SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4x8j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3G1U_B_ADNB438_2 (ADENOSYLHOMOCYSTEINA SE)	4x8j	12F4 FAB HEAVY CHAIN (Mus musculus)	3 / 3	THR H 112 GLU H 150 HIS H 201	None	0.76A	3g1uB-4x8jH: undetectable	3g1uB-4x8jH: 19.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3QXT_B_MTXB2000_1 (ANTI-METHOTREXATE CDR1-3 GRAFT VHH)	4x8j	12F4 FAB HEAVY CHAIN (Mus musculus)	6 / 12	VAL H 2 LEU H 4 MET H 34 ARG H 74 VAL H 81 TYR H 104	None None None None None 2PE H 302 ( 4.6A)	0.65A	3qxtB-4x8jH: 15.8	3qxtB-4x8jH: 34.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3QXV_B_MTXB2000_1 (ANTI-METHOTREXATE CDR1-4 GRAFT VHH)	4x8j	12F4 FAB HEAVY CHAIN (Mus musculus)	5 / 12	VAL H 2 MET H 34 ARG H 74 VAL H 81 TYR H 104	None None None None 2PE H 302 ( 4.6A)	0.83A	3qxvB-4x8jH: 15.4	3qxvB-4x8jH: 33.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3QXV_D_MTXD2000_1 (ANTI-METHOTREXATE CDR1-4 GRAFT VHH)	4x8j	12F4 FAB HEAVY CHAIN (Mus musculus)	5 / 12	VAL H 2 MET H 34 ARG H 74 VAL H 81 TYR H 104	None None None None 2PE H 302 ( 4.6A)	0.67A	3qxvD-4x8jH: 15.5	3qxvD-4x8jH: 33.82

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3G1U_B_ADNB438_2","ADENOSYLHOMOCYSTEINASE","4x8j","12F4 FAB HEAVY CHAIN","Mus musculus",3,"THR H 112;GLU H 150;HIS H 201","None","0.76A","3g1uB-4x8jH:undetectable","3g1uB-4x8jH:19.40"],["3QXT_B_MTXB2000_1","ANTI-METHOTREXATE CDR1-3 GRAFT VHH","4x8j","12F4 FAB HEAVY CHAIN","Mus musculus",6,"VAL H   2;LEU H   4;MET H  34;ARG H  74;VAL H  81;TYR H 104","None;None;None;None;None;2PE H 302 ( 4.6A)","0.65A","3qxtB-4x8jH:15.8","3qxtB-4x8jH:34.78"],["3QXV_B_MTXB2000_1","ANTI-METHOTREXATE CDR1-4 GRAFT VHH","4x8j","12F4 FAB HEAVY CHAIN","Mus musculus",5,"VAL H   2;MET H  34;ARG H  74;VAL H  81;TYR H 104","None;None;None;None;2PE H 302 ( 4.6A)","0.83A","3qxvB-4x8jH:15.4","3qxvB-4x8jH:33.82"],["3QXV_D_MTXD2000_1","ANTI-METHOTREXATE CDR1-4 GRAFT VHH","4x8j","12F4 FAB HEAVY CHAIN","Mus musculus",5,"VAL H   2;MET H  34;ARG H  74;VAL H  81;TYR H 104","None;None;None;None;2PE H 302 ( 4.6A)","0.67A","3qxvD-4x8jH:15.5","3qxvD-4x8jH:33.82"]]