SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4x8i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_1
(ADENOSINE DEAMINASE)		 4x8i LYSYL AMINOPEPTIDASE
(Pyrococcus
furiosus) 		5 / 12 HIS A 314
PHE A 233
GLU A 207
HIS A  63
ASP A 177
 CO  A 402 (-3.5A)
None
CL  A 403 ( 2.8A)
ZN  A 401 (-3.3A)
ZN  A 401 ( 2.6A)
 1.32A 1a4lA-4x8iA:
undetectable		 1a4lA-4x8iA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_1
(ADENOSINE DEAMINASE)		 4x8i LYSYL AMINOPEPTIDASE
(Pyrococcus
furiosus) 		5 / 12 HIS A 314
PHE A 233
GLU A 207
HIS A  63
ASP A 177
 CO  A 402 (-3.5A)
None
CL  A 403 ( 2.8A)
ZN  A 401 (-3.3A)
ZN  A 401 ( 2.6A)
 1.30A 1a4lB-4x8iA:
undetectable		 1a4lB-4x8iA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_1
(ADENOSINE DEAMINASE)		 4x8i LYSYL AMINOPEPTIDASE
(Pyrococcus
furiosus) 		5 / 12 HIS A 314
PHE A 233
GLU A 207
HIS A  63
ASP A 177
 CO  A 402 (-3.5A)
None
CL  A 403 ( 2.8A)
ZN  A 401 (-3.3A)
ZN  A 401 ( 2.6A)
 1.28A 1a4lC-4x8iA:
undetectable		 1a4lC-4x8iA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		 4x8i LYSYL AMINOPEPTIDASE
(Pyrococcus
furiosus) 		5 / 12 HIS A 314
PHE A 233
GLU A 207
HIS A  63
ASP A 177
 CO  A 402 (-3.5A)
None
CL  A 403 ( 2.8A)
ZN  A 401 (-3.3A)
ZN  A 401 ( 2.6A)
 1.31A 1a4lD-4x8iA:
undetectable		 1a4lD-4x8iA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_B_DAHB208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 4x8i LYSYL AMINOPEPTIDASE
(Pyrococcus
furiosus) 		5 / 12 HIS A 314
GLU A 207
ARG A 212
ILE A  67
GLU A 208
 CO  A 402 (-3.5A)
CL  A 403 ( 2.8A)
None
None
CO  A 402 (-1.8A)
 1.32A 1rnrB-4x8iA:
undetectable		 1rnrB-4x8iA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_B_DAHB208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 4x8i LYSYL AMINOPEPTIDASE
(Pyrococcus
furiosus) 		5 / 12 HIS A 314
LEU A 211
GLU A 207
ILE A  67
GLU A 208
 CO  A 402 (-3.5A)
None
CL  A 403 ( 2.8A)
None
CO  A 402 (-1.8A)
 1.33A 1rnrB-4x8iA:
undetectable		 1rnrB-4x8iA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_B_SAMB2501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 4x8i LYSYL AMINOPEPTIDASE
(Pyrococcus
furiosus) 		4 / 7 THR A 289
THR A 287
SER A 283
VAL A 280
 None
 1.23A 1tv8B-4x8iA:
undetectable		 1tv8B-4x8iA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4x8i LYSYL AMINOPEPTIDASE
(Pyrococcus
furiosus) 		5 / 12 VAL A 231
ASP A 230
SER A 204
GLY A  68
ILE A 156
 None
ZN  A 401 ( 1.8A)
None
None
None
 1.34A 1xvaA-4x8iA:
undetectable		 1xvaA-4x8iA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_A_NCAA506_0
(NAD-DEPENDENT
DEACETYLASE 2)		 4x8i LYSYL AMINOPEPTIDASE
(Pyrococcus
furiosus) 		4 / 6 ALA A 214
ASN A  46
ILE A  48
ASP A  42
 None
 0.97A 1yc2A-4x8iA:
undetectable		 1yc2A-4x8iA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_D_NCAD510_0
(NAD-DEPENDENT
DEACETYLASE 2)		 4x8i LYSYL AMINOPEPTIDASE
(Pyrococcus
furiosus) 		4 / 5 ALA A 214
ASN A  46
ILE A  48
ASP A  42
 None
 0.88A 1yc2D-4x8iA:
undetectable		 1yc2D-4x8iA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC5_A_NCAA2001_0
(NAD-DEPENDENT
DEACETYLASE)		 4x8i LYSYL AMINOPEPTIDASE
(Pyrococcus
furiosus) 		4 / 7 ALA A 214
ASN A  46
ILE A  48
ASP A  42
 None
 0.99A 1yc5A-4x8iA:
undetectable		 1yc5A-4x8iA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H4J_A_NCAA1002_0
(NAD-DEPENDENT
DEACETYLASE)		 4x8i LYSYL AMINOPEPTIDASE
(Pyrococcus
furiosus) 		4 / 5 ALA A 214
ASN A  46
ILE A  48
ASP A  42
 None
 1.06A 2h4jA-4x8iA:
