SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4x2d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_A_SAMA105_0
(PROTEIN (MET
REPRESSOR))		 4x2d FIC FAMILY PROTEIN
PUTATIVE
FILAMENTATION
INDUCED BY CAMP
PROTEIN
(Clostridioides
difficile) 		4 / 8 PHE A 165
ARG A 171
LEU A  95
GLU A  64
 None
ATP  A 302 (-4.0A)
None
None
 1.06A 1cmaA-4x2dA:
undetectable
1cmaB-4x2dA:
undetectable		 1cmaA-4x2dA:
15.51
1cmaB-4x2dA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GEB_A_CAMA418_0
(CYTOCHROME P450-CAM)		 4x2d FIC FAMILY PROTEIN
PUTATIVE
FILAMENTATION
INDUCED BY CAMP
PROTEIN
(Clostridioides
difficile) 		5 / 9 PHE A 165
TYR A 110
LEU A 134
VAL A 176
ILE A 172
 None
 1.43A 1gebA-4x2dA:
undetectable		 1gebA-4x2dA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_B_SAMB200_0
(METHIONINE REPRESSOR)		 4x2d FIC FAMILY PROTEIN
PUTATIVE
FILAMENTATION
INDUCED BY CAMP
PROTEIN
(Clostridioides
difficile) 		5 / 11 PHE A 165
ARG A 171
LEU A  95
GLU A  64
LEU A 101
 None
ATP  A 302 (-4.0A)
None
None
None
 1.43A 1mjqA-4x2dA:
undetectable
1mjqB-4x2dA:
undetectable		 1mjqA-4x2dA:
15.51
1mjqB-4x2dA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_H_SAMH200_0
(METHIONINE REPRESSOR)		 4x2d FIC FAMILY PROTEIN
PUTATIVE
FILAMENTATION
INDUCED BY CAMP
PROTEIN
(Clostridioides
difficile) 		5 / 10 PHE A 165
ARG A 171
LEU A  95
GLU A  64
LEU A 101
 None
ATP  A 302 (-4.0A)
None
None
None
 1.42A 1mjqG-4x2dA:
undetectable
1mjqH-4x2dA:
undetectable		 1mjqG-4x2dA:
15.51
1mjqH-4x2dA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1100_1
(SERUM ALBUMIN)		 4x2d FIC FAMILY PROTEIN
PUTATIVE
FILAMENTATION
INDUCED BY CAMP
PROTEIN
(Clostridioides
difficile) 		4 / 6 HIS A 156
PHE A 159
ARG A 200
GLY A 170
 None
None
ATP  A 302 (-3.5A)
ATP  A 302 (-3.2A)
 1.47A 2i30A-4x2dA:
undetectable		 2i30A-4x2dA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NPN_A_SAMA4633_0
(PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN)		 4x2d FIC FAMILY PROTEIN
PUTATIVE
FILAMENTATION
INDUCED BY CAMP
PROTEIN
(Clostridioides
difficile) 		5 / 9 LEU A 161
TYR A 157
LEU A 203
LEU A 118
THR A 120
 None
ATP  A 302 ( 4.8A)
ATP  A 302 (-3.7A)
None
ATP  A 302 ( 4.0A)
 1.29A 2npnA-4x2dA:
undetectable		 2npnA-4x2dA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKS_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4x2d FIC FAMILY PROTEIN
PUTATIVE
FILAMENTATION
INDUCED BY CAMP
PROTEIN
(Clostridioides
difficile) 		5 / 12 ASN A 169
ILE A 172
GLY A 173
ILE A  83
GLU A 160
 None
None
None
None
ATP  A 302 (-3.6A)
 0.95A 4jksA-4x2dA:
undetectable		 4jksA-4x2dA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKS_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4x2d FIC FAMILY PROTEIN
PUTATIVE
FILAMENTATION
INDUCED BY CAMP
PROTEIN
(Clostridioides
difficile) 		5 / 12 ASN A 169
ILE A 172
GLY A 173
ILE A  83
GLU A 160
 None
None
None
None
ATP  A 302 (-3.6A)
 0.96A 4jksB-4x2dA:
