SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4x81'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXV_B_PNNB1001_0
(PENICILLIN ACYLASE)		 4x81 MYCINAMICIN III
3''-O-METHYLTRANSFER
ASE
(Micromonospora
griseorubida) 		4 / 7 PHE A 118
SER A 114
ALA A 195
PHE A 171
 SAH  A 301 (-4.5A)
SAH  A 301 (-3.2A)
SAH  A 301 ( 4.0A)
SAH  A 301 (-3.2A)
 0.99A 1fxvA-4x81A:
undetectable
1fxvB-4x81A:
undetectable		 1fxvA-4x81A:
21.15
1fxvB-4x81A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_C_ADNC2502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4x81 MYCINAMICIN III
3''-O-METHYLTRANSFER
ASE
(Micromonospora
griseorubida) 		3 / 3 GLU A  83
THR A  84
LEU A 183
 SAH  A 301 (-3.0A)
None
None
 0.60A 1v8bC-4x81A:
4.1		 1v8bC-4x81A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_1
(ADENOSYLHOMOCYSTEINA
SE)		 4x81 MYCINAMICIN III
3''-O-METHYLTRANSFER
ASE
(Micromonospora
griseorubida) 		5 / 12 LEU A 200
THR A  84
LEU A 183
LEU A 207
GLY A 211
 None
 1.29A 3g1uB-4x81A:
3.9		 3g1uB-4x81A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_2
(ENDOTHIAPEPSIN)		 4x81 MYCINAMICIN III
3''-O-METHYLTRANSFER
ASE
(Micromonospora
griseorubida) 		5 / 12 ASP A  48
ASP A 191
GLY A 190
GLY A 247
ASP A 189
 None
MVI  A 305 ( 2.7A)
SAH  A 301 ( 4.0A)
None
MG  A 304 (-2.5A)
 1.14A 3prsA-4x81A:
undetectable		 3prsA-4x81A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VKX_A_T3A301_1
(PROLIFERATING CELL
NUCLEAR ANTIGEN)		 4x81 MYCINAMICIN III
3''-O-METHYLTRANSFER
ASE
(Micromonospora
griseorubida) 		4 / 6 MET A 197
LEU A 200
PRO A 205
TYR A 204
 None
 1.28A 3vkxA-4x81A:
undetectable		 3vkxA-4x81A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD501_1
(HEMOLYTIC LECTIN
CEL-III)		 4x81 MYCINAMICIN III
3''-O-METHYLTRANSFER
ASE
(Micromonospora
griseorubida) 		4 / 5 ASP A 244
SER A  45
GLY A  46
ASP A 216
 None
None
None
MG  A 304 ( 2.9A)
 1.35A 3w9tD-4x81A:
undetectable		 3w9tD-4x81A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEM_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 4x81 MYCINAMICIN III
3''-O-METHYLTRANSFER
ASE
(Micromonospora
griseorubida) 		5 / 12 ASP A 244
ASP A 191
ILE A 220
ASP A 216
ARG A  61
 None
MVI  A 305 ( 2.7A)
MVI  A 305 ( 4.3A)
MG  A 304 ( 2.9A)
MVI  A 305 ( 4.3A)
 1.47A 3wemA-4x81A:
undetectable		 3wemA-4x81A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEN_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 4x81 MYCINAMICIN III
3''-O-METHYLTRANSFER
ASE
(Micromonospora
griseorubida) 		5 / 12 ASP A 244
ASP A 191
ILE A 220
ASP A 216
ARG A  61
 None
MVI  A 305 ( 2.7A)
MVI  A 305 ( 4.3A)
MG  A 304 ( 2.9A)
MVI  A 305 ( 4.3A)
 1.46A 3wenA-4x81A:
undetectable		 3wenA-4x81A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEO_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 4x81 MYCINAMICIN III
3''-O-METHYLTRANSFER
ASE
(Micromonospora
griseorubida) 		5 / 12 ASP A 244
ASP A 191
ILE A 220
ASP A 216
ARG A  61
 None
MVI  A 305 ( 2.7A)
MVI  A 305 ( 4.3A)
MG  A 304 ( 2.9A)
MVI  A 305 ( 4.3A)
 1.47A 3weoA-4x81A:
undetectable		 3weoA-4x81A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4x81 MYCINAMICIN III
3''-O-METHYLTRANSFER
ASE
(Micromonospora
griseorubida) 		4 / 7 TYR A 230
HIS A 234
ILE A 236
PRO A 205
 None
 1.15A 4g5jA-4x81A:
undetectable		 4g5jA-4x81A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_A_ACTA603_0
(CHOLINE OXIDASE)		 4x81 MYCINAMICIN III
3''-O-METHYLTRANSFER
ASE
(Micromonospora
griseorubida) 		3 / 3 ARG A 156
HIS A  54
SER A 155
 None
 1.02A 4mjwA-4x81A:
3.2
4mjwB-4x81A:
undetectable		 4mjwA-4x81A:
19.40
4mjwB-4x81A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_B_ACTB603_0
