SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4x8d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OM5_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4x8d SULFOXIDE SYNTHASE
EGTB
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 8 TRP A 359
TRP A 299
TRP A 361
GLU A 360
 None
None
None
CA  A 517 (-3.9A)
 1.20A 1om5A-4x8dA:
undetectable
1om5B-4x8dA:
undetectable		 1om5A-4x8dA:
19.80
1om5B-4x8dA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4x8d SULFOXIDE SYNTHASE
EGTB
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 8 TRP A 299
TRP A 361
GLU A 360
TRP A 359
 None
None
CA  A 517 (-3.9A)
None
 1.27A 1rs6A-4x8dA:
undetectable
1rs6B-4x8dA:
2.6		 1rs6A-4x8dA:
19.80
1rs6B-4x8dA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_B_SAMB1500_0
(ASPARTOKINASE)		 4x8d SULFOXIDE SYNTHASE
EGTB
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 7 SER A 110
ASP A 114
LEU A  61
GLU A  57
 None
 1.03A 2cdqB-4x8dA:
undetectable		 2cdqB-4x8dA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G6H_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4x8d SULFOXIDE SYNTHASE
EGTB
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 8 TRP A 359
TRP A 299
TRP A 361
GLU A 360
 None
None
None
CA  A 517 (-3.9A)
 1.20A 2g6hA-4x8dA:
undetectable
2g6hB-4x8dA:
undetectable		 2g6hA-4x8dA:
20.33
2g6hB-4x8dA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_2
(PROTEASE RETROPEPSIN)		 4x8d SULFOXIDE SYNTHASE
EGTB
(Mycolicibacteriu
m
thermoresistibil
e) 		3 / 3 ARG A 165
THR A 171
VAL A 168
 None
 0.77A 2q64A-4x8dA:
undetectable		 2q64A-4x8dA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1104_0
(FERROCHELATASE)		 4x8d SULFOXIDE SYNTHASE
EGTB
(Mycolicibacteriu
m
thermoresistibil
e) 		3 / 3 LEU A  93
PRO A  94
LEU A  79
 None
 0.41A 2qd5B-4x8dA:
undetectable		 2qd5B-4x8dA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_B_BEZB143_0
(PUTATIVE REDOX
PROTEIN)		 4x8d SULFOXIDE SYNTHASE
EGTB
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 6 THR A 125
ALA A 123
ARG A   9
PRO A   7
 None
 1.18A 2ql8A-4x8dA:
undetectable
2ql8B-4x8dA:
undetectable		 2ql8A-4x8dA:
13.86
2ql8B-4x8dA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_B_CTCB1385_0
(TETX2 PROTEIN)		 4x8d SULFOXIDE SYNTHASE
EGTB
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 8 GLN A 230
PHE A 222
GLY A 226
GLY A 290
 None
None
None
GOL  A 504 (-3.2A)
 0.92A 2y6rB-4x8dA:
undetectable		 2y6rB-4x8dA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B3P_B_H4BB760_1
(NITRIC-OXIDE
SYNTHASE)		 4x8d SULFOXIDE SYNTHASE
EGTB
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 8 TRP A 299
TRP A 361
GLU A 360
TRP A 359
 None
None
CA  A 517 (-3.9A)
None
 1.22A 3b3pA-4x8dA:
undetectable
3b3pB-4x8dA:
2.5		 3b3pA-4x8dA:
20.24
3b3pB-4x8dA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7P_A_SPMA501_1
(SPERMIDINE SYNTHASE)		 4x8d SULFOXIDE SYNTHASE
EGTB
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 TRP A 361
GLN A 422
ASP A  39
ASP A 416
ILE A 419
 None
None
None
3GC  A 501 (-2.8A)
CL  A 512 ( 4.1A)
 1.20A 3b7pA-4x8dA:
undetectable		 3b7pA-4x8dA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7P_B_SPMB502_1
(SPERMIDINE SYNTHASE)		 4x8d SULFOXIDE SYNTHASE
EGTB
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 TRP A 361
GLN A 422
ASP A  39
ASP A 416
ILE A 419
 None
None
None
3GC  A 501 (-2.8A)
CL  A 512 ( 4.1A)
 1.24A 3b7pB-4x8dA:
