SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4x7m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WU8_C_ADNC502_1
(HYPOTHETICAL PROTEIN
PH0463)		 4x7m TARM
(Staphylococcus
aureus) 		4 / 7 PHE A 134
ARG A  95
HIS A  91
VAL A 151
 None
 1.35A 1wu8A-4x7mA:
2.8
1wu8C-4x7mA:
2.8		 1wu8A-4x7mA:
21.75
1wu8C-4x7mA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_B_BEZB12_0
(CES1 PROTEIN)		 4x7m TARM
(Staphylococcus
aureus) 		4 / 4 GLY A 356
SER A 325
VAL A 360
LEU A 379
 UDP  A 500 (-3.2A)
None
None
None
 1.35A 1yajB-4x7mA:
3.7		 1yajB-4x7mA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZT7_A_GLYA1300_0
(GLYCYL-TRNA
SYNTHETASE)		 4x7m TARM
(Staphylococcus
aureus) 		4 / 7 TYR A 122
ARG A 110
GLU A 104
SER A 105
 None
 1.24A 2zt7A-4x7mA:
3.3		 2zt7A-4x7mA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_2
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT
LIGHT CHAIN OF
ANTIBODY FAB
FRAGMENT)		 4x7m TARM
(Staphylococcus
aureus) 		4 / 5 TYR A 402
GLN A 401
ILE A 446
LEU A 335
 None
 1.21A 3ls4L-4x7mA:
undetectable		 3ls4L-4x7mA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_F_SAMF228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 4x7m TARM
(Staphylococcus
aureus) 		5 / 12 LYS A 331
GLY A 427
SER A 303
ALA A 285
GLN A 286
 UDP  A 500 (-3.0A)
None
None
None
None
 1.36A 3nmuA-4x7mA:
undetectable
3nmuF-4x7mA:
3.9		 3nmuA-4x7mA:
22.33
3nmuF-4x7mA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4x7m TARM
(Staphylococcus
aureus) 		4 / 8 ILE A 414
PHE A 431
GLN A 405
GLY A 406
 None
None
None
UDP  A 500 ( 3.8A)
 0.83A 4acbC-4x7mA:
6.9		 4acbC-4x7mA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4x7m TARM
(Staphylococcus
aureus) 		3 / 3 LEU A  88
ILE A  92
ARG A  95
 None
 0.58A 4mk4B-4x7mA:
3.1		 4mk4B-4x7mA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_2
(GLUCOCORTICOID
RECEPTOR)		 4x7m TARM
(Staphylococcus
aureus) 		3 / 3 MET A 327
MET A 409
TYR A 355
 None
 1.21A 4p6xI-4x7mA:
undetectable		 4p6xI-4x7mA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_A_SAMA1546_0
(CYSTATHIONINE
BETA-SYNTHASE)		 4x7m TARM
(Staphylococcus
aureus) 		5 / 11 ALA A 450
HIS A 444
THR A 399
ILE A 333
ASP A 334
 None
 1.18A 4uuuA-4x7mA:
undetectable
4uuuB-4x7mA:
undetectable		 4uuuA-4x7mA:
14.78
4uuuB-4x7mA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUC_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 4x7m TARM
(Staphylococcus
aureus) 		5 / 12 VAL A 457
GLY A 322
ILE A 354
ILE A 324
HIS A 353
 None
 1.20A 4xucA-4x7mA:
5.0		 4xucA-4x7mA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KLA_A_ACTA1505_0
(MATERNAL PROTEIN
PUMILIO)		 4x7m TARM
(Staphylococcus
aureus) 		3 / 3 HIS A 353
LYS A 351
PHE A 378
 None
 1.11A 5klaA-4x7mA:
undetectable		 5klaA-4x7mA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 4x7m TARM
(Staphylococcus
aureus) 		4 / 5 LEU A  54
LYS A  15
LEU A  11
GLU A  10
 None
 1.32A 5weaA-4x7mA:
4.8		 5weaA-4x7mA:
19.80