SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4x3m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_1
(POL POLYPROTEIN)		 4x3m RNA 2'-O RIBOSE
METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 10 LEU A  70
GLY A  53
ASP A  60
GLY A  33
THR A  49
 None
 0.92A 1t7iA-4x3mA:
undetectable		 1t7iA-4x3mA:
18.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V2X_A_SAMA400_0
(TRNA (GM18)
METHYLTRANSFERASE)		 4x3m RNA 2'-O RIBOSE
METHYLTRANSFERASE
(Thermus
thermophilus) 		6 / 12 GLY A 208
ILE A 228
MET A 230
SER A 236
LEU A 237
VAL A 239
 ADN  A 301 (-3.1A)
ADN  A 301 (-3.8A)
ADN  A 301 (-3.5A)
ADN  A 301 (-4.5A)
ADN  A 301 (-4.9A)
ADN  A 301 ( 4.2A)
 0.44A 1v2xA-4x3mA:
18.6		 1v2xA-4x3mA:
30.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1X7P_A_SAMA301_0
(RRNA
METHYLTRANSFERASE)		 4x3m RNA 2'-O RIBOSE
METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 11 GLY A 208
ILE A 228
MET A 230
SER A 236
LEU A 237
 ADN  A 301 (-3.1A)
ADN  A 301 (-3.8A)
ADN  A 301 (-3.5A)
ADN  A 301 (-4.5A)
ADN  A 301 (-4.9A)
 0.95A 1x7pA-4x3mA:
28.3
1x7pB-4x3mA:
23.7		 1x7pA-4x3mA:
34.12
1x7pB-4x3mA:
34.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_1
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 4x3m RNA 2'-O RIBOSE
METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 12 ALA A 186
THR A 242
ALA A 130
ALA A 135
LEU A 176
 ADN  A 301 ( 4.1A)
ADN  A 301 (-3.5A)
None
None
None
 1.05A 2nyrA-4x3mA:
3.1		 2nyrA-4x3mA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA509_0
(CHORISMATE SYNTHASE)		 4x3m RNA 2'-O RIBOSE
METHYLTRANSFERASE
(Thermus
thermophilus) 		3 / 3 ARG A  23
GLN A 150
PRO A 149
 None
 1.00A 2qhfA-4x3mA:
undetectable		 2qhfA-4x3mA:
26.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_G_SAMG302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 4x3m RNA 2'-O RIBOSE
METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 12 LEU A 207
GLY A 208
GLY A 213
ASP A 211
LEU A 114
 ADN  A 301 (-4.5A)
ADN  A 301 (-3.1A)
None
None
None
 1.16A 3cjtG-4x3mA:
2.7		 3cjtG-4x3mA:
27.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 4x3m RNA 2'-O RIBOSE
METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 12 ILE A 126
VAL A 239
ILE A 228
ALA A 129
VAL A 138
 None
ADN  A 301 ( 4.2A)
ADN  A 301 (-3.8A)
None
None
 0.96A 3fpjA-4x3mA:
undetectable		 3fpjA-4x3mA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_A_SAMA270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 4x3m RNA 2'-O RIBOSE
METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 12 GLY A 208
ILE A 228
MET A 230
SER A 236
LEU A 237
 ADN  A 301 (-3.1A)
ADN  A 301 (-3.8A)
ADN  A 301 (-3.5A)
ADN  A 301 (-4.5A)
ADN  A 301 (-4.9A)
 0.94A 3gyqA-4x3mA:
22.8
3gyqB-4x3mA:
23.3		 3gyqA-4x3mA:
29.23
3gyqB-4x3mA:
29.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_B_SAMB270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 4x3m RNA 2'-O RIBOSE
METHYLTRANSFERASE
(Thermus
thermophilus) 		6 / 11 GLY A 208
ILE A 228
MET A 230
SER A 236
LEU A 237
VAL A 239
 ADN  A 301 (-3.1A)
ADN  A 301 (-3.8A)
ADN  A 301 (-3.5A)
ADN  A 301 (-4.5A)