undetectable		 3b7pB-4x8dA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7P_C_SPMC503_1
(SPERMIDINE SYNTHASE)		 4x8d SULFOXIDE SYNTHASE
EGTB
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 TRP A 361
GLN A 422
ASP A  39
ASP A 416
ILE A 419
 None
None
None
3GC  A 501 (-2.8A)
CL  A 512 ( 4.1A)
 1.17A 3b7pC-4x8dA:
undetectable		 3b7pC-4x8dA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_D_H4BD3902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4x8d SULFOXIDE SYNTHASE
EGTB
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 8 TRP A 299
TRP A 361
GLU A 360
TRP A 359
 None
None
CA  A 517 (-3.9A)
None
 1.12A 3e7gC-4x8dA:
undetectable
3e7gD-4x8dA:
undetectable		 3e7gC-4x8dA:
21.44
3e7gD-4x8dA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4x8d SULFOXIDE SYNTHASE
EGTB
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 5 PRO A 336
VAL A 358
THR A 171
GLY A 170
 None
 1.02A 3elzB-4x8dA:
undetectable		 3elzB-4x8dA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLQ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4x8d SULFOXIDE SYNTHASE
EGTB
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 8 TRP A 359
TRP A 299
TRP A 361
GLU A 360
 None
None
None
CA  A 517 (-3.9A)
 1.15A 3nlqA-4x8dA:
undetectable
3nlqB-4x8dA:
undetectable		 3nlqA-4x8dA:
20.68
3nlqB-4x8dA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PEO_F_CU9F301_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4x8d SULFOXIDE SYNTHASE
EGTB
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 6 THR A 141
GLN A 137
GLN A 422
ILE A 423
 3GC  A 501 ( 4.6A)
AVI  A 502 (-3.1A)
None
None
 0.90A 3peoG-4x8dA:
undetectable		 3peoG-4x8dA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL6_A_NIMA614_1
(LACTOPEROXIDASE)		 4x8d SULFOXIDE SYNTHASE
EGTB
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 7 GLN A  55
HIS A 134
PHE A  83
PRO A 383
 CL  A 510 ( 4.6A)
MN  A 503 ( 3.3A)
None
None
 1.25A 3ql6A-4x8dA:
undetectable		 3ql6A-4x8dA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3C_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4x8d SULFOXIDE SYNTHASE
EGTB
(Mycolicibacteriu
m
thermoresistibil
e) 		3 / 3 HIS A  51
HIS A 134
HIS A 138
 MN  A 503 ( 3.5A)
MN  A 503 ( 3.3A)
MN  A 503 (-3.4A)
 0.79A 3s3cA-4x8dA:
undetectable		 3s3cA-4x8dA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TX2_A_BEZA251_0
(PROBABLE
6-PHOSPHOGLUCONOLACT
ONASE)		 4x8d SULFOXIDE SYNTHASE
EGTB
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 7 ALA A 286
TRP A 233
TRP A 288
ALA A 291
 None
None
None
GOL  A 504 ( 4.1A)
 1.44A 3tx2A-4x8dA:
undetectable		 3tx2A-4x8dA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_B_MIYB2001_1
(TETX2 PROTEIN)		 4x8d SULFOXIDE SYNTHASE
EGTB
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 8 GLN A 230
PHE A 222
GLY A 226
GLY A 290
 None
None
None
GOL  A 504 (-3.2A)
 0.96A 3v3nB-4x8dA:
undetectable		 3v3nB-4x8dA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_C_MIYC2001_1
(TETX2 PROTEIN)		 4x8d SULFOXIDE SYNTHASE
EGTB
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 8 GLN A 230
PHE A 222
GLY A 226
GLY A 290
 None
None
None
GOL  A 504 (-3.2A)
 0.97A 3v3nC-4x8dA:
undetectable		 3v3nC-4x8dA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4x8d SULFOXIDE SYNTHASE
EGTB
(Mycolicibacteriu
m
thermoresistibil
e) 		3 / 3 LEU A  93
PRO A  94
LEU A  79
 None
 0.45A 3w1wB-4x8dA:
undetectable		 3w1wB-4x8dA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_0
