SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4x0l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_A_RBFA501_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4x0l HAPTOGLOBIN
(Homo
sapiens) 		5 / 12 GLY C 188
SER C 357
ILE C 374
ILE C 250
LEU C 198
 None
 1.21A 1kyvA-4x0lC:
undetectable
1kyvE-4x0lC:
undetectable		 1kyvA-4x0lC:
24.33
1kyvE-4x0lC:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_C_RBFC503_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4x0l HAPTOGLOBIN
(Homo
sapiens) 		5 / 12 ILE C 250
LEU C 198
GLY C 188
SER C 357
ILE C 374
 None
 1.23A 1kyvB-4x0lC:
undetectable
1kyvC-4x0lC:
undetectable		 1kyvB-4x0lC:
24.33
1kyvC-4x0lC:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_D_RBFD504_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4x0l HAPTOGLOBIN
(Homo
sapiens) 		5 / 12 ILE C 250
LEU C 198
GLY C 188
SER C 357
ILE C 374
 None
 1.20A 1kyvC-4x0lC:
undetectable
1kyvD-4x0lC:
undetectable		 1kyvC-4x0lC:
24.33
1kyvD-4x0lC:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_E_RBFE505_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4x0l HAPTOGLOBIN
(Homo
sapiens) 		5 / 12 ILE C 250
LEU C 198
GLY C 188
SER C 357
ILE C 374
 None
 1.19A 1kyvD-4x0lC:
undetectable
1kyvE-4x0lC:
undetectable		 1kyvD-4x0lC:
24.33
1kyvE-4x0lC:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_A_SAMA1300_0
(UPF0088 PROTEIN
AQ_165)		 4x0l HAPTOGLOBIN
(Homo
sapiens) 		5 / 12 LEU C 198
GLY C 356
GLY C 188
LEU C 249
THR C 200
 None
 0.75A 2egvA-4x0lC:
2.5		 2egvA-4x0lC:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_B_SAMB1400_0
(UPF0088 PROTEIN
AQ_165)		 4x0l HAPTOGLOBIN
(Homo
sapiens) 		5 / 12 LEU C 198
GLY C 356
GLY C 188
LEU C 249
THR C 200
 None
 0.76A 2egvB-4x0lC:
2.4		 2egvB-4x0lC:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_1
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 4x0l HAPTOGLOBIN
(Homo
sapiens) 		3 / 3 SER C 357
ASP C 246
ASP C 378
 None
 0.76A 2plwA-4x0lC:
undetectable		 2plwA-4x0lC:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 4x0l HAPTOGLOBIN
(Homo
sapiens) 		5 / 12 GLY C 353
GLY C 188
LEU C 375
VAL C 180
ASP C 354
 None
 0.91A 2yvlB-4x0lC:
undetectable		 2yvlB-4x0lC:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_D_SAMD603_0
(HYPOTHETICAL PROTEIN)		 4x0l HAPTOGLOBIN
(Homo
sapiens) 		5 / 12 GLY C 353
GLY C 188
LEU C 375
VAL C 180
ASP C 354
 None
 0.94A 2yvlD-4x0lC:
undetectable		 2yvlD-4x0lC:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOB_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4x0l HAPTOGLOBIN
(Homo
sapiens) 		5 / 12 PHE C 377
THR C 350
ASN C 203
GLY C 188
LEU C 206
 None
 1.25A 3aobC-4x0lC:
undetectable		 3aobC-4x0lC:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4x0l HAPTOGLOBIN
(Homo
sapiens) 		5 / 12 PHE C 377
THR C 350
ASN C 203
GLY C 188
LEU C 206
 None
 1.29A 3aodC-4x0lC:
undetectable		 3aodC-4x0lC:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1X_A_ROCA201_2
(HIV-1 PROTEASE)		 4x0l HAPTOGLOBIN
(Homo
sapiens) 		5 / 12 GLY C 188
ALA C 189
