SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4x8k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_A_NCAA700_0
(EXOTOXIN A)		 4x8k RNA POLYMERASE SIGMA
FACTOR SIGA
(Mycobacterium
tuberculosis) 		4 / 7 GLY A 256
ALA A 259
TYR A 258
GLU A 265
 None
 0.92A 1dmaA-4x8kA:
undetectable		 1dmaA-4x8kA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)		 4x8k RNA
POLYMERASE-BINDING
PROTEIN RBPA
(Mycobacterium
tuberculosis) 		4 / 6 LEU B 102
LEU B  98
ILE B 105
ARG B 101
 None
None
None
EDO  A 403 (-3.5A)
 0.97A 2rlfC-4x8kB:
undetectable
2rlfD-4x8kB:
undetectable		 2rlfC-4x8kB:
21.92
2rlfD-4x8kB:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)		 4x8k RNA POLYMERASE SIGMA
FACTOR SIGA
RNA
POLYMERASE-BINDING
PROTEIN RBPA
(Mycobacterium
tuberculosis) 		4 / 8 TYR A 337
TYR A 341
TYR A 346
LEU B  85
 None
 0.82A 2w98B-4x8kA:
undetectable		 2w98B-4x8kA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_A_KKKA413_1
(FLAVOHEMOGLOBIN)		 4x8k RNA POLYMERASE SIGMA
FACTOR SIGA
(Mycobacterium
tuberculosis) 		4 / 8 ILE A 351
GLN A 322
ALA A 307
LEU A 306
 None
 0.79A 3ozwA-4x8kA:
undetectable		 3ozwA-4x8kA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_A_NCAA1536_0
(DIPHTHERIA TOXIN)		 4x8k RNA POLYMERASE SIGMA
FACTOR SIGA
(Mycobacterium
tuberculosis) 		4 / 6 GLY A 256
ALA A 259
TYR A 258
GLU A 265
 None
 0.94A 4ae1A-4x8kA:
undetectable		 4ae1A-4x8kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_E_DVAE7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 4x8k RNA POLYMERASE SIGMA
FACTOR SIGA
RNA
POLYMERASE-BINDING
PROTEIN RBPA
(Mycobacterium
tuberculosis;
Mycobacterium
tuberculosis) 		3 / 3 TYR A 258
SER B  90
TRP B  82
 None
 1.08A 5n8jB-4x8kA:
undetectable		 5n8jB-4x8kA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_P_DVAP5_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 4x8k RNA POLYMERASE SIGMA
FACTOR SIGA
RNA
POLYMERASE-BINDING
PROTEIN RBPA
(Mycobacterium
tuberculosis;
Mycobacterium
tuberculosis) 		3 / 3 TYR A 258
SER B  90
TRP B  82
 None
 1.04A 5n8jD-4x8kA:
undetectable		 5n8jD-4x8kA:
20.11