undetectable		 4jksB-4x2dA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKU_A_ADNA500_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4x2d FIC FAMILY PROTEIN
PUTATIVE
FILAMENTATION
INDUCED BY CAMP
PROTEIN
(Clostridioides
difficile) 		5 / 12 ASN A 169
ILE A 172
GLY A 173
ILE A  83
GLU A 160
 None
None
None
None
ATP  A 302 (-3.6A)
 0.95A 4jkuA-4x2dA:
undetectable		 4jkuA-4x2dA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_1
(SUGAR KINASE)		 4x2d FIC FAMILY PROTEIN
PUTATIVE
FILAMENTATION
INDUCED BY CAMP
PROTEIN
(Clostridioides
difficile) 		5 / 12 ASN A 169
ILE A 172
GLY A 173
ILE A  83
GLU A 160
 None
None
None
None
ATP  A 302 (-3.6A)
 0.96A 4k8cA-4x2dA:
undetectable		 4k8cA-4x2dA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_B_ADNB401_1
(SUGAR KINASE)		 4x2d FIC FAMILY PROTEIN
PUTATIVE
FILAMENTATION
INDUCED BY CAMP
PROTEIN
(Clostridioides
difficile) 		5 / 12 ASN A 169
ILE A 172
GLY A 173
ILE A  83
GLU A 160
 None
None
None
None
ATP  A 302 (-3.6A)
 0.96A 4k8cB-4x2dA:
undetectable		 4k8cB-4x2dA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8K_A_ADNA401_1
(SUGAR KINASE)		 4x2d FIC FAMILY PROTEIN
PUTATIVE
FILAMENTATION
INDUCED BY CAMP
PROTEIN
(Clostridioides
difficile) 		5 / 12 ASN A 169
ILE A 172
GLY A 173
ILE A  83
GLU A 160
 None
None
None
None
ATP  A 302 (-3.6A)
 0.95A 4k8kA-4x2dA:
undetectable		 4k8kA-4x2dA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8K_B_ADNB403_1
(SUGAR KINASE)		 4x2d FIC FAMILY PROTEIN
PUTATIVE
FILAMENTATION
INDUCED BY CAMP
PROTEIN
(Clostridioides
difficile) 		5 / 12 ASN A 169
ILE A 172
GLY A 173
ILE A  83
GLU A 160
 None
None
None
None
ATP  A 302 (-3.6A)
 0.95A 4k8kB-4x2dA:
undetectable		 4k8kB-4x2dA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4x2d FIC FAMILY PROTEIN
PUTATIVE
FILAMENTATION
INDUCED BY CAMP
PROTEIN
(Clostridioides
difficile) 		5 / 12 ASN A 169
ILE A 172
GLY A 173
ILE A  83
GLU A 160
 None
None
None
None
ATP  A 302 (-3.6A)
 0.97A 4kahA-4x2dA:
undetectable		 4kahA-4x2dA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4x2d FIC FAMILY PROTEIN
PUTATIVE
FILAMENTATION
INDUCED BY CAMP
PROTEIN
(Clostridioides
difficile) 		5 / 12 ASN A 169
ILE A 172
GLY A 173
ILE A  83
GLU A 160
 None
None
None
None
ATP  A 302 (-3.6A)
 0.97A 4kahB-4x2dA:
undetectable		 4kahB-4x2dA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAL_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4x2d FIC FAMILY PROTEIN
PUTATIVE
FILAMENTATION
INDUCED BY CAMP
PROTEIN
(Clostridioides
difficile) 		5 / 12 ASN A 169
ILE A 172
GLY A 173
ILE A  83
GLU A 160
 None
None
None
None
ATP  A 302 (-3.6A)
 0.95A 4kalA-4x2dA:
undetectable		 4kalA-4x2dA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAL_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4x2d FIC FAMILY PROTEIN
PUTATIVE
FILAMENTATION
INDUCED BY CAMP
PROTEIN
(Clostridioides
difficile) 		5 / 12 ASN A 169
ILE A 172
GLY A 173
ILE A  83
GLU A 160
 None
None
None
None
ATP  A 302 (-3.6A)
 0.96A 4kalB-4x2dA:
undetectable		 4kalB-4x2dA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4x2d FIC FAMILY PROTEIN
