SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4x0r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_C_URFC999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 4x0r INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX2
(Homo
sapiens) 		4 / 5 MET B 155
ALA B 152
TYR B 212
ILE B 209
 None
 0.94A 1upfC-4x0rB:
undetectable		 1upfC-4x0rB:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_D_URFD999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 4x0r INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX2
(Homo
sapiens) 		4 / 4 MET B 155
ALA B 152
TYR B 212
ILE B 209
 None
 0.89A 1upfD-4x0rB:
undetectable		 1upfD-4x0rB:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO5_A_CHDA131_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 4x0r INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX2
(Homo
sapiens) 		5 / 12 ILE B 229
ILE B 141
THR B 140
LEU B 222
PHE B  17
 None
 0.93A 2qo5A-4x0rB:
undetectable		 2qo5A-4x0rB:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4x0r INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX2
(Homo
sapiens) 		5 / 12 ILE B 156
ILE B 209
ALA B 152
ALA B 111
ILE B  42
 None
 0.79A 3uvvA-4x0rB:
undetectable		 3uvvA-4x0rB:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4x0r INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX2
(Homo
sapiens) 		4 / 8 ILE B  63
GLU B  66
GLU B  67
ILE B  91
 None
 0.87A 4mj8A-4x0rB:
undetectable		 4mj8A-4x0rB:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_2
(GLUCOCORTICOID
RECEPTOR)		 4x0r INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX2
(Homo
sapiens) 		3 / 3 MET B 155
MET B 112
TYR B 212
 None
 1.34A 4p6xI-4x0rB:
undetectable		 4p6xI-4x0rB:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CK2_C_IPHC101_0
(INSULIN A CHAIN
INSULIN B CHAIN)		 4x0r INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX2
(Homo
sapiens) 		4 / 4 ILE B 115
LEU B 108
HIS B 148
ALA B 152
 None
 0.68A 6ck2C-4x0rB:
undetectable
6ck2D-4x0rB:
undetectable		 6ck2C-4x0rB:
8.20
6ck2D-4x0rB:
9.09