(METHYLTRANSFERASE
NSUN4)		 4x8d SULFOXIDE SYNTHASE
EGTB
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 GLY A 331
GLY A 330
LEU A 154
ASP A 139
LEU A  45
 CL  A 514 ( 4.2A)
None
None
None
None
 0.91A 4fp9A-4x8dA:
undetectable		 4fp9A-4x8dA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_0
(METHYLTRANSFERASE
NSUN4)		 4x8d SULFOXIDE SYNTHASE
EGTB
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 GLY A 331
GLY A 330
LEU A 154
ASP A 139
LEU A  45
 CL  A 514 ( 4.2A)
None
None
None
None
 0.90A 4fp9C-4x8dA:
undetectable		 4fp9C-4x8dA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_0
(METHYLTRANSFERASE
NSUN4)		 4x8d SULFOXIDE SYNTHASE
EGTB
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 GLY A 331
GLY A 330
LEU A 154
ASP A 139
LEU A  45
 CL  A 514 ( 4.2A)
None
None
None
None
 0.90A 4fp9F-4x8dA:
undetectable		 4fp9F-4x8dA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMA_D_ADND604_1
(PYRUVATE KINASE)		 4x8d SULFOXIDE SYNTHASE
EGTB
(Mycolicibacteriu
m
thermoresistibil
e) 		3 / 3 ARG A 259
GLU A 272
ASN A 216
 None
 0.88A 4imaD-4x8dA:
undetectable		 4imaD-4x8dA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCH_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4x8d SULFOXIDE SYNTHASE
EGTB
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 8 TRP A 299
TRP A 361
GLU A 360
TRP A 359
 None
None
CA  A 517 (-3.9A)
None
 1.19A 4uchA-4x8dA:
undetectable
4uchB-4x8dA:
undetectable		 4uchA-4x8dA:
21.54
4uchB-4x8dA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3W_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4x8d SULFOXIDE SYNTHASE
EGTB
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 7 TRP A 299
TRP A 361
GLU A 360
TRP A 359
 None
None
CA  A 517 (-3.9A)
None
 1.13A 4v3wA-4x8dA:
2.4
4v3wB-4x8dA:
undetectable		 4v3wA-4x8dA:
20.24
4v3wB-4x8dA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_F_TR6F101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 4x8d SULFOXIDE SYNTHASE
EGTB
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 5 GLY A 167
ARG A 211
GLY A 340
GLU A 352
 None
 1.26A 4z2eB-4x8dA:
2.6
4z2eC-4x8dA:
undetectable		 4z2eB-4x8dA:
21.48
4z2eC-4x8dA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_D_ACTD403_0
(PROTON-GATED ION
CHANNEL)		 4x8d SULFOXIDE SYNTHASE
EGTB
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 4 ILE A 223
ARG A 421
TYR A 228
GLU A 281
 None
 0.96A 4zzbD-4x8dA:
2.0		 4zzbD-4x8dA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_E_ACTE403_0
(PROTON-GATED ION
CHANNEL)		 4x8d SULFOXIDE SYNTHASE
EGTB
(Mycolicibacteriu
m
thermoresistibil
e) 		3 / 3 ARG A 421
TYR A 228
GLU A 281
 None
 0.42A 4zzbE-4x8dA:
2.1		 4zzbE-4x8dA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_E_ACTE406_0
(PROTON-GATED ION
CHANNEL)		 4x8d SULFOXIDE SYNTHASE
EGTB
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 5 ILE A 223
ARG A 421
TYR A 228
GLU A 281
 None
 0.89A 4zzcE-4x8dA:
undetectable		 4zzcE-4x8dA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD9_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4x8d SULFOXIDE SYNTHASE
EGTB
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 7 VAL A 427
TRP A 361
HIS A 276
GLU A 281
 None
 1.22A 5ad9A-4x8dA:
undetectable
5ad9B-4x8dA:
undetectable		 5ad9A-4x8dA:
20.24
5ad9B-4x8dA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6N_B_SALB504_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 4x8d SULFOXIDE SYNTHASE
