LEU A 301
LEU A 298
ILE A 348
ILE A 314
None
1.24A 1tw4B-4wzzA:
undetectable
1tw4B-4wzzA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1434_1
(CHITINASE)
4wzz PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Lachnoclostridiu
m
phytofermentans)
3 / 3 TRP A 192
THR A 245
TYR A  64
None
RAM  A 401 (-3.1A)
RAM  A 401 (-3.1A)
1.20A 2a3aA-4wzzA:
undetectable
2a3aA-4wzzA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_B_TEPB2434_1
(CHITINASE)
4wzz PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Lachnoclostridiu
m
phytofermentans)
3 / 3 TRP A 192
THR A 245
TYR A  64
None
RAM  A 401 (-3.1A)
RAM  A 401 (-3.1A)
1.22A 2a3aB-4wzzA:
2.2
2a3aB-4wzzA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_A_CFFA1434_1
(CHITINASE)
4wzz PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Lachnoclostridiu
m
phytofermentans)
3 / 3 TRP A 192
THR A 245
TYR A  64
None
RAM  A 401 (-3.1A)
RAM  A 401 (-3.1A)
1.21A 2a3bA-4wzzA:
undetectable
2a3bA-4wzzA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_0
(CATECHOL-O-METHYLTRA
NSFERASE)
4wzz PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Lachnoclostridiu
m
phytofermentans)
5 / 12 MET A 249
GLY A 268
VAL A 239
ALA A 166
TYR A 289
None
1.35A 2avdB-4wzzA:
undetectable
2avdB-4wzzA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_1
(HIV-1 PROTEASE)
4wzz PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Lachnoclostridiu
m
phytofermentans)
5 / 12 ASP A 342
GLY A 344
ALA A 340
ILE A 348
ALA A 191
EDO  A 402 ( 4.2A)
None
None
None
EDO  A 402 ( 3.6A)
0.96A 2b7zA-4wzzA:
undetectable
2b7zA-4wzzA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_2
(HIV-1 PROTEASE)
4wzz PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Lachnoclostridiu
m
phytofermentans)
5 / 12 ASP A 342
GLY A 344
ALA A 340
ILE A 348
ALA A 191
EDO  A 402 ( 4.2A)
None
None
None
EDO  A 402 ( 3.6A)
0.98A 2b7zB-4wzzA:
undetectable
2b7zB-4wzzA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_2
(VITAMIN D RECEPTOR)
4wzz PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Lachnoclostridiu
m
phytofermentans)
4 / 7 LEU A 298
LEU A 301
ILE A 337
SER A 321
None
0.87A 2hc4A-4wzzA:
undetectable
2hc4A-4wzzA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMY_A_ROCA401_2
(PROTEASE)
4wzz PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Lachnoclostridiu
m
phytofermentans)
5 / 12 ASP A 342
GLY A 344
ALA A 340
ILE A 348
ALA A 191
EDO  A 402 ( 4.2A)
None
None
None
EDO  A 402 ( 3.6A)
0.97A 2nmyB-4wzzA:
undetectable
2nmyB-4wzzA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGR_A_T27A556_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H
P51 RT)
4wzz PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Lachnoclostridiu
m
phytofermentans)
5 / 11 LEU A 138
VAL A  57
TYR A  53
LEU A 136
GLU A  68
None
1.31A 3bgrA-4wzzA:
2.1
3bgrB-4wzzA:
undetectable
3bgrA-4wzzA:
21.07
3bgrB-4wzzA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_E_RTLE177_0
(PLASMA
RETINOL-BINDING
PROTEIN)
4wzz PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Lachnoclostridiu
m
phytofermentans)
5 / 11 ALA A 183
ALA A 182
LEU A 269
GLN A 153
GLN A  96
None
RAM  A 401 ( 3.7A)
RAM  A 401 ( 3.9A)
RAM  A 401 (-4.1A)
None
1.25A 3bszE-4wzzA:
undetectable
3bszE-4wzzA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_C_478C200_1
(PROTEASE)
4wzz PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Lachnoclostridiu
m
phytofermentans)
5 / 10 ASP A 225
GLY A 247
ILE A 248
ALA A 178
ILE A 230
None
0.90A 3ekpC-4wzzA:
undetectable
3ekpC-4wzzA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKW_B_DR7B100_2
(PROTEASE)
4wzz PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Lachnoclostridiu
m
phytofermentans)
5 / 12 ASP A 342
GLY A 344
ALA A 340
ILE A 348
ALA A 191
EDO  A 402 ( 4.2A)
None
None
None
EDO  A 402 ( 3.6A)
0.97A 3ekwB-4wzzA:
undetectable
