SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4x4w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4x4w CCA TRNA
NUCLEOTIDYLTRANSFERA
SE 1, MITOCHONDRIAL
(Homo
sapiens) 		5 / 9 LEU A 235
ASP A 234
LEU A 231
ILE A 219
ILE A 241
 None
 1.44A 1hzeA-4x4wA:
undetectable
1hzeB-4x4wA:
undetectable		 1hzeA-4x4wA:
13.94
1hzeB-4x4wA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4x4w CCA TRNA
NUCLEOTIDYLTRANSFERA
SE 1, MITOCHONDRIAL
(Homo
sapiens) 		5 / 9 ILE A 241
LEU A 235
ASP A 234
LEU A 231
ILE A 219
 None
 1.44A 1hzeA-4x4wA:
undetectable
1hzeB-4x4wA:
undetectable		 1hzeA-4x4wA:
13.94
1hzeB-4x4wA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4x4w CCA TRNA
NUCLEOTIDYLTRANSFERA
SE 1, MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 ILE A 241
LEU A 235
ASP A 234
LEU A 231
ILE A 219
 None
 1.34A 1i18A-4x4wA:
undetectable
1i18B-4x4wA:
undetectable		 1i18A-4x4wA:
13.94
1i18B-4x4wA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA443_1
(ALPHA AMYLASE)		 4x4w CCA TRNA
NUCLEOTIDYLTRANSFERA
SE 1, MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 THR A 128
ASN A 130
ASP A 126
GLU A 215
 None
FLC  A 501 ( 3.6A)
FLC  A 501 ( 4.7A)
FLC  A 501 ( 4.8A)
 1.08A 1mxgA-4x4wA:
undetectable		 1mxgA-4x4wA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4x4w CCA TRNA
NUCLEOTIDYLTRANSFERA
SE 1, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 232
ILE A 207
LEU A 204
VAL A 237
ILE A 172
 None
CL  A 505 ( 4.3A)
None
None
None
 1.03A 1oipA-4x4wA:
2.4		 1oipA-4x4wA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN)		 4x4w CCA TRNA
NUCLEOTIDYLTRANSFERA
SE 1, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A  89
LEU A  25
THR A  56
MET A  63
ILE A  75
 None
 1.10A 1tw4A-4x4wA:
undetectable		 1tw4A-4x4wA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_B_CHDB1130_0
(FATTY ACID-BINDING
PROTEIN)		 4x4w CCA TRNA
NUCLEOTIDYLTRANSFERA
SE 1, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A  89
LEU A  25
THR A  56
MET A  63
ILE A  75
 None
 1.00A 1tw4B-4x4wA:
undetectable		 1tw4B-4x4wA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VIF_A_FOLA1_0
(DIHYDROFOLATE
REDUCTASE)		 4x4w CCA TRNA
NUCLEOTIDYLTRANSFERA
SE 1, MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 GLN A 166
ILE A 165
TYR A 169
 None
 0.73A 1vifA-4x4wA:
undetectable		 1vifA-4x4wA:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1436_1
(CHITINASE)		 4x4w CCA TRNA
NUCLEOTIDYLTRANSFERA
SE 1, MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ASP A 121
PHE A 133
ARG A 125
 None
None
GOL  A 502 ( 2.9A)
 0.61A 2a3aA-4x4wA:
undetectable		 2a3aA-4x4wA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_G_BEZG2352_0
(D-AMINO-ACID OXIDASE)		 4x4w CCA TRNA
NUCLEOTIDYLTRANSFERA
SE 1, MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 TYR A 179
TYR A 175
ILE A 197
GLY A 187
 None
 1.29A 2du8G-4x4wA:
undetectable		 2du8G-4x4wA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H77_A_T3A1_1
(THRA PROTEIN)		 4x4w CCA TRNA
NUCLEOTIDYLTRANSFERA
SE 1, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ALA A  70
ALA A  87
LEU A  89
LEU A  33
ILE A  96
