SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4x04'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC339_0
(ADP-RIBOSYL CYCLASE)		 4x04 SOLUTE BINDING
PROTEIN
(Citrobacter
koseri) 		3 / 3 GLU A 240
ASN A  42
TRP A 275
 BDP  A 401 (-2.9A)
None
None
 1.25A 1r15C-4x04A:
undetectable		 1r15C-4x04A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_D_NCAD349_0
(ADP-RIBOSYL CYCLASE)		 4x04 SOLUTE BINDING
PROTEIN
(Citrobacter
koseri) 		3 / 3 GLU A 240
ASN A  42
TRP A 275
 BDP  A 401 (-2.9A)
None
None
 1.25A 1r15D-4x04A:
undetectable		 1r15D-4x04A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_E_NCAE359_0
(ADP-RIBOSYL CYCLASE)		 4x04 SOLUTE BINDING
PROTEIN
(Citrobacter
koseri) 		3 / 3 GLU A 240
ASN A  42
TRP A 275
 BDP  A 401 (-2.9A)
None
None
 1.27A 1r15E-4x04A:
undetectable		 1r15E-4x04A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF369_0
(ADP-RIBOSYL CYCLASE)		 4x04 SOLUTE BINDING
PROTEIN
(Citrobacter
koseri) 		3 / 3 GLU A 240
ASN A  42
TRP A 275
 BDP  A 401 (-2.9A)
None
None
 1.26A 1r15F-4x04A:
undetectable		 1r15F-4x04A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA801_1
(TRANSPORTER)		 4x04 SOLUTE BINDING
PROTEIN
(Citrobacter
koseri) 		5 / 11 LEU A  53
VAL A  65
ILE A 260
ALA A  32
LEU A 145
 None
 1.22A 2q72A-4x04A:
undetectable		 2q72A-4x04A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 4x04 SOLUTE BINDING
PROTEIN
(Citrobacter
koseri) 		3 / 3 VAL A  35
ASP A  34
GLU A  74
 BDP  A 401 (-4.9A)
None
BDP  A 401 ( 2.9A)
 0.75A 2qeuA-4x04A:
undetectable		 2qeuA-4x04A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_C_ACTC141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 4x04 SOLUTE BINDING
PROTEIN
(Citrobacter
koseri) 		3 / 3 VAL A  35
ASP A  34
GLU A  74
 BDP  A 401 (-4.9A)
None
BDP  A 401 ( 2.9A)
 0.73A 2qeuC-4x04A:
undetectable		 2qeuC-4x04A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4x04 SOLUTE BINDING
PROTEIN
(Citrobacter
koseri) 		4 / 7 GLU A 240
GLN A  76
ALA A  85
ILE A  83
 BDP  A 401 (-2.9A)
MG  A 404 ( 4.4A)
None
None
 0.85A 2xkwA-4x04A:
undetectable		 2xkwA-4x04A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA801_1
(PROSTAGLANDIN
REDUCTASE 1)		 4x04 SOLUTE BINDING
PROTEIN
(Citrobacter
koseri) 		4 / 8 VAL A 174
ARG A 153
VAL A 308
TYR A 312
 None
BDP  A 401 (-2.9A)
None
None
 1.33A 2y05A-4x04A:
undetectable
2y05B-4x04A:
undetectable		 2y05A-4x04A:
22.92
2y05B-4x04A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4x04 SOLUTE BINDING
PROTEIN
(Citrobacter
koseri) 		5 / 10 GLY A 127
ASP A 123
GLY A 124
HIS A 119
VAL A 326
 None
 1.23A 4c5nB-4x04A:
undetectable		 4c5nB-4x04A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4x04 SOLUTE BINDING
PROTEIN
(Citrobacter
koseri) 		4 / 8 PHE A 144
GLU A 240
MET A 148
ILE A 122
 None
BDP  A 401 (-2.9A)
None
None
 1.36A 4cx7A-4x04A:
undetectable
4cx7B-4x04A:
undetectable		 4cx7A-4x04A:
19.27
4cx7B-4x04A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 4x04 SOLUTE BINDING
PROTEIN
(Citrobacter
koseri) 		4 / 7 TYR A 244
ILE A 260
LEU A 242
GLY A 146
 None
 0.89A 4iqqB-4x04A:
undetectable		 4iqqB-4x04A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 4x04 SOLUTE BINDING
PROTEIN
(Citrobacter
koseri) 		4 / 7 TYR A 244
ILE A 260
LEU A 242
GLY A 146
 None
 0.83A 4iqqC-4x04A:
undetectable		 4iqqC-4x04A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_1
