SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4x00'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_B_NIOB145_1
(LEGHEMOGLOBIN A)		 4x00 PUTATIVE HYDROLASE
(Burkholderia
cenocepacia) 		4 / 8 TYR A  62
ILE A  37
LEU A 281
VAL A 107
 None
 0.81A 1fslB-4x00A:
undetectable		 1fslB-4x00A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_C_ADNC1503_1
(CLASS B ACID
PHOSPHATASE)		 4x00 PUTATIVE HYDROLASE
(Burkholderia
cenocepacia) 		4 / 8 PHE A 269
TYR A 254
LEU A 225
GLY A 110
 None
EDO  A 304 (-4.6A)
None
None
 0.99A 1rmtC-4x00A:
undetectable		 1rmtC-4x00A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_C_CHDC3271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 4x00 PUTATIVE HYDROLASE
(Burkholderia
cenocepacia) 		4 / 8 LEU A  59
GLN A  60
LEU A 273
PHE A 269
 None
 0.74A 1v54C-4x00A:
undetectable
1v54J-4x00A:
undetectable		 1v54C-4x00A:
21.50
1v54J-4x00A:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_P_CHDP4271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 4x00 PUTATIVE HYDROLASE
(Burkholderia
cenocepacia) 		4 / 8 LEU A  59
GLN A  60
LEU A 273
PHE A 269
 None
 0.76A 1v54P-4x00A:
undetectable
1v54W-4x00A:
undetectable		 1v54P-4x00A:
21.50
1v54W-4x00A:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_C_CHDC3271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 4x00 PUTATIVE HYDROLASE
(Burkholderia
cenocepacia) 		4 / 7 LEU A  59
GLN A  60
LEU A 273
PHE A 269
 None
 0.76A 1v55C-4x00A:
undetectable
1v55J-4x00A:
undetectable		 1v55C-4x00A:
21.50
1v55J-4x00A:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA501_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 4x00 PUTATIVE HYDROLASE
(Burkholderia
cenocepacia) 		5 / 9 GLY A  42
SER A 112
LEU A 113
PHE A 172
HIS A 259
 None
GOL  A 308 (-3.5A)
GOL  A 308 ( 4.4A)
None
GOL  A 308 ( 4.5A)
 0.88A 1y7iA-4x00A:
21.9		 1y7iA-4x00A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B82_A_ADNA1001_1
(CLASS B ACID
PHOSPHATASE)		 4x00 PUTATIVE HYDROLASE
(Burkholderia
cenocepacia) 		5 / 10 PHE A 269
GLU A 252
TYR A 254
LEU A 225
GLY A 110
 None
EDO  A 304 (-3.5A)
EDO  A 304 (-4.6A)
None
None
 1.08A 2b82A-4x00A:
undetectable		 2b82A-4x00A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4x00 PUTATIVE HYDROLASE
(Burkholderia
cenocepacia) 		4 / 8 LEU A  59
GLN A  60
LEU A 273
PHE A 269
 None
 0.75A 2dyrC-4x00A:
undetectable
2dyrJ-4x00A:
undetectable		 2dyrC-4x00A:
21.50
2dyrJ-4x00A:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4x00 PUTATIVE HYDROLASE
(Burkholderia
cenocepacia) 		4 / 8 LEU A  59
GLN A  60
LEU A 273
PHE A 269
 None
 0.76A 2dyrP-4x00A:
undetectable
2dyrW-4x00A:
undetectable		 2dyrP-4x00A:
21.50
2dyrW-4x00A:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_P_CHDP310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4x00 PUTATIVE HYDROLASE
(Burkholderia
cenocepacia) 		4 / 7 LEU A  59
GLN A  60
LEU A 273
PHE A 269
 None
 0.87A 2dysP-4x00A:
undetectable
2dysW-4x00A:
undetectable		 2dysP-4x00A:
21.50
2dysW-4x00A:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4x00 PUTATIVE HYDROLASE
(Burkholderia
