SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4x3h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2DYS_P_CHDP310_0 (CYTOCHROME C OXIDASE POLYPEPTIDE VIIA-HEART CYTOCHROME C OXIDASE SUBUNIT 3)	4x3h	ACTIVITY-REGULATED CYTOSKELETON-ASSOCIA TED PROTEIN (Rattus norvegicus)	4 / 7	LEU A 272 GLN A 273 LEU A 221 PHE A 220	None	1.04A	2dysP-4x3hA: undetectable 2dysW-4x3hA: undetectable	2dysP-4x3hA: 15.00 2dysW-4x3hA: 20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2EIN_P_CHDP1271_0 (CYTOCHROME C OXIDASE POLYPEPTIDE VIIA-HEART CYTOCHROME C OXIDASE SUBUNIT 3)	4x3h	ACTIVITY-REGULATED CYTOSKELETON-ASSOCIA TED PROTEIN (Rattus norvegicus)	4 / 6	LEU A 272 GLN A 273 LEU A 221 PHE A 220	None	1.02A	2einP-4x3hA: undetectable 2einW-4x3hA: undetectable	2einP-4x3hA: 15.00 2einW-4x3hA: 20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3AG1_C_CHDC271_0 (CYTOCHROME C OXIDASE POLYPEPTIDE 7A1 CYTOCHROME C OXIDASE SUBUNIT 3)	4x3h	ACTIVITY-REGULATED CYTOSKELETON-ASSOCIA TED PROTEIN (Rattus norvegicus)	4 / 6	LEU A 272 GLN A 273 LEU A 221 PHE A 220	None	0.95A	3ag1C-4x3hA: undetectable 3ag1J-4x3hA: undetectable	3ag1C-4x3hA: 15.00 3ag1J-4x3hA: 20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3THR_A_C2FA1100_0 (GLYCINE N-METHYLTRANSFERASE)	4x3h	ACTIVITY-REGULATED CYTOSKELETON-ASSOCIA TED PROTEIN (Rattus norvegicus)	4 / 6	SER A 222 LEU A 224 HIS A 245 ARG A 229	None	1.28A	3thrB-4x3hA: undetectable	3thrB-4x3hA: 12.29

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2DYS_P_CHDP310_0","CYTOCHROME C OXIDASE POLYPEPTIDE VIIA-HEART;CYTOCHROME C OXIDASE SUBUNIT 3","4x3h","ACTIVITY-REGULATED CYTOSKELETON-ASSOCIATED PROTEIN","Rattus norvegicus",4,"LEU A 272;GLN A 273;LEU A 221;PHE A 220","None","1.04A","2dysP-4x3hA:undetectable;2dysW-4x3hA:undetectable","2dysP-4x3hA:15.00;2dysW-4x3hA:20.55"],["2EIN_P_CHDP1271_0","CYTOCHROME C OXIDASE POLYPEPTIDE VIIA-HEART;CYTOCHROME C OXIDASE SUBUNIT 3","4x3h","ACTIVITY-REGULATED CYTOSKELETON-ASSOCIATED PROTEIN","Rattus norvegicus",4,"LEU A 272;GLN A 273;LEU A 221;PHE A 220","None","1.02A","2einP-4x3hA:undetectable;2einW-4x3hA:undetectable","2einP-4x3hA:15.00;2einW-4x3hA:20.55"],["3AG1_C_CHDC271_0","CYTOCHROME C OXIDASE POLYPEPTIDE 7A1;CYTOCHROME C OXIDASE SUBUNIT 3","4x3h","ACTIVITY-REGULATED CYTOSKELETON-ASSOCIATED PROTEIN","Rattus norvegicus",4,"LEU A 272;GLN A 273;LEU A 221;PHE A 220","None","0.95A","3ag1C-4x3hA:undetectable;3ag1J-4x3hA:undetectable","3ag1C-4x3hA:15.00;3ag1J-4x3hA:20.55"],["3THR_A_C2FA1100_0","GLYCINE N-METHYLTRANSFERASE","4x3h","ACTIVITY-REGULATED CYTOSKELETON-ASSOCIATED PROTEIN","Rattus norvegicus",4,"SER A 222;LEU A 224;HIS A 245;ARG A 229","None","1.28A","3thrB-4x3hA:undetectable","3thrB-4x3hA:12.29"]]