SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4x6d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB8_0
(GRAMICIDIN A)		 4x6d T-CELL SURFACE
GLYCOPROTEIN CD1A
(Homo
sapiens) 		3 / 3 VAL A  12
VAL A  98
TRP A  31
 None
 0.61A 1bdwA-4x6dA:
undetectable
1bdwB-4x6dA:
undetectable		 1bdwA-4x6dA:
3.75
1bdwB-4x6dA:
3.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		 4x6d T-CELL SURFACE
GLYCOPROTEIN CD1A
(Homo
sapiens) 		3 / 3 SER A  33
THR A  37
PHE A  70
 None
None
OLA  A 304 ( 4.4A)
 0.76A 2x91A-4x6dA:
undetectable		 2x91A-4x6dA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA304_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4x6d T-CELL SURFACE
GLYCOPROTEIN CD1A
(Homo
sapiens) 		3 / 3 ARG A 183
HIS A 180
TYR A 212
 None
 1.16A 4fu8A-4x6dA:
undetectable		 4fu8A-4x6dA:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA312_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4x6d T-CELL SURFACE
GLYCOPROTEIN CD1A
(Homo
sapiens) 		3 / 3 ARG A 183
HIS A 180
TYR A 212
 None
 1.28A 4fu9A-4x6dA:
undetectable		 4fu9A-4x6dA:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTQ_A_FLPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4x6d T-CELL SURFACE
GLYCOPROTEIN CD1A
(Homo
sapiens) 		5 / 10 TRP A  14
VAL A  28
ILE A  13
LEU A 162
LEU A 114
 OLA  A 304 ( 4.3A)
None
None
None
None
 1.29A 4jtqA-4x6dA:
undetectable		 4jtqA-4x6dA:
20.95