SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4x84'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ESW_A_ACRA652_1
(AMYLOMALTASE)		 4x84 RIBOSE-5-PHOSPHATE
ISOMERASE A
(Pseudomonas
aeruginosa) 		4 / 6 GLY A  86
ASP A  85
GLY A  99
SER A  34
 FLC  A 300 ( 4.5A)
None
FLC  A 300 (-3.8A)
FLC  A 300 (-2.7A)
 0.99A 1eswA-4x84A:
undetectable		 1eswA-4x84A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQU_B_DR7B300_1
(HIV-1 PROTEASE)		 4x84 RIBOSE-5-PHOSPHATE
ISOMERASE A
(Pseudomonas
aeruginosa) 		5 / 10 GLY A 101
ALA A 102
GLY A 200
ILE A  97
ILE A 172
 FLC  A 300 (-3.3A)
None
None
None
None
 0.95A 2aquA-4x84A:
undetectable		 2aquA-4x84A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_1
(HIV-1 PROTEASE)		 4x84 RIBOSE-5-PHOSPHATE
ISOMERASE A
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 101
ALA A 102
GLY A 200
ILE A  97
ILE A 172
 FLC  A 300 (-3.3A)
None
None
None
None
 0.99A 2hs1A-4x84A:
undetectable		 2hs1A-4x84A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMY_A_ROCA401_2
(PROTEASE)		 4x84 RIBOSE-5-PHOSPHATE
ISOMERASE A
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 101
ALA A 102
GLY A 200
ILE A  97
ILE A 172
 FLC  A 300 (-3.3A)
None
None
None
None
 0.97A 2nmyB-4x84A:
undetectable		 2nmyB-4x84A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_A_DP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 4x84 RIBOSE-5-PHOSPHATE
ISOMERASE A
(Pseudomonas
aeruginosa) 		5 / 12 PHE A 117
PHE A 202
ALA A 103
SER A  57
TYR A  83
 None
 1.46A 3apwA-4x84A:
undetectable		 3apwA-4x84A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_1
(PROTEASE)		 4x84 RIBOSE-5-PHOSPHATE
ISOMERASE A
(Pseudomonas
aeruginosa) 		5 / 10 GLY A 101
ALA A 102
GLY A 200
ILE A  97
ILE A 172
 FLC  A 300 (-3.3A)
None
None
None
None
 0.99A 3ekyA-4x84A:
undetectable		 3ekyA-4x84A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL1_A_DR7A100_1
(PROTEASE)		 4x84 RIBOSE-5-PHOSPHATE
ISOMERASE A
(Pseudomonas
aeruginosa) 		5 / 11 GLY A 101
ALA A 102
GLY A 200
ILE A  97
ILE A 172
 FLC  A 300 (-3.3A)
None
None
None
None
 1.00A 3el1A-4x84A:
undetectable		 3el1A-4x84A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB303_0
(DISULFIDE
INTERCHANGE PROTEIN)		 4x84 RIBOSE-5-PHOSPHATE
ISOMERASE A
(Pseudomonas
aeruginosa) 		4 / 4 LEU A  43
ALA A  53
VAL A  71
PRO A  70
 None
 1.13A 3gv1B-4x84A:
undetectable		 3gv1B-4x84A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZS_A_017A200_2
(HIV-1 PROTEASE)		 4x84 RIBOSE-5-PHOSPHATE
ISOMERASE A
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 101
ALA A 102
GLY A 200
ILE A  97
ILE A 172
 FLC  A 300 (-3.3A)
None
None
None
None
 0.96A 3lzsB-4x84A:
undetectable		 3lzsB-4x84A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZU_A_017A200_1
(HIV-1 PROTEASE)		 4x84 RIBOSE-5-PHOSPHATE
ISOMERASE A
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 101