cenocepacia) 		4 / 7 LEU A  59
GLN A  60
LEU A 273
PHE A 269
 None
 0.75A 2eijC-4x00A:
undetectable
2eijJ-4x00A:
undetectable		 2eijC-4x00A:
21.50
2eijJ-4x00A:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4x00 PUTATIVE HYDROLASE
(Burkholderia
cenocepacia) 		4 / 7 LEU A  59
GLN A  60
LEU A 273
PHE A 269
 None
 0.77A 2eikC-4x00A:
undetectable
2eikJ-4x00A:
undetectable		 2eikC-4x00A:
21.50
2eikJ-4x00A:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4x00 PUTATIVE HYDROLASE
(Burkholderia
cenocepacia) 		4 / 8 LEU A  59
GLN A  60
LEU A 273
PHE A 269
 None
 0.75A 2eikP-4x00A:
undetectable
2eikW-4x00A:
undetectable		 2eikP-4x00A:
21.50
2eikW-4x00A:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4x00 PUTATIVE HYDROLASE
(Burkholderia
cenocepacia) 		4 / 8 LEU A  59
GLN A  60
LEU A 273
PHE A 269
 None
 0.77A 2eilC-4x00A:
undetectable
2eilJ-4x00A:
undetectable		 2eilC-4x00A:
21.50
2eilJ-4x00A:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4x00 PUTATIVE HYDROLASE
(Burkholderia
cenocepacia) 		4 / 7 LEU A  59
GLN A  60
LEU A 273
PHE A 269
 None
 0.81A 2eimC-4x00A:
undetectable
2eimJ-4x00A:
undetectable		 2eimC-4x00A:
21.50
2eimJ-4x00A:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4x00 PUTATIVE HYDROLASE
(Burkholderia
cenocepacia) 		4 / 7 LEU A  59
GLN A  60
LEU A 273
PHE A 269
 None
 0.81A 2einC-4x00A:
undetectable
2einJ-4x00A:
undetectable		 2einC-4x00A:
21.50
2einJ-4x00A:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4x00 PUTATIVE HYDROLASE
(Burkholderia
cenocepacia) 		4 / 6 LEU A  59
GLN A  60
LEU A 273
PHE A 269
 None
 0.72A 2einP-4x00A:
undetectable
2einW-4x00A:
undetectable		 2einP-4x00A:
21.50
2einW-4x00A:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4x00 PUTATIVE HYDROLASE
(Burkholderia
cenocepacia) 		4 / 6 LEU A  59
GLN A  60
LEU A 273
PHE A 269
 None
 0.74A 2zxwP-4x00A:
undetectable
2zxwW-4x00A:
undetectable		 2zxwP-4x00A:
21.50
2zxwW-4x00A:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4x00 PUTATIVE HYDROLASE
(Burkholderia
cenocepacia) 		4 / 6 LEU A  59
GLN A  60
LEU A 273
PHE A 269
 None
 0.84A 3ag1C-4x00A:
undetectable
3ag1J-4x00A:
undetectable		 3ag1C-4x00A:
21.50
3ag1J-4x00A:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4x00 PUTATIVE HYDROLASE
(Burkholderia
cenocepacia) 		4 / 7 LEU A  59
GLN A  60
LEU A 273
PHE A 269
 None
 0.91A 3ag2P-4x00A:
undetectable
3ag2W-4x00A:
undetectable		 3ag2P-4x00A:
21.50
3ag2W-4x00A:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4x00 PUTATIVE HYDROLASE
(Burkholderia
cenocepacia) 		4 / 8 LEU A  59
GLN A  60
LEU A 273
PHE A 269
 None
 0.75A 3ag4C-4x00A:
undetectable
3ag4J-4x00A:
undetectable		 3ag4C-4x00A:
21.50
3ag4J-4x00A:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4x00 PUTATIVE HYDROLASE
(Burkholderia
cenocepacia) 		4 / 7 LEU A  59
GLN A  60
LEU A 273
PHE A 269
 None
 0.74A 3ag4P-4x00A:
undetectable
3ag4W-4x00A:
undetectable		 3ag4P-4x00A:
21.50
3ag4W-4x00A:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 4x00 PUTATIVE HYDROLASE
(Burkholderia
cenocepacia) 		4 / 7 LEU A  59
GLN A  60
LEU A 273
PHE A 269
 None
 0.82A 3asnC-4x00A:
