SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4x2r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB8_0
(GRAMICIDIN A)		 4x2r 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE
(Actinomyces
urogenitalis) 		3 / 3 VAL A   8
VAL A  16
TRP A  39
 None
 0.98A 1bdwA-4x2rA:
undetectable
1bdwB-4x2rA:
undetectable		 1bdwA-4x2rA:
15.00
1bdwB-4x2rA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA501_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 4x2r 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE
(Actinomyces
urogenitalis) 		5 / 12 THR A 164
ASP A 128
GLY A  21
ARG A 137
ALA A  15
 None
None
None
PO4  A 303 (-4.0A)
None
 1.26A 1oltA-4x2rA:
4.9		 1oltA-4x2rA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4x2r 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE
(Actinomyces
urogenitalis) 		5 / 10 SER A 194
PHE A  56
LEU A  52
VAL A  16
VAL A  50
 PO4  A 303 ( 4.2A)
None
None
None
PO4  A 303 (-4.7A)
 1.39A 1q23E-4x2rA:
undetectable		 1q23E-4x2rA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4x2r 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE
(Actinomyces
urogenitalis) 		5 / 11 SER A 194
PHE A  56
LEU A  52
VAL A  16
VAL A  50
 PO4  A 303 ( 4.2A)
None
None
None
PO4  A 303 (-4.7A)
 1.37A 1q23I-4x2rA:
undetectable		 1q23I-4x2rA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4x2r 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE
(Actinomyces
urogenitalis) 		5 / 11 THR A 164
SER A 194
PHE A  56
LEU A  52
VAL A  16
 None
PO4  A 303 ( 4.2A)
None
None
None
 1.43A 1q23I-4x2rA:
undetectable		 1q23I-4x2rA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4x2r 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE
(Actinomyces
urogenitalis) 		5 / 11 SER A 194
PHE A  56
LEU A  52
VAL A  16
VAL A  50
 PO4  A 303 ( 4.2A)
None
None
None
PO4  A 303 (-4.7A)
 1.43A 1q23J-4x2rA:
undetectable		 1q23J-4x2rA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4x2r 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE
(Actinomyces
urogenitalis) 		5 / 10 THR A 164
SER A 194
PHE A  56
LEU A  52
VAL A  16
 None
PO4  A 303 ( 4.2A)
None
None
None
 1.48A 1q23K-4x2rA:
undetectable		 1q23K-4x2rA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4x2r 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE
(Actinomyces
urogenitalis) 		5 / 10 THR A 164
SER A 194
PHE A  56
LEU A  52
VAL A  50
 None
PO4  A 303 ( 4.2A)
None
None
PO4  A 303 (-4.7A)
 1.23A 1q23K-4x2rA:
undetectable		 1q23K-4x2rA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4x2r 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE
(Actinomyces
urogenitalis) 		5 / 11 SER A 194
PHE A  56
LEU A  52
VAL A  16
VAL A  50
 PO4  A 303 ( 4.2A)
None
None
None
PO4  A 303 (-4.7A)
 1.41A 1q23L-4x2rA:
undetectable		 1q23L-4x2rA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_F_REAF177_1
(RETINOL BINDING
PROTEIN)		 4x2r 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE
(Actinomyces
urogenitalis) 		5 / 11 LEU A  78
ALA A  94
VAL A  99
LEU A 101
LEU A  88
 None
 1.10A 1rlbF-4x2rA:
undetectable		 1rlbF-4x2rA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4x2r 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE
(Actinomyces
urogenitalis) 		3 / 3 SER A 194
GLY A 195
ARG A 137
 PO4  A 303 ( 4.2A)
PO4  A 301 (-3.6A)
PO4  A 303 (-4.0A)
 0.54A 1t9wA-4x2rA:
undetectable		 1t9wA-4x2rA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA502_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 4x2r 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE
(Actinomyces
urogenitalis) 		3 / 3 LEU A  92
HIS A 119
LYS A 122
 None
 1.12A 1y7iA-4x2rA:
2.1		 1y7iA-4x2rA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4x2r 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE
(Actinomyces
urogenitalis) 		5 / 12 GLY A 170
GLY A 174
LEU A  18
ASP A 165
VAL A 166
 PO4  A 301 (-3.4A)
None
None
None
None
 1.01A 2oxtC-4x2rA:
undetectable		 2oxtC-4x2rA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_C_VD3C2001_1
(VITAMIN D
HYDROXYLASE)		 4x2r 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE
(Actinomyces
urogenitalis) 		5 / 11 ILE A 123
LEU A  78
LEU A 101
ILE A  82
LEU A  92
 None
 1.25A 3a50C-4x2rA:
undetectable		 3a50C-4x2rA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_E_VD3E2001_1
(VITAMIN D
HYDROXYLASE)		 4x2r 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE
(Actinomyces
urogenitalis) 		5 / 12 ILE A 123
LEU A  78
LEU A 101
ILE A  82
LEU A  92
 None
 1.26A 3a50E-4x2rA:
undetectable		 3a50E-4x2rA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A7E_A_SAMA216_1
(CATECHOL
O-METHYLTRANSFERASE)		 4x2r 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE
(Actinomyces
urogenitalis) 		4 / 6 GLY A 195
ILE A 197
ILE A 218
ASP A 165
 PO4  A 301 (-3.6A)
None
None
None
 0.96A 3a7eA-4x2rA:
undetectable		 3a7eA-4x2rA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CWK_A_REAA300_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 4x2r 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE
(Actinomyces
urogenitalis) 		5 / 12 LEU A  52
VAL A 162
THR A 164
VAL A 166
GLU A  77
 None
 1.13A 3cwkA-4x2rA:
undetectable		 3cwkA-4x2rA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 4x2r 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE
(Actinomyces
urogenitalis) 		5 / 12 LEU A 179
ILE A 123
VAL A 191
VAL A 183
LEU A 150
 None
 1.01A 3gwxB-4x2rA:
undetectable		 3gwxB-4x2rA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4x2r 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE
(Actinomyces
urogenitalis) 		3 / 3 VAL A  50
VAL A 162
SER A 194
 PO4  A 303 (-4.7A)
None
PO4  A 303 ( 4.2A)
 0.70A 3n8xB-4x2rA:
undetectable		 3n8xB-4x2rA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_A_017A201_2
(PROTEASE)		 4x2r 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE
(Actinomyces
urogenitalis) 		5 / 11 ARG A 181
LEU A 209
ALA A 217
ILE A 203
GLY A 196
 None
None
None
None
PO4  A 301 (-3.6A)
 1.03A 3s53B-4x2rA:
undetectable		 3s53B-4x2rA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_B_CLMB221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4x2r 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE
(Actinomyces
urogenitalis) 		5 / 12 THR A 164
SER A 194
LEU A  52
VAL A  16
VAL A  50
 None
PO4  A 303 ( 4.2A)
None
None
PO4  A 303 (-4.7A)
 1.38A 3u9fB-4x2rA:
undetectable
3u9fC-4x2rA:
undetectable		 3u9fB-4x2rA:
21.37
3u9fC-4x2rA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_S_CLMS221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4x2r 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE
(Actinomyces
urogenitalis) 		5 / 12 THR A 164
SER A 194
LEU A  52
VAL A  16
VAL A  50
 None
PO4  A 303 ( 4.2A)
None
None
PO4  A 303 (-4.7A)
 1.31A 3u9fP-4x2rA:
undetectable
3u9fS-4x2rA:
undetectable		 3u9fP-4x2rA:
21.37
3u9fS-4x2rA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA1_A_08YA600_1
(CYTOCHROME P450 3A4)		 4x2r 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE
(Actinomyces
urogenitalis) 		5 / 12 ASP A   9
ARG A  17
SER A 199
THR A 177
ALA A 193
 PO4  A 303 (-2.6A)