ILE C 192
VAL C 236
ILE C 250
 None
 0.93A 3d1xB-4x0lC:
undetectable		 3d1xB-4x0lC:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_1
(PROTEASE)		 4x0l HAPTOGLOBIN
(Homo
sapiens) 		5 / 11 GLY C 188
ALA C 189
ILE C 192
VAL C 236
ILE C 250
 None
 0.93A 3em4U-4x0lC:
undetectable		 3em4U-4x0lC:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_D_ROCD100_1
(PROTEASE)		 4x0l HAPTOGLOBIN
(Homo
sapiens) 		5 / 12 GLY C 188
ALA C 189
ILE C 192
VAL C 236
ILE C 250
 None
 0.91A 3ndtC-4x0lC:
undetectable		 3ndtC-4x0lC:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_A_ROCA101_1
(PROTEASE)		 4x0l HAPTOGLOBIN
(Homo
sapiens) 		5 / 12 GLY C 188
ALA C 189
ILE C 192
VAL C 236
ILE C 250
 None
 0.90A 3nduA-4x0lC:
undetectable		 3nduA-4x0lC:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_1
(PROTEASE)		 4x0l HAPTOGLOBIN
(Homo
sapiens) 		5 / 12 GLY C 188
ALA C 189
ILE C 192
VAL C 236
ILE C 250
 None
 0.91A 3oxcA-4x0lC:
undetectable		 3oxcA-4x0lC:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_3
(PROTEASE)		 4x0l HAPTOGLOBIN
(Homo
sapiens) 		5 / 12 GLY C 188
ALA C 189
ILE C 192
VAL C 236
ILE C 250
 None
 0.93A 3oxcB-4x0lC:
undetectable		 3oxcB-4x0lC:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_A_PFLA319_1
(GLR4197 PROTEIN)		 4x0l HAPTOGLOBIN
(Homo
sapiens) 		4 / 7 LEU C 267
THR C 402
ILE C 403
ASN C 193
 None
 0.90A 3p50A-4x0lC:
undetectable		 3p50A-4x0lC:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_B_PFLB319_1
(GLR4197 PROTEIN)		 4x0l HAPTOGLOBIN
(Homo
sapiens) 		4 / 7 LEU C 267
THR C 402
ILE C 403
ASN C 193
 None
 0.89A 3p50B-4x0lC:
undetectable		 3p50B-4x0lC:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_C_PFLC319_1
(GLR4197 PROTEIN)		 4x0l HAPTOGLOBIN
(Homo
sapiens) 		4 / 7 LEU C 267
THR C 402
ILE C 403
ASN C 193
 None
 0.89A 3p50C-4x0lC:
undetectable		 3p50C-4x0lC:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_D_PFLD320_1
(GLR4197 PROTEIN)		 4x0l HAPTOGLOBIN
(Homo
sapiens) 		4 / 7 LEU C 267
THR C 402
ILE C 403
ASN C 193
 None
 0.89A 3p50D-4x0lC:
undetectable		 3p50D-4x0lC:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_E_PFLE319_1
(GLR4197 PROTEIN)		 4x0l HAPTOGLOBIN
(Homo
sapiens) 		4 / 7 LEU C 267
THR C 402
ILE C 403
ASN C 193
 None
 0.89A 3p50E-4x0lC:
undetectable		 3p50E-4x0lC:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_3
(PROTEASE)		 4x0l HAPTOGLOBIN
(Homo
sapiens) 		5 / 12 GLY C 188
ALA C 189
ILE C 192
VAL C 236
ILE C 250
 None
 0.92A 3pwrB-4x0lC:
undetectable		 3pwrB-4x0lC:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_B_ROCB801_1
(PROTEASE)		 4x0l HAPTOGLOBIN
(Homo
sapiens) 		5 / 12 GLY C 188
ALA C 189
ILE C 192
VAL C 236
ILE C 250
 None
 0.90A 3tkgA-4x0lC:
undetectable		 3tkgA-4x0lC:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 4x0l HAPTOGLOBIN
(Homo
sapiens) 		4 / 5 LEU C 206
ALA C 201
MET C 179
THR C 187
 None
 1.17A 3vasB-4x0lC:
undetectable		 3vasB-4x0lC:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 4x0l HAPTOGLOBIN
(Homo
sapiens) 		4 / 6 PHE C 339
ALA C 273