undetectable
3asnJ-4x00A:
undetectable		 3asnC-4x00A:
21.50
3asnJ-4x00A:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_B_ACRB820_1
(ALPHA-AMYLASE, SUSG)		 4x00 PUTATIVE HYDROLASE
(Burkholderia
cenocepacia) 		4 / 7 TYR A 135
GLU A 141
LEU A 222
ASN A 246
 None
 1.42A 3k8mB-4x00A:
undetectable		 3k8mB-4x00A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_C_ACTC800_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 4x00 PUTATIVE HYDROLASE
(Burkholderia
cenocepacia) 		3 / 3 ASP A  93
ARG A  89
ALA A  18
 None
 0.69A 3mbgC-4x00A:
undetectable		 3mbgC-4x00A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFT_D_QMRD301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4x00 PUTATIVE HYDROLASE
(Burkholderia
cenocepacia) 		4 / 8 TYR A 226
VAL A 139
TYR A 135
VAL A 209
 None
 1.14A 4aftD-4x00A:
undetectable
4aftE-4x00A:
undetectable		 4aftD-4x00A:
21.62
4aftE-4x00A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_2
(GUANINE DEAMINASE)		 4x00 PUTATIVE HYDROLASE
(Burkholderia
cenocepacia) 		4 / 5 HIS A 102
LEU A  94
LEU A  24
ASP A  92
 None
 1.27A 4aqlA-4x00A:
undetectable		 4aqlA-4x00A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		 4x00 PUTATIVE HYDROLASE
(Burkholderia
cenocepacia) 		5 / 12 GLY A 168
SER A 112
VAL A 139
VAL A 233
HIS A 259
 None
GOL  A 308 (-3.5A)
None
None
GOL  A 308 ( 4.5A)
 0.87A 4ffwA-4x00A:
15.4		 4ffwA-4x00A:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_1
(DIPEPTIDYL PEPTIDASE
4)		 4x00 PUTATIVE HYDROLASE
(Burkholderia
cenocepacia) 		5 / 12 GLY A 168
SER A 112
VAL A 139
VAL A 233
HIS A 259
 None
GOL  A 308 (-3.5A)
None
None
GOL  A 308 ( 4.5A)
 0.84A 4ffwB-4x00A:
6.1		 4ffwB-4x00A:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_E_ACTE403_0
(PROTON-GATED ION
CHANNEL)		 4x00 PUTATIVE HYDROLASE
(Burkholderia
cenocepacia) 		3 / 3 ARG A  63
TYR A  14
GLU A  28
 None
 0.67A 4zzbE-4x00A:
undetectable		 4zzbE-4x00A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4x00 PUTATIVE HYDROLASE
(Burkholderia
cenocepacia) 		4 / 7 LEU A  59
GLN A  60
LEU A 273
PHE A 269
 None
 0.84A 5b1bP-4x00A:
undetectable
5b1bW-4x00A:
undetectable		 5b1bP-4x00A:
21.50
5b1bW-4x00A:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_F_MFXF2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4x00 PUTATIVE HYDROLASE
(Burkholderia
cenocepacia) 		4 / 6 ASP A  92
ARG A  88
GLY A  87
GLU A 210
 None
 0.75A 5cdqA-4x00A:
undetectable
5cdqC-4x00A:
undetectable
5cdqD-4x00A:
3.3		 5cdqA-4x00A:
22.17
5cdqC-4x00A:
22.17
5cdqD-4x00A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MFX_A_ACTA701_0
(GENOME POLYPROTEIN)		 4x00 PUTATIVE HYDROLASE
(Burkholderia
cenocepacia) 		4 / 5 THR A 164
HIS A 165
ALA A 159
ASP A 161
 None
 1.32A 5mfxA-4x00A:
undetectable		 5mfxA-4x00A:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW4_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 4x00 PUTATIVE HYDROLASE
(Burkholderia
cenocepacia) 		5 / 9 GLY A  45
ALA A 193
GLY A  42
LEU A 113
SER A 112
 None
None
None
GOL  A 308 ( 4.4A)
GOL  A 308 (-3.5A)
 1.12A 5vw4A-4x00A:
undetectable		 5vw4A-4x00A:
22.45