PO4  A 303 ( 3.6A)
None
None
None
 1.25A 3ua1A-4x2rA:
undetectable		 3ua1A-4x2rA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_1
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 4x2r 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE
(Actinomyces
urogenitalis) 		5 / 11 SER A 216
VAL A 219
LEU A   4
THR A   3
HIS A  48
 None
PO4  A 301 ( 4.7A)
None
None
PO4  A 303 (-4.1A)
 1.11A 4e0fA-4x2rA:
undetectable		 4e0fA-4x2rA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_1
(TRANSPORTER)		 4x2r 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE
(Actinomyces
urogenitalis) 		5 / 12 VAL A  16
ALA A  15
VAL A   8
PHE A  56
GLY A  13
 None
 1.11A 4mm4B-4x2rA:
undetectable		 4mm4B-4x2rA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1Y_A_017A106_2
(ASPARTYL PROTEASE)		 4x2r 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE
(Actinomyces
urogenitalis) 		5 / 12 ARG A 181
LEU A 209
ALA A 217
ILE A 203
GLY A 196
 None
None
None
None
PO4  A 301 (-3.6A)
 0.99A 4q1yB-4x2rA:
undetectable		 4q1yB-4x2rA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4x2r 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE
(Actinomyces
urogenitalis) 		5 / 9 THR A 149
ALA A 105
ALA A 104
GLY A 144
GLY A 143
 None
 1.11A 4qwuY-4x2rA:
undetectable
4qwuZ-4x2rA:
undetectable		 4qwuY-4x2rA:
22.14
4qwuZ-4x2rA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_C_SAMC301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4x2r 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE
(Actinomyces
urogenitalis) 		5 / 12 ASP A  53
ALA A  11
THR A 164
GLY A  21
THR A 171
 None
 1.34A 5hfjC-4x2rA:
undetectable		 5hfjC-4x2rA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_H_SAMH301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4x2r 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE
(Actinomyces
urogenitalis) 		5 / 12 ASP A  53
ALA A  11
THR A 164
GLY A  21
THR A 171
 None
 1.28A 5hfjH-4x2rA:
undetectable		 5hfjH-4x2rA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0I_B_ACTB303_0
(SWI5-DEPENDENT HO
EXPRESSION PROTEIN 2)		 4x2r 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE
(Actinomyces
urogenitalis) 		4 / 5 VAL A  16
ASN A  61
ASP A  51
LEU A  52
 None
 1.24A 5m0iB-4x2rA:
undetectable		 5m0iB-4x2rA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_A_SAMA501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 4x2r 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE
(Actinomyces
urogenitalis) 		5 / 12 ALA A 189
PRO A 190
GLY A 213
LEU A 134
LEU A 146
 None
 1.12A 5wwsA-4x2rA:
undetectable		 5wwsA-4x2rA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNI_A_SAMA401_0
(NSP16 PROTEIN)		 4x2r 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE
(Actinomyces
urogenitalis) 		5 / 12 GLY A 170
PRO A 175
GLY A 174
ASP A 169
LEU A  18
 PO4  A 301 (-3.4A)
None
None
PO4  A 301 (-3.1A)
None
 1.15A 5yniA-4x2rA:
undetectable		 5yniA-4x2rA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNM_A_SAMA401_0
(NSP16 PROTEIN)		 4x2r 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE
(Actinomyces
urogenitalis) 		5 / 12 GLY A 170
PRO A 175
GLY A 174
ASP A 169
LEU A  18
 PO4  A 301 (-3.4A)
None
None
PO4  A 301 (-3.1A)
None
 1.17A 5ynmA-4x2rA:
undetectable		 5ynmA-4x2rA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 4x2r 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE
(Actinomyces
urogenitalis) 		4 / 6 PHE A  56
LEU A  52
ALA A  55
THR A 164
 None
None
PO4  A 304 (-3.2A)
None
 1.02A 6f88A-4x2rA:
undetectable		 6f88A-4x2rA:
16.47