SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4x8n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_A_SAMA302_0
(HYPOTHETICAL PROTEIN
PH0226)		 4x8n SET1/ASH2 HISTONE
METHYLTRANSFERASE
COMPLEX SUBUNIT ASH2
(Homo
sapiens) 		5 / 12 TYR A 364
GLY A 345
SER A 473
ALA A 318
ILE A 396
 None
 1.05A 1ve3A-4x8nA:
undetectable		 1ve3A-4x8nA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_B_SAMB301_0
(HYPOTHETICAL PROTEIN
PH0226)		 4x8n SET1/ASH2 HISTONE
METHYLTRANSFERASE
COMPLEX SUBUNIT ASH2
(Homo
sapiens) 		5 / 12 TYR A 364
GLY A 345
SER A 473
ALA A 318
ILE A 396
 None
 1.06A 1ve3B-4x8nA:
undetectable		 1ve3B-4x8nA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_B_TYLB2198_1
(CREB-BINDING PROTEIN)		 4x8n SET1/ASH2 HISTONE
METHYLTRANSFERASE
COMPLEX SUBUNIT ASH2
(Homo
sapiens) 		4 / 5 VAL A 316
LEU A 298
ILE A 300
VAL A 480
 None
 0.96A 4a9kB-4x8nA:
undetectable		 4a9kB-4x8nA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 4x8n SET1/ASH2 HISTONE
METHYLTRANSFERASE
COMPLEX SUBUNIT ASH2
(Homo
sapiens) 		4 / 8 ASP A 360
SER A 363
ALA A 355
TYR A 359
 None
 1.15A 4lv9A-4x8nA:
undetectable
4lv9B-4x8nA:
undetectable		 4lv9A-4x8nA:
19.07
4lv9B-4x8nA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4x8n SET1/ASH2 HISTONE
METHYLTRANSFERASE
COMPLEX SUBUNIT ASH2
(Homo
sapiens) 		5 / 12 TYR A 386
GLY A 371
LEU A 357
PHE A 394
THR A 372
 None
 1.33A 4ze1A-4x8nA:
undetectable		 4ze1A-4x8nA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 4x8n SET1/ASH2 HISTONE
METHYLTRANSFERASE
COMPLEX SUBUNIT ASH2
(Homo
sapiens) 		4 / 6 PRO A 470
HIS A 292
ILE A 300
VAL A 307
 None
 0.97A 4zj8A-4x8nA:
undetectable		 4zj8A-4x8nA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_A_SALA301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 4x8n SET1/ASH2 HISTONE
METHYLTRANSFERASE
COMPLEX SUBUNIT ASH2
(Homo
sapiens) 		4 / 5 ALA A 318
VAL A 316
PHE A 484
ILE A 300
 None
 0.80A 5of1A-4x8nA:
undetectable		 5of1A-4x8nA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_B_SALB301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 4x8n SET1/ASH2 HISTONE
METHYLTRANSFERASE
COMPLEX SUBUNIT ASH2
(Homo
sapiens) 		4 / 5 ALA A 318
VAL A 316
PHE A 484
ILE A 300
 None
 0.85A 5of1B-4x8nA:
2.2		 5of1B-4x8nA:
22.42