SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4x68'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D0V_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4x68 BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		4 / 8 GLY A 297
GLY A 183
PHE A 185
GLY A 248
 None
 0.69A 1d0vA-4x68A:
undetectable		 1d0vA-4x68A:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3004_0
(BETA-CARBONIC
ANHYDRASE)		 4x68 BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		4 / 6 GLN A 146
TYR A 249
VAL A 239
GLY A 242
 OP0  A 401 (-3.0A)
OP0  A 401 (-3.6A)
None
None
 1.09A 1ekjC-4x68A:
undetectable
1ekjD-4x68A:
undetectable		 1ekjC-4x68A:
22.31
1ekjD-4x68A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3007_0
(BETA-CARBONIC
ANHYDRASE)		 4x68 BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		4 / 6 VAL A 239
GLY A 242
GLN A 146
TYR A 249
 None
None
OP0  A 401 (-3.0A)
OP0  A 401 (-3.6A)
 1.16A 1ekjC-4x68A:
undetectable
1ekjD-4x68A:
undetectable		 1ekjC-4x68A:
22.31
1ekjD-4x68A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHA_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4x68 BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		4 / 8 GLY A 297
GLY A 183
PHE A 185
GLY A 248
 None
 0.70A 1jhaA-4x68A:
undetectable		 1jhaA-4x68A:
23.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KVL_A_CLSA371_1
(BETA-LACTAMASE)		 4x68 BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		6 / 10 GLY A  89
GLN A 146
ASN A 179
TYR A 249
THR A 343
GLY A 344
 OP0  A 401 ( 3.9A)
OP0  A 401 (-3.0A)
OP0  A 401 (-3.5A)
OP0  A 401 (-3.6A)
OP0  A 401 (-4.0A)
OP0  A 401 (-3.3A)
 1.21A 1kvlA-4x68A:
56.1		 1kvlA-4x68A:
43.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KVL_A_CLSA371_1
(BETA-LACTAMASE)		 4x68 BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		8 / 10 LEU A 145
GLN A 146
TYR A 177
ASN A 179
TYR A 249
LYS A 342
THR A 343
GLY A 344
 OP0  A 401 ( 4.8A)
OP0  A 401 (-3.0A)
OP0  A 401 (-4.2A)
OP0  A 401 (-3.5A)
OP0  A 401 (-3.6A)
OP0  A 401 (-2.9A)
OP0  A 401 (-4.0A)
OP0  A 401 (-3.3A)
 0.36A 1kvlA-4x68A:
56.1		 1kvlA-4x68A:
43.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_A_SAMA301_0
(RRNA
METHYLTRANSFERASE)		 4x68 BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		6 / 11 THR A 346
GLY A 348
GLY A 229
ILE A  88
LEU A 366
ALA A 351
 None
 1.44A 1x7pA-4x68A:
undetectable
1x7pB-4x68A:
undetectable		 1x7pA-4x68A:
21.11
1x7pB-4x68A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_B_SAMB302_0
(RRNA
METHYLTRANSFERASE)		 4x68 BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		6 / 10 THR A 346
GLY A 348
GLY A 229
ILE A  88
LEU A 366
ALA A 351
 None
 1.49A 1x7pA-4x68A:
undetectable
1x7pB-4x68A:
undetectable		 1x7pA-4x68A:
21.11
1x7pB-4x68A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_2
(MINERALOCORTICOID
RECEPTOR)		 4x68 BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		4 / 4 LEU A 384
LEU A  60
SER A  59
LEU A 266
 None
 0.95A 1ya3A-4x68A:
undetectable		 1ya3A-4x68A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AV6_A_SAMA1_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1)		 4x68 BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 362
LEU A 361
LEU A 307
ASN A 341
VAL A 356
 None
 1.07A 3av6A-4x68A:
undetectable		 3av6A-4x68A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA300_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 4x68 BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		5 / 12 LYS A  93
ASN A 179
LYS A 342
THR A 343
GLY A 344
 OP0  A 401 ( 4.2A)
OP0  A 401 (-3.5A)
OP0  A 401 (-2.9A)
OP0  A 401 (-4.0A)
OP0  A 401 (-3.3A)
 0.39A 3huoA-4x68A:
15.8		 3huoA-4x68A:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_B_VORB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 4x68 BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		5 / 11 LEU A 387
SER A 385
ILE A  58
ALA A  41
ALA A  36
 None
 1.05A 3mdtB-4x68A:
undetectable		 3mdtB-4x68A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 4x68 BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		6 / 12 SER A  90
LYS A  93
ASN A 179
GLY A 344
THR A 346
ARG A 376
 OP0  A 401 (-1.3A)
OP0  A 401 ( 4.2A)
OP0  A 401 (-3.5A)
