SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4x0e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 4x0e PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 5 PHE A  71
PHE A  38
PHE A  13
HIS A  20
 None
 1.04A 2lh6A-4x0eA:
undetectable		 2lh6A-4x0eA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKS_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4x0e PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  10
GLY A  11
ILE A 114
THR A  86
ASP A  77
 None
 0.94A 4jksA-4x0eA:
undetectable		 4jksA-4x0eA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKS_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4x0e PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  10
GLY A  11
ILE A 114
THR A  86
ASP A  77
 None
 0.93A 4jksB-4x0eA:
undetectable		 4jksB-4x0eA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKU_A_ADNA500_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4x0e PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  10
GLY A  11
ILE A 114
THR A  86
ASP A  77
 None
 0.94A 4jkuA-4x0eA:
undetectable		 4jkuA-4x0eA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_1
(SUGAR KINASE)		 4x0e PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  10
GLY A  11
ILE A 114
THR A  86
ASP A  77
 None
 0.94A 4k8cA-4x0eA:
undetectable		 4k8cA-4x0eA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_B_ADNB401_1
(SUGAR KINASE)		 4x0e PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  10
GLY A  11
ILE A 114
THR A  86
ASP A  77
 None
 0.94A 4k8cB-4x0eA:
undetectable		 4k8cB-4x0eA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8K_A_ADNA401_1
(SUGAR KINASE)		 4x0e PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  10
GLY A  11
ILE A 114
THR A  86
ASP A  77
 None
 0.92A 4k8kA-4x0eA:
undetectable		 4k8kA-4x0eA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8K_B_ADNB403_1
(SUGAR KINASE)		 4x0e PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  10
GLY A  11
ILE A 114
THR A  86
ASP A  77
 None
 0.93A 4k8kB-4x0eA:
undetectable		 4k8kB-4x0eA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4x0e PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  10
GLY A  11
ILE A 114
THR A  86
ASP A  77
 None
 0.94A 4kahA-4x0eA:
2.1		 4kahA-4x0eA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAL_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4x0e PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  10
GLY A  11
ILE A 114
THR A  86
ASP A  77
 None
 0.94A 4kalA-4x0eA:
undetectable		 4kalA-4x0eA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAL_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4x0e PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  10
GLY A  11
ILE A 114
THR A  86
ASP A  77
 None
 0.94A 4kalB-4x0eA:
undetectable		 4kalB-4x0eA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4x0e PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  10
GLY A  11
ILE A 114
THR A  86
ASP A  77
 None
 0.94A 4kanA-4x0eA:
2.0		 4kanA-4x0eA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4x0e PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  10
GLY A  11
ILE A 114
THR A  86
ASP A  77
 None
 0.95A 4kbeA-4x0eA:
undetectable		 4kbeA-4x0eA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4x0e PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  10
GLY A  11
ILE A 114
THR A  86
ASP A  77
 None
 0.93A 4lbgB-4x0eA:
undetectable		 4lbgB-4x0eA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LCA_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4x0e PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  10
GLY A  11
ILE A 114
THR A  86
ASP A  77
 None
 0.95A 4lcaB-4x0eA:
undetectable		 4lcaB-4x0eA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 4x0e PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 TYR A 137
GLY A 131
LEU A 156
SER A 133
ALA A 110
 None
 1.13A 4qtuB-4x0eA:
undetectable		 4qtuB-4x0eA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 4x0e PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 12 TYR A 137
GLY A 131
SER A 133
ILE A 114
ALA A 110
 None
 0.99A 4qtuB-4x0eA:
undetectable		 4qtuB-4x0eA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		 4x0e PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 8 GLY A  10
ILE A 161
SER A 133
GLY A 107
 None
 0.62A 5alcL-4x0eA:
undetectable		 5alcL-4x0eA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		 4x0e PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 6 GLY A  42
ASP A  77
ARG A  80
GLY A  82
 None
 0.95A 5cdpA-4x0eA:
undetectable
5cdpB-4x0eA:
3.2		 5cdpA-4x0eA:
18.18
5cdpB-4x0eA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K50_A_ACTA1403_0
(L-THREONINE
3-DEHYDROGENASE)		 4x0e PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 5 SER A 133
VAL A 132
GLY A 107
ALA A 108
 None
 1.02A 5k50A-4x0eA:
3.8		 5k50A-4x0eA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA410_0
(UNCHARACTERIZED
PROTEIN KDOO)		 4x0e PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Mycobacterium
tuberculosis) 		4 / 4 GLY A   7
LEU A   6
VAL A  37
GLU A  35
 None
 1.27A 5yw0A-4x0eA:
undetectable		 5yw0A-4x0eA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JMJ_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4x0e PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 5 GLY A  11
THR A  12
HIS A  20
SER A 167
SER A 168
 None
 0.67A 6jmjA-4x0eA:
14.9		 6jmjA-4x0eA:
27.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4x0e PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Mycobacterium
tuberculosis) 		6 / 7 GLY A  11
THR A  12
PHE A  13
HIS A  20
SER A 167
SER A 168
 None
 0.66A 6jnhA-4x0eA:
15.0		 6jnhA-4x0eA:
27.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4x0e PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Mycobacterium
tuberculosis) 		5 / 6 GLY A  11
THR A  12
HIS A  20
SER A 167
SER A 168
 None
 0.71A 6jogA-4x0eA:
14.9		 6jogA-4x0eA:
27.63