3ekwB-4wzzA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_B_PNNB301_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)
4wzz PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Lachnoclostridiu
m
phytofermentans)
5 / 12 GLY A 172
GLY A 173
SER A 174
GLY A 175
ASP A 176
None
0.83A 3huoB-4wzzA:
undetectable
3huoB-4wzzA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)
4wzz PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Lachnoclostridiu
m
phytofermentans)
3 / 3 SER A 184
ASP A 217
ASP A 117
None
0.72A 3iv6A-4wzzA:
undetectable
3iv6A-4wzzA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)
4wzz PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Lachnoclostridiu
m
phytofermentans)
3 / 3 SER A 184
ASP A 217
ASP A 117
None
0.76A 3iv6C-4wzzA:
2.6
3iv6C-4wzzA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_C_TFPC202_1
(PROTEIN S100-A4)
4wzz PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Lachnoclostridiu
m
phytofermentans)
5 / 11 ASP A 169
PHE A 355
ILE A 360
GLU A 356
ASP A 281
None
EDO  A 403 ( 4.8A)
None
None
None
1.25A 3ko0A-4wzzA:
undetectable
3ko0B-4wzzA:
undetectable
3ko0C-4wzzA:
undetectable
3ko0D-4wzzA:
undetectable
3ko0A-4wzzA:
13.01
3ko0B-4wzzA:
13.01
3ko0C-4wzzA:
13.01
3ko0D-4wzzA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD202_1
(PROTEIN S100-A4)
4wzz PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Lachnoclostridiu
m
phytofermentans)
5 / 11 GLU A 356
ASP A 281
PHE A 355
ILE A 360
ASP A 169
None
None
EDO  A 403 ( 4.8A)
None
None
1.33A 3ko0C-4wzzA:
undetectable
3ko0D-4wzzA:
undetectable
3ko0E-4wzzA:
undetectable
3ko0F-4wzzA:
undetectable
3ko0C-4wzzA:
13.01
3ko0D-4wzzA:
13.01
3ko0E-4wzzA:
13.01
3ko0F-4wzzA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE202_1
(PROTEIN S100-A4)
4wzz PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Lachnoclostridiu
m
phytofermentans)
5 / 11 ASP A 169
PHE A 355
ILE A 360
GLU A 356
ASP A 281
None
EDO  A 403 ( 4.8A)
None
None
None
1.30A 3ko0C-4wzzA:
undetectable
3ko0D-4wzzA:
undetectable
3ko0E-4wzzA:
undetectable
3ko0F-4wzzA:
undetectable
3ko0C-4wzzA:
13.01
3ko0D-4wzzA:
13.01
3ko0E-4wzzA:
13.01
3ko0F-4wzzA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_F_TFPF202_1
(PROTEIN S100-A4)
4wzz PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Lachnoclostridiu
m
phytofermentans)
5 / 11 GLU A 356
ASP A 281
PHE A 355
ILE A 360
ASP A 169
None
None
EDO  A 403 ( 4.8A)
None
None
1.32A 3ko0E-4wzzA:
undetectable
3ko0F-4wzzA:
undetectable
3ko0G-4wzzA:
undetectable
3ko0H-4wzzA:
undetectable
3ko0E-4wzzA:
13.01
3ko0F-4wzzA:
13.01
3ko0G-4wzzA:
13.01
3ko0H-4wzzA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_G_TFPG202_1
(PROTEIN S100-A4)
4wzz PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Lachnoclostridiu
m
phytofermentans)
5 / 10 ASP A 169
PHE A 355
ILE A 360
GLU A 356
ASP A 281
None
EDO  A 403 ( 4.8A)
None
None
None
1.31A 3ko0E-4wzzA:
undetectable
3ko0F-4wzzA:
undetectable
3ko0G-4wzzA:
undetectable
3ko0H-4wzzA:
undetectable
3ko0E-4wzzA:
13.01
3ko0F-4wzzA:
13.01
3ko0G-4wzzA:
13.01
3ko0H-4wzzA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_H_TFPH202_1
(PROTEIN S100-A4)
4wzz PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Lachnoclostridiu
m
phytofermentans)
5 / 12 GLU A 356
ASP A 281
PHE A 355
ILE A 360
ASP A 169
None
None
EDO  A 403 ( 4.8A)
None
None
1.27A 3ko0G-4wzzA:
undetectable
3ko0H-4wzzA:
undetectable
3ko0I-4wzzA:
undetectable
3ko0J-4wzzA:
undetectable
3ko0G-4wzzA:
13.01
3ko0H-4wzzA:
13.01
3ko0I-4wzzA:
13.01
3ko0J-4wzzA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_N_TFPN202_1
(PROTEIN S100-A4)
4wzz PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Lachnoclostridiu
m
phytofermentans)
5 / 11 ASP A 169
GLU A 356
ASP A 281
PHE A 355
ILE A 360
None
None
None
EDO  A 403 ( 4.8A)
None
1.31A 3ko0K-4wzzA:
undetectable
3ko0L-4wzzA:
undetectable
3ko0M-4wzzA:
undetectable
3ko0N-4wzzA:
undetectable
3ko0K-4wzzA:
13.01
3ko0L-4wzzA:
13.01
3ko0M-4wzzA:
13.01
3ko0N-4wzzA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO202_1
(PROTEIN S100-A4)
4wzz PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Lachnoclostridiu
m
phytofermentans)
5 / 11 PHE A 355
ILE A 360
GLU A 356
ASP A 281
ASP A 169
EDO  A 403 ( 4.8A)
None
None
None
None
1.33A 3ko0O-4wzzA:
undetectable
3ko0P-4wzzA:
undetectable
3ko0Q-4wzzA:
undetectable
3ko0R-4wzzA:
undetectable
3ko0O-4wzzA:
13.01
3ko0P-4wzzA:
13.01
3ko0Q-4wzzA:
13.01
3ko0R-4wzzA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_R_TFPR202_1
(PROTEIN S100-A4)
4wzz PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Lachnoclostridiu
m
phytofermentans)
5 / 11 GLU A 356
ASP A 281
PHE A 355
ILE A 360
ASP A 169
None
None
EDO  A 403 ( 4.8A)
None
None
1.21A 3ko0Q-4wzzA:
undetectable
3ko0R-4wzzA:
undetectable
3ko0S-4wzzA:
undetectable
3ko0T-4wzzA:
undetectable
3ko0Q-4wzzA:
13.01
3ko0R-4wzzA:
13.01
3ko0S-4wzzA:
13.01
3ko0T-4wzzA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT202_1
(PROTEIN S100-A4)
4wzz PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Lachnoclostridiu
m
phytofermentans)
5 / 11 ASP A 169
GLU A 356
ASP A 281
PHE A 355
ILE A 360
None
None
None
EDO  A 403 ( 4.8A)
None
1.32A 3ko0Q-4wzzA:
undetectable
3ko0R-4wzzA:
undetectable
3ko0S-4wzzA:
undetectable
3ko0T-4wzzA:
undetectable
3ko0Q-4wzzA:
13.01
3ko0R-4wzzA:
13.01
3ko0S-4wzzA:
13.01
3ko0T-4wzzA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_C_P77C203_1
(PROTEIN S100-A4)
4wzz PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Lachnoclostridiu
m
phytofermentans)
5 / 10 ASP A 169
PHE A 355
ILE A 360
GLU A 356
ASP A 281
None
EDO  A 403 ( 4.8A)
None
None
None
1.38A 3m0wC-4wzzA:
undetectable
3m0wD-4wzzA:
undetectable
3m0wE-4wzzA:
undetectable
3m0wF-4wzzA:
undetectable
3m0wC-4wzzA:
15.05
3m0wD-4wzzA:
15.05
3m0wE-4wzzA:
15.05
3m0wF-4wzzA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)
4wzz PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Lachnoclostridiu
m
phytofermentans)
5 / 11 ALA A 191
ALA A 114
THR A 142
ALA A 141
ASP A 342
EDO  A 402 ( 3.6A)
None
None
None
EDO  A 402 ( 4.2A)
1.14A 3mg0V-4wzzA:
undetectable
3mg0W-4wzzA:
undetectable
3mg0V-4wzzA:
22.31
3mg0W-4wzzA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_1
(PROTEASE)
4wzz PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Lachnoclostridiu
m
phytofermentans)
5 / 9 ALA A 178
ILE A 167
GLY A 268
ILE A 248
VAL A 264
None
1.06A 3nuoA-4wzzA:
undetectable
3nuoA-4wzzA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_I_SAMI228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)
4wzz PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Lachnoclostridiu
m
phytofermentans)
5 / 12 GLY A 316
ALA A 318
ILE A 314
ALA A 305
VAL A 149
None
1.09A 3nvkI-4wzzA:
3.9
3nvkI-4wzzA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_C_BEZC264_0
(CARNITINYL-COA
DEHYDRATASE)
4wzz PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Lachnoclostridiu
m
phytofermentans)
4 / 6 ALA A 112
ILE A  55
LEU A 138
ALA A 305
None
0.83A 3r9sC-4wzzA:
4.3
3r9sC-4wzzA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)
4wzz PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Lachnoclostridiu
m
phytofermentans)
5 / 11 ALA A 251
ILE A 170
GLY A 268
ALA A 242
VAL A 213
None
1.03A 3rukD-4wzzA:
undetectable
3rukD-4wzzA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_A_SAMA801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)
4wzz PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Lachnoclostridiu
m
phytofermentans)
5 / 12 ILE A 159
GLY A 270
SER A 273
VAL A 366
PRO A 295
None
1.19A 3v8vA-4wzzA:
2.2
3v8vA-4wzzA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA8_C_Z80C301_1