OP0  A 401 (-3.3A)
None
None
 0.95A 3mzeA-4x68A:
15.1		 3mzeA-4x68A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 4x68 BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		6 / 12 SER A  90
LYS A  93
ASN A 179
THR A 343
GLY A 344
THR A 346
 OP0  A 401 (-1.3A)
OP0  A 401 ( 4.2A)
OP0  A 401 (-3.5A)
OP0  A 401 (-4.0A)
OP0  A 401 (-3.3A)
None
 0.69A 3mzeA-4x68A:
15.1		 3mzeA-4x68A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		 4x68 BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 184
ALA A 190
ARG A 191
LEU A 135
 None
 1.03A 3rd0A-4x68A:
undetectable		 3rd0A-4x68A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 4x68 BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		4 / 4 LEU A 237
GLY A 229
GLY A 348
THR A 346
 None
 0.87A 3si7A-4x68A:
undetectable		 3si7A-4x68A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_C_ACTC4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 4x68 BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		4 / 4 GLY A 285
GLY A 295
THR A 137
LEU A 133
 None
 0.71A 3si7C-4x68A:
undetectable
3si7D-4x68A:
undetectable		 3si7C-4x68A:
21.07
3si7D-4x68A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_D_ACTD4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 4x68 BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		4 / 5 LEU A 133
GLY A 285
GLY A 295
THR A 137
 None
 0.76A 3si7C-4x68A:
undetectable
3si7D-4x68A:
undetectable		 3si7C-4x68A:
21.07
3si7D-4x68A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_1
(POL POLYPROTEIN)		 4x68 BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		5 / 9 LEU A 111
ALA A 189
GLY A 183
ILE A 182
LEU A 133
 None
 1.07A 3u7sA-4x68A:
undetectable		 3u7sA-4x68A:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_B_017B202_1
(PROTEASE)		 4x68 BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		4 / 7 PRO A 304
ARG A 359
GLY A 358
PRO A 357
 None
 1.34A 3ucbB-4x68A:
undetectable		 3ucbB-4x68A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1002_1
(HEMOLYTIC LECTIN
CEL-III)		 4x68 BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		3 / 3 ASP A 257
GLU A 212
GLY A 210
 None
 0.65A 3w9tA-4x68A:
undetectable		 3w9tA-4x68A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_A_MXMA606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4x68 BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 387
VAL A  56
LEU A 363
ALA A  41
LEU A  37
 None
 1.08A 4m11A-4x68A:
undetectable		 4m11A-4x68A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_B_MXMB606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4x68 BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		6 / 12 ILE A  58
VAL A  56
LEU A  54
LEU A 363
ALA A  41
LEU A  37
 None
 1.05A 4m11B-4x68A:
undetectable		 4m11B-4x68A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 4x68 BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 367
GLY A 350
SER A 345
GLY A  53
ASN A  49
 None
None
OP0  A 401 (-4.6A)
None
None
 1.10A 4obwA-4x68A:
undetectable		 4obwA-4x68A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_A_SAMA304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 4x68 BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		6 / 12 THR A 346
GLY A 348
GLY A 229
ILE A  88
LEU A 366
ALA A 351
 None
 1.41A 5l0zA-4x68A:
undetectable		 5l0zA-4x68A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 4x68 BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 135
LEU A 188
ALA A 115
SER A 125
TYR A 161
 None
 1.09A 5ljeA-4x68A:
undetectable		 5ljeA-4x68A:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4x68 BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  54
GLN A 311
ILE A 305
TYR A 301
LEU A 339
 None
 1.21A 5y2tB-4x68A:
undetectable		 5y2tB-4x68A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4x68 BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		5 / 9 ASP A 257
ALA A 351
ILE A  88
PHE A 261
SER A 254
 None
 1.18A 6awoA-4x68A:
undetectable		 6awoA-4x68A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4x68 BETA-LACTAMASE
(Pseudomonas
aeruginosa) 		5 / 9 ASP A 257
ALA A 351
ILE A  88
PHE A 261
SER A 254
 None
 1.18A 6awqA-4x68A:
undetectable		 6awqA-4x68A:
20.35