EGTB
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 6 SER A 381
PHE A 412
GLN A 137
MET A 375
 None
None
AVI  A 502 (-3.1A)
None
 1.43A 5u6nB-4x8dA:
undetectable		 5u6nB-4x8dA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO9_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4x8d SULFOXIDE SYNTHASE
EGTB
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 7 TRP A 299
TRP A 361
GLU A 360
TRP A 359
 None
None
CA  A 517 (-3.9A)
None
 1.19A 5uo9A-4x8dA:
0.0
5uo9B-4x8dA:
0.0		 5uo9A-4x8dA:
22.77
5uo9B-4x8dA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV9_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4x8d SULFOXIDE SYNTHASE
EGTB
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 7 TRP A 359
TRP A 299
TRP A 361
GLU A 360
 None
None
None
CA  A 517 (-3.9A)
 1.12A 5vv9A-4x8dA:
undetectable
5vv9B-4x8dA:
2.5		 5vv9A-4x8dA:
22.89
5vv9B-4x8dA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVA_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4x8d SULFOXIDE SYNTHASE
EGTB
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 7 TRP A 359
TRP A 299
TRP A 361
GLU A 360
 None
None
None
CA  A 517 (-3.9A)
 1.10A 5vvaA-4x8dA:
undetectable
5vvaB-4x8dA:
undetectable		 5vvaA-4x8dA:
22.89
5vvaB-4x8dA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVD_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4x8d SULFOXIDE SYNTHASE
EGTB
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 7 TRP A 299
TRP A 361
GLU A 360
TRP A 359
 None
None
CA  A 517 (-3.9A)
None
 1.11A 5vvdA-4x8dA:
undetectable
5vvdB-4x8dA:
undetectable		 5vvdA-4x8dA:
22.77
5vvdB-4x8dA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4x8d SULFOXIDE SYNTHASE
EGTB
(Mycolicibacteriu
m
thermoresistibil
e) 		3 / 3 HIS A  51
HIS A 134
HIS A 138
 MN  A 503 ( 3.5A)
MN  A 503 ( 3.3A)
MN  A 503 (-3.4A)
 0.71A 5x19N-4x8dA:
undetectable		 5x19N-4x8dA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4x8d SULFOXIDE SYNTHASE
EGTB
(Mycolicibacteriu
m
thermoresistibil
e) 		3 / 3 HIS A  51
HIS A 134
HIS A 138
 MN  A 503 ( 3.5A)
MN  A 503 ( 3.3A)
MN  A 503 (-3.4A)
 0.70A 5x1bN-4x8dA:
undetectable		 5x1bN-4x8dA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4x8d SULFOXIDE SYNTHASE
EGTB
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 7 TRP A 359
TRP A 299
TRP A 361
GLU A 360
 None
None
None
CA  A 517 (-3.9A)
 1.11A 6auuA-4x8dA:
2.8
6auuB-4x8dA:
undetectable		 6auuA-4x8dA:
9.93
6auuB-4x8dA:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_B_H4BB503_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4x8d SULFOXIDE SYNTHASE
EGTB
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 7 TRP A 299
TRP A 361
GLU A 360
TRP A 359
 None
None
CA  A 517 (-3.9A)
None
 1.12A 6av6A-4x8dA:
undetectable
6av6B-4x8dA:
0.0		 6av6A-4x8dA:
10.88
6av6B-4x8dA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIE_B_H4BB502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4x8d SULFOXIDE SYNTHASE
EGTB
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 7 TRP A 299
TRP A 361
GLU A 360
TRP A 359
 None
None
CA  A 517 (-3.9A)
None
 1.09A 6cieA-4x8dA:
0.0
6cieB-4x8dA:
0.0		 6cieA-4x8dA:
10.88
6cieB-4x8dA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 4x8d SULFOXIDE SYNTHASE
EGTB
(Mycolicibacteriu
m
thermoresistibil
e) 		3 / 3 HIS A  51
HIS A 134
HIS A 138
 MN  A 503 ( 3.5A)
MN  A 503 ( 3.3A)
MN  A 503 (-3.4A)
 0.62A 6giqa-4x8dA:
2.5		 6giqa-4x8dA:
21.90