(MAJOR PRION PROTEIN)
4wzz PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Lachnoclostridiu
m
phytofermentans)
4 / 5 LEU A 292
GLY A 270
ILE A 159
GLN A 153
RAM  A 401 ( 4.6A)
None
None
RAM  A 401 (-4.1A)
0.99A 4ma8C-4wzzA:
undetectable
4ma8C-4wzzA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)
4wzz PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Lachnoclostridiu
m
phytofermentans)
5 / 12 ILE A 170
ILE A 167
GLY A 268
ALA A 242
ILE A 230
None
0.93A 4nkxA-4wzzA:
undetectable
4nkxA-4wzzA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)
4wzz PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Lachnoclostridiu
m
phytofermentans)
4 / 6 GLU A 346
GLY A 344
GLY A 343
ASP A 342
None
None
None
EDO  A 402 ( 4.2A)
0.90A 5a06D-4wzzA:
3.9
5a06D-4wzzA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHQ_A_SAMA301_0
(CATECHOL
O-METHYLTRANSFERASE)
4wzz PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Lachnoclostridiu
m
phytofermentans)
5 / 12 VAL A 324
TYR A 304
ASN A 152
ALA A 339
ASP A 319
None
1.34A 5fhqA-4wzzA:
4.4
5fhqA-4wzzA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIO_B_LOCB502_1
(TUBULIN BETA CHAIN)
4wzz PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Lachnoclostridiu
m
phytofermentans)
5 / 12 CYH A  99
THR A  52
ALA A  54
ILE A  56
ILE A 111
None
1.10A 5mioB-4wzzA:
4.0
5mioB-4wzzA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)
4wzz PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Lachnoclostridiu
m
phytofermentans)
4 / 7 VAL A 108
ILE A 111
VAL A  84
ALA A  54
None
0.75A 5osrA-4wzzA:
undetectable
5osrA-4wzzA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGZ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)
4wzz PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Lachnoclostridiu
m
phytofermentans)
3 / 3 VAL A 213
VAL A 179
GLN A 189
None
None
RAM  A 401 (-3.1A)
0.68A 5qgzA-4wzzA:
undetectable
5qgzA-4wzzA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH6_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)
4wzz PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Lachnoclostridiu
m
phytofermentans)
3 / 3 VAL A 213
VAL A 179
GLN A 189
None
None
RAM  A 401 (-3.1A)
0.67A 5qh6A-4wzzA:
undetectable
5qh6A-4wzzA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHA_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)
4wzz PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Lachnoclostridiu
m
phytofermentans)
3 / 3 VAL A 213
VAL A 179
GLN A 189
None
None
RAM  A 401 (-3.1A)
0.64A 5qhaA-4wzzA:
undetectable
5qhaA-4wzzA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_0
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)
4wzz PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Lachnoclostridiu
m
phytofermentans)
5 / 12 GLY A 316
SER A 308
LEU A 309
VAL A 149
LEU A 136
None
1.27A 5ubbA-4wzzA:
undetectable
5ubbA-4wzzA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_I_EY4I500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)
4wzz PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Lachnoclostridiu
m
phytofermentans)
4 / 5 GLN A 158
TRP A 192
PRO A 352
THR A 187
None
1.32A 6cduI-4wzzA:
undetectable
6cduJ-4wzzA:
undetectable
6cduI-4wzzA:
22.65
6cduJ-4wzzA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7U_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)
4wzz PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Lachnoclostridiu
m
phytofermentans)
4 / 6 ASN A 294
PRO A 295
ILE A 296
GLU A  70
EDO  A 403 (-4.4A)
None
None
None
1.23A 6h7uA-4wzzA:
undetectable
6h7uA-4wzzA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_1
(TYROSINE-PROTEIN
KINASE ABL1)
4wzz PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Lachnoclostridiu
m
phytofermentans)
4 / 5 LEU A 329
TYR A 335
ILE A 113
GLY A 350
None
1.03A 6hd6A-4wzzA:
undetectable
6hd6A-4wzzA:
13.44