SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4x33'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		 4x33 PROTEIN ATS1
(Saccharomyces
cerevisiae) 		4 / 7 SER B 154
ASN B 140
ASP B 190
LYS B 189
 None
 1.37A 1hwiC-4x33B:
undetectable		 1hwiC-4x33B:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		 4x33 PROTEIN ATS1
(Saccharomyces
cerevisiae) 		4 / 7 SER B 154
ASN B 140
ASP B 190
LYS B 189
 None
 1.37A 1hwiD-4x33B:
undetectable		 1hwiD-4x33B:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA442_1
(ALPHA AMYLASE)		 4x33 PROTEIN ATS1
(Saccharomyces
cerevisiae) 		5 / 11 GLY B 153
PHE B 141
GLY B 113
GLY B 112
ASP B  97
 None
 1.06A 1mxgA-4x33B:
undetectable		 1mxgA-4x33B:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RI4_A_SAMA299_0
(MRNA CAPPING ENZYME)		 4x33 PROTEIN ATS1
(Saccharomyces
cerevisiae) 		5 / 12 GLY B  16
GLY B  18
SER B  48
GLN B  27
SER B  29
 None
DXE  B 406 (-4.5A)
None
None
None
 1.12A 1ri4A-4x33B:
undetectable		 1ri4A-4x33B:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1435_1
(CHITINASE)		 4x33 DIPHTHAMIDE
BIOSYNTHESIS PROTEIN
3
PROTEIN ATS1
(Saccharomyces
cerevisiae) 		3 / 3 TRP B 229
GLU B 271
TYR A   4
 None
 1.14A 2a3aA-4x33B:
undetectable		 2a3aA-4x33B:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_B_ACTB141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 4x33 PROTEIN ATS1
(Saccharomyces
cerevisiae) 		3 / 3 PRO B 262
ASN B 240
ARG B 258
 None
 0.98A 2qeuB-4x33B:
undetectable		 2qeuB-4x33B:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4x33 PROTEIN ATS1
(Saccharomyces
cerevisiae) 		4 / 8 SER B 127
GLN B 120
GLN B 145
ILE B 132
 None
 1.17A 2xz5B-4x33B:
undetectable
2xz5E-4x33B:
undetectable		 2xz5B-4x33B:
20.06
2xz5E-4x33B:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_A_CGEA501_1
(CYTOCHROME P450 2B4)		 4x33 PROTEIN ATS1
(Saccharomyces
cerevisiae) 		5 / 10 VAL B 289
ILE B 274
PHE B   7
ALA B   6
ILE B  41
 None
 1.06A 3me6A-4x33B:
undetectable		 3me6A-4x33B:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 4x33 PROTEIN ATS1
(Saccharomyces
cerevisiae) 		5 / 12 GLY B 295
GLY B 273
GLN B 311
VAL B 313
ASN B 299
 None
 1.22A 3qowA-4x33B:
undetectable		 3qowA-4x33B:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_0
(METHYLTRANSFERASE
NSUN4)		 4x33 PROTEIN ATS1
(Saccharomyces
cerevisiae) 		5 / 12 GLY B 113
GLY B 112
LEU B 168
SER B 167
GLY B 151
 None
 0.97A 4fp9A-4x33B:
undetectable		 4fp9A-4x33B:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_0
(METHYLTRANSFERASE
NSUN4)		 4x33 PROTEIN ATS1
(Saccharomyces
cerevisiae) 		5 / 12 GLY B 113
GLY B 112
LEU B 168
SER B 167
GLY B 151
 None
 0.98A 4fp9C-4x33B:
undetectable		 4fp9C-4x33B:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_0
(METHYLTRANSFERASE
NSUN4)		 4x33 PROTEIN ATS1
(Saccharomyces
cerevisiae) 		5 / 12 GLY B 113
GLY B 112
LEU B 168
SER B 167
GLY B 151
 None
 0.97A 4fp9D-4x33B:
undetectable		 4fp9D-4x33B:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_0
(METHYLTRANSFERASE
NSUN4)		 4x33 PROTEIN ATS1
(Saccharomyces
cerevisiae) 		5 / 12 GLY B 113
GLY B 112
LEU B 168
SER B 167
GLY B 151
 None
 0.98A 4fp9F-4x33B:
undetectable		 4fp9F-4x33B:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_0
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 4x33 PROTEIN ATS1
(Saccharomyces
cerevisiae) 		5 / 12 GLY B 113