undetectable		 2h4jA-4x8iA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_2
(CYTOCHROME P450 2R1)		 4x8i LYSYL AMINOPEPTIDASE
(Pyrococcus
furiosus) 		3 / 3 MET A 342
VAL A 225
GLU A 196
 None
 0.91A 3c6gA-4x8iA:
undetectable		 3c6gA-4x8iA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_A_ADNA300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 4x8i LYSYL AMINOPEPTIDASE
(Pyrococcus
furiosus) 		5 / 11 SER A 167
LEU A 166
LEU A 319
THR A 173
ALA A 172
 None
 1.15A 3kw2A-4x8iA:
undetectable		 3kw2A-4x8iA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_B_ADNB300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 4x8i LYSYL AMINOPEPTIDASE
(Pyrococcus
furiosus) 		5 / 11 SER A 167
LEU A 166
LEU A 319
THR A 173
ALA A 172
 None
 1.12A 3kw2B-4x8iA:
undetectable		 3kw2B-4x8iA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_2
(FIV PROTEASE)		 4x8i LYSYL AMINOPEPTIDASE
(Pyrococcus
furiosus) 		5 / 10 ILE A 134
VAL A 136
GLY A 157
ILE A 156
LEU A  80
 None
 1.13A 3ogpB-4x8iA:
undetectable		 3ogpB-4x8iA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		 4x8i LYSYL AMINOPEPTIDASE
(Pyrococcus
furiosus) 		4 / 5 LEU A 247
ILE A 180
ALA A 322
PHE A 171
 None
 0.98A 4dc3B-4x8iA:
undetectable		 4dc3B-4x8iA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_1
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 4x8i LYSYL AMINOPEPTIDASE
(Pyrococcus
furiosus) 		3 / 3 GLU A 187
ASP A   3
ASP A 326
 None
 0.69A 4gc9A-4x8iA:
undetectable		 4gc9A-4x8iA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVR_A_SALA203_1
(3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE)		 4x8i LYSYL AMINOPEPTIDASE
(Pyrococcus
furiosus) 		4 / 7 ASP A 177
GLU A 208
HIS A 314
GLU A 207
 ZN  A 401 ( 2.6A)
CO  A 402 (-1.8A)
CO  A 402 (-3.5A)
CL  A 403 ( 2.8A)
 0.92A 4hvrA-4x8iA:
undetectable		 4hvrA-4x8iA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PQA_A_X8ZA401_1
(SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE)		 4x8i LYSYL AMINOPEPTIDASE
(Pyrococcus
furiosus) 		5 / 11 HIS A  63
ASP A 177
GLU A 207
GLU A 208
HIS A 314
 ZN  A 401 (-3.3A)
ZN  A 401 ( 2.6A)
CL  A 403 ( 2.8A)
CO  A 402 (-1.8A)
CO  A 402 (-3.5A)
 0.51A 4pqaA-4x8iA:
23.1		 4pqaA-4x8iA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGW_A_CTYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4x8i LYSYL AMINOPEPTIDASE
(Pyrococcus
furiosus) 		5 / 12 ILE A  67
GLY A  68
ASP A 230
ARG A 179
SER A 204
 None
None
ZN  A 401 ( 1.8A)
None
None
 1.39A 5igwA-4x8iA:
undetectable		 5igwA-4x8iA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ITZ_B_LOCB502_1
(TUBULIN BETA-2B
CHAIN)		 4x8i LYSYL AMINOPEPTIDASE
(Pyrococcus
furiosus) 		5 / 12 LEU A 278
ALA A 271
LEU A 335
ALA A 304
ILE A 227
 None
 1.10A 5itzB-4x8iA:
3.7		 5itzB-4x8iA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA612_1
(SERUM ALBUMIN)		 4x8i LYSYL AMINOPEPTIDASE
(Pyrococcus
furiosus) 		5 / 12 GLU A 269
LEU A 306
LEU A 335
ILE A 276
ALA A 271
 None
 1.14A 5v0vA-4x8iA:
undetectable		 5v0vA-4x8iA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA605_0
(ALPHA-AMYLASE)		 4x8i LYSYL AMINOPEPTIDASE
(Pyrococcus
furiosus) 		4 / 8 GLY A 210
ILE A 209
ASP A 290
HIS A  63
 None
None
None
ZN  A 401 (-3.3A)
 0.83A 6ag0A-4x8iA:
undetectable		 6ag0A-4x8iA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC605_0
(ALPHA-AMYLASE)		 4x8i LYSYL AMINOPEPTIDASE
(Pyrococcus
furiosus) 		4 / 8 GLY A 210
ILE A 209
ASP A 290
HIS A  63
 None
None
None
ZN  A 401 (-3.3A)
 0.90A 6ag0C-4x8iA:
undetectable		 6ag0C-4x8iA:
13.33