SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4x5t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 4x5t PROTON-GATED ION
CHANNEL,GLRA1
PROTEIN,GLRA1
PROTEIN
(Gloeobacter
violaceus;
Homo
sapiens) 		4 / 6 LEU A  24
GLN A 219
ILE A 162
PHE A 165
 None
 1.06A 2jn3A-4x5tA:
undetectable		 2jn3A-4x5tA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_0
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 4x5t PROTON-GATED ION
CHANNEL,GLRA1
PROTEIN,GLRA1
PROTEIN
(Homo
sapiens;
Gloeobacter
violaceus) 		5 / 12 PHE A 106
ILE A 128
ALA A  41
VAL A  18
LEU A 130
 None
 1.36A 2rctA-4x5tA:
undetectable		 2rctA-4x5tA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4x5t PROTON-GATED ION
CHANNEL,GLRA1
PROTEIN,GLRA1
PROTEIN
(Gloeobacter
violaceus;
Homo
sapiens) 		4 / 8 TYR A 129
LEU A 130
ALA A 167
HIS A 127
 None
 0.99A 2wekA-4x5tA:
undetectable		 2wekA-4x5tA:
22.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4F8H_A_RKEA401_1
(PROTON-GATED ION
CHANNEL)		 4x5t PROTON-GATED ION
CHANNEL,GLRA1
PROTEIN,GLRA1
PROTEIN
(Gloeobacter
violaceus;
Homo
sapiens) 		4 / 8 TYR A  23
ASN A 152
ASP A 153
ASP A 154
 None
 0.62A 4f8hA-4x5tA:
34.3
4f8hB-4x5tA:
34.2		 4f8hA-4x5tA:
71.91
4f8hB-4x5tA:
71.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4F8H_B_RKEB401_1
(PROTON-GATED ION
CHANNEL)		 4x5t PROTON-GATED ION
CHANNEL,GLRA1
PROTEIN,GLRA1
PROTEIN
(Gloeobacter
violaceus;
Homo
sapiens) 		4 / 8 TYR A  23
ASN A 152
ASP A 153
ASP A 154
 None
 0.62A 4f8hB-4x5tA:
34.2
4f8hC-4x5tA:
34.3		 4f8hB-4x5tA:
71.91
4f8hC-4x5tA:
71.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4F8H_C_RKEC401_1
(PROTON-GATED ION
CHANNEL)		 4x5t PROTON-GATED ION
CHANNEL,GLRA1
PROTEIN,GLRA1
PROTEIN
(Gloeobacter
violaceus;
Homo
sapiens) 		4 / 8 TYR A  23
ASN A 152
ASP A 153
ASP A 154
 None
 0.62A 4f8hC-4x5tA:
34.3
4f8hD-4x5tA:
34.2		 4f8hC-4x5tA:
71.91
4f8hD-4x5tA:
71.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4F8H_D_RKED401_1
(PROTON-GATED ION
CHANNEL)		 4x5t PROTON-GATED ION
CHANNEL,GLRA1
PROTEIN,GLRA1
PROTEIN
(Gloeobacter
violaceus;
Homo
sapiens) 		4 / 8 TYR A  23
ASN A 152
ASP A 153
ASP A 154
 None
 0.62A 4f8hD-4x5tA:
34.2
4f8hE-4x5tA:
34.2		 4f8hD-4x5tA:
71.91
4f8hE-4x5tA:
71.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4F8H_E_RKEE401_1
(PROTON-GATED ION
CHANNEL)		 4x5t PROTON-GATED ION
CHANNEL,GLRA1
PROTEIN,GLRA1
PROTEIN
(Gloeobacter
violaceus;
Homo
sapiens) 		4 / 8 TYR A  23
ASN A 152
ASP A 153
ASP A 154
 None
 0.62A 4f8hA-4x5tA:
34.3
4f8hE-4x5tA:
34.2		 4f8hA-4x5tA:
71.91
4f8hE-4x5tA:
71.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 4x5t PROTON-GATED ION
CHANNEL,GLRA1
PROTEIN,GLRA1
PROTEIN
(Homo
sapiens;
Gloeobacter
violaceus) 		5 / 12 PHE A 106
ILE A 128
ALA A  41
VAL A  18
LEU A 130
 None
 1.32A 4qzuA-4x5tA:
0.8		 4qzuA-4x5tA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 4x5t PROTON-GATED ION
CHANNEL,GLRA1
PROTEIN,GLRA1
PROTEIN
(Homo
sapiens;
Gloeobacter
violaceus) 		5 / 12 PHE A 106
ILE A 128
ALA A  41
VAL A  18
LEU A 130
 None
 1.20A 4qzuC-4x5tA:
undetectable		 4qzuC-4x5tA:
16.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZZB_A_ACTA404_0
(PROTON-GATED ION
CHANNEL)		 4x5t PROTON-GATED ION
CHANNEL,GLRA1
PROTEIN,GLRA1
PROTEIN
(Homo
sapiens;
Gloeobacter
violaceus) 		4 / 4 LEU A  45
ILE A  73
ARG A  85
TYR A 102
 None
None
CL  A 502 (-4.3A)
None
 0.13A 4zzbA-4x5tA:
35.1		 4zzbA-4x5tA:
70.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZZB_C_ACTC401_0
(PROTON-GATED ION
CHANNEL)		 4x5t PROTON-GATED ION
CHANNEL,GLRA1
PROTEIN,GLRA1
PROTEIN
(Homo
sapiens;
Gloeobacter
violaceus) 		4 / 7 ARG A  77
VAL A  79
ILE A 131
GLU A 181