GLY B 112
LEU B 168
SER B 167
GLY B 151
 None
 0.97A 4fzvA-4x33B:
undetectable		 4fzvA-4x33B:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 4x33 PROTEIN ATS1
(Saccharomyces
cerevisiae) 		3 / 3 PRO B 209
LEU B 208
GLN B 217
 None
 0.62A 4pevB-4x33B:
undetectable		 4pevB-4x33B:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YJI_A_TYLA502_1
(ARYL ACYLAMIDASE)		 4x33 PROTEIN ATS1
(Saccharomyces
cerevisiae) 		4 / 7 LEU B  15
GLY B 325
GLY B 324
ILE B 274
 None
 0.59A 4yjiA-4x33B:
undetectable		 4yjiA-4x33B:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA602_1
(CHITINASE)		 4x33 DIPHTHAMIDE
BIOSYNTHESIS PROTEIN
3
PROTEIN ATS1
(Saccharomyces
cerevisiae) 		3 / 3 TRP B 229
GLU B 271
ASP A   5
 None
 0.99A 5gqbA-4x33B:
undetectable		 5gqbA-4x33B:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGJ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4x33 PROTEIN ATS1
(Saccharomyces
cerevisiae) 		3 / 3 VAL B 134
VAL B 143
GLN B 121
 None
 0.39A 5qgjA-4x33B:
undetectable		 5qgjA-4x33B:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGM_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4x33 PROTEIN ATS1
(Saccharomyces
cerevisiae) 		3 / 3 VAL B 134
VAL B 143
GLN B 121
 None
 0.35A 5qgmA-4x33B:
undetectable		 5qgmA-4x33B:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGN_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4x33 PROTEIN ATS1
(Saccharomyces
cerevisiae) 		3 / 3 VAL B 134
VAL B 143
GLN B 121
 None
 0.42A 5qgnA-4x33B:
undetectable		 5qgnA-4x33B:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGY_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4x33 PROTEIN ATS1
(Saccharomyces
cerevisiae) 		3 / 3 VAL B 134
VAL B 143
GLN B 121
 None
 0.41A 5qgyA-4x33B:
undetectable		 5qgyA-4x33B:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGZ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4x33 PROTEIN ATS1
(Saccharomyces
cerevisiae) 		3 / 3 VAL B 134
VAL B 143
GLN B 121
 None
 0.40A 5qgzA-4x33B:
undetectable		 5qgzA-4x33B:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH0_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4x33 PROTEIN ATS1
(Saccharomyces
cerevisiae) 		3 / 3 VAL B 134
VAL B 143
GLN B 121
 None
 0.41A 5qh0A-4x33B:
undetectable		 5qh0A-4x33B:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH2_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4x33 PROTEIN ATS1
(Saccharomyces
cerevisiae) 		3 / 3 VAL B 134
VAL B 143
GLN B 121
 None
 0.40A 5qh2A-4x33B:
undetectable		 5qh2A-4x33B:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH3_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4x33 PROTEIN ATS1
(Saccharomyces
cerevisiae) 		3 / 3 VAL B 134
VAL B 143
GLN B 121
 None
 0.40A 5qh3A-4x33B:
undetectable		 5qh3A-4x33B:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH5_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4x33 PROTEIN ATS1
(Saccharomyces
cerevisiae) 		3 / 3 VAL B 134
VAL B 143
GLN B 121
 None
 0.40A 5qh5A-4x33B:
undetectable		 5qh5A-4x33B:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH6_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4x33 PROTEIN ATS1
(Saccharomyces
cerevisiae) 		3 / 3 VAL B 134
VAL B 143
GLN B 121
 None
 0.37A 5qh6A-4x33B:
undetectable		 5qh6A-4x33B:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH7_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4x33 PROTEIN ATS1