(PROLINE--TRNA LIGASE)		 4x04 SOLUTE BINDING
PROTEIN
(Citrobacter
koseri) 		3 / 3 GLU A  74
THR A 217
HIS A  36
 BDP  A 401 ( 2.9A)
BDP  A 401 (-3.8A)
BDP  A 401 (-4.1A)
 0.86A 4q15A-4x04A:
undetectable		 4q15A-4x04A:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_1
(PROLINE--TRNA LIGASE)		 4x04 SOLUTE BINDING
PROTEIN
(Citrobacter
koseri) 		3 / 3 GLU A  74
THR A 217
HIS A  36
 BDP  A 401 ( 2.9A)
BDP  A 401 (-3.8A)
BDP  A 401 (-4.1A)
 0.83A 4q15B-4x04A:
undetectable		 4q15B-4x04A:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_1
(PROLINE--TRNA LIGASE)		 4x04 SOLUTE BINDING
PROTEIN
(Citrobacter
koseri) 		3 / 3 GLU A  74
THR A 217
HIS A  36
 BDP  A 401 ( 2.9A)
BDP  A 401 (-3.8A)
BDP  A 401 (-4.1A)
 0.80A 4ydqB-4x04A:
undetectable		 4ydqB-4x04A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_2
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 4x04 SOLUTE BINDING
PROTEIN
(Citrobacter
koseri) 		4 / 4 VAL A 291
ILE A 156
ASN A 222
VAL A 226
 None
 1.28A 5ajqA-4x04A:
undetectable		 5ajqA-4x04A:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA202_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 4x04 SOLUTE BINDING
PROTEIN
(Citrobacter
koseri) 		4 / 8 GLY A  68
GLY A  69
VAL A  43
HIS A  36
 None
None
None
BDP  A 401 (-4.1A)
 0.78A 5f8yA-4x04A:
undetectable		 5f8yA-4x04A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB201_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 4x04 SOLUTE BINDING
PROTEIN
(Citrobacter
koseri) 		4 / 8 GLY A  68
GLY A  69
VAL A  43
HIS A  36
 None
None
None
BDP  A 401 (-4.1A)
 0.77A 5f8yB-4x04A:
undetectable		 5f8yB-4x04A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_K_BO2K305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)		 4x04 SOLUTE BINDING
PROTEIN
(Citrobacter
koseri) 		5 / 11 ALA A 282
GLY A 290
GLY A 289
ALA A 288
TYR A 230
 None
 0.92A 5lf3K-4x04A:
undetectable
5lf3L-4x04A:
undetectable		 5lf3K-4x04A:
21.59
5lf3L-4x04A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_Y_BO2Y305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)		 4x04 SOLUTE BINDING
PROTEIN
(Citrobacter
koseri) 		5 / 11 ALA A 282
GLY A 290
GLY A 289
ALA A 288
TYR A 230
 None
 0.91A 5lf3Y-4x04A:
undetectable
5lf3Z-4x04A:
undetectable		 5lf3Y-4x04A:
21.59
5lf3Z-4x04A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 4x04 SOLUTE BINDING
PROTEIN
(Citrobacter
koseri) 		4 / 7 TYR A 244
ILE A 260
LEU A 242
GLY A 146
 None
 0.83A 5nooB-4x04A:
undetectable		 5nooB-4x04A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4x04 SOLUTE BINDING
PROTEIN
(Citrobacter
koseri) 		3 / 3 GLY A 127
THR A 152
PRO A 239
 None
 0.60A 5v5zA-4x04A:
undetectable		 5v5zA-4x04A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		 4x04 SOLUTE BINDING
PROTEIN
(Citrobacter
koseri) 		4 / 7 SER A 233
HIS A 235
GLY A 234
LEU A 167
 None
 1.05A 6btxA-4x04A:
undetectable		 6btxA-4x04A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_2
(-)		 4x04 SOLUTE BINDING
PROTEIN
(Citrobacter
koseri) 		4 / 6 TYR A 223
ASN A 154
TYR A 230
GLU A 115
 None
 1.26A 6gneA-4x04A:
undetectable		 6gneA-4x04A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_2
(-)		 4x04 SOLUTE BINDING
PROTEIN
(Citrobacter
koseri) 		4 / 8 TYR A 223
ASN A 154
TYR A 230
GLU A 115
 None
 1.28A 6gneB-4x04A:
undetectable		 6gneB-4x04A:
22.01