 None
 1.14A 2h77A-4x4wA:
undetectable		 2h77A-4x4wA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JB7_B_ACTB1169_0
(HYPOTHETICAL PROTEIN
PAE2307)		 4x4w CCA TRNA
NUCLEOTIDYLTRANSFERA
SE 1, MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ARG A  41
ARG A 177
ARG A 181
 FLC  A 501 (-2.5A)
FLC  A 501 (-2.4A)
None
 0.94A 2jb7A-4x4wA:
undetectable
2jb7B-4x4wA:
undetectable
2jb7C-4x4wA:
undetectable		 2jb7A-4x4wA:
18.58
2jb7B-4x4wA:
18.58
2jb7C-4x4wA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JB7_B_ACTB1169_0
(HYPOTHETICAL PROTEIN
PAE2307)		 4x4w CCA TRNA
NUCLEOTIDYLTRANSFERA
SE 1, MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ARG A 177
ARG A 181
ARG A  41
 FLC  A 501 (-2.4A)
None
FLC  A 501 (-2.5A)
 0.94A 2jb7A-4x4wA:
undetectable
2jb7B-4x4wA:
undetectable
2jb7C-4x4wA:
undetectable		 2jb7A-4x4wA:
18.58
2jb7B-4x4wA:
18.58
2jb7C-4x4wA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JB7_B_ACTB1169_0
(HYPOTHETICAL PROTEIN
PAE2307)		 4x4w CCA TRNA
NUCLEOTIDYLTRANSFERA
SE 1, MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ARG A 181
ARG A  41
ARG A 177
 None
FLC  A 501 (-2.5A)
FLC  A 501 (-2.4A)
 0.85A 2jb7A-4x4wA:
undetectable
2jb7B-4x4wA:
undetectable
2jb7C-4x4wA:
undetectable		 2jb7A-4x4wA:
18.58
2jb7B-4x4wA:
18.58
2jb7C-4x4wA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_A_EV1A1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 4x4w CCA TRNA
NUCLEOTIDYLTRANSFERA
SE 1, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 235
VAL A 237
ILE A 165
PHE A 157
PHE A 176
 None
 1.17A 2weyA-4x4wA:
4.0		 2weyA-4x4wA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 4x4w CCA TRNA
NUCLEOTIDYLTRANSFERA
SE 1, MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ASP A 102
ASP A 121
ASP A 168
 None
 0.78A 3douA-4x4wA:
undetectable		 3douA-4x4wA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4x4w CCA TRNA
NUCLEOTIDYLTRANSFERA
SE 1, MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 SER A  13
GLN A  12
PHE A  15
 None
 0.84A 3g4lC-4x4wA:
undetectable		 3g4lC-4x4wA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 4x4w CCA TRNA
NUCLEOTIDYLTRANSFERA
SE 1, MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 LEU A 273
VAL A 225
LEU A 216
LEU A 194
 None
 0.84A 3g8iA-4x4wA:
1.2		 3g8iA-4x4wA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_B_URFB400_1
(URIDINE
PHOSPHORYLASE 1)		 4x4w CCA TRNA
NUCLEOTIDYLTRANSFERA
SE 1, MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 GLY A 379
LEU A 381
LEU A 382
ILE A 367
 None
 0.92A 3nbqB-4x4wA:
undetectable		 3nbqB-4x4wA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_0
(PUTATIVE REGULATORY
PROTEIN)		 4x4w CCA TRNA
NUCLEOTIDYLTRANSFERA
SE 1, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 204
THR A 193
ILE A 212
VAL A 155
PHE A 176
 None
 1.06A 3vw1D-4x4wA:
undetectable		 3vw1D-4x4wA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA612_1
(SERUM ALBUMIN)		 4x4w CCA TRNA
NUCLEOTIDYLTRANSFERA
SE 1, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A  33
LEU A  22
LEU A  19
ILE A  52
GLU A  95
 None
 1.15A 5v0vA-4x4wA:
2.8		 5v0vA-4x4wA:
20.44