SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4x3f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3003_1
(SERUM ALBUMIN)		 4x3f SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		3 / 4 LYS A 164
ALA A 163
MET A  24
 None
 1.06A 1hk3A-4x3fA:
undetectable		 1hk3A-4x3fA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT6_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4x3f SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		5 / 11 LEU A 203
VAL A 206
MET A 121
LEU A 103
HIS A  70
 None
 1.40A 1kt6A-4x3fA:
undetectable		 1kt6A-4x3fA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_1
(PHOSPHOLIPASE A2
HOMOLOG 2)		 4x3f SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		6 / 12 LEU A 237
GLY A 204
GLY A 207
LEU A 113
ARG A 275
PRO A 242
 None
 1.39A 1y4lA-4x3fA:
undetectable		 1y4lA-4x3fA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 4x3f SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		5 / 12 HIS A  70
GLY A 264
LEU A 122
VAL A 206
ILE A 147
 None
 1.26A 1zq9A-4x3fA:
undetectable		 1zq9A-4x3fA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_A_FLPA1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4x3f SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 245
LEU A 248
LEU A 241
PHE A 267
ALA A 118
 None
 0.96A 2aylA-4x3fA:
undetectable		 2aylA-4x3fA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_A_ADNA1501_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 4x3f SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		4 / 7 ARG A 260
GLU A 247
PRO A 280
ALA A 270
 None
 1.35A 2ejgA-4x3fA:
2.1		 2ejgA-4x3fA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_G_ACTG601_0
(CHOLINE OXIDASE)		 4x3f SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		4 / 6 ALA A 189
ILE A 184
HIS A 229
VAL A 225
 None
None
None
TPO  A 224 ( 3.3A)
 1.20A 3nneG-4x3fA:
undetectable		 3nneG-4x3fA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4x3f SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		6 / 12 LEU A  44
LEU A  93
ASN A 146
ASP A 159
GLY A 161
GLY A 179
 None
 1.42A 4an2A-4x3fA:
24.5		 4an2A-4x3fA:
27.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 4x3f SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 126
GLY A 265
PRO A 266
LEU A 203
VAL A 142
 None
 0.92A 4gc9A-4x3fA:
undetectable		 4gc9A-4x3fA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_G_TMQG202_1
(DIHYDROFOLATE
REDUCTASE)		 4x3f SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		5 / 12 ILE A  73
GLN A 130
LEU A 203
VAL A 200
ILE A 157
 None
 1.10A 4m2xG-4x3fA:
undetectable		 4m2xG-4x3fA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KF8_A_GCSA404_1
(PREDICTED
ACETYLTRANSFERASE)		 4x3f SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		4 / 8 ARG A 215
GLU A 209
GLY A 145
PRO A 144
 None
 1.16A 5kf8A-4x3fA:
undetectable		 5kf8A-4x3fA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_A_GCSA407_1
(PREDICTED
ACETYLTRANSFERASE)		 4x3f SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		4 / 8 ARG A 215
GLU A 209
GLY A 145
PRO A 144
 None
 1.07A 5kgpA-4x3fA:
undetectable		 5kgpA-4x3fA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_B_GCSB405_1
(PREDICTED
ACETYLTRANSFERASE)		 4x3f SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		4 / 8 ARG A 215
GLU A 209
GLY A 145
PRO A 144
 None
 1.04A 5kgpB-4x3fA:
undetectable		 5kgpB-4x3fA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_B_RBFB502_1
(RIBOFLAVIN LYASE)		 4x3f SERINE/THREONINE-PRO
TEIN KINASE PKNA
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 132
ALA A 128
GLY A 126
ALA A 194
VAL A 142
 None
 0.99A 5w4zB-4x3fA:
undetectable		 5w4zB-4x3fA:
18.10