ADN  A 301 (-4.9A)
ADN  A 301 ( 4.2A)
 0.69A 3gyqB-4x3mA:
23.3		 3gyqB-4x3mA:
29.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4x3m RNA 2'-O RIBOSE
METHYLTRANSFERASE
(Thermus
thermophilus) 		3 / 3 VAL A 164
VAL A 151
SER A 155
 None
 0.70A 3n8xB-4x3mA:
undetectable		 3n8xB-4x3mA:
19.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NK7_A_SAMA770_0
(23S RRNA
METHYLTRANSFERASE)		 4x3m RNA 2'-O RIBOSE
METHYLTRANSFERASE
(Thermus
thermophilus) 		8 / 12 ASN A 122
GLY A 208
GLY A 213
ILE A 228
MET A 230
SER A 236
ASN A 238
VAL A 239
 None
ADN  A 301 (-3.1A)
None
ADN  A 301 (-3.8A)
ADN  A 301 (-3.5A)
ADN  A 301 (-4.5A)
None
ADN  A 301 ( 4.2A)
 0.75A 3nk7A-4x3mA:
21.0		 3nk7A-4x3mA:
30.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NK7_A_SAMA770_0
(23S RRNA
METHYLTRANSFERASE)		 4x3m RNA 2'-O RIBOSE
METHYLTRANSFERASE
(Thermus
thermophilus) 		6 / 12 ASN A 122
LEU A 246
ILE A 228
MET A 230
ASN A 238
VAL A 239
 None
None
ADN  A 301 (-3.8A)
ADN  A 301 (-3.5A)
None
ADN  A 301 ( 4.2A)
 1.35A 3nk7A-4x3mA:
21.0		 3nk7A-4x3mA:
30.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NK7_B_SAMB770_0
(23S RRNA
METHYLTRANSFERASE)		 4x3m RNA 2'-O RIBOSE
METHYLTRANSFERASE
(Thermus
thermophilus) 		7 / 12 ASN A 122
GLY A 208
GLY A 213
ILE A 228
SER A 236
LEU A 237
VAL A 239
 None
ADN  A 301 (-3.1A)
None
ADN  A 301 (-3.8A)
ADN  A 301 (-4.5A)
ADN  A 301 (-4.9A)
ADN  A 301 ( 4.2A)
 0.81A 3nk7B-4x3mA:
25.2		 3nk7B-4x3mA:
30.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NK7_B_SAMB770_0
(23S RRNA
METHYLTRANSFERASE)		 4x3m RNA 2'-O RIBOSE
METHYLTRANSFERASE
(Thermus
thermophilus) 		7 / 12 ASN A 122
GLY A 208
ILE A 228
MET A 230
SER A 236
LEU A 237
VAL A 239
 None
ADN  A 301 (-3.1A)
ADN  A 301 (-3.8A)
ADN  A 301 (-3.5A)
ADN  A 301 (-4.5A)
ADN  A 301 (-4.9A)
ADN  A 301 ( 4.2A)
 0.59A 3nk7B-4x3mA:
25.2		 3nk7B-4x3mA:
30.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NK7_B_SAMB770_0
(23S RRNA
METHYLTRANSFERASE)		 4x3m RNA 2'-O RIBOSE
METHYLTRANSFERASE
(Thermus
thermophilus) 		6 / 12 ASN A 122
LEU A 246
ILE A 228
MET A 230
LEU A 237
VAL A 239
 None
None
ADN  A 301 (-3.8A)
ADN  A 301 (-3.5A)
ADN  A 301 (-4.9A)
ADN  A 301 ( 4.2A)
 1.29A 3nk7B-4x3mA:
25.2		 3nk7B-4x3mA:
30.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NK7_B_SAMB770_0
(23S RRNA
METHYLTRANSFERASE)		 4x3m RNA 2'-O RIBOSE
METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 12 GLY A 208
ILE A 228
MET A 230
SER A 236
LEU A 237
 ADN  A 301 (-3.1A)
ADN  A 301 (-3.8A)
ADN  A 301 (-3.5A)
ADN  A 301 (-4.5A)
ADN  A 301 (-4.9A)
 1.01A 3nk7B-4x3mA:
25.2		 3nk7B-4x3mA:
30.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_C_BEZC264_0
(CARNITINYL-COA
DEHYDRATASE)		 4x3m RNA 2'-O RIBOSE
METHYLTRANSFERASE
(Thermus
thermophilus) 		4 / 6 ALA A 243
ILE A 126
LEU A 112
ALA A 186
 None
None
None
ADN  A 301 ( 4.1A)
 0.84A 3r9sC-4x3mA:
undetectable		 3r9sC-4x3mA:
26.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K38_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME
KP18CYS PEPTIDE)		 4x3m RNA 2'-O RIBOSE
METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 12 TYR A 199