ALA A 102
GLY A 200
ILE A  97
ILE A 172
 FLC  A 300 (-3.3A)
None
None
None
None
 0.95A 3lzuA-4x84A:
undetectable		 3lzuA-4x84A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZS3_A_ACTA1224_0
(THAUMATIN-LIKE
PROTEIN)		 4x84 RIBOSE-5-PHOSPHATE
ISOMERASE A
(Pseudomonas
aeruginosa) 		4 / 5 SER A  57
GLU A 107
THR A  60
ASP A  85
 None
FLC  A 300 ( 4.1A)
None
None
 1.17A 3zs3A-4x84A:
undetectable		 3zs3A-4x84A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_A_RITA500_1
(PROTEASE)		 4x84 RIBOSE-5-PHOSPHATE
ISOMERASE A
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 101
ALA A 102
GLY A 200
ILE A  97
ILE A 172
 FLC  A 300 (-3.3A)
None
None
None
None
 1.05A 4njvA-4x84A:
undetectable		 4njvA-4x84A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_F_SAMF301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4x84 RIBOSE-5-PHOSPHATE
ISOMERASE A
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 200
GLY A  99
GLY A 100
ALA A 203
LEU A 130
 None
FLC  A 300 (-3.8A)
FLC  A 300 (-3.5A)
None
None
 0.77A 5c0oF-4x84A:
3.1		 5c0oF-4x84A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_B_010B607_0
(HNL ISOENZYME 5)		 4x84 RIBOSE-5-PHOSPHATE
ISOMERASE A
(Pseudomonas
aeruginosa) 		5 / 10 ALA A  44
ALA A  42
VAL A  15
LEU A  64
HIS A  46
 None
 1.46A 5eb5B-4x84A:
undetectable		 5eb5B-4x84A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIH_A_8CVA201_1
(DIHYDROFOLATE
REDUCTASE)		 4x84 RIBOSE-5-PHOSPHATE
ISOMERASE A
(Pseudomonas
aeruginosa) 		4 / 8 ILE A 118
ALA A 207
LEU A 221
ILE A 120
 None
 0.88A 5uihA-4x84A:
undetectable		 5uihA-4x84A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_1
(REGULATORY PROTEIN
TETR)		 4x84 RIBOSE-5-PHOSPHATE
ISOMERASE A
(Pseudomonas
aeruginosa) 		4 / 8 GLY A 200
ARG A 161
ASP A 174
ASP A  88
 None
None
None
FLC  A 300 (-2.8A)
 0.96A 5vlmB-4x84A:
undetectable		 5vlmB-4x84A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_1
(REGULATORY PROTEIN
TETR)		 4x84 RIBOSE-5-PHOSPHATE
ISOMERASE A
(Pseudomonas
aeruginosa) 		4 / 8 ILE A 172
ARG A 161
VAL A 175
ASP A  88
 None
None
None
FLC  A 300 (-2.8A)
 1.00A 5vlmF-4x84A:
undetectable		 5vlmF-4x84A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 4x84 RIBOSE-5-PHOSPHATE
ISOMERASE A
(Pseudomonas
aeruginosa) 		4 / 8 LEU A 173
VAL A 137
VAL A 139
ILE A 193
 None
 0.73A 5y9mX-4x84A:
undetectable		 5y9mX-4x84A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_1
(CYTOCHROME P450 1A1)		 4x84 RIBOSE-5-PHOSPHATE
ISOMERASE A
(Pseudomonas
aeruginosa) 		4 / 7 GLY A  52
ALA A  53
VAL A 110
LEU A  80
 None
 0.81A 6dwnB-4x84A:
undetectable		 6dwnB-4x84A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_0
(CYTOCHROME P450 1A1)		 4x84 RIBOSE-5-PHOSPHATE
ISOMERASE A
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 120
ASN A  37
GLY A  31
ILE A  18
LEU A  43
 None
 1.08A 6dwnC-4x84A:
undetectable		 6dwnC-4x84A:
18.61