GLY C 279
VAL C 361
 None
 0.45A 4dubA-4x0lC:
undetectable		 4dubA-4x0lC:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 4x0l HAPTOGLOBIN
(Homo
sapiens) 		4 / 4 PHE C 359
VAL C 281
ALA C 360
PHE C 173
 None
 1.46A 4f3tA-4x0lC:
undetectable		 4f3tA-4x0lC:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4x0l HAPTOGLOBIN
(Homo
sapiens) 		4 / 4 PHE C 359
VAL C 281
ALA C 360
PHE C 173
 None
 1.41A 4w5qA-4x0lC:
undetectable		 4w5qA-4x0lC:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5R_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4x0l HAPTOGLOBIN
(Homo
sapiens) 		4 / 4 PHE C 359
VAL C 281
ALA C 360
PHE C 173
 None
 1.46A 4w5rA-4x0lC:
undetectable		 4w5rA-4x0lC:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4x0l HAPTOGLOBIN
(Homo
sapiens) 		4 / 4 PHE C 359
VAL C 281
ALA C 360
PHE C 173
 None
 1.47A 4w5tA-4x0lC:
undetectable		 4w5tA-4x0lC:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4x0l HAPTOGLOBIN
(Homo
sapiens) 		4 / 4 PHE C 359
VAL C 281
ALA C 360
PHE C 173
 None
 1.44A 4z4gA-4x0lC:
undetectable		 4z4gA-4x0lC:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A211_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 4x0l HAPTOGLOBIN
(Homo
sapiens) 		4 / 6 VAL C 231
GLN C 229
VAL C 225
TYR C 224
 None
 0.94A 5i8fA-4x0lC:
undetectable		 5i8fA-4x0lC:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4x0l HAPTOGLOBIN
(Homo
sapiens) 		4 / 4 PHE C 359
VAL C 281
ALA C 360
PHE C 173
 None
 1.44A 5ki6A-4x0lC:
undetectable		 5ki6A-4x0lC:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_1
(PROTEASE E35D-SQV)		 4x0l HAPTOGLOBIN
(Homo
sapiens) 		5 / 12 GLY C 188
ALA C 189
ILE C 192
VAL C 236
ILE C 250
 None
 0.88A 5kqxA-4x0lC:
undetectable		 5kqxA-4x0lC:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4x0l HAPTOGLOBIN
(Homo
sapiens) 		6 / 12 ILE C 265
HIS C 362
ALA C 360
ILE C 374
ALA C 358
VAL C 392
 None
 1.49A 5n0tB-4x0lC:
undetectable		 5n0tB-4x0lC:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_G_SAMG501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4x0l HAPTOGLOBIN
(Homo
sapiens) 		5 / 11 LEU C 198
GLY C 356
GLY C 188
LEU C 249
THR C 200
 None
 0.94A 5o96G-4x0lC:
undetectable		 5o96G-4x0lC:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_H_SAMH501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4x0l HAPTOGLOBIN
(Homo
sapiens) 		5 / 10 LEU C 198
GLY C 356
GLY C 188
LEU C 249
THR C 200
 None
 0.93A 5o96G-4x0lC:
undetectable
5o96H-4x0lC:
undetectable		 5o96G-4x0lC:
22.18
5o96H-4x0lC:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_B_SAMB201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 4x0l HAPTOGLOBIN
(Homo
sapiens) 		5 / 10 LEU C 198
ILE C 250
ILE C 374
GLY C 356
GLY C 188
 None
 1.16A 5twjB-4x0lC:
undetectable		 5twjB-4x0lC:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW4_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 4x0l HAPTOGLOBIN
(Homo
sapiens) 		5 / 9 SER C 357
THR C 187
GLY C 353
ALA C 355
GLY C 285
 None
 1.25A 5vw4A-4x0lC:
undetectable		 5vw4A-4x0lC:
22.73