GLU A 191
LEU A 183
VAL A 203
LEU A 247
 None
 1.37A 4k38A-4x3mA:
undetectable
4k38D-4x3mA:
undetectable		 4k38A-4x3mA:
20.84
4k38D-4x3mA:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4x3m RNA 2'-O RIBOSE
METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 10 LEU A  70
LEU A  51
LEU A  30
ILE A   3
THR A  82
 None
 1.39A 4mk4A-4x3mA:
undetectable		 4mk4A-4x3mA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_G_IPHG101_0
(INSULIN)		 4x3m RNA 2'-O RIBOSE
METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 11 VAL A 140
LEU A 114
LEU A 162
LEU A 127
ALA A 130
 None
 0.96A 4p65B-4x3mA:
undetectable
4p65D-4x3mA:
undetectable
4p65G-4x3mA:
undetectable
4p65H-4x3mA:
undetectable		 4p65B-4x3mA:
9.81
4p65D-4x3mA:
9.81
4p65G-4x3mA:
5.56
4p65H-4x3mA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_K_IPHK101_0
(INSULIN)		 4x3m RNA 2'-O RIBOSE
METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 12 VAL A 140
LEU A 114
LEU A 162
LEU A 127
ALA A 130
 None
 0.93A 4p65F-4x3mA:
undetectable
4p65H-4x3mA:
undetectable
4p65K-4x3mA:
undetectable
4p65L-4x3mA:
undetectable		 4p65F-4x3mA:
9.81
4p65H-4x3mA:
9.81
4p65K-4x3mA:
5.56
4p65L-4x3mA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_A_ADNA1002_1
(MYOSIN HEAVY CHAIN
KINASE A)		 4x3m RNA 2'-O RIBOSE
METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 11 ALA A 130
GLY A 134
VAL A 164
LEU A 100
LEU A 139
 None
 1.10A 4zmeA-4x3mA:
undetectable		 4zmeA-4x3mA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4x3m RNA 2'-O RIBOSE
METHYLTRANSFERASE
(Thermus
thermophilus) 		4 / 5 ARG A 221
LEU A 183
PHE A 205
LEU A 176
 None
 1.20A 5iy5P-4x3mA:
undetectable
5iy5W-4x3mA:
undetectable		 5iy5P-4x3mA:
20.79
5iy5W-4x3mA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 4x3m RNA 2'-O RIBOSE
METHYLTRANSFERASE
(Thermus
thermophilus) 		4 / 6 ARG A 221
LEU A 183
PHE A 205
LEU A 176
 None
 1.19A 5x19P-4x3mA:
undetectable		 5x19P-4x3mA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4x3m RNA 2'-O RIBOSE
METHYLTRANSFERASE
(Thermus
thermophilus) 		4 / 5 ARG A 221
LEU A 183
PHE A 205
LEU A 176
 None
 1.20A 5x1fC-4x3mA:
undetectable
5x1fJ-4x3mA:
undetectable		 5x1fC-4x3mA:
20.14
5x1fJ-4x3mA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 4x3m RNA 2'-O RIBOSE
METHYLTRANSFERASE
(Thermus
thermophilus) 		4 / 5 ARG A 221
LEU A 183
PHE A 205
LEU A 176
 None
 1.23A 5xdxC-4x3mA:
undetectable
5xdxJ-4x3mA:
undetectable		 5xdxC-4x3mA:
20.79
5xdxJ-4x3mA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 4x3m RNA 2'-O RIBOSE
METHYLTRANSFERASE
(Thermus
thermophilus) 		4 / 5 ARG A 221
LEU A 183
PHE A 205
LEU A 176
 None
 1.24A 5xdxP-4x3mA:
undetectable
5xdxW-4x3mA:
undetectable		 5xdxP-4x3mA:
20.79
5xdxW-4x3mA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)		 4x3m RNA 2'-O RIBOSE
METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 9 ALA A 130
VAL A 159
ALA A 158
VAL A 151
SER A 155
 None
 1.12A 6bklA-4x3mA:
undetectable
6bklB-4x3mA:
undetectable
6bklC-4x3mA:
undetectable
6bklD-4x3mA:
undetectable		 6bklA-4x3mA:
7.73
6bklB-4x3mA:
7.73
6bklC-4x3mA:
7.73
6bklD-4x3mA:
7.73