SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4x22'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA799_1
(ADENOSINE KINASE)		 4x22 TRIOSEPHOSPHATE
ISOMERASE
(Leptospira
interrogans) 		5 / 10 GLY A 215
VAL A 218
ALA A 185
ASN A 222
ILE A 232
 None
 1.03A 1likA-4x22A:
undetectable		 1likA-4x22A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_H_TRUH800_1
(GLUTAMATE RECEPTOR 2)		 4x22 TRIOSEPHOSPHATE
ISOMERASE
(Leptospira
interrogans) 		3 / 3 ILE A 196
SER A 209
SER A 205
 None
 0.57A 3iltH-4x22A:
undetectable		 3iltH-4x22A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_1
(ANDROGEN RECEPTOR)		 4x22 TRIOSEPHOSPHATE
ISOMERASE
(Leptospira
interrogans) 		5 / 12 LEU A 236
LEU A 213
GLY A 235
LEU A 250
VAL A  42
 None
 1.33A 4olmA-4x22A:
undetectable		 4olmA-4x22A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_A_HISA302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4x22 TRIOSEPHOSPHATE
ISOMERASE
(Leptospira
interrogans) 		5 / 10 GLY A 239
VAL A 237
LEU A  23
SER A 246
LEU A 250
 None
 1.23A 4yb6A-4x22A:
undetectable
4yb6E-4x22A:
undetectable		 4yb6A-4x22A:
24.37
4yb6E-4x22A:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_C_HISC302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4x22 TRIOSEPHOSPHATE
ISOMERASE
(Leptospira
interrogans) 		5 / 10 GLY A 239
VAL A 237
LEU A  23
SER A 246
LEU A 250
 None
 1.21A 4yb6C-4x22A:
undetectable
4yb6F-4x22A:
undetectable		 4yb6C-4x22A:
24.37
4yb6F-4x22A:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_D_HISD302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4x22 TRIOSEPHOSPHATE
ISOMERASE
(Leptospira
interrogans) 		5 / 10 LEU A  23
SER A 246
LEU A 250
GLY A 239
VAL A 237
 None
 1.19A 4yb6A-4x22A:
undetectable
4yb6D-4x22A:
undetectable		 4yb6A-4x22A:
24.37
4yb6D-4x22A:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_F_HISF302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4x22 TRIOSEPHOSPHATE
ISOMERASE
(Leptospira
interrogans) 		5 / 10 LEU A  23
SER A 246
LEU A 250
GLY A 239
VAL A 237
 None
 1.22A 4yb6B-4x22A:
undetectable
4yb6F-4x22A:
undetectable		 4yb6B-4x22A:
24.37
4yb6F-4x22A:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)		 4x22 TRIOSEPHOSPHATE
ISOMERASE
(Leptospira
interrogans) 		5 / 11 PHE A 247
VAL A  61
ILE A  62
ILE A 165
ILE A 223
 None
None
EDO  A 301 ( 4.2A)
None
None
 0.97A 5hw8A-4x22A:
undetectable
5hw8D-4x22A:
undetectable		 5hw8A-4x22A:
22.73
5hw8D-4x22A:
22.73