SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4x4y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_2
(ALPHA-AMYLASE)		 4x4y HUMAN VARIABLE HEAVY
CHAIN OF HERCEPTIN
HUMAN VARIABLE LIGHT
CHAIN OF HERCEPTIN
(Homo
sapiens) 		3 / 3 TRP A  99
TYR A 105
LEU B  46
 None
 0.87A 1kxhA-4x4yA:
undetectable		 1kxhA-4x4yA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OLD_B_IPHB2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 4x4y HUMAN VARIABLE HEAVY
CHAIN OF HERCEPTIN
HUMAN VARIABLE LIGHT
CHAIN OF HERCEPTIN
(Homo
sapiens;
Homo
sapiens) 		4 / 7 TYR A  95
TYR B  36
PRO B  44
TYR B  87
 None
 0.70A 2oldA-4x4yA:
14.3
2oldB-4x4yA:
14.5		 2oldA-4x4yA:
25.68
2oldB-4x4yA:
25.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OLD_B_IPHB2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 4x4y HUMAN VARIABLE HEAVY
CHAIN OF HERCEPTIN
HUMAN VARIABLE LIGHT
CHAIN OF HERCEPTIN
(Homo
sapiens;
Homo
sapiens) 		4 / 7 TYR B  36
PRO B  44
TYR B  87
TYR A  95
 None
 0.65A 2oldA-4x4yB:
18.3
2oldB-4x4yB:
18.3		 2oldA-4x4yB:
26.67
2oldB-4x4yB:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6K_A_ADNA699_1
(CHLORINASE)		 4x4y HUMAN VARIABLE HEAVY
CHAIN OF HERCEPTIN
(Homo
sapiens) 		4 / 7 TYR A  57
TYR A  52
PRO A  53
THR A  54
 None
 1.27A 2q6kA-4x4yA:
undetectable		 2q6kA-4x4yA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D9L_A_ACTA501_0
(CTD-PEPTIDE
RNA-BINDING PROTEIN
16)		 4x4y HUMAN VARIABLE HEAVY
CHAIN OF HERCEPTIN
(Homo
sapiens) 		4 / 5 ILE A  34
PRO A  53
TYR A  52
TYR A  33
 None
 1.11A 3d9lA-4x4yA:
undetectable
3d9lY-4x4yA:
undetectable		 3d9lA-4x4yA:
16.33
3d9lY-4x4yA:
5.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		 4x4y HUMAN VARIABLE LIGHT
CHAIN OF HERCEPTIN
(Homo
sapiens) 		3 / 3 PHE B  71
TYR B  92
LEU B  47
 None
 0.63A 3keeB-4x4yB:
undetectable		 3keeB-4x4yB:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PEO_F_CU9F301_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4x4y HUMAN VARIABLE LIGHT
CHAIN OF HERCEPTIN
(Homo
sapiens) 		4 / 6 GLN B  37
TYR B  86
GLN B   6
ILE B  21
 None
 1.30A 3peoG-4x4yB:
undetectable		 3peoG-4x4yB:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4x4y HUMAN VARIABLE LIGHT
CHAIN OF HERCEPTIN
(Homo
sapiens) 		3 / 3 PHE B  71
TYR B  92
LEU B  47
 None
 0.73A 3sueB-4x4yB:
undetectable		 3sueB-4x4yB:
17.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UIL_H_QI9H1223_0
(FAB 314.1)		 4x4y HUMAN VARIABLE HEAVY
CHAIN OF HERCEPTIN
HUMAN VARIABLE LIGHT
CHAIN OF HERCEPTIN
(Homo
sapiens;
Homo
sapiens) 		5 / 12 HIS A  35
GLY A 100
GLN B  89
GLN B  90
PRO B  96
 None
 1.14A 4uilH-4x4yA:
20.3
4uilL-4x4yA:
5.1		 4uilH-4x4yA:
32.87
4uilL-4x4yA:
22.52