SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4x0q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA154_1
(CALMODULIN)		 4x0q DNA POLYMERASE THETA
(Homo
sapiens) 		5 / 10 GLU A2049
ALA A2046
MET A2023
LEU A2020
GLU A2016
 None
 1.33A 1a29A-4x0qA:
undetectable		 1a29A-4x0qA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_B_DESB128_1
(TRANSTHYRETIN)		 4x0q DNA POLYMERASE THETA
(Homo
sapiens) 		4 / 5 LEU A1903
ALA A2046
LEU A1854
SER A2031
 None
 1.14A 1tt6B-4x0qA:
undetectable		 1tt6B-4x0qA:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_1
(FATTY ACID-BINDING
PROTEIN)		 4x0q DNA POLYMERASE THETA
(Homo
sapiens) 		3 / 3 TYR A2420
ARG A2337
GLN A2333
 None
 1.00A 1tw4A-4x0qA:
undetectable		 1tw4A-4x0qA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 4x0q DNA POLYMERASE THETA
(Homo
sapiens) 		3 / 3 PHE A2212
ARG A2202
ASN A2205
 None
 0.90A 1xzxX-4x0qA:
undetectable		 1xzxX-4x0qA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OA1_B_ADNB2005_1
(TRYPTOPHAN
HALOGENASE)		 4x0q DNA POLYMERASE THETA
(Homo
sapiens) 		4 / 7 GLY A2532
GLY A2531
VAL A2558
LEU A2327
 None
 0.59A 2oa1B-4x0qA:
2.5		 2oa1B-4x0qA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_C_TOPC1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4x0q DNA POLYMERASE THETA
(Homo
sapiens) 		5 / 10 ILE A2326
ALA A2328
LEU A2538
ILE A2535
ILE A2249
 None
 1.16A 2w9sC-4x0qA:
undetectable		 2w9sC-4x0qA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Z_B_017B201_1
(HIV-1 PROTEASE)		 4x0q DNA POLYMERASE THETA
(Homo
sapiens) 		5 / 12 ASP A2479
GLY A2475
ALA A2478
ILE A2242
VAL A2076
 None
 0.96A 3d1zA-4x0qA:
undetectable		 3d1zA-4x0qA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_2
(DIHYDROFOLATE
REDUCTASE)		 4x0q DNA POLYMERASE THETA
(Homo
sapiens) 		3 / 3 ARG A2315
ILE A2535
THR A2485
 None
 0.69A 3ia4D-4x0qA:
undetectable		 3ia4D-4x0qA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4x0q DNA POLYMERASE THETA
(Homo
sapiens) 		4 / 6 GLU A2335
THR A2237
ALA A2477
ALA A2478
 DG3  A2604 ( 4.4A)
None
None
None
 1.04A 3ns1C-4x0qA:
undetectable		 3ns1C-4x0qA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_1
(PROTEASE)		 4x0q DNA POLYMERASE THETA
(Homo
sapiens) 		5 / 12 ALA A2329
ASP A2330
ILE A2326
VAL A2554
VAL A2558
 None
MG  A2603 ( 2.3A)
None
None
None
 1.07A 3ucbA-4x0qA:
undetectable		 3ucbA-4x0qA:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4x0q DNA POLYMERASE THETA
(Homo
sapiens) 		4 / 7 GLU A2049
ILE A2053
HIS A2236
VAL A2232
 None
None
None
GOL  A2602 (-4.5A)
 0.96A 4a97A-4x0qA:
undetectable		 4a97A-4x0qA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4x0q DNA POLYMERASE THETA
(Homo
sapiens) 		4 / 7 GLU A2049
ILE A2053
HIS A2236
VAL A2232
 None
None
None
GOL  A2602 (-4.5A)
 1.03A 4a97D-4x0qA:
undetectable		 4a97D-4x0qA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4x0q DNA POLYMERASE THETA
(Homo
sapiens) 		4 / 7 GLU A2049
ILE A2053
HIS A2236
VAL A2232
 None
None
None
GOL  A2602 (-4.5A)
 0.94A 4a97H-4x0qA:
0.0		 4a97H-4x0qA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4x0q DNA POLYMERASE THETA