 ACT  A 503 (-3.7A)
None
ACT  A 503 (-3.7A)
ACT  A 503 (-3.5A)
 0.57A 4zzbC-4x5tA:
35.2
4zzbD-4x5tA:
35.2		 4zzbC-4x5tA:
70.99
4zzbD-4x5tA:
70.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZZB_C_ACTC404_0
(PROTON-GATED ION
CHANNEL)		 4x5t PROTON-GATED ION
CHANNEL,GLRA1
PROTEIN,GLRA1
PROTEIN
(Homo
sapiens;
Gloeobacter
violaceus) 		4 / 4 ILE A  73
ILE A  76
ARG A  85
TYR A 102
 None
None
CL  A 502 (-4.3A)
None
 0.12A 4zzbC-4x5tA:
35.2		 4zzbC-4x5tA:
70.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZZB_D_ACTD403_0
(PROTON-GATED ION
CHANNEL)		 4x5t PROTON-GATED ION
CHANNEL,GLRA1
PROTEIN,GLRA1
PROTEIN
(Homo
sapiens;
Gloeobacter
violaceus) 		4 / 4 ILE A  73
ARG A  85
TYR A 102
GLU A 104
 None
CL  A 502 (-4.3A)
None
None
 0.13A 4zzbD-4x5tA:
35.1		 4zzbD-4x5tA:
70.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZZB_E_ACTE403_0
(PROTON-GATED ION
CHANNEL)		 4x5t PROTON-GATED ION
CHANNEL,GLRA1
PROTEIN,GLRA1
PROTEIN
(Homo
sapiens;
Gloeobacter
violaceus) 		3 / 3 ARG A  85
TYR A 102
GLU A 104
 CL  A 502 (-4.3A)
None
None
 0.11A 4zzbE-4x5tA:
35.0		 4zzbE-4x5tA:
70.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZZC_A_ACTA406_0
(PROTON-GATED ION
CHANNEL)		 4x5t PROTON-GATED ION
CHANNEL,GLRA1
PROTEIN,GLRA1
PROTEIN
(Homo
sapiens;
Gloeobacter
violaceus) 		4 / 4 LEU A  45
ILE A  73
ARG A  85
TYR A 102
 None
None
CL  A 502 (-4.3A)
None
 0.19A 4zzcA-4x5tA:
34.8		 4zzcA-4x5tA:
71.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZZC_B_ACTB406_0
(PROTON-GATED ION
CHANNEL)		 4x5t PROTON-GATED ION
CHANNEL,GLRA1
PROTEIN,GLRA1
PROTEIN
(Homo
sapiens;
Gloeobacter
violaceus) 		4 / 4 LEU A  45
ILE A  73
ARG A  85
TYR A 102
 None
None
CL  A 502 (-4.3A)
None
 0.17A 4zzcB-4x5tA:
34.5		 4zzcB-4x5tA:
71.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZZC_C_ACTC407_0
(PROTON-GATED ION
CHANNEL)		 4x5t PROTON-GATED ION
CHANNEL,GLRA1
PROTEIN,GLRA1
PROTEIN
(Homo
sapiens;
Gloeobacter
violaceus) 		4 / 4 ILE A  73
ILE A  76
ARG A  85
TYR A 102
 None
None
CL  A 502 (-4.3A)
None
 0.21A 4zzcC-4x5tA:
34.7		 4zzcC-4x5tA:
71.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZZC_D_ACTD406_0
(PROTON-GATED ION
CHANNEL)		 4x5t PROTON-GATED ION
CHANNEL,GLRA1
PROTEIN,GLRA1
PROTEIN
(Homo
sapiens;
Gloeobacter
violaceus) 		4 / 4 ILE A  73
ILE A  76
ARG A  85
TYR A 102
 None
None
CL  A 502 (-4.3A)
None
 0.21A 4zzcD-4x5tA:
34.6		 4zzcD-4x5tA:
71.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZZC_E_ACTE406_0
(PROTON-GATED ION
CHANNEL)		 4x5t PROTON-GATED ION
CHANNEL,GLRA1
PROTEIN,GLRA1
PROTEIN
(Homo
sapiens;
Gloeobacter
violaceus) 		5 / 5 ILE A  73
ILE A  76
ARG A  85
TYR A 102
GLU A 104
 None
None
CL  A 502 (-4.3A)
None
None
 0.21A 4zzcE-4x5tA:
34.7		 4zzcE-4x5tA:
71.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_E_DVAE7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 4x5t PROTON-GATED ION
CHANNEL,GLRA1
PROTEIN,GLRA1
PROTEIN
(Homo
sapiens;
Gloeobacter
violaceus) 		3 / 3 TYR A 102
SER A  44
TRP A  47
 None
 0.83A 5n8jB-4x5tA:
undetectable		 5n8jB-4x5tA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_O_DVAO7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 4x5t PROTON-GATED ION
CHANNEL,GLRA1
PROTEIN,GLRA1
PROTEIN
(Homo
sapiens;
Gloeobacter
violaceus) 		3 / 3 TYR A 102
SER A  44
TRP A  47
 None
 0.81A 5n8jA-4x5tA:
undetectable		 5n8jA-4x5tA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_P_DVAP5_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 4x5t PROTON-GATED ION
CHANNEL,GLRA1
PROTEIN,GLRA1
PROTEIN
(Homo
sapiens;
Gloeobacter
violaceus) 		3 / 3 TYR A 102
SER A  44
TRP A  47
 None
 0.83A 5n8jD-4x5tA:
undetectable		 5n8jD-4x5tA:
17.40