PUTATIVE
FILAMENTATION
INDUCED BY CAMP
PROTEIN
(Clostridioides
difficile) 		5 / 12 ASN A 169
ILE A 172
GLY A 173
ILE A  83
GLU A 160
 None
None
None
None
ATP  A 302 (-3.6A)
 0.96A 4kanA-4x2dA:
undetectable		 4kanA-4x2dA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4x2d FIC FAMILY PROTEIN
PUTATIVE
FILAMENTATION
INDUCED BY CAMP
PROTEIN
(Clostridioides
difficile) 		5 / 12 ASN A 169
ILE A 172
GLY A 173
ILE A  83
GLU A 160
 None
None
None
None
ATP  A 302 (-3.6A)
 0.96A 4kanB-4x2dA:
undetectable		 4kanB-4x2dA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4x2d FIC FAMILY PROTEIN
PUTATIVE
FILAMENTATION
INDUCED BY CAMP
PROTEIN
(Clostridioides
difficile) 		5 / 12 ASN A 169
ILE A 172
GLY A 173
ILE A  83
GLU A 160
 None
None
None
None
ATP  A 302 (-3.6A)
 0.94A 4kbeA-4x2dA:
undetectable		 4kbeA-4x2dA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4x2d FIC FAMILY PROTEIN
PUTATIVE
FILAMENTATION
INDUCED BY CAMP
PROTEIN
(Clostridioides
difficile) 		5 / 12 ASN A 169
ILE A 172
GLY A 173
ILE A  83
GLU A 160
 None
None
None
None
ATP  A 302 (-3.6A)
 0.95A 4kbeB-4x2dA:
undetectable		 4kbeB-4x2dA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4x2d FIC FAMILY PROTEIN
PUTATIVE
FILAMENTATION
INDUCED BY CAMP
PROTEIN
(Clostridioides
difficile) 		5 / 12 ASN A 169
ILE A 172
GLY A 173
ILE A  83
GLU A 160
 None
None
None
None
ATP  A 302 (-3.6A)
 0.96A 4lbgA-4x2dA:
undetectable		 4lbgA-4x2dA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4x2d FIC FAMILY PROTEIN
PUTATIVE
FILAMENTATION
INDUCED BY CAMP
PROTEIN
(Clostridioides
difficile) 		5 / 12 ASN A 169
ILE A 172
GLY A 173
ILE A  83
GLU A 160
 None
None
None
None
ATP  A 302 (-3.6A)
 0.96A 4lbgB-4x2dA:
undetectable		 4lbgB-4x2dA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LCA_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4x2d FIC FAMILY PROTEIN
PUTATIVE
FILAMENTATION
INDUCED BY CAMP
PROTEIN
(Clostridioides
difficile) 		5 / 12 ASN A 169
ILE A 172
GLY A 173
ILE A  83
GLU A 160
 None
None
None
None
ATP  A 302 (-3.6A)
 0.96A 4lcaA-4x2dA:
undetectable		 4lcaA-4x2dA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LCA_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4x2d FIC FAMILY PROTEIN
PUTATIVE
FILAMENTATION
INDUCED BY CAMP
PROTEIN
(Clostridioides
difficile) 		5 / 12 ASN A 169
ILE A 172
GLY A 173
ILE A  83
GLU A 160
 None
None
None
None
ATP  A 302 (-3.6A)
 0.96A 4lcaB-4x2dA:
undetectable		 4lcaB-4x2dA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA602_1
(SERUM ALBUMIN)		 4x2d FIC FAMILY PROTEIN
PUTATIVE
FILAMENTATION
INDUCED BY CAMP
PROTEIN
(Clostridioides
difficile) 		5 / 12 LEU A 178
PHE A   5
LEU A   9
TYR A  20
LEU A  79
 None
 1.38A 4zbrA-4x2dA:
undetectable		 4zbrA-4x2dA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4x2d FIC FAMILY PROTEIN
PUTATIVE
FILAMENTATION
INDUCED BY CAMP
PROTEIN
(Clostridioides
difficile) 		3 / 3 GLY A 173
THR A 112
PRO A 164
 None
 0.52A 5v5zA-4x2dA:
1.6		 5v5zA-4x2dA:
19.39