SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4x2x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3003_1
(SERUM ALBUMIN)		 4x2x NS6 PROTEASE
(Norwalk
virus) 		4 / 6 PHE A  12
ILE A  26
LYS A  29
ALA A  32
 None
 1.27A 1hk2A-4x2xA:
undetectable		 1hk2A-4x2xA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1501_1
(CYTOCHROME P450 3A4)		 4x2x NS6 PROTEASE
(Norwalk
virus) 		5 / 10 PHE A  40
SER A   4
ILE A   5
LEU A  56
THR A  27
 None
 1.22A 2v0mA-4x2xA:
undetectable		 2v0mA-4x2xA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM8_A_ACAA511_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4x2x NS6 PROTEASE
(Norwalk
virus) 		4 / 8 ALA A 159
ILE A 168
ILE A 109
HIS A 115
 None
 0.93A 2zm8A-4x2xA:
undetectable		 2zm8A-4x2xA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4x2x NS6 PROTEASE
(Norwalk
virus) 		4 / 8 ALA A 159
ILE A 168
ILE A 109
HIS A 115
 None
 0.94A 2zmaA-4x2xA:
undetectable		 2zmaA-4x2xA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_A_30BA500_1
(GENOME POLYPROTEIN)		 4x2x NS6 PROTEASE
(Norwalk
virus) 		5 / 12 HIS A  30
ASP A  54
GLY A 137
ALA A 159
ALA A 160
 None
 0.65A 3keeA-4x2xA:
11.6		 3keeA-4x2xA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_1
(GENOME POLYPROTEIN)		 4x2x NS6 PROTEASE
(Norwalk
virus) 		5 / 12 HIS A  30
ASP A  54
GLY A 137
ALA A 159
ALA A 160
 None
 0.57A 3keeB-4x2xA:
11.8		 3keeB-4x2xA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_C_30BC500_1
(GENOME POLYPROTEIN)		 4x2x NS6 PROTEASE
(Norwalk
virus) 		5 / 12 HIS A  30
ASP A  54
GLY A 137
ALA A 159
ALA A 160
 None
 0.60A 3keeC-4x2xA:
11.0		 3keeC-4x2xA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_1
(GENOME POLYPROTEIN)		 4x2x NS6 PROTEASE
(Norwalk
virus) 		5 / 12 HIS A  30
ASP A  54
GLY A 137
ALA A 159
ALA A 160
 None
 0.61A 3keeD-4x2xA:
11.5		 3keeD-4x2xA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4x2x NS6 PROTEASE
(Norwalk
virus) 		6 / 12 HIS A  30
ASP A  54
GLY A 137
ALA A 139
ALA A 159
ALA A 160
 None
 0.55A 3sudA-4x2xA:
10.6		 3sudA-4x2xA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4x2x NS6 PROTEASE
(Norwalk
virus) 		5 / 12 HIS A  30
ASP A  54
GLY A 137
ALA A 139
ALA A 159
 None
 0.59A 3sudB-4x2xA:
10.2		 3sudB-4x2xA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4x2x NS6 PROTEASE
(Norwalk
virus) 		6 / 12 HIS A  30
ASP A  54
GLY A 137
ALA A 139
ALA A 159
ALA A 160
 None
 0.65A 3sudC-4x2xA:
9.8		 3sudC-4x2xA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4x2x NS6 PROTEASE
(Norwalk
virus) 		6 / 12 HIS A  30
ASP A  54
GLY A 137
ALA A 139
ALA A 159
ALA A 160
 None
 0.64A 3sudD-4x2xA:
7.4		 3sudD-4x2xA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4x2x NS6 PROTEASE
(Norwalk
virus) 		5 / 12 HIS A  30
ASP A  54
GLY A 137
ALA A 159
ALA A 160
 None
 0.66A 3sueA-4x2xA:
7.5		 3sueA-4x2xA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4x2x NS6 PROTEASE
(Norwalk
virus) 		5 / 12 HIS A  30
ASP A  54
GLY A 137
ALA A 159
ALA A 160
 None
 0.73A 3sueB-4x2xA:
5.9		 3sueB-4x2xA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4x2x NS6 PROTEASE
(Norwalk
virus) 		5 / 12 HIS A  30
ASP A  54
GLY A 137
ALA A 159
ALA A 160
 None
 0.69A 3sueC-4x2xA:
10.4		 3sueC-4x2xA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4x2x NS6 PROTEASE
(Norwalk
virus) 		5 / 12 HIS A  30
ASP A  54
GLY A 137
ALA A 159
ALA A 160
 None
 0.66A 3sufA-4x2xA:
10.7		 3sufA-4x2xA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4x2x NS6 PROTEASE
(Norwalk
virus) 		5 / 12 HIS A  30
ASP A  54
GLY A 137
ALA A 159
ALA A 160
 None
 0.77A 3sufB-4x2xA:
10.3		 3sufB-4x2xA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4x2x NS6 PROTEASE
(Norwalk
virus) 		5 / 11 HIS A  30
ASP A  54
GLY A 137
ALA A 159
ALA A 160
 None
 0.60A 3sufC-4x2xA:
10.3		 3sufC-4x2xA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4x2x NS6 PROTEASE
(Norwalk
virus) 		5 / 12 HIS A  30
ASP A  54
GLY A 137
ALA A 159
ALA A 160
 None
 0.65A 3sufD-4x2xA:
10.0		 3sufD-4x2xA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUG_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4x2x NS6 PROTEASE
(Norwalk
virus) 		5 / 12 HIS A  30
ASP A  54
GLY A 137
ALA A 139
ALA A 160
 None
 0.42A 3sugA-4x2xA:
10.3		 3sugA-4x2xA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7J_A_TESA502_0
(CYTOCHROME P450)		 4x2x NS6 PROTEASE
(Norwalk
virus) 		4 / 7 ALA A 106
ALA A 105
THR A 118
THR A 166
 None
 0.89A 6a7jA-4x2xA:
undetectable		 6a7jA-4x2xA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_0
(NS3 PROTEASE)		 4x2x NS6 PROTEASE
(Norwalk
virus) 		5 / 12 HIS A  30
ASP A  54
GLY A 137
ALA A 159
ALA A 160
 None
 0.67A 6c2mC-4x2xA:
10.4		 6c2mC-4x2xA:
21.38