SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4x1z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_B_CHDB4085_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE II
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART)		 4x1z VP1
(Rabbit
hemorrhagic
disease
virus) 		5 / 11 GLY A 486
THR A 253
ARG A 469
ARG A 468
GLY A 424
 None
 1.27A 1v54A-4x1zA:
undetectable
1v54B-4x1zA:
undetectable
1v54T-4x1zA:
undetectable		 1v54A-4x1zA:
21.03
1v54B-4x1zA:
19.71
1v54T-4x1zA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		 4x1z VP1
(Rabbit
hemorrhagic
disease
virus) 		4 / 7 PRO A 239
LEU A 528
GLY A 527
LEU A 507
 None
 0.89A 1ya4B-4x1zA:
undetectable		 1ya4B-4x1zA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_N_CHDN1604_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 4x1z VP1
(Rabbit
hemorrhagic
disease
virus) 		5 / 11 ARG A 469
ARG A 468
GLY A 424
GLY A 486
THR A 253
 None
 1.33A 2eimG-4x1zA:
undetectable
2eimN-4x1zA:
undetectable
2eimO-4x1zA:
undetectable		 2eimG-4x1zA:
12.26
2eimN-4x1zA:
21.03
2eimO-4x1zA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4x1z VP1
(Rabbit
hemorrhagic
disease
virus) 		5 / 9 LEU A 550
LEU A 547
ILE A 261
LEU A 243
ILE A 553
 None
 1.05A 2f78A-4x1zA:
undetectable		 2f78A-4x1zA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4x1z VP1
(Rabbit
hemorrhagic
disease
virus) 		5 / 9 LEU A 550
LEU A 547
ILE A 261
LEU A 243
ILE A 553
 None
 0.93A 2f7aB-4x1zA:
undetectable		 2f7aB-4x1zA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_A_BEZA1222_0
(PEROXIREDOXIN 6)		 4x1z VP1
(Rabbit
hemorrhagic
disease
virus) 		4 / 7 THR A 459
PRO A 460
VAL A 267
PRO A 454
 None
 1.03A 2v2gA-4x1zA:
undetectable
2v2gB-4x1zA:
undetectable		 2v2gA-4x1zA:
21.80
2v2gB-4x1zA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_B_BEZB1220_0
(PEROXIREDOXIN 6)		 4x1z VP1
(Rabbit
hemorrhagic
disease
virus) 		4 / 7 PRO A 454
THR A 459
PRO A 460
VAL A 267
 None
 1.05A 2v2gA-4x1zA:
undetectable
2v2gB-4x1zA:
undetectable		 2v2gA-4x1zA:
21.80
2v2gB-4x1zA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_D_BEZD1221_0
(PEROXIREDOXIN 6)		 4x1z VP1
(Rabbit
hemorrhagic
disease
virus) 		4 / 7 PRO A 454
THR A 459
PRO A 460
VAL A 267
 None
 1.01A 2v2gC-4x1zA:
undetectable
2v2gD-4x1zA:
undetectable		 2v2gC-4x1zA:
21.80
2v2gD-4x1zA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_E_BEZE1222_0
(PEROXIREDOXIN 6.)		 4x1z VP1
(Rabbit
hemorrhagic
disease
virus) 		4 / 7 THR A 459
PRO A 460
VAL A 267
PRO A 454
 None
 1.02A 2v41E-4x1zA:
undetectable
2v41F-4x1zA:
undetectable		 2v41E-4x1zA:
21.80
2v41F-4x1zA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_F_BEZF1222_0
(PEROXIREDOXIN 6.)		 4x1z VP1
(Rabbit
hemorrhagic
disease
virus) 		4 / 7 PRO A 454
THR A 459
PRO A 460
VAL A 267
 None
 0.97A 2v41E-4x1zA:
undetectable
2v41F-4x1zA:
undetectable		 2v41E-4x1zA:
21.80
2v41F-4x1zA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_H_BEZH1222_0
(PEROXIREDOXIN 6.)		 4x1z VP1
(Rabbit
hemorrhagic
disease
virus) 		4 / 8 PRO A 454
THR A 459
PRO A 460
VAL A 267
 None
 0.99A 2v41G-4x1zA:
undetectable
2v41H-4x1zA:
undetectable		 2v41G-4x1zA:
21.80
2v41H-4x1zA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_A_ACRA5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4x1z VP1
(Rabbit
hemorrhagic
disease
virus) 		3 / 3 LEU A 528
TRP A 278
TYR A 533
 None
 0.92A 3aicA-4x1zA:
undetectable		 3aicA-4x1zA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4x1z VP1
(Rabbit
hemorrhagic
disease
virus) 		3 / 3 LEU A 528
TRP A 278
TYR A 533
 None
 0.92A 3aicB-4x1zA:
undetectable		 3aicB-4x1zA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4x1z VP1
(Rabbit
hemorrhagic
disease
virus) 		3 / 3 LEU A 528
