SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4x8q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_P_CHDP1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4x8q UNCHARACTERIZED
PROTEIN
(Streptococcus
mutans) 		4 / 5 PHE A  97
PHE A  94
LEU A 129
PHE A 138
 None
 1.35A 2y69P-4x8qA:
undetectable
2y69W-4x8qA:
undetectable		 2y69P-4x8qA:
18.15
2y69W-4x8qA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4x8q UNCHARACTERIZED
PROTEIN
(Streptococcus
mutans) 		4 / 5 PHE A  97
PHE A  94
LEU A 129
PHE A 138
 None
 1.37A 3abmP-4x8qA:
undetectable
3abmW-4x8qA:
undetectable		 3abmP-4x8qA:
18.15
3abmW-4x8qA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R55_A_PZAA598_0
(LACTOPEROXIDASE)		 4x8q UNCHARACTERIZED
PROTEIN
(Streptococcus
mutans) 		3 / 3 GLU A  77
PHE A  73
GLN A  47
 None
 1.01A 3r55A-4x8qA:
undetectable		 3r55A-4x8qA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4x8q UNCHARACTERIZED
PROTEIN
(Streptococcus
mutans) 		4 / 8 SER A 163
ARG A 123
GLU A 158
ASN A 166
 None
 1.08A 4d33A-4x8qA:
undetectable		 4d33A-4x8qA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4x8q UNCHARACTERIZED
PROTEIN
(Streptococcus
mutans) 		4 / 8 SER A 163
ARG A 123
GLU A 158
ASN A 166
 None
 1.05A 4d39A-4x8qA:
undetectable		 4d39A-4x8qA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_2
(ADENOSINE KINASE)		 4x8q UNCHARACTERIZED
PROTEIN
(Streptococcus
mutans) 		4 / 4 LEU A 152
SER A 163
LEU A 119
LEU A 114
 None
 1.12A 4n09A-4x8qA:
undetectable		 4n09A-4x8qA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA617_0
(SERUM ALBUMIN)		 4x8q UNCHARACTERIZED
PROTEIN
(Streptococcus
mutans) 		3 / 3 TRP A 132
ARG A 148
LEU A 152
 None
 0.85A 5dbyA-4x8qA:
undetectable		 5dbyA-4x8qA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A211_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 4x8q UNCHARACTERIZED
PROTEIN
(Streptococcus
mutans) 		4 / 6 VAL A  89
LYS A  92
ALA A  93
VAL A  58
 None
NA  A 303 ( 4.0A)
None
None
 1.06A 5i8fA-4x8qA:
undetectable		 5i8fA-4x8qA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4x8q UNCHARACTERIZED
PROTEIN
(Streptococcus
mutans) 		4 / 5 PHE A  97
PHE A  94
LEU A 129
PHE A 138
 None
 1.30A 5xdqC-4x8qA:
undetectable
5xdqJ-4x8qA:
undetectable		 5xdqC-4x8qA:
18.15
5xdqJ-4x8qA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4x8q UNCHARACTERIZED
PROTEIN
(Streptococcus
mutans) 		4 / 5 PHE A  97
PHE A  94
LEU A 129
PHE A 138
 None
 1.33A 5xdqP-4x8qA:
undetectable
5xdqW-4x8qA:
undetectable		 5xdqP-4x8qA:
18.15
5xdqW-4x8qA:
13.21