(Homo
sapiens) 		4 / 6 GLU A2049
ILE A2053
HIS A2236
VAL A2232
 None
None
None
GOL  A2602 (-4.5A)
 0.97A 4a97I-4x0qA:
undetectable		 4a97I-4x0qA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_B_2FAB301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4x0q DNA POLYMERASE THETA
(Homo
sapiens) 		5 / 12 ARG A2228
GLY A2532
VAL A2546
GLU A2545
VAL A2554
 None
 1.30A 4danA-4x0qA:
undetectable
4danB-4x0qA:
undetectable		 4danA-4x0qA:
16.33
4danB-4x0qA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_B_IMNB201_1
(TRANSTHYRETIN)		 4x0q DNA POLYMERASE THETA
(Homo
sapiens) 		4 / 6 LEU A2087
LEU A2084
SER A2080
THR A2485
 None
 1.07A 4ikiB-4x0qA:
undetectable		 4ikiB-4x0qA:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_B_ADNB501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 4x0q DNA POLYMERASE THETA
(Homo
sapiens) 		4 / 5 GLN A2441
THR A2442
LEU A2064
LEU A2069
 None
 1.00A 4lvcB-4x0qA:
undetectable		 4lvcB-4x0qA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_A_PPFA602_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4x0q DNA POLYMERASE THETA
(Homo
sapiens) 		4 / 6 LYS A2383
ARG A2379
ASP A2540
ASP A2330
 DG3  A2604 (-2.5A)
DG3  A2604 (-3.4A)
MG  A2603 ( 2.6A)
MG  A2603 ( 2.3A)
 1.29A 5hp1A-4x0qA:
4.7		 5hp1A-4x0qA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_C_PPFC601_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4x0q DNA POLYMERASE THETA
(Homo
sapiens) 		4 / 6 ARG A2379
ASP A2330
ASP A2540
LYS A2575
 DG3  A2604 (-3.4A)
MG  A2603 ( 2.3A)
MG  A2603 ( 2.6A)
DG3  A2604 ( 3.7A)
 1.06A 5hp1C-4x0qA:
4.5		 5hp1C-4x0qA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4x0q DNA POLYMERASE THETA
(Homo
sapiens) 		4 / 4 GLN A2441
THR A2442
LEU A2064
LEU A2069
 None
 1.01A 5m5kB-4x0qA:
undetectable		 5m5kB-4x0qA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NKN_A_LOCA201_2
(NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN)		 4x0q DNA POLYMERASE THETA
(Homo
sapiens) 		3 / 3 VAL A2551
LYS A2559
MET A2562
 None
 1.03A 5nknA-4x0qA:
undetectable		 5nknA-4x0qA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIG_A_EDTA501_0
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 4x0q DNA POLYMERASE THETA
(Homo
sapiens) 		4 / 6 THR A2471
ARG A2448
ILE A2453
GLU A2465
 None
 0.96A 5uigA-4x0qA:
undetectable		 5uigA-4x0qA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4x0q DNA POLYMERASE THETA
(Homo
sapiens) 		4 / 6 GLN A2176
PHE A2177
PHE A2138
LEU A2137
 None
 1.12A 5z84P-4x0qA:
undetectable
5z84W-4x0qA:
undetectable		 5z84P-4x0qA:
15.71
5z84W-4x0qA:
5.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4x0q DNA POLYMERASE THETA
(Homo
sapiens) 		4 / 6 GLN A2176
PHE A2177
PHE A2138
LEU A2137
 None
 1.08A 5z85P-4x0qA:
undetectable
5z85W-4x0qA:
undetectable		 5z85P-4x0qA:
15.71
5z85W-4x0qA:
5.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4x0q DNA POLYMERASE THETA
(Homo
sapiens) 		4 / 6 GLN A2176
PHE A2177
PHE A2138
LEU A2137
 None
 1.09A 5z86P-4x0qA:
undetectable
5z86W-4x0qA:
undetectable		 5z86P-4x0qA:
15.71
5z86W-4x0qA:
5.33