TRP A 278
TYR A 533
 None
 0.93A 3aicE-4x1zA:
undetectable		 3aicE-4x1zA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_F_ACRF5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4x1z VP1
(Rabbit
hemorrhagic
disease
virus) 		3 / 3 LEU A 528
TRP A 278
TYR A 533
 None
 0.96A 3aicF-4x1zA:
undetectable		 3aicF-4x1zA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_G_ACRG5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4x1z VP1
(Rabbit
hemorrhagic
disease
virus) 		3 / 3 LEU A 528
TRP A 278
TYR A 533
 None
 0.98A 3aicG-4x1zA:
undetectable		 3aicG-4x1zA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4x1z VP1
(Rabbit
hemorrhagic
disease
virus) 		3 / 3 LEU A 528
TRP A 278
TYR A 533
 None
 0.93A 3aicH-4x1zA:
undetectable		 3aicH-4x1zA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_A_PNXA902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		 4x1z VP1
(Rabbit
hemorrhagic
disease
virus) 		5 / 9 LEU A 243
PRO A 491
THR A 495
GLN A 490
PHE A 534
 None
 1.47A 3tvxA-4x1zA:
undetectable		 3tvxA-4x1zA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_A_SALA404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 4x1z VP1
(Rabbit
hemorrhagic
disease
virus) 		4 / 7 ALA A 332
PRO A 333
ARG A 299
ALA A 318
 None
 1.11A 3twpA-4x1zA:
undetectable		 3twpA-4x1zA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_0
(METHYLTRANSFERASE
WBDD)		 4x1z VP1
(Rabbit
hemorrhagic
disease
virus) 		5 / 12 GLY A 486
ALA A 464
ARG A 469
ILE A 426
ILE A 434
 None
 1.12A 4aztA-4x1zA:
undetectable		 4aztA-4x1zA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_A_SVRA301_1
(NUCLEOCAPSID PROTEIN)		 4x1z VP1
(Rabbit
hemorrhagic
disease
virus) 		5 / 11 GLY A 270
VAL A 267
GLN A 265
MET A 462
ILE A 443
 None
 1.30A 4j4vA-4x1zA:
undetectable		 4j4vA-4x1zA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTV_A_ADNA403_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4x1z VP1
(Rabbit
hemorrhagic
disease
virus) 		5 / 12 ASP A 325
SER A 322
ASP A 334
ILE A 295
ILE A 399
 None
 1.40A 4ktvA-4x1zA:
undetectable
4ktvB-4x1zA:
undetectable		 4ktvA-4x1zA:
20.95
4ktvB-4x1zA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4x1z VP1
(Rabbit
hemorrhagic
disease
virus) 		5 / 12 GLY A 321
ILE A 404
GLY A 356
LEU A 418
HIS A 297
 None
 1.08A 4zdyA-4x1zA:
undetectable		 4zdyA-4x1zA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4x1z VP1
(Rabbit
hemorrhagic
disease
virus) 		5 / 12 GLY A 321
ILE A 404
GLY A 356
LEU A 418
HIS A 297
 None
 1.14A 4ze2A-4x1zA:
undetectable		 4ze2A-4x1zA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C6P_A_4YHA601_1
(PROTEIN C)		 4x1z VP1
(Rabbit
hemorrhagic
disease
virus) 		4 / 6 ALA A 397
SER A 319
SER A 329
PRO A 447
 None
None
None
NA  A 605 (-4.5A)
 0.94A 5c6pA-4x1zA:
undetectable		 5c6pA-4x1zA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4x1z VP1
(Rabbit
hemorrhagic
disease
virus) 		4 / 5 THR A 459
ALA A 536
THR A 538
TYR A 567
 None
 1.32A 5ecmA-4x1zA:
undetectable		 5ecmA-4x1zA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4x1z VP1
(Rabbit
hemorrhagic
disease
virus) 		3 / 3 TYR A 436
TYR A 567
SER A 541
 None
 0.79A 5iktB-4x1zA:
undetectable		 5iktB-4x1zA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_0
(REGULATORY PROTEIN
TETR)		 4x1z VP1
(Rabbit
hemorrhagic
disease
virus) 		5 / 12 GLN A 374
ALA A 375
SER A 403
ILE A 360
VAL A 420
 None
 1.33A 5vlmB-4x1zA:
undetectable		 5vlmB-4x1zA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E8Q_A_X2NA602_0
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4x1z VP1
(Rabbit
hemorrhagic
disease
virus) 		5 / 12 GLY A 321
ILE A 404
GLY A 356
LEU A 418
HIS A 297
 None
 1.08A 6e8qA-4x1zA:
undetectable		 6e8qA-4x1zA:
13.31