(Saccharomyces
cerevisiae) 		3 / 3 VAL B 134
VAL B 143
GLN B 121
 None
 0.40A 5qh7A-4x33B:
undetectable		 5qh7A-4x33B:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHA_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4x33 PROTEIN ATS1
(Saccharomyces
cerevisiae) 		3 / 3 VAL B 134
VAL B 143
GLN B 121
 None
 0.40A 5qhaA-4x33B:
undetectable		 5qhaA-4x33B:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHH_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4x33 PROTEIN ATS1
(Saccharomyces
cerevisiae) 		3 / 3 VAL B 134
VAL B 143
GLN B 121
 None
 0.42A 5qhhA-4x33B:
undetectable		 5qhhA-4x33B:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4x33 DIPHTHAMIDE
BIOSYNTHESIS PROTEIN
3
PROTEIN ATS1
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 ASP B  62
ASN B  46
ASP A  29
 None
 0.79A 5vopA-4x33B:
undetectable		 5vopA-4x33B:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4x33 DIPHTHAMIDE
BIOSYNTHESIS PROTEIN
3
PROTEIN ATS1
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 ASP B  62
ASN B  46
ASP A  29
 None
 0.84A 5vopB-4x33B:
undetectable		 5vopB-4x33B:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_1
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 4x33 PROTEIN ATS1
(Saccharomyces
cerevisiae) 		3 / 3 THR B 230
GLU B 271
HIS B 250
 None
None
CL  A 102 ( 4.8A)
 0.84A 5xioA-4x33B:
undetectable		 5xioA-4x33B:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 4x33 PROTEIN ATS1
(Saccharomyces
cerevisiae) 		3 / 3 THR B 230
GLU B 271
HIS B 250
 None
None
CL  A 102 ( 4.8A)
 0.88A 5xiqB-4x33B:
undetectable		 5xiqB-4x33B:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 4x33 PROTEIN ATS1
(Saccharomyces
cerevisiae) 		3 / 3 THR B 230
GLU B 271
HIS B 250
 None
None
CL  A 102 ( 4.8A)
 0.86A 5xiqD-4x33B:
undetectable		 5xiqD-4x33B:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YN6_A_SAMA401_0
(NSP16 PROTEIN)		 4x33 DIPHTHAMIDE
BIOSYNTHESIS PROTEIN
3
PROTEIN ATS1
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 12 GLY B  11
GLY B  18
ASN B  46
ASP A  29
ASP B  20
 None
DXE  B 406 (-4.5A)
None
None
DXE  B 406 (-4.1A)
 1.06A 5yn6A-4x33B:
undetectable		 5yn6A-4x33B:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNI_A_SAMA401_0
(NSP16 PROTEIN)		 4x33 DIPHTHAMIDE
BIOSYNTHESIS PROTEIN
3
PROTEIN ATS1
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 12 GLY B  11
GLY B  18
ASN B  46
ASP A  29
ASP B  20
 None
DXE  B 406 (-4.5A)
None
None
DXE  B 406 (-4.1A)
 1.03A 5yniA-4x33B:
undetectable		 5yniA-4x33B:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNM_A_SAMA401_0
(NSP16 PROTEIN)		 4x33 DIPHTHAMIDE
BIOSYNTHESIS PROTEIN
3
PROTEIN ATS1
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 12 GLY B  11
GLY B  18
ASN B  46
ASP A  29
ASP B  20
 None
DXE  B 406 (-4.5A)
None
None
DXE  B 406 (-4.1A)
 1.06A 5ynmA-4x33B:
undetectable		 5ynmA-4x33B:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_1
(RIFAMPIN
MONOOXYGENASE)		 4x33 PROTEIN ATS1
(Saccharomyces
cerevisiae) 		5 / 12 GLY B  59
VAL B  83
PHE B 118
THR B  98
GLY B 113
 None
 1.18A 6brdB-4x33B:
undetectable		 6brdB-4x33B:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		 4x33 PROTEIN ATS1
(Saccharomyces
cerevisiae) 		4 / 6 ASP B 260
ASN B 288
LEU B 275
PHE B 254
 None
 0.92A 6ekuA-4x33B:
9.3		 6ekuA-4x33B:
19.71