SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4x3n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PNL_B_PACB559_0
(PENICILLIN
AMIDOHYDROLASE)		 4x3n CALCIUM-REGULATED
ACTIN-BUNDLING
PROTEIN
(Dictyostelium
discoideum) 		4 / 8 MET A  31
PHE A  34
SER A 152
ALA A  38
 None
 1.12A 1pnlA-4x3nA:
undetectable
1pnlB-4x3nA:
2.2		 1pnlA-4x3nA:
20.52
1pnlB-4x3nA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_D_ACTD229_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4x3n CALCIUM-REGULATED
ACTIN-BUNDLING
PROTEIN
(Dictyostelium
discoideum) 		4 / 4 ASP A 229
GLY A 231
LYS A 234
GLU A 235
 None
 1.04A 3hznD-4x3nA:
undetectable		 3hznD-4x3nA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3006_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4x3n CALCIUM-REGULATED
ACTIN-BUNDLING
PROTEIN
(Dictyostelium
discoideum) 		4 / 6 ILE A 276
GLU A 179
LYS A 271
ASN A  51
 None
 1.46A 3kp6A-4x3nA:
1.3
3kp6B-4x3nA:
0.5		 3kp6A-4x3nA:
20.39
3kp6B-4x3nA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_1
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 4x3n CALCIUM-REGULATED
ACTIN-BUNDLING
PROTEIN
(Dictyostelium
discoideum) 		3 / 3 ARG A 198
ASP A  76
GLN A  45
 None
 0.71A 3lcvB-4x3nA:
undetectable		 3lcvB-4x3nA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_D_ACTD601_0
(CHOLINE OXIDASE)		 4x3n CALCIUM-REGULATED
ACTIN-BUNDLING
PROTEIN
(Dictyostelium
discoideum) 		4 / 5 TRP A  54
ILE A 276
TRP A 277
VAL A  47
 None
 1.31A 3nneD-4x3nA:
undetectable		 3nneD-4x3nA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L3G_F_ACTF401_0
(METHYLAMINE
DEHYDROGENASE HEAVY
CHAIN)		 4x3n CALCIUM-REGULATED
ACTIN-BUNDLING
PROTEIN
(Dictyostelium
discoideum) 		3 / 3 ARG A 187
LEU A 188
GLU A 191
 None
 0.61A 4l3gF-4x3nA:
undetectable		 4l3gF-4x3nA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_E_SPME202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4x3n CALCIUM-REGULATED
ACTIN-BUNDLING
PROTEIN
(Dictyostelium
discoideum) 		4 / 5 GLU A 202
GLU A 201
TYR A 200
GLU A 203
 None
 1.42A 4r87E-4x3nA:
undetectable		 4r87E-4x3nA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H8T_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 4x3n CALCIUM-REGULATED
ACTIN-BUNDLING
PROTEIN
(Dictyostelium
discoideum) 		5 / 12 PHE A 153
TYR A 156
LEU A 157
LEU A  50
ALA A  46
 None
 0.90A 5h8tA-4x3nA:
undetectable		 5h8tA-4x3nA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MSD_A_BEZA1202_0
(CARBOXYLIC ACID
REDUCTASE)		 4x3n CALCIUM-REGULATED
ACTIN-BUNDLING
PROTEIN
(Dictyostelium
discoideum) 		4 / 5 HIS A 180
ILE A 183
SER A 271
ALA A 275
 None
 1.09A 5msdA-4x3nA:
undetectable		 5msdA-4x3nA:
13.68