SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4x36'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_0
(AMINOMETHYLTRANSFERA
SE)		 4x36 AUTOLYSIN
(Streptococcus
pneumoniae) 		5 / 12 THR A 121
LEU A 122
ILE A 130
VAL A  23
TYR A 105
 None
 1.08A 1wsvA-4x36A:
undetectable		 1wsvA-4x36A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_B_THHB4001_0
(AMINOMETHYLTRANSFERA
SE)		 4x36 AUTOLYSIN
(Streptococcus
pneumoniae) 		5 / 12 THR A 121
LEU A 122
ILE A 130
VAL A  23
TYR A 105
 None
 1.07A 1wsvB-4x36A:
undetectable		 1wsvB-4x36A:
20.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X8O_A_OINA1317_1
(CHOLINE-BINDING
PROTEIN F)		 4x36 AUTOLYSIN
(Streptococcus
pneumoniae) 		4 / 4 TRP A 220
TRP A 228
TYR A 249
MET A 257
 CHT  A 408 (-3.7A)
CHT  A 408 (-3.5A)
CHT  A 408 ( 4.7A)
CHT  A 408 ( 3.7A)
 0.36A 2x8oA-4x36A:
6.9		 2x8oA-4x36A:
30.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X8O_A_OINA1317_1
(CHOLINE-BINDING
PROTEIN F)		 4x36 AUTOLYSIN
(Streptococcus
pneumoniae) 		4 / 4 TRP A 241
TRP A 248
TYR A 269
MET A 278
 CHT  A 409 ( 3.7A)
CHT  A 409 (-3.8A)
CHT  A 409 (-4.0A)
CHT  A 409 ( 4.1A)
 0.97A 2x8oA-4x36A:
6.9		 2x8oA-4x36A:
30.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X8P_A_OINA1313_1
(CHOLINE-BINDING
PROTEIN F)		 4x36 AUTOLYSIN
(Streptococcus
pneumoniae) 		4 / 4 TRP A 220
LYS A 222
TRP A 228
TYR A 249
 CHT  A 408 (-3.7A)
None
CHT  A 408 (-3.5A)
CHT  A 408 ( 4.7A)
 0.40A 2x8pA-4x36A:
9.0		 2x8pA-4x36A:
30.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_C_ADNC251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4x36 AUTOLYSIN
(Streptococcus
pneumoniae) 		5 / 12 SER A  91
GLY A  57
VAL A  35
GLU A  38
CYH A  60
 None
None
None
GOL  A 402 (-3.0A)
None
 1.42A 3u40B-4x36A:
undetectable
3u40C-4x36A:
undetectable		 3u40B-4x36A:
18.77
3u40C-4x36A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_E_ADNE251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4x36 AUTOLYSIN
(Streptococcus
pneumoniae) 		5 / 12 SER A  91
GLY A  57
VAL A  35
GLU A  38
CYH A  60
 None
None
None
GOL  A 402 (-3.0A)
None
 1.41A 3u40D-4x36A:
undetectable
3u40E-4x36A:
undetectable		 3u40D-4x36A:
18.77
3u40E-4x36A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4x36 AUTOLYSIN
(Streptococcus
pneumoniae) 		5 / 12 ALA A  71
LEU A  12
PHE A  52
VAL A  35
THR A  82
 None
 1.13A 4eckA-4x36A:
undetectable		 4eckA-4x36A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UAC_A_ACRA501_2
(CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-))		 4x36 AUTOLYSIN
(Streptococcus
pneumoniae) 		4 / 7 PRO A 152
GLU A 134
SER A 160
GLU A 162
 None
 1.31A 4uacA-4x36A:
undetectable		 4uacA-4x36A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_A_HISA302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4x36 AUTOLYSIN
(Streptococcus
pneumoniae) 		5 / 10 VAL A  67
HIS A  54
LEU A 108
SER A  53
LEU A   8
 None
 1.21A 4yb6A-4x36A:
undetectable
4yb6E-4x36A:
undetectable		 4yb6A-4x36A:
22.86
4yb6E-4x36A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_B_HISB302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4x36 AUTOLYSIN
(Streptococcus
pneumoniae) 		5 / 10 VAL A  67
HIS A  54
LEU A 108
SER A  53
LEU A   8
 None
 1.22A 4yb6B-4x36A:
undetectable
4yb6C-4x36A:
undetectable		 4yb6B-4x36A:
22.86
4yb6C-4x36A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_C_HISC302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4x36 AUTOLYSIN
(Streptococcus
pneumoniae) 		5 / 10 VAL A  67
HIS A  54
LEU A 108
SER A  53
LEU A   8
 None
 1.18A 4yb6C-4x36A:
undetectable
4yb6F-4x36A:
undetectable		 4yb6C-4x36A:
22.86
4yb6F-4x36A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_D_HISD302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4x36 AUTOLYSIN
(Streptococcus
pneumoniae) 		5 / 10 HIS A  54
LEU A 108
SER A  53
LEU A   8
VAL A  67
 None
 1.17A 4yb6A-4x36A:
undetectable
4yb6D-4x36A:
undetectable		 4yb6A-4x36A:
22.86
4yb6D-4x36A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_E_HISE302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4x36 AUTOLYSIN
(Streptococcus
pneumoniae) 		5 / 10 HIS A  54
LEU A 108
SER A  53
LEU A   8
VAL A  67
 None
 1.19A 4yb6D-4x36A:
undetectable
4yb6E-4x36A:
undetectable		 4yb6D-4x36A:
22.86
4yb6E-4x36A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_F_HISF302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4x36 AUTOLYSIN
(Streptococcus
pneumoniae) 		5 / 10 HIS A  54
LEU A 108
SER A  53
LEU A   8
VAL A  67
 None
 1.22A 4yb6B-4x36A:
undetectable
4yb6F-4x36A:
undetectable		 4yb6B-4x36A:
22.86
4yb6F-4x36A:
22.86