SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4x57'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_1
(PROTEASE)		 4x57 MEMBRANE-ANCHORED
UBIQUITIN-FOLD
PROTEIN 3
UBIQUITIN-CONJUGATIN
G ENZYME E2 8
(Arabidopsis
thaliana) 		5 / 11 GLY B  61
ALA A  35
VAL A  67
ILE A 106
ILE A  54
 None
 0.95A 1n49C-4x57B:
undetectable		 1n49C-4x57B:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7R_A_NCTA440_1
(CYTOCHROME P450-CAM)		 4x57 UBIQUITIN-CONJUGATIN
G ENZYME E2 8
(Arabidopsis
thaliana) 		4 / 7 PHE A  56
TYR A  60
VAL A 102
ILE A  54
 None
 0.99A 1p7rA-4x57A:
undetectable		 1p7rA-4x57A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OMB_A_IPHA2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 4x57 UBIQUITIN-CONJUGATIN
G ENZYME E2 8
(Arabidopsis
thaliana) 		4 / 5 HIS A  75
PRO A  76
TYR A  45
PRO A  44
 None
 1.48A 2ombA-4x57A:
undetectable
2ombB-4x57A:
undetectable		 2ombA-4x57A:
20.00
2ombB-4x57A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZB7_A_NCAA901_0
(PROSTAGLANDIN
REDUCTASE 2)		 4x57 MEMBRANE-ANCHORED
UBIQUITIN-FOLD
PROTEIN 3
(Arabidopsis
thaliana) 		4 / 5 TYR B  24
ILE B   9
LEU B  64
LEU B  57
 None
 1.15A 2zb7A-4x57B:
undetectable		 2zb7A-4x57B:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZSE_A_PAUA600_0
(PANTOTHENATE KINASE)		 4x57 UBIQUITIN-CONJUGATIN
G ENZYME E2 8
(Arabidopsis
thaliana) 		4 / 7 ARG A  70
PHE A  69
ILE A  78
ASN A  79
 None
 1.14A 2zseA-4x57A:
undetectable		 2zseA-4x57A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_A_VDYA6178_1
(VITAMIN D
HYDROXYLASE)		 4x57 UBIQUITIN-CONJUGATIN
G ENZYME E2 8
(Arabidopsis
thaliana) 		5 / 11 ILE A  99
LEU A 103
ILE A 106
PRO A  65
LEU A  89
 None
 1.23A 3a51A-4x57A:
undetectable		 3a51A-4x57A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4x57 UBIQUITIN-CONJUGATIN
G ENZYME E2 8
(Arabidopsis
thaliana) 		5 / 12 LEU A  89
ILE A   6
ILE A  99
VAL A 102
LEU A 103
 None
 0.97A 3w68D-4x57A:
undetectable		 3w68D-4x57A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB501_1
(HEMOLYTIC LECTIN
CEL-III)		 4x57 MEMBRANE-ANCHORED
UBIQUITIN-FOLD
PROTEIN 3
UBIQUITIN-CONJUGATIN
G ENZYME E2 8
(Arabidopsis
thaliana) 		4 / 5 ASP B  18
SER B  17
GLY B  16
ASP A  16
 None
 1.35A 3w9tB-4x57B:
undetectable		 3w9tB-4x57B:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1003_1
(HEMOLYTIC LECTIN
CEL-III)		 4x57 MEMBRANE-ANCHORED
UBIQUITIN-FOLD
PROTEIN 3
UBIQUITIN-CONJUGATIN
G ENZYME E2 8
(Arabidopsis
thaliana) 		4 / 5 ASP B  18
SER B  17
GLY B  16
ASP A  16
 None
 1.35A 3w9tC-4x57B:
undetectable		 3w9tC-4x57B:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD501_1
(HEMOLYTIC LECTIN
CEL-III)		 4x57 MEMBRANE-ANCHORED
UBIQUITIN-FOLD
PROTEIN 3
UBIQUITIN-CONJUGATIN
G ENZYME E2 8
(Arabidopsis
thaliana) 		4 / 5 ASP B  18
SER B  17
GLY B  16
ASP A  16
 None
 1.35A 3w9tD-4x57B:
undetectable		 3w9tD-4x57B:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4x57 UBIQUITIN-CONJUGATIN
G ENZYME E2 8
(Arabidopsis
thaliana) 		5 / 10 LEU A 109
GLY A  39
ILE A  37
ILE A  84
ILE A  78
 None
 1.07A 6ebpD-4x57A:
undetectable		 6ebpD-4x57A:
27.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 4x57 UBIQUITIN-CONJUGATIN
G ENZYME E2 8
(Arabidopsis
thaliana) 		5 / 11 VAL A  73
PHE A  69
THR A  71
ILE A 106
LEU A 110
 None
 1.32A 6h1lB-4x57A:
undetectable		 6h1lB-4x57A:
15.82