SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4x6g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4003_1
(SERUM ALBUMIN)		 4x6g OXYR
(Pseudomonas
aeruginosa) 		5 / 9 LEU A 105
VAL A  95
GLY A  96
ALA A 143
LEU A 289
 None
 1.12A 1e7bA-4x6gA:
undetectable		 1e7bA-4x6gA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4x6g OXYR
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 113
LEU A 122
ALA A 275
LEU A 160
ILE A 146
 None
 0.94A 2h42C-4x6gA:
undetectable		 2h42C-4x6gA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA270_0
(PROTEIN SSM1)		 4x6g OXYR
(Pseudomonas
aeruginosa) 		4 / 5 LEU A 227
SER A 241
LEU A 243
PRO A 244
 None
 1.13A 3onnA-4x6gA:
undetectable		 3onnA-4x6gA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1002_1
(HEMOLYTIC LECTIN
CEL-III)		 4x6g OXYR
(Pseudomonas
aeruginosa) 		3 / 3 ASP A 202
GLU A 196
GLY A 197
 None
 0.62A 3w9tA-4x6gA:
undetectable		 3w9tA-4x6gA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_C_EPAC502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 4x6g OXYR
(Pseudomonas
aeruginosa) 		4 / 8 LEU A 289
ILE A 145
ALA A  97
PHE A 106
 None
 0.98A 5m0oC-4x6gA:
undetectable		 5m0oC-4x6gA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_ACTA405_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4x6g OXYR
(Pseudomonas
aeruginosa) 		4 / 6 THR A 129
PRO A 149
GLN A 203
ILE A 146
 PEO  A 401 (-3.7A)
None
None
None
 1.43A 6ef6A-4x6gA:
undetectable		 6ef6A-4x6gA:
22.76