(CHOLINE OXIDASE)		 4x81 MYCINAMICIN III
3''-O-METHYLTRANSFER
ASE
(Micromonospora
griseorubida) 		3 / 3 SER A 155
ARG A 156
HIS A  54
 None
 1.02A 4mjwA-4x81A:
3.2
4mjwB-4x81A:
undetectable		 4mjwA-4x81A:
19.40
4mjwB-4x81A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTS_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 4x81 MYCINAMICIN III
3''-O-METHYLTRANSFER
ASE
(Micromonospora
griseorubida) 		5 / 12 GLY A 117
GLY A 190
ASP A 189
ILE A  57
ASP A 113
 SAH  A 301 (-3.0A)
SAH  A 301 ( 4.0A)
MG  A 304 (-2.5A)
SAH  A 301 (-4.3A)
SAH  A 301 (-2.7A)
 1.18A 4rtsA-4x81A:
7.3		 4rtsA-4x81A:
25.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CXV_A_0HKA501_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)		 4x81 MYCINAMICIN III
3''-O-METHYLTRANSFER
ASE
(Micromonospora
griseorubida) 		3 / 3 THR A 145
THR A 149
PHE A 154
 None
 0.92A 5cxvA-4x81A:
undetectable		 5cxvA-4x81A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW4_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 4x81 MYCINAMICIN III
3''-O-METHYLTRANSFER
ASE
(Micromonospora
griseorubida) 		5 / 9 THR A  84
GLY A  85
ALA A 112
GLY A 190
SER A 192
 None
SAH  A 301 (-3.3A)
None
SAH  A 301 ( 4.0A)
SAH  A 301 ( 4.9A)
 1.25A 5vw4A-4x81A:
2.5		 5vw4A-4x81A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4x81 MYCINAMICIN III
3''-O-METHYLTRANSFER
ASE
(Micromonospora
griseorubida) 		3 / 3 TYR A  49
LEU A 143
ASP A 113
 MVI  A 305 ( 4.3A)
SAH  A 301 (-4.4A)
SAH  A 301 (-2.7A)
 0.88A 5zv2B-4x81A:
undetectable		 5zv2B-4x81A:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_A_ZOLA401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4x81 MYCINAMICIN III
3''-O-METHYLTRANSFER
ASE
(Micromonospora
griseorubida) 		4 / 7 ASP A 216
ASP A 217
ARG A 187
GLN A 246
 MG  A 304 ( 2.9A)
MG  A 304 ( 2.6A)
None
MVI  A 305 (-3.3A)
 1.49A 6g31A-4x81A:
undetectable		 6g31A-4x81A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_B_ZOLB401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4x81 MYCINAMICIN III
3''-O-METHYLTRANSFER
ASE
(Micromonospora
griseorubida) 		4 / 6 ASP A 216
ASP A 217
ARG A 187
GLN A 246
 MG  A 304 ( 2.9A)
MG  A 304 ( 2.6A)
None
MVI  A 305 (-3.3A)
 1.46A 6g31B-4x81A:
undetectable		 6g31B-4x81A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_C_ZOLC401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4x81 MYCINAMICIN III
3''-O-METHYLTRANSFER
ASE
(Micromonospora
griseorubida) 		4 / 5 ASP A 216
ASP A 217
ARG A 187
GLN A 246
 MG  A 304 ( 2.9A)
MG  A 304 ( 2.6A)
None
MVI  A 305 (-3.3A)
 1.41A 6g31C-4x81A:
undetectable		 6g31C-4x81A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_K_ZOLK401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4x81 MYCINAMICIN III
3''-O-METHYLTRANSFER
ASE
(Micromonospora
griseorubida) 		4 / 4 ASP A 216
ASP A 217
ARG A 187
GLN A 246
 MG  A 304 ( 2.9A)
MG  A 304 ( 2.6A)
None
MVI  A 305 (-3.3A)
 1.34A 6g31K-4x81A:
undetectable		 6g31K-4x81A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_L_ZOLL401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 4x81 MYCINAMICIN III
3''-O-METHYLTRANSFER
ASE
(Micromonospora
griseorubida) 		4 / 6 ASP A 216
ASP A 217
ARG A 187
GLN A 246
 MG  A 304 ( 2.9A)
MG  A 304 ( 2.6A)
None
MVI  A 305 (-3.3A)
 1.38A 6g31L-4x81A:
undetectable		 6g31L-4x81A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_B_IXXB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 4x81 MYCINAMICIN III
3''-O-METHYLTRANSFER
ASE
(Micromonospora
griseorubida) 		4 / 5 ARG A  74
ALA A  72
GLN A  66
ILE A  98
 None
 1.41A 6g9bA-4x81A:
undetectable
6g9bB-4x81A:
undetectable		 6g9bA-4x81A:
13.31
